JPS60184025A - 多糖類，その単離法及び用途 - Google Patents
多糖類，その単離法及び用途Info
- Publication number
- JPS60184025A JPS60184025A JP59040745A JP4074584A JPS60184025A JP S60184025 A JPS60184025 A JP S60184025A JP 59040745 A JP59040745 A JP 59040745A JP 4074584 A JP4074584 A JP 4074584A JP S60184025 A JPS60184025 A JP S60184025A
- Authority
- JP
- Japan
- Prior art keywords
- ganoderan
- nakahiro
- water
- ganoderma
- molecular weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000004676 glycans Chemical class 0.000 title claims abstract description 14
- 229920001282 polysaccharide Polymers 0.000 title claims abstract description 14
- 239000005017 polysaccharide Substances 0.000 title claims abstract description 14
- 238000000926 separation method Methods 0.000 title description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 25
- BFSVOASYOCHEOV-UHFFFAOYSA-N 2-diethylaminoethanol Chemical compound CCN(CC)CCO BFSVOASYOCHEOV-UHFFFAOYSA-N 0.000 claims abstract description 17
- 238000010828 elution Methods 0.000 claims abstract description 16
- 238000004587 chromatography analysis Methods 0.000 claims abstract description 15
- 239000000203 mixture Substances 0.000 claims abstract description 14
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims abstract description 11
- 239000008103 glucose Substances 0.000 claims abstract description 11
- 240000008397 Ganoderma lucidum Species 0.000 claims abstract description 10
- 235000001637 Ganoderma lucidum Nutrition 0.000 claims abstract description 10
- 238000000921 elemental analysis Methods 0.000 claims abstract description 10
- 238000000862 absorption spectrum Methods 0.000 claims abstract description 9
- 239000003365 glass fiber Substances 0.000 claims abstract description 9
- 238000000655 nuclear magnetic resonance spectrum Methods 0.000 claims abstract description 9
- 239000003472 antidiabetic agent Substances 0.000 claims abstract description 7
- 229940126904 hypoglycaemic agent Drugs 0.000 claims abstract description 7
- 239000000243 solution Substances 0.000 claims description 22
- 238000000034 method Methods 0.000 claims description 15
- 238000000502 dialysis Methods 0.000 claims description 14
- 241000222336 Ganoderma Species 0.000 claims description 13
- 239000003960 organic solvent Substances 0.000 claims description 12
- 238000002523 gelfiltration Methods 0.000 claims description 9
- 230000002218 hypoglycaemic effect Effects 0.000 claims description 8
- 238000005194 fractionation Methods 0.000 claims description 7
- 239000000126 substance Substances 0.000 claims description 7
- 239000002244 precipitate Substances 0.000 claims description 6
- 238000002955 isolation Methods 0.000 claims description 5
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 4
- 230000003287 optical effect Effects 0.000 claims description 4
- 238000000108 ultra-filtration Methods 0.000 claims description 4
- 239000004480 active ingredient Substances 0.000 claims description 3
- 239000007864 aqueous solution Substances 0.000 claims description 3
- DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 claims 1
- AMGNHZVUZWILSB-UHFFFAOYSA-N 1,2-bis(2-chloroethylsulfanyl)ethane Chemical compound ClCCSCCSCCCl AMGNHZVUZWILSB-UHFFFAOYSA-N 0.000 claims 1
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 claims 1
- 241001480597 Ganoderma tsugae Species 0.000 claims 1
- 208000013016 Hypoglycemia Diseases 0.000 claims 1
- 238000003287 bathing Methods 0.000 claims 1
- 101150084411 crn1 gene Proteins 0.000 claims 1
- 239000011152 fibreglass Substances 0.000 claims 1
- 239000003456 ion exchange resin Substances 0.000 claims 1
- 229920003303 ion-exchange polymer Polymers 0.000 claims 1
- 239000000463 material Substances 0.000 abstract description 3
- 238000001962 electrophoresis Methods 0.000 abstract description 2
- 238000002360 preparation method Methods 0.000 abstract description 2
- 241000123326 Fomes Species 0.000 abstract 2
- 241000233866 Fungi Species 0.000 abstract 1
- 235000013399 edible fruits Nutrition 0.000 abstract 1
- 235000013311 vegetables Nutrition 0.000 abstract 1
- 239000000843 powder Substances 0.000 description 10
- 239000007788 liquid Substances 0.000 description 9
- 239000000284 extract Substances 0.000 description 8
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
- 238000000605 extraction Methods 0.000 description 6
- 235000001674 Agaricus brunnescens Nutrition 0.000 description 5
- 239000012506 Sephacryl® Substances 0.000 description 5
- 239000012141 concentrate Substances 0.000 description 5
- 235000008504 concentrate Nutrition 0.000 description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 239000000546 pharmaceutical excipient Substances 0.000 description 4
- 241000196324 Embryophyta Species 0.000 description 3
- 229920005654 Sephadex Polymers 0.000 description 3
- 239000012507 Sephadex™ Substances 0.000 description 3
- 229920002684 Sepharose Polymers 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 239000000872 buffer Substances 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- 239000011780 sodium chloride Substances 0.000 description 3
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 238000002835 absorbance Methods 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 235000013402 health food Nutrition 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- -1 methanol and ethanol Chemical class 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 1
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 1
- 229920000936 Agarose Polymers 0.000 description 1
- 235000018185 Betula X alpestris Nutrition 0.000 description 1
- 235000018212 Betula X uliginosa Nutrition 0.000 description 1
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 description 1
- 206010006458 Bronchitis chronic Diseases 0.000 description 1
- 244000223760 Cinnamomum zeylanicum Species 0.000 description 1
- 206010052895 Coronary artery insufficiency Diseases 0.000 description 1
- 239000004375 Dextrin Substances 0.000 description 1
- 229920001353 Dextrin Polymers 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- DCXXMTOCNZCJGO-UHFFFAOYSA-N Glycerol trioctadecanoate Natural products CCCCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCCCC DCXXMTOCNZCJGO-UHFFFAOYSA-N 0.000 description 1
- 208000031226 Hyperlipidaemia Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 208000007443 Neurasthenia Diseases 0.000 description 1
- 241000195888 Physcomitrella Species 0.000 description 1
- 241000222341 Polyporaceae Species 0.000 description 1
- 101100409194 Rattus norvegicus Ppargc1b gene Proteins 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
- 239000003957 anion exchange resin Substances 0.000 description 1
- 239000006286 aqueous extract Substances 0.000 description 1
- 206010003549 asthenia Diseases 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 239000012267 brine Substances 0.000 description 1
- 206010006451 bronchitis Diseases 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 235000010216 calcium carbonate Nutrition 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 229910000389 calcium phosphate Inorganic materials 0.000 description 1
- 235000011010 calcium phosphates Nutrition 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 208000007451 chronic bronchitis Diseases 0.000 description 1
- 235000017803 cinnamon Nutrition 0.000 description 1
- 238000004440 column chromatography Methods 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 235000019425 dextrin Nutrition 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 239000000395 magnesium oxide Substances 0.000 description 1
- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 description 1
- AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 1
- 239000007901 soft capsule Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000006190 sub-lingual tablet Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP59040745A JPS60184025A (ja) | 1984-03-02 | 1984-03-02 | 多糖類，その単離法及び用途 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP59040745A JPS60184025A (ja) | 1984-03-02 | 1984-03-02 | 多糖類，その単離法及び用途 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS60184025A true JPS60184025A (ja) | 1985-09-19 |
| JPS6338325B2 JPS6338325B2 (enrdf_load_stackoverflow) | 1988-07-29 |
Family
ID=12589166
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP59040745A Granted JPS60184025A (ja) | 1984-03-02 | 1984-03-02 | 多糖類，その単離法及び用途 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS60184025A (enrdf_load_stackoverflow) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000143526A (ja) * | 1998-11-13 | 2000-05-23 | Asuke Yakuhin Kk | 田七人参、霊芝、アガリクス茸を主成分とする糖尿・高血圧・肝機能改善剤およびこれの製造方法 |
| JP2001131083A (ja) * | 1999-11-01 | 2001-05-15 | Sakamoto Bio:Kk | 鹿角霊芝抽出物活性物質及びそれを含む医薬、健康食品、化粧料 |
| JP2002173441A (ja) * | 2000-09-27 | 2002-06-21 | Nonogawa Shoji Kk | 生体の酸化防止または予防剤 |
| JP2005104938A (ja) * | 2003-10-02 | 2005-04-21 | Matsukawa Kagaku:Kk | 皮膚用化粧料 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS54138116A (en) * | 1978-04-17 | 1979-10-26 | Morinaga & Co | Medical constituent of mannentake |
| JPS5657801A (en) * | 1979-10-16 | 1981-05-20 | Morinaga & Co Ltd | Ganoderma lucidum karst component and its preparation |
| JPS57112331A (en) * | 1980-12-29 | 1982-07-13 | Toyo Yakushiyoku Kogyo Kk | Medical composition of ganoderma lucidum component |
-
1984
- 1984-03-02 JP JP59040745A patent/JPS60184025A/ja active Granted
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS54138116A (en) * | 1978-04-17 | 1979-10-26 | Morinaga & Co | Medical constituent of mannentake |
| JPS5657801A (en) * | 1979-10-16 | 1981-05-20 | Morinaga & Co Ltd | Ganoderma lucidum karst component and its preparation |
| JPS57112331A (en) * | 1980-12-29 | 1982-07-13 | Toyo Yakushiyoku Kogyo Kk | Medical composition of ganoderma lucidum component |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000143526A (ja) * | 1998-11-13 | 2000-05-23 | Asuke Yakuhin Kk | 田七人参、霊芝、アガリクス茸を主成分とする糖尿・高血圧・肝機能改善剤およびこれの製造方法 |
| JP2001131083A (ja) * | 1999-11-01 | 2001-05-15 | Sakamoto Bio:Kk | 鹿角霊芝抽出物活性物質及びそれを含む医薬、健康食品、化粧料 |
| JP2002173441A (ja) * | 2000-09-27 | 2002-06-21 | Nonogawa Shoji Kk | 生体の酸化防止または予防剤 |
| JP2005104938A (ja) * | 2003-10-02 | 2005-04-21 | Matsukawa Kagaku:Kk | 皮膚用化粧料 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6338325B2 (enrdf_load_stackoverflow) | 1988-07-29 |
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