JPS60130561A - アミジン誘導体およびそれを含む強心剤 - Google Patents

アミジン誘導体およびそれを含む強心剤

Info

Publication number
JPS60130561A
JPS60130561A JP58237715A JP23771583A JPS60130561A JP S60130561 A JPS60130561 A JP S60130561A JP 58237715 A JP58237715 A JP 58237715A JP 23771583 A JP23771583 A JP 23771583A JP S60130561 A JPS60130561 A JP S60130561A
Authority
JP
Japan
Prior art keywords
group
ethyl
compound
benzamidine
decomposition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP58237715A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0310616B2 (en, 2012
Inventor
Setsuo Fujii
藤井　節郎
Takuo Sato
佐藤　拓夫
Hiroyuki Kawamura
博之 川村
Takashi Yaegashi
隆 八重樫
Masateru Kurumi
来海　正輝
Takuo Aoyama
青山　卓夫
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Torii Pharmaceutical Co Ltd
Original Assignee
Torii Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Torii Pharmaceutical Co Ltd filed Critical Torii Pharmaceutical Co Ltd
Priority to JP58237715A priority Critical patent/JPS60130561A/ja
Priority to GB08431598A priority patent/GB2152501B/en
Priority to DE19843445691 priority patent/DE3445691A1/de
Priority to FR8419150A priority patent/FR2556720B1/fr
Priority to US06/681,476 priority patent/US4598077A/en
Publication of JPS60130561A publication Critical patent/JPS60130561A/ja
Publication of JPH0310616B2 publication Critical patent/JPH0310616B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/38—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/225—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D233/22—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D233/24—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP58237715A 1983-12-16 1983-12-16 アミジン誘導体およびそれを含む強心剤 Granted JPS60130561A (ja)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP58237715A JPS60130561A (ja) 1983-12-16 1983-12-16 アミジン誘導体およびそれを含む強心剤
GB08431598A GB2152501B (en) 1983-12-16 1984-12-14 Amidine derivatives and cardiotonics comprising same
DE19843445691 DE3445691A1 (de) 1983-12-16 1984-12-14 Amidinderivate, verfahren zu ihrer herstellung und pharmazeutische mittel
FR8419150A FR2556720B1 (fr) 1983-12-16 1984-12-14 Derives de l'amidine et tonicardiaques les contenant
US06/681,476 US4598077A (en) 1983-12-16 1984-12-14 Amidine derivatives and cardiotonic compositions

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP58237715A JPS60130561A (ja) 1983-12-16 1983-12-16 アミジン誘導体およびそれを含む強心剤

Publications (2)

Publication Number Publication Date
JPS60130561A true JPS60130561A (ja) 1985-07-12
JPH0310616B2 JPH0310616B2 (en, 2012) 1991-02-14

Family

ID=17019421

Family Applications (1)

Application Number Title Priority Date Filing Date
JP58237715A Granted JPS60130561A (ja) 1983-12-16 1983-12-16 アミジン誘導体およびそれを含む強心剤

Country Status (5)

Country Link
US (1) US4598077A (en, 2012)
JP (1) JPS60130561A (en, 2012)
DE (1) DE3445691A1 (en, 2012)
FR (1) FR2556720B1 (en, 2012)
GB (1) GB2152501B (en, 2012)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0521615U (ja) * 1991-09-04 1993-03-23 株式会社丸山製作所 噴頭の折曲装置
WO1998007421A1 (fr) * 1996-08-16 1998-02-26 Ishihara Sangyo Kaisha, Ltd. Composition medicinale
JP2013216665A (ja) * 2007-11-01 2013-10-24 Acucela Inc 眼の疾患及び障害治療用のアミン誘導体化合物

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6133173A (ja) * 1984-07-25 1986-02-17 Torii Yakuhin Kk アミジン化合物
GB8520774D0 (en) * 1985-08-20 1985-09-25 Shell Int Research Diphenyl ether herbicides
DE4309285A1 (de) * 1993-03-23 1994-09-29 Boehringer Ingelheim Kg Heterocyclen enthaltende Amidinderivate, ihre Herstellung und Verwendung
RU2130017C1 (ru) * 1993-08-12 1999-05-10 Астра Актиенболаг Производные амидина, способ их получения и лекарственное средство на их основе, обладающее свойством ингибировать активность синтетазы оксида азота (у)
DE69508875T2 (de) * 1994-09-20 1999-09-16 Ono Pharmaceutical Co. Ltd., Osaka Amidinophenol-Derivate als Protease-hemmende Verbindungen
AU707215B2 (en) * 1995-01-05 1999-07-08 Torii Pharmaceutical Co., Ltd. Thrombolytic agents
US7375125B2 (en) * 1999-08-04 2008-05-20 Ore Pharmaceuticals, Inc. Melanocortin-4 receptor binding compounds and methods of use thereof
CN103012200B (zh) * 2011-09-20 2014-12-17 北京大学 具有β-分泌酶抑制功能的化合物及其制备方法与应用
DK3247699T3 (da) 2015-01-22 2019-08-12 Sanofi Aventis Deutschland Proces til produktion of 2-[4-(cyclopropancarbonyl)phenyl]-2-methyl-propannitril
CA3086099C (en) 2017-11-16 2023-05-09 Montdorex Inc. Mono- and di-amidine endo-exonuclease inhibitors and methods for inhibiting endo-exonuclease activity

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1241832B (de) * 1963-02-23 1967-06-08 Hoechst Ag Verfahren zur Herstellung von Pyrimidiniumverbindungen
US4025555A (en) * 1976-07-23 1977-05-24 Pfizer Inc. Aromatic amidines as antiviral agents in animals

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0521615U (ja) * 1991-09-04 1993-03-23 株式会社丸山製作所 噴頭の折曲装置
WO1998007421A1 (fr) * 1996-08-16 1998-02-26 Ishihara Sangyo Kaisha, Ltd. Composition medicinale
US6429212B1 (en) * 1996-08-16 2002-08-06 Ishihara Sangyo Kaisha Ltd. Medicinal composition
US6515129B1 (en) 1996-08-16 2003-02-04 Ishihara Sangyo Kaisha Ltd. Pharmaceutical composition
JP2013216665A (ja) * 2007-11-01 2013-10-24 Acucela Inc 眼の疾患及び障害治療用のアミン誘導体化合物
US9452153B2 (en) 2007-11-01 2016-09-27 Acucela Inc. Amine derivative compounds for treating ophthalmic diseases and disorders

Also Published As

Publication number Publication date
GB8431598D0 (en) 1985-01-30
DE3445691C2 (en, 2012) 1988-07-14
GB2152501B (en) 1987-08-26
FR2556720B1 (fr) 1988-01-08
US4598077A (en) 1986-07-01
GB2152501A (en) 1985-08-07
FR2556720A1 (fr) 1985-06-21
DE3445691A1 (de) 1985-07-04
JPH0310616B2 (en, 2012) 1991-02-14

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