JPS60109516A - Composition for oral cavity - Google Patents

Abstract

PURPOSE:The titled composition, containing an extract of a beehive of long-legged wasps, wasps or hornets or Vespula lewisi Lameron, and useful for preventing and treating gingivitis. CONSTITUTION:A composition for the oral cavity containing an extract of a beehive of long-legged wasps, or hornets of Vespula lewisi Lameron. The inflammation of gingivitis is supposed to be caused by action of oral bacteria in the sordes on teeth, i.e. action of collagenase, protease, hyaluronidase, etc. derived from bacteria on the periodontal tissues or local cause of action of amines, endotoxins etc. derived from bacteria or systemic causes such as nutritional conditions or diabetes, etc. The composition containing the extract of the beehive exhibits particularly effective action on reduction and suppression of periodontal inflammations. Water or an organic solvent, e.g. methanol or ethanol, is used as a solvent for extracting the beehive. The amount of the extract to be incorporated is preferably 0.001-10wt% based on the total composition, and particularly preferably 0.01-5wt% from the viewpoint of anti-inflammatory effect and feeling of use.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to an oral composition, and more particularly to an oral composition having anti-gingivitis activity.

Gingival inflammation is caused by local causes such as the action of oral bacteria in dental plaque, the action of bacterial collagenase, zolotease, and hyaluronidase on the periodontal tissue, or the action of bacterial amines and endotoxins. It is thought that this condition is caused by systemic causes such as nutritional status and diabetes. For the prevention and treatment of gingivitis, we have used disinfectants such as chlorhexicine; enzymes such as lysozyme, amylase, dext2nase, and mutanase; hemostatic agents such as e-amitsukazoronic acid and tranexamic acid; and allantoin. Salt and other substances have been used, but they have not been sufficiently effective.

In view of the current situation, the present inventor conducted intensive research to find an oral composition that is effective in reducing and suppressing gingival inflammation. The present invention was completed based on the discovery that an oral composition effective for the prevention and treatment of gingivitis can be obtained by incorporating the following.

That is, the present invention provides an oral composition containing an extract of honeycombs (Rohobo) of paper wasps, wasps, and wasps.

The honeycombs of paper wasps, wasps, and black hornets used in the present invention are called dew bees in Chinese medicine, and are used for the purposes of analgesia, anti-inflammation, sedation, detoxification, lactation, etc. Honeycomb extracts can be used to prevent and treat gingivitis. There is no example of it being used in external preparations for this purpose, and the solvent used for extracting the honeycomb in oral compositions includes water or organic solvents such as methanol, ethanol, acetone, ethyl acetate, benzene, hexane, and petroleum ether. used. Further, mixed solvents such as water-alcohol (methanol, ethanol, etc.), water-acetone, etc. can also be used. Among these extraction solvents, a water-ethanol mixed solvent is particularly preferred.

In the present invention, the extract used as an active ingredient is obtained by extracting the honeycomb with water, an organic solvent, or a mixed solvent of water and an organic solvent by a known method, removing undesired substances from the extract, and then extracting the extract as necessary. It can be produced by distilling off the solvent from the extract.

In the present invention, the amount of the honeycomb extract blended into the oral composition is not necessarily limited, but as a residue (extract) after distilling off the extraction solvent, o, ooi to 10
0.0% by weight is preferable from the viewpoint of anti-inflammatory effect and usability.
Particularly preferred is 1 to 5% by weight.

In addition to the above-mentioned extract, the oral composition of the present invention may contain any of the components normally used in oral compositions. For example, in the case of toothpaste, these ingredients include abrasives such as calcium diphosphate, calcium carbonate, aluminum hydroxide, amorphous silica, and crystalline silica; Binder; surfactant such as sodium lauryl sulfate, sodium lauroyl sarcosinate, N-acylglutamate, sucrose fatty acid ester; wetting agent such as glycerin, sorbitol, zoropylene glycol. Furthermore, other medicinal agents can also be used in combination, such as various fluorine compounds, aluminum allantoinate, glycyrrhizinate, hinokitiol, chlorhexicine, lysozyme,
Dextranase, salt, azulene, vitamin E, etc. can be added and blended.

The oral composition of the present invention can be used, for example, as a toothpaste, toothpaste, water toothpaste, mouthwash, troche, Noqster, liniment,
Used in gum pine surge cream, gargling tablets, chewing gum, etc.

Next, the present invention will be explained with reference to Examples.

Example 1 350 ml of ethanol and 150 ml of water were added to 100 ml of dry powder of wasp nest, heated with a mantle heater, and refluxed for 3 hours using a cooling tube. Then, the extract was separated by centrifugation. This extracted extract was heated and concentrated to obtain extract 50f.

Next, the extract was used as a test sample to examine its anti-inflammatory effect on gingivitis in the lower anterior teeth of guinea pigs by the method described below. The results are shown in Figure 1.

(Test method) Hartley white guinea pigs (weight 40
0F, female), each group consisted of 8 animals, and they were anesthetized with Nemptal ■. Next, a puncture wound was made in the anterior teeth of the mandible using a bundle of 10 No. 6 needles, and the patient was treated with 1% sodium n-butyrate to cause inflammation. 24 hours after the onset of inflammation,
Using the degree of swelling as an index, it was scored on a 4-point scale from 0 to 3 by visual inspection, and was defined as the degree of swelling.

The test sample was a toothpaste containing no surfactants or fragrances containing 1.0% (wt%) of the extract, which was applied to the inflamed area under Nemptal anesthesia for 20 minutes once a day. The degree of swelling was checked every 24 hours. A toothpaste containing no extract was used as a control.

(Evaluation criteria) 0: No swelling observed l: Slight swelling observed 2: Moderate swelling observed 3: Severe swelling clearly seen in Figure 1. It has been found that extracts of wasp berries) effectively inhibit inflammation.

Example 2 #! Toothpaste composition Calcium hydrogen diphosphate 49.0% Carrageenan 1.4 Glycerin 20.0 Sodium saccharin 0.1 Cliff bee extract (Example 1) 1. Q Sodium lauryl sulfate 1. (1 Sodium benzoate 0.3 Flavor 0.8 Water Remaining amount 100.0% Example 3 Toothpaste composition: Calcium carbonate 45.0% Carboxymethyl cellulose 1,2 Nlupit 20.0 Zolopyrene glycol 4.0 Satucalin Sodium ゛ o,i Dew bee extract (Example 1) 0.5 Sodium lauryl sulfate 1.2 Sodium benzoate 0.3 Fragrance 0.8 Water Remaining amount 100.0% Example 4 Toothpaste composition: Silicic anhydride 27 .0% Glycerin 15.0 Sorbit 400 Carboxymethyl cellulose 1.0 Saccharin sodium 0.2 Dew beetle extract (Example 1) 2.0 Sodium diurylphosphate 1.5 Methyl oxybenzoate 0.2 Fragrance 0 .8 Water remaining amount 100.0% Example 5 Mouthwash composition: Ethanol 15.0% Saccharin sodium 0.03 Lauryl diethanolamide 0.4 Rohobou extract (Example 1) 1.0 Fragrance 0.8 Water remaining amount xoo, OX Fuse Vsu 6 Gingival pine surge cream composition: White petrolatum 9.0% Noropyrene glycol 4.0 Stearyl alcohol 7.5 Polyethylene glycol 4000 25.0?Lyethylene glycol 46 g 35.0 Sida sugar stearic acid :
f-sufk 0.5 Kohofusa extract (Example 1) 1.5 Water Remaining amount lQo, o%

[Brief explanation of drawings]

Figure 1 shows the change over time in the degree of swelling. that's all Applicant: Kao Soap Co., Ltd. 1234567 number of days

Claims (1)

[Scope of Claims] 1. An oral composition characterized by containing an extract of the fruit (j1 bee cluster) of paper wasp, wasp, or wasp. 2. The oral composition according to claim 1, wherein the extract is extracted with a water-ethanol mixed solvent. 3. The oral composition according to claim 1 or 2, which contains the extract in an amount of 0.01 to 5% by weight based on the total composition.