JPH0419206B2 - - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to an oral composition, and more particularly to an oral composition having anti-gingivitis activity.

Gingival inflammation is caused by the effects of oral bacteria in dental plaque.
That is, bacterial-derived collagenase, protease,
It is thought to be caused by local causes such as the action of hyaluronidase on the periodontal tissue or the action of bacterial amines and endotoxins, as well as systemic causes such as nutritional status and diabetes. For the purpose of preventing and treating this gingivitis, disinfectants such as chlorhexidine; enzymes such as lysozyme, amylase, dextranase, and mutanase;
Hemostatic agents such as ε-aminocaproic acid and tranexamic acid; and other agents such as allantoin and salt have been used, but sufficient effects have not yet been obtained.

In view of the current situation, the present inventor conducted extensive research to find an oral composition that is effective in reducing and suppressing gingival inflammation, and as a result, the inventor of the present invention has formulated an extract of a specific beehive (Ruw beehive) into an oral composition. This will help prevent gingivitis,
The present invention was completed based on the discovery that a therapeutically effective oral composition can be obtained.

That is, the present invention provides an oral composition containing an extract of honeycombs of paper wasps, wasps, and wasps.

Paper wasp, wasp used in the present invention,
The honeycomb of the black hornet is called dew beehive in Chinese medicine and is used for the purposes of analgesia, anti-inflammation, sedation, detoxification, lactation, etc., and honeycomb extract has been used as an external preparation for the prevention and treatment of gingivitis. There are no examples, and there are no examples of it being incorporated into oral compositions.

As the solvent used for extracting the honeycomb, water or an organic solvent such as methanol, ethanol, acetone, ethyl acetate, benzene, hexane, petroleum ether, etc. is used. Further, mixed solvents such as water-alcohol (methanol, ethanol, etc.), water-acetone, etc. can also be used. Among these extraction solvents, a water-ethanol mixed solvent is particularly preferred.

In the present invention, the extract used as an active ingredient is obtained by extracting the honeycomb with water, an organic solvent, or a mixed solvent of water and an organic solvent by a known method, removing insoluble matter from the extract, and adding the extract as necessary. It can be produced by distilling off the solvent from.

In the present invention, the amount of the honeycomb extract incorporated into the oral composition is not necessarily limited, but
The residue (extract) after distilling off the extraction solvent is preferably 0.001 to 10% by weight in the total composition, and particularly preferably 0.01 to 5% by weight from the viewpoint of anti-inflammatory effect and feeling of use.

In addition to the above-mentioned extract, any of the components normally used in oral compositions can be added to the oral composition of the present invention. These ingredients include, for example, in the case of toothpaste, abrasives such as dicalcium phosphate, calcium carbonate, aluminum hydroxide, amorphous silica, and crystalline silica; sodium carboxymethyl cellulose, carrageenan,
Binder such as hydroxyethylcellulose; surfactant such as sodium lauryl sulfate, sodium lauroyl sarcosinate, N-acylglutamate, sucrose fatty acid ester; wetting agent such as glycerin, sorbitol, propylene glycol. In addition, other medicinal agents can be used in combination, such as various fluorine compounds, aluminum allantoinate, glycyrrhizinate, hinokitiol, chlorhexidine, lysozyme, dextranase, salt, azulene, vitamin E, etc. Can be blended.

The oral composition of the present invention can be used, for example, in toothpaste, powder toothpaste, water toothpaste, mouthwash, troche, pasta, liniment, gingival massage cream, gargling tablet, chewing gum, and the like.

Next, the present invention will be explained with reference to Examples.

Example 1 Dry powder of black wasp nest 100
350 ml of ethanol and 150 ml of water were added to the mixture, heated with a mantle heater, and refluxed for 3 hours using a cooling tube. The extract was then separated by centrifugation. Heat and concentrate this extracted extract, extract 50%
I got g. Next, the extract was used as a test sample to examine its anti-inflammatory effect on lower anterior gingivitis in guinea pigs by the method described below. The results are shown in Figure 1.

(Test method) Hartley white guinea pigs (weight 400 g, female) were used as experimental animals, 8 animals per group, and anesthetized with Nembutal. Next, use a No. 6 gas needle
After creating a puncture wound in the mandibular anterior teeth with a bundle of 10,
Inflammation occurred after treatment with 1% sodium n-butyrate.
From 24 hours after the onset of inflammation, the degree of swelling is evaluated with the naked eye on a 4-point scale from 0 to 3.
It was defined as the degree of swelling.

The test sample was prepared by adding 1.0% (wt%) of the extract to toothpaste that did not contain surfactants or fragrances, and administering it to the inflamed area under Nembutal anesthesia for 20 minutes once a day. The degree of swelling was checked hourly. A toothpaste containing no extract was used as a control.

(Evaluation criteria) 0: No swelling observed 1: Slight swelling observed 2: Moderate swelling observed 3: Severe swelling observed As is clear from Figure 1, the It was found that the extract of wasp's nest (wasp's nest) effectively suppresses inflammation.

Example 2 toothpaste composition: Calcium hydrogen phosphate 49.0% carrageenan 1.4 Glycerin 20.0 Satucalin sodium 0.1 Dew bee extract (Example 1) 1.0 Sodium lauryl sulfate 1.0 Sodium benzoate 0.3 Fragrance 0.8 Water remaining amount 100.0% Example 3 toothpaste composition: Calcium carbonate 45.0% Carboxymethylcellulose 1.2 Sorbittu 20.0 Propylene glycol 4.0 Satucalin sodium 0.1 Dew bee extract (Example 1) 0.5 Sodium lauryl sulfate 1.2 Sodium benzoate 0.3 Fragrance 0.8 Water remaining amount 100.0% Example 4 toothpaste composition: Silicic anhydride 27.0% Glycerin 15.0 Sorbittu 40.0 Carboxymethylcellulose 1.0 Satucalin sodium 0.2 Dew bee extract (Example 1) 2.0 Sodium lauryl sulfate 1.5 Methyl paraoxybenzoate 0.2 Fragrance 0.8 Water remaining amount 100.0% Example 5 mouthwash composition: Ethanol 15.0% Satucalin sodium 0.03 Lauryl diethanolamide 0.4 Dew bee extract (Example 1) 1.0 Fragrance 0.8 Water remaining amount 100.0% Example 6 Gum pine surge cream composition: White petrolatum 9.0% Propylene glycol 4.0 Stearyl alcohol 7.5 Polyethylene glycol 4000 25.0 Polyethylene glycol 400 35.0 Sucrose stearate 0.5 Dew beehive extract (Example 1) 1.5 Water remaining amount 100.0%

[Brief explanation of drawings]

Figure 1 shows the change over time in the degree of swelling.

Claims (1)

[Scope of Claims] 1. An oral composition characterized by containing an extract of a honeycomb (dew bee cluster) of a paper wasp, a wasp, or a wasp. 2. The oral composition according to claim 1, wherein the extract is extracted with a water-ethanol mixed solvent. 3. Claim 1 or 2, which contains the extract in an amount of 0.01 to 5% by weight based on the total composition.
Oral composition as described in .