JPH10306019A - Oral composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain an oral composition having excellent activation effect for cells arising from the mouth by formulating a distillation residue of the extract extracted from a specific plant used as a natural perfume raw material as an active ingredient. SOLUTION: This composition is obtained by formulating a distillation residue of the extract obtained by extracting from the plant selected from Hyacinthus orientalis L. (Liliaceae), Calendula arvensis L. (Compositae), Tagetes patula L. (Compositae), laudanum or Cistus (Cistaceae), Vanilla (Orchidaceae) (V. planifolia, V. pompone, V. tahitensis), benzoin (resin oil obtained from Styrax benzoides) and Osmanthus (Oleaceae) (O. fragrans var. aurantiacus, O. fragrans var. latifolius, O.illicifolius) with the solvent selected from water, a lower alcohol, a polyol-based organic solvent, petroleum ether, hexane and toluene as an active ingredient. Further, the distillation residue of the extract is preferably formulated in an amount of 0.001-10 wt.% in the objective composition.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to an oral composition, and more particularly to an oral composition containing, as an active ingredient, a distillation residue of a plant extract which is effective in preventing and treating tissue destruction by periodontal disease bacteria. The composition for oral cavity of the present invention has an excellent activating effect on cells derived from the oral cavity, and is highly safe, and has toothpaste, mouthwash, gel, oral pasta, chewing gum, troche, soft candy, hard candy, and tablet. , Gummy jelly and the like.

[0002]

2. Description of the Related Art A major disease state of periodontal disease represented by gingivitis and marginal periodontitis is the destruction of connective tissues such as gingiva and periodontal ligament. As a method of relieving the condition of periodontal disease, a method of repairing destroyed periodontal tissue and regenerating the original healthy tissue is currently being attempted, and specific methods include (1) rooting with citric acid. Surface treatment, (2) A method for suppressing downgrowth of the epithelium with a highly biocompatible barrier membrane and securing a space for periodontal ligament regeneration (GTR method)
, (3) topical application of cell growth factors, and the like.

[0003] However, these are methods used in medical treatment by doctors, and are not applied in daily oral hygiene by patients themselves. Therefore, there is a demand for a product that activates periodontal tissue and that is safe even when used repeatedly on a daily basis. Use of natural products as active ingredients in oral compositions has been studied. For example, an azulene derivative extracted from a plant or cultured cell of a genus Calipogea (Japanese Patent Application Laid-Open No. 5-78716), an extract of a Cucurbitaceae plant and a triterpenoid purified therefrom (Japanese Patent Application Laid-Open No. 6-345630). Has been proposed. However, these substances and extracts having a cell activating effect must be incorporated in large amounts in order to exhibit a sufficient effect in the oral cavity, and there are problems in storage stability and safety. There were many.

[0004] Some of the inventors have described Hyacint.
hus orientalis) (Lily family), Marigold (Tagetes e)
recta L.), French Marigold (T. patura) (Kikusaceae), Labdanum or Cistus (Cistus ladaniferus)
L., C. cretics L.) (Hanchinbana family), Vanilla (Vanil)
la planifolia Andrews or V. tahitience Moore) (Ranaceae), benzoin (Styrax tonkinensis, S. benzoi)
n), Osmanthus (Osmanthus fragrans)
, Litris (Liatris odoratissima) (Asteraceae), Tonka (Dipteryx odorata, Coumarouna odorata Aubl.) (Fabaceae), Camomil (Matricaria chamomilla) (Asteraceae),
Mill (Commiphora abyssinica) (Orchidaceae), Orivanum (Boswellia, Damara Orientalis) (Orchidaceae), Coriander (Coriandrum sativum) (Aceraceae) and thyme
It has been found that the distillation residue of one or more extracts selected from (Thymus vulgaris) (Lamiaceae) has a cell activating effect and has no harmful side effects on the human body (Japanese Patent Application No. 8- No. 284572).

[0005]

SUMMARY OF THE INVENTION An object of the present invention is to solve the above-mentioned conventional problems, and to obtain a periodontal disease originating in a periodontal disease bacterium which is derived from a natural product and has an excellent cell activating effect. An object of the present invention is to provide an oral composition having a preventive and therapeutic effect on tissue destruction.

[0006]

Means for Solving the Problems The present invention according to claim 1 comprises hyacinth (Hyacinthus orientalis) (Lily family), marigold (Tagetes erecta L.), French marigold (T. patura) (Kiku family). , Labdanham or Cistus
(Cistus ladaniferus L., C. cretics L.) (Hanchinbana family), vanilla (Vanilla planifolia Andrews or V.
tahitience Moore) (Ranaceae), benzoin (Styrax tonk)
inensis, S. benzoin) and Osmanthus fr
agrans) (one or more plants selected from the group consisting of water, lower alcohols, polyol organic solvents, petroleum ether, hexane and toluene from one or more plants selected from the group consisting of plants) An oral composition comprising, as an active ingredient, a distillation residue of an extract obtained by extraction with an extract. According to the present invention, the distillation residue of the extract is contained in 0.1% of the whole oral composition.
The oral composition according to claim 1, which contains 001 to 10% by weight. According to a third aspect of the present invention, there is provided a composition for an oral cavity, comprising a perfume containing a distillation residue of the extract according to the first aspect as an active ingredient. The present invention according to claim 4 is an agent for preventing and treating tissue destruction caused by periodontal disease bacteria, which comprises a distillation residue of the extract according to claim 1 as an active ingredient.

[0007]

BEST MODE FOR CARRYING OUT THE INVENTION The plant extract and its distillation residue used in the present invention can be obtained by a conventional method, not by a special method. For example, the above-mentioned plants are used as raw materials, and these are used alone or in combination of two or more. Flowers, leaves,
Twigs, fruits, bark, resin, etc. are dried as necessary and ground to facilitate extraction. Extraction from the plant can be carried out by a conventional method, and the solvent used at this time includes water, lower alcohol, polyol organic solvent, petroleum ether, hexane and toluene. Use species or two or more.
Here, as the lower alcohol, methanol, ethanol, propanol, butanol and the like are preferable. Also,
Specific examples of the polyol-based organic solvent include ethylene glycol and propylene glycol. The extraction method may be appropriately determined in consideration of the type of the plant, the extraction site, and the like.
Extract at 0 ° C. as such or with gentle stirring. The time required for the extraction is usually about 30 minutes to 24 hours, preferably 5 to 16 hours.

[0008] Extracts are classified as follows depending on the method of extraction. Generally, essential oils (oils)
It is obtained by squeezing fruits and pericarp, or by steam distilling flowers, leaves, stems and the like. Absolute is a concrete obtained by extracting flowers mainly by various methods, further extracting the concrete with alcohols, and concentrating the concrete to remove wax components, proteins, pigments, and the like. Resinoids are those obtained by extracting and concentrating dried rhizomes and lichens with alcohol, and those obtained by extracting resinous secretions with a hydrocarbon solvent and concentrating them. In.

Next, these extracts are distilled to obtain distillation residues. The distillation is carried out under reduced pressure, usually at 1 to 200 mmHg, preferably 1 to 20 mmHg, at a bath temperature of 40 to 80 ° C. until there is no effluent component. The time required is generally 3
It is about 0 minutes to 24 hours. Distillation is performed using a simple Claisen-equipped distilling apparatus in addition to a conventional through-distillation method. After distillation in this manner, the remaining solids are used as distillation residues. The distillation residue is used as it is, or dissolved and diluted with a solvent such as ethanol or propylene glycol or a mixture thereof, and used at a concentration that is easy to use. In particular, it is preferable to use the extract at the concentration of the original extract. The distillation residue may be powdered depending on the use form. For example, when used as a tablet or the like, it can be used as a dry powder by a spray drying method or the like.

[0010] Distillation residues of the extract of the present invention can be used in various forms of dentifrice, mouthwash, gel, oral pasta, chewing gum,
Lozenges, soft candies, hard candies,
It can be used by blending it with oral compositions such as tablets and gummy jelly. The method of compounding is arbitrary, and there are a method of directly compounding the distillation residue of the extract and a method of compounding it as a compounded flavor. The amount of the distillation residue of the extract is usually 0.001 to 10% by weight, preferably 0.01 to 1% by weight in the oral composition.

[0011] In the composition of the present invention containing the distillation residue of the extract as an active ingredient, other components can be appropriately selected and blended according to the intended use of the composition, and the blending amount is also commonly used. The amount may be used. Here, as other components, for example, in the case of toothpaste, an abrasive, a foaming agent, a binder, a wetting agent,
Conventional ingredients can be blended such that a flavoring agent, a sweetening agent, a medicinal ingredient and the like are used, and a surfactant, a flavoring agent, a sweetening agent and the like are used when a mouthwash is prepared. Examples of abrasives include dibasic calcium phosphate dihydrate and anhydride, calcium phosphate, tribasic calcium phosphate, calcium carbonate, calcium pyrophosphate, aluminum hydroxide, alumina, silicic anhydride, silica gel, aluminum silicate, insoluble sodium metaphosphate, Magnesium triphosphate, magnesium carbonate, calcium sulfate, polymethyl methacrylate, bentonite, zirconium silicate, synthetic resins, and the like can be used. These abrasives may be used alone or in combination of two or more. The compounding amount is suitably 5 to 90% by weight, and in the case of toothpaste, 5 to 60% by weight based on the total composition. .

As a foaming agent, sucrose fatty acid esters,
Maltose fatty acid ester, maltitol fatty acid ester, maltotriitol fatty acid ester, maltotetriitol fatty acid ester, maltopentitol fatty acid ester, maltohexaitol fatty acid ester, maltoheptitol fatty acid ester, sorbitan fatty acid ester, lactose fatty acid ester , Lactinose fatty acid ester, polyoxyethylene polyoxypropylene copolymer, polyoxyethylene alkyl ethers, polyoxyethylene fatty acid esters, fatty acid alkanolamides, polyoxyethylene sorbitan fatty acid esters, polyoxyethylene hydrogenated castor oil, poly Nonionic surfactants such as glycerin fatty acid fatty acid esters can be used.

In addition, alkyl groups such as sodium lauryl sulfate and sodium myristyl sulfate have 8 to 1 carbon atoms.
8, a water-soluble salt of a higher alkyl sulfate, polyoxyethylene alkyl sulfate, alkyl sulfoacetate,
α-olefin sulfonate, sulfosuccinic acid derivative,
Higher fatty acid sodium monoglyceride monosulfate, N-methyl-N-palmitoyl tauride salt, N-
Long-chain acyl basic amino acid salts, anionic surfactants such as taurate derivatives, betaine-type amphoteric surfactants,
An imidazolium type amphoteric surfactant, an imidazolium betaine type amphoteric surfactant, a carboxylic acid type amphoteric surfactant and the like can also be used. These blowing agents may be used alone or in combination of two or more. The compounding amount is suitably from 0.1 to 10% by weight based on the whole composition.

Examples of the binder include cellulose derivatives such as carboxymethylcellulose, alkali metal alginate such as sodium alginate, propylene glycol alginate, gelatin, xanthan gum, tragacanth gum, karaya gum, gum arabic, gum such as carrageenan, polyvinyl alcohol, polyalcohol and the like. Examples include synthetic binders such as sodium acrylate, carboxyvinyl polymer, and polyvinylpyrrolidone, and inorganic binders such as silica gel, aluminum silica gel, veegum, and laponite. These binders may be used alone or in combination of two or more, and the compounding amount is suitably from 0.3 to 5% by weight based on the whole composition.

Further, if necessary, sorbitol, glycerin, ethylene glycol, propylene glycol,
Wetting agents such as 1,3-butylene glycol, polyethylene glycol, polypropylene glycol, maltite, lactit; cinamic aldehyde, limonene, ocimene, n-decyl alcohol, citronellol, α-
Terpineol, methyl acetate, citronellyl acetate, methyl eugenol, linalool, ethyl linalool, crocodile, thymol, spearmint oil, peppermint oil, lemon oil, orange oil, sage oil, rosemary oil, cinnamon oil, pimento oil, diatom oil, perilla Flavoring agents such as oil, winter green oil, clove oil, eucalyptus oil; saccharin sodium, acetyl farm potassium, stevioside,
Neohesporidyldihydrochalcone, glycyrrhizin,
Sweeteners such as xylit, perillartin, thaumatin, aspartylphenylalanine methyl ester, p-methoxycinnamic aldehyde, maltitol, and lactit may be blended.

Bactericides such as chlorhexidine gluconate, cetylpyridinium chloride, triclosan; dextranase, amylase, protease, mutanase;
Enzymes such as lysozyme and lytic enzyme (Litec enzyme); alkali metal monofluorophosphates such as sodium monofluorophosphate and potassium monofluorophosphate; fluorides and vitamin derivatives such as sodium fluoride and stannous fluoride; tranexamic acid And epsilon aminocaproic acid, aluminum chlorohydroxyl allantoin, dihydrocholesterol, glycyrrhizin salts,
Various components such as glycyrrhetinic acid, glycerophosphate, chlorophyll, sodium chloride, caropeptide, and a water-soluble inorganic phosphate compound may be used alone or in combination of two or more.

The oral composition of the present invention prevents the progression of tissue destruction by periodontal disease bacteria by activating the proliferation activity of gingival and periodontal ligament fibroblasts constituting periodontal tissue, To help repair and regenerate damaged tissue. Further, since the distillation residue of the plant extract used in the present invention is also used as a fragrance, its safety is high even when used daily.

[0018]

Next, the present invention will be described in detail with reference to examples and the like, but the present invention is not limited to these examples. Production Example An active ingredient was extracted from various plants by the following method, and the extract was distilled to obtain a distillation residue. (1) Production of Extract Marigold flowers, which are asteraceous plants, were extracted with petroleum ether or hexane, and the solvent was recovered by distillation under reduced pressure to obtain concrete. The obtained concrete was heated and dissolved with 10 times the amount of ethanol, and then left at room temperature overnight. Next, after removing the precipitate by filtration, the precipitate was left at 4 ° C. to further remove the precipitate, which was concentrated under reduced pressure to obtain an absolute as a marigold extract.
Hyacinth was used in place of marigold, and hyacinth absolute was obtained in the same manner.

In the case of Rabdanum, among other extracts, leaves and twigs of the plant were extracted with hot water to obtain a gum-like substance, which was extracted with alcohol to obtain a Rabdanum extract. The Cistus extract was obtained by steam distillation of gum material obtained from Labdanum. The benzoin extract is obtained by collecting the resin that leaches by injuring the trunk and then extracts it with ethanol. In addition, vanilla was obtained by extracting the fruit with alcohol and then distilling off the alcohol.

Further, the following extracts (commercial products) whose production methods have been confirmed can also be used. Hyacinth Absolute (COMPAGNIE D ARGEVILLE SA) Marigold Absolute (CAMILLI ARBERT & LALOUS) Lab Dunham Resinoid (PIERRE CHAUVET) Cistus Oil (Nippon Sanofa) Vanilla Absolute (QUEST) Benzoin (PIERRE CHUVET) Made)

(2) Distillation method 9 g of hyacinth absolute of the above-mentioned extract was charged into a still, and heated at a reduced pressure of 10 mmHg.
The temperature was raised to 0 ° C. and allowed to flow over 2 hours. The obtained effluent was 5 g and the distillation residue was 4 g. Each of the other extracts was similarly treated to obtain a distillation residue. In addition,
The amount (%) of the distillation residue obtained by distillation of the extract varies depending on the manner of distillation, for example, 74% for Marigold Absolute and 14% for Cistus Absolute. When this distillation residue was used for a formulation or a test, alcohol was added to the distillation residue, and the weight was returned to its pre-distillation weight before use (hereinafter referred to as an adjusted product). In the above example of hyacinth absolute, 4 g of distillation residue and 5 g of alcohol
Was added and mixed and dissolved, and used as an adjustment product as it was.

Test Example 1 2000 cells / w in a 96-well tissue culture plate
After inoculating ell and incubating at 37 ° C. for 1 day, the adjusted preparations of various plant extract distillation residues were diluted and added to Dulbecco's modified MEM (DMEM) medium containing 1% fetal calf serum. As a control, medium alone and PDGF (platelet-derived cell growth factor, PI
atelet Derived Growth Factor-BB, manufactured by Wako Pure Chemical Industries). After cultivation for 5 days, the cells were fixed with a 10% formalin solution, stained with crystal violet, and the number of cells was counted from the absorbance at 590 nm. The effects are shown in relative proportions. The results are shown in Table 1. As is clear from the table, the distillation residue of the plant extract is
It can be seen that it has an excellent cell growth promoting action on gingival and periodontal ligament fibroblasts.

[0023]

[Table 1] Table 1-Distillation residue of plant extract Cell growth promotion Preparation of action (%) ¹⁾ Gingival fibroblasts Periodontal ligament fibroblasts ──────────────────────────────── ─── Control (medium only) 100 100 PDGF-BB (10 ng / ml) ²⁾ 167.2 192.6 Marigold (50 ppm) 179.4 184.9 Hyacinthus (20 ppm) 133.8 157.3 Osmanthus (20 ppm) 128.5 150.0 Rabdanum (10 ppm) 119.8 132.2 Vanilla (50 ppm) 110.0 120.5 Benzoin (20 ppm) 111.5 130.7 ────────────────────── ¹⁾ ) Numbers in indicates the concentration in the medium. ²⁾ Positive control

Test Example 2 The following clinical experiment was conducted in a dental clinic. The target patients were 100 patients who had subjective symptoms of periodontal disease and did not have a specific underlying disease, and this patient was a panelist. In the experimental method, the conditions for cleaning the mouth of the target patient were unified, and Example 2 was used.
Were divided into four groups using a total of four types of dentifrices, two types of dentifrices and two types of dentifrices of Comparative Examples 1 and 2, and had their mouth cleaned for one month. The comparison of the effects was performed based on the degree of improvement of the average periodontal pocket depth (mm) per tooth of each group in the diseased site. The periodontal pocket depth was measured using a probe. The results are shown in Table 2. Group A used toothpaste 1 of Example 2, Group B used toothpaste 2 of Example 2, Group C used Comparative Toothpaste 1 of Comparative Example 1, and Group D used Comparative Toothpaste 2 of Comparative Example 2.

[0025]

[Table 2] Table II Group Average Periodontal Pocket Depth (mm) Test At the start At the end of the test Degree of improvement (%) ──────────────────────────────── A 7.8 4.9 38 5.5 B 8.2 4.5 45.1 C 7.4 7.2 2.7 D 7.7 7.4 3.9} ──────────────

As is clear from the table, A and B using toothpaste blended with the preparation of the distillation residue of the plant extract of the present invention.
The average periodontal pocket depth per tooth of the panelists of the group was significantly improved compared to that of the panelists of the control C and D groups. Thereby, it became clear that the destruction of connective tissue by periodontal disease bacteria was suppressed by the present invention, and the destructed tissue was repaired.

Example 1 In accordance with the following formulation, various compounded fragrances containing the plant extract distillation residue of the present invention were prepared. (1) Peppermint-type fragrance for oral composition (prepared fragrance-A) Compounding component weight% peppermint oil 20.0 l-menthol 15.0 anethole 5.0 1,8-cineole 2.0 eugenol 0.5 sage oil 0 .25 95% ethanol 7.25 Preparation of Marigold extract distillation residue 50.0

(2) Spearmint-type fragrance for oral composition (prepared fragrance-B) Ingredients% by weight l-menthol 16.0 spearmint oil 12.0 l-carvone 8.0 anethole 2.4 lemon oil 1.6 mari Adjusted product of distillation residue of gold extract 30.0 Adjusted product of distillation residue of hyacinth extract 30.0

(3) Peppermint flavor for confectionery (mixed flavoring agent-C) Ingredients% by weight Peppermint oil 35.0 l-menthol 7.5 Spearmint oil 2.5 Vegetable oil 5.0 Adjusted product of marigold extract distillation residue 50 .0

(4) Pineapple flavor for confectionery (preparation flavor-D) Compounding component weight% ethyl acetate 7.5 ethyl butyrate 9.0 ethyl hexanoate 9.0 allyl hexanoate 3.0 allyl cyclohexane propionate 0.6 Vanillin 0.6 Maltole 0.3 Lemon oil 10.0 Vegetable oil 10.0 Adjusted product of distillation residue of hyacinth extract 30.0 Adjusted product of distillation residue of vanilla distillate 20.0

(5) Pineapple flavor for powdered confectionery (powder blended flavor-E) Compounding component weight% Formulated flavor-D (Example 1- (4)) 5.0 Dextrin 10.0 Arabic gum 10.0 Water 75.0 The above materials are mixed, emulsified, and dried with a spray dryer to remove water.

Example 2 A toothpaste was produced according to the following formulation by a conventional method. (1) Toothpaste 1 Ingredients% by weight Calcium carbonate 30 Propylene glycol 3 Sorbitol 35 Sodium lauryl sulfate 1.5 Carboxymethylcellulose sodium 1.5 Saccharin sodium 0.1 Fragrance 1 Methyl parahydroxybenzoate 0.1 Adjustment of distillation residue of marigold extract Product 0.5 water 27.3

(2) Toothpaste 2 Ingredients% by weight Calcium phosphate 30 Glycerin 10 Sorbitol 20 Sodium lauryl sulfate 1.5 Sodium carboxymethylcellulose 1.0 Carrageenan 0.5 Sodium saccharin 0.1 Fragrance 1 Sodium benzoate 0.3 Marigold extract Adjusted product of distillation residue 0.3 Adjusted product of distillation residue of hyacinth extract 0.3 Water 35

Comparative Example 1 A dentifrice 1 was prepared by diluting it with alcohol to the same concentration except for the preparation of the extract distillation residue from the formulation of the dentifrice 1 of Example 2.

Comparative Example 2 Comparative toothpaste 2 was prepared by diluting with alcohol to the same concentration except for the preparation of the extract distillation residue from the formulation of toothpaste 2 of Example 2.

Example 3 A toothpaste was produced in the usual manner according to the following formulation. (1) Toothpaste 3 Ingredients% by weight Silicic anhydride 20 Sorbitol 60 Sodium lauryl sulfate 1.5 Sodium carboxymethyl cellulose 1.0 Carrageenan 0.5 Sodium polyacrylate 0.5 Saccharin sodium 0.1 Fragrance 0.8 Sodium benzoate 0 0.3 Preparation of distillation residue of Labdanum extract 0.2 Preparation of distillation residue of Osmanthus extract 0.1 Water 15

(2) Liquid dentifrice Ingredients% by weight Silicic anhydride 10 Polyoxyethylene hydrogenated castor oil 1.0 Sodium lauryl sulfate 1.0 Xanthan gum 0.25 Glycerin 10 Sorbite 20 Sodium polyacrylate 0.25 Saccharin sodium 0.1 Fragrance 0.9 Preparation of distillation residue of vanilla extract 0.3 Preparation of distillation residue of benzoin extract 0.2 Water 56

Example 4 A mouthwash was prepared in the usual manner according to the following formulation. Ingredients% by weight Ethanol 10 Glycerin 5 Citric acid 0.01 Sodium citrate 0.1 Polyoxyethylene hydrogenated castor oil 0.5 Methyl parahydroxybenzoate 0.1 Perfume 0.2 Preparation of distillation residue of marigold extract 0.5 Water 83.59

Example 5 A chewing gum was produced in the usual manner according to the following formulation. (1) Chewing gum (plate gum) Ingredients% by weight plate gum base 24.0 syrup 12.0 powdered sugar 62.0 citric acid 1.0 Compounding flavor-C (Example 1- (3)) 1.0

(2) Chewing gum (balloon gum) Ingredients% by weight Bubble gum base 23.0 Ginger syrup 14.0 Powdered sugar 61.0 Citric acid 1.0 Compounding flavor-D (Example 1- (4)) 1.0

Example 6 A candy was produced by the following method according to a conventional method. (1) Soft candy Ingredients wt% Granulated sugar 22.7 starch syrup 30.4 whole fat condensed milk 30.9 vegetable hardened oil 6.2 lecithin 0.2 fondant (*) 7.7 50% citric acid aqueous solution 0. 9 Compounded flavoring-D (Example 1- (4)) 1.0 Dye appropriate amount * Composition of fondant Granulated sugar 800 g Ginger syrup 200 g Water 250 g After heating and dissolving the above components, cooling to 40 ° C and stirring to crystallize sugar crystals. Raise and put.

(2) Hard candy Ingredients% by weight Granulated sugar 44.5 Candy syrup 40.5 Water 13.0 Citric acid 1.0 Compounding flavor-D (Example 1- (4)) 1.0 Dye Suitable amount

Example 7 A tablet was produced in the usual manner according to the following formulation. Ingredients% by weight Powdered sugar 96.0 Sucrose fatty acid ester 2.0 Powdered compounded fragrance-E (Example 1- (5)) 2.0

Example 8 Gummy jelly was produced according to the following recipe by a conventional method. Ingredients weight% sugar 31.8 starch syrup 32.3 water 16.4 gelatin solution (*) 18.0 citric acid 1.0 compounding flavor-D (Example 1- (4)) 0.5 * composition of gelatin solution Gelatin 80g Water 140g A gelatin solution is prepared and placed in a water bath at 70 ° C in advance.

Example 9 A gel was produced according to the following formulation by a conventional method. Ingredients% by weight Carboxymethylcellulose 2 Glycerin 40 Preparation of distillation residue of marigold extract 0.3 Preparation of distillation residue of hyacinth extract 0.2 Water 57.5

[0046]

Industrial Applicability According to the present invention, there is provided a composition for oral use which contains, as an active ingredient, a distillation residue of an extract from a specific plant used as a natural flavoring material and has an excellent activating effect on cells derived from the oral cavity. A composition is provided. This composition for oral cavity is applied to toothpastes, mouthwashes, candies and the like, and is effective in preventing and treating cell destruction by periodontal disease bacteria. In addition, the extract distillation residue described above is also used as an active ingredient of a compounded flavor, and the compounded flavor can be blended in various oral compositions.

Continued on the front page (72) Inventor Akane Takemura 13-17 Koyanagicho, Ibaraki-shi, Osaka

Claims (4)

[Claims] [Claim 1] Hyacinth (Hyacinthus orientalis) (Lily family), Marigold (Tagetes erecta L.), French marigold (T. patura) (Kiku family), Rabdanum or Cistus (Cistus ladaniferus L., C. cretics L) .)
(Family Hanbana), Vanilla (Vanilla planifolia Andr
ews or V. tahitience Moore) (Ranaceae), benzoin
(Styrax tonkinensis, S. benzoin) and Osmanthus fragrans (Osmanthus fragrans) from one or more plants selected from water, lower alcohols, polyol organic solvents, petroleum ether, hexane and toluene. An oral composition comprising, as an active ingredient, a distillation residue of an extract obtained by extraction with one or more solvents selected from the group consisting of: 2. The oral composition according to claim 1, wherein the distillation residue of the extract is contained in an amount of 0.001 to 10% by weight of the whole oral composition. 3. An oral composition comprising a compounded flavor containing the distillation residue of the extract according to claim 1 as an active ingredient. 4. An agent for preventing and treating tissue destruction by periodontal disease bacteria, comprising a distillation residue of the extract according to claim 1 as an active ingredient.