JPS5924999B2 - 新規な5−フルオロ−2′−デオキシ−β−ウリジン誘導体の製造法 - Google Patents
新規な5−フルオロ−2′−デオキシ−β−ウリジン誘導体の製造法Info
- Publication number
- JPS5924999B2 JPS5924999B2 JP53069383A JP6938378A JPS5924999B2 JP S5924999 B2 JPS5924999 B2 JP S5924999B2 JP 53069383 A JP53069383 A JP 53069383A JP 6938378 A JP6938378 A JP 6938378A JP S5924999 B2 JPS5924999 B2 JP S5924999B2
- Authority
- JP
- Japan
- Prior art keywords
- fluoro
- deoxy
- uridine
- group
- added
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP53069383A JPS5924999B2 (ja) | 1978-06-10 | 1978-06-10 | 新規な5−フルオロ−2′−デオキシ−β−ウリジン誘導体の製造法 |
GB7918944A GB2025401B (en) | 1978-06-10 | 1979-05-31 | 5-fluoro ( uridine or 2 deoxy uridine derivatives |
US06/046,109 US4472386A (en) | 1978-06-10 | 1979-06-06 | 5-Fluoro-(β-uridine or 2'-deoxy-β-uridine) derivatives, a process for producing the same and a carcinostatic agent containing the same |
FR7914738A FR2428052A1 (fr) | 1978-06-10 | 1979-06-08 | Nouveaux derives de 5-fluoro-(b-uridine ou 2'-desoxy-b-uridine), procede pour les preparer et agents carcinostatiques les renfermant |
DE19792923368 DE2923368A1 (de) | 1978-06-10 | 1979-06-08 | Neue 5-fluor-( beta -uridin oder 2'-desoxy- beta -uridin)-derivate, verfahren zur herstellung derselben und carcinostatische mittel mit einem gehalt derselben |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP53069383A JPS5924999B2 (ja) | 1978-06-10 | 1978-06-10 | 新規な5−フルオロ−2′−デオキシ−β−ウリジン誘導体の製造法 |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP58030948A Division JPS58185523A (ja) | 1983-02-28 | 1983-02-28 | 新規な5−フルオロ−2′−デオキシ−β−ウリジン誘導体を含有する制癌剤 |
JP58030947A Division JPS58185522A (ja) | 1983-02-28 | 1983-02-28 | 新規な5−フルオロ−2′−デオキシ−β−ウリジン誘導体 |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS54163586A JPS54163586A (en) | 1979-12-26 |
JPS5924999B2 true JPS5924999B2 (ja) | 1984-06-13 |
Family
ID=13400994
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP53069383A Expired JPS5924999B2 (ja) | 1978-06-10 | 1978-06-10 | 新規な5−フルオロ−2′−デオキシ−β−ウリジン誘導体の製造法 |
Country Status (5)
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS56113796A (en) * | 1980-02-13 | 1981-09-07 | Funai Corp | 3'- or 5'-o-acetyl-2'-deoxy-5-fluorouridine derivative, its preparation and antitumor agent containing the same |
JPS56113795A (en) * | 1980-02-13 | 1981-09-07 | Funai Corp | 2'-deoxy-3',5'-di-o-acetyl-5-fluorouridine derivative, its preparation and antitumor agent containing the same |
JPS56113797A (en) * | 1980-02-14 | 1981-09-07 | Funai Corp | 3-benzoyl-5-fluorouridine derivative, its preparation and antitumor agent containing the same |
JPS5751000A (en) | 1980-09-11 | 1982-03-25 | Funai Corp | Ester derivative of alkoxybenzoyldeoxyfluorouridine |
GB2072164B (en) * | 1980-02-15 | 1983-12-21 | Funai Pharmaceutical Ind Ltd | 2'-deoxy-3',5'-di-o-alkylcarbonyl-5-fluorouridine derivatives a process for the preparation of the derivatives and antitumor agents containing the derivatives |
JPS5735596A (en) * | 1980-08-13 | 1982-02-26 | Funai Corp | Ester derivative of deoxyfluorouridine |
JPS56115799A (en) * | 1980-02-15 | 1981-09-11 | Funai Corp | 2'-deoxy-3',5'-di-o-alkylcarbonyl-5-fluorouridine derivative, its preparation, and antitumor agnet containing the same |
DE3263939D1 (en) * | 1981-12-09 | 1985-07-04 | Teijin Ltd | 5-fluoro-2'-deoxyuridine derivatives and a process for the preparation thereof |
KR860001865B1 (ko) * | 1983-05-23 | 1986-10-24 | 다이호야꾸힝 고오교 가부시끼가이샤 | 2'-데옥시-5-치환 우리딘 유도체의 제조방법 |
US5250673A (en) * | 1983-05-23 | 1993-10-05 | Taiho Pharmaceutical Company, Ltd. | 2'-deoxy-5-substituted uridine derivatives |
EP0323441B1 (en) * | 1984-10-30 | 1996-04-24 | Otsuka Pharmaceutical Co., Ltd. | 5-Fluorouracil derivatives |
JPS63301880A (ja) * | 1985-09-03 | 1988-12-08 | Otsuka Pharmaceut Co Ltd | 5−フルオロウラシル誘導体 |
US4864021A (en) * | 1984-10-30 | 1989-09-05 | Otsuka Pharmaceutical Co., Ltd. | 5-fluorouracil derivatives |
DE3786834T2 (de) * | 1986-04-30 | 1994-03-03 | Otsuka Pharma Co Ltd | 5-Fluoro-Uracil-Derivate. |
US4992534A (en) * | 1987-08-12 | 1991-02-12 | Otsuka Pharmaceutical Co., Ltd. | 3'-O-,5'-O-derivatives of 2'-deoxy-5-fluorouridine |
US5420117A (en) * | 1988-07-11 | 1995-05-30 | Taiho Pharmaceutical Co., Ltd. | 5-substituted uridine derivatives |
US5637688A (en) * | 1994-12-13 | 1997-06-10 | Eli Lilly And Company | Process for preparing 1-(2'-deoxy-2'-difluoro-d-ribofuranosyl)-4-aminopyrimidin-2-one hydrochloride |
CN113980075B (zh) * | 2021-11-23 | 2024-06-04 | 聊城大学 | 氟铁龙衍生物及其用途 |
CN113980005A (zh) * | 2021-11-23 | 2022-01-28 | 聊城大学 | 替加氟衍生物及其用途 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3168513A (en) * | 1962-03-02 | 1965-02-02 | Hoffmann La Roche | Derivative of 2'-deoxy-5-fluorouridine |
US3309359A (en) * | 1965-10-22 | 1967-03-14 | Hoffmann La Roche | N-mono-acyl-5-fluorocytosine derivatives and process |
US3975367A (en) * | 1971-06-08 | 1976-08-17 | The Upjohn Company | Arabinofuranosyl N4 -aminoacyl cytosine containing compounds |
DE2658672A1 (de) * | 1976-12-23 | 1978-06-29 | Robugen Gmbh | Neue nucleosid-verbindungen und verfahren zu ihrer herstellung |
JPS5535057A (en) * | 1978-09-05 | 1980-03-11 | Funai Corp | 2'-deoxy-5-fluorouridine derivative, its preparation, and antitumor agent comprising it |
-
1978
- 1978-06-10 JP JP53069383A patent/JPS5924999B2/ja not_active Expired
-
1979
- 1979-05-31 GB GB7918944A patent/GB2025401B/en not_active Expired
- 1979-06-06 US US06/046,109 patent/US4472386A/en not_active Expired - Lifetime
- 1979-06-08 FR FR7914738A patent/FR2428052A1/fr active Granted
- 1979-06-08 DE DE19792923368 patent/DE2923368A1/de active Granted
Also Published As
Publication number | Publication date |
---|---|
GB2025401A (en) | 1980-01-23 |
JPS54163586A (en) | 1979-12-26 |
FR2428052A1 (fr) | 1980-01-04 |
US4472386A (en) | 1984-09-18 |
FR2428052B1 (US07754267-20100713-C00021.png) | 1982-07-02 |
DE2923368A1 (de) | 1980-01-03 |
DE2923368C2 (US07754267-20100713-C00021.png) | 1989-07-06 |
GB2025401B (en) | 1982-12-22 |
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