JPS59227870A - 新規２−グアニジノチアゾリン誘導体ならびにその製造法 - Google Patents

新規２−グアニジノチアゾリン誘導体ならびにその製造法

Info

Publication number
JPS59227870A
JPS59227870A JP58102206A JP10220683A JPS59227870A JP S59227870 A JPS59227870 A JP S59227870A JP 58102206 A JP58102206 A JP 58102206A JP 10220683 A JP10220683 A JP 10220683A JP S59227870 A JPS59227870 A JP S59227870A
Authority
JP
Japan
Prior art keywords
formula
compound
reaction
guanidinothiazoline
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP58102206A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0460990B2 (enExample
Inventor
Yasufumi Hirata
平田　康文
Isao Yanagisawa
柳沢　勲
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Astellas Pharma Inc
Original Assignee
Yamanouchi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamanouchi Pharmaceutical Co Ltd filed Critical Yamanouchi Pharmaceutical Co Ltd
Priority to JP58102206A priority Critical patent/JPS59227870A/ja
Priority to US06/597,234 priority patent/US4562261A/en
Priority to EP84303793A priority patent/EP0128736B1/en
Publication of JPS59227870A publication Critical patent/JPS59227870A/ja
Priority to US06/742,581 priority patent/US4609737A/en
Publication of JPH0460990B2 publication Critical patent/JPH0460990B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/18—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/48—Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
JP58102206A 1983-06-07 1983-06-07 新規２−グアニジノチアゾリン誘導体ならびにその製造法 Granted JPS59227870A (ja)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP58102206A JPS59227870A (ja) 1983-06-07 1983-06-07 新規２−グアニジノチアゾリン誘導体ならびにその製造法
US06/597,234 US4562261A (en) 1983-06-07 1984-04-05 2-Guanidinothiazoline compounds, and process for preparing them
EP84303793A EP0128736B1 (en) 1983-06-07 1984-06-05 Novel 2-guanidinothiazoline compounds, their preparation, and their use as intermediates
US06/742,581 US4609737A (en) 1983-06-07 1985-06-07 Novel 2-guanidinothiazoline compounds, and process for preparing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP58102206A JPS59227870A (ja) 1983-06-07 1983-06-07 新規２−グアニジノチアゾリン誘導体ならびにその製造法

Publications (2)

Publication Number Publication Date
JPS59227870A true JPS59227870A (ja) 1984-12-21
JPH0460990B2 JPH0460990B2 (enExample) 1992-09-29

Family

ID=14321187

Family Applications (1)

Application Number Title Priority Date Filing Date
JP58102206A Granted JPS59227870A (ja) 1983-06-07 1983-06-07 新規２−グアニジノチアゾリン誘導体ならびにその製造法

Country Status (3)

Country Link
US (2) US4562261A (enExample)
EP (1) EP0128736B1 (enExample)
JP (1) JPS59227870A (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6399065A (ja) * 1986-08-05 1988-04-30 リヒタ−　ゲデオン　ベジエセテイ　ジヤ−ル　ア−ル．テ−． 形態学的に均質型のチアゾ−ル誘導体の製造方法

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR71929B (enExample) * 1979-11-13 1983-08-19 Ici Ltd
HU191408B (en) * 1984-04-25 1987-02-27 Egis Gyogyszergyar,Hu Process for preparing new imino-thiazolidine derivatives
DE3644246A1 (de) * 1986-06-20 1987-12-23 Uriach & Cia Sa J Verfahren zur herstelung von 3-(((2-((aminoiminomethyl)-amino)-4-thiazolyl)-methyl)-thio)-n-(aminosulfonyl)-propanimidamid
NO882037L (no) * 1987-06-22 1988-12-23 Marga Para La Investigacion Sa Famotidin, polymerte former og fremstilling derav.
KR890014504A (ko) * 1988-03-11 1989-10-24 우대규 4-(2'-시아노 에틸티오)메틸-2-구아니디노티아졸의 제조방법
KR900004907B1 (ko) * 1988-06-10 1990-07-09 한일약품공업 주식회사 N-술파모일-3-[(2-구아니디노티아졸-4-일)메틸티오]프로피온 아미딘 유도체의 제조방법
US5856500A (en) * 1997-03-11 1999-01-05 Albemarle Corporation Synthesis of thiazole derivatives
US5731442A (en) * 1997-03-11 1998-03-24 Albemarle Corporation Synthesis of thiazole derivatives
US20010031244A1 (en) 1997-06-13 2001-10-18 Chiesi Farmaceutici S.P.A. Pharmaceutical aerosol composition
SE0000774D0 (sv) * 2000-03-08 2000-03-08 Astrazeneca Ab New formulation
SE0000773D0 (sv) * 2000-03-08 2000-03-08 Astrazeneca Ab New formulation
DK1411900T4 (da) * 2001-06-01 2014-01-27 Pozen Inc Farmaceutiske sammensætninger til den koordinerede frigørelse af NSAIDs
US8206741B2 (en) 2001-06-01 2012-06-26 Pozen Inc. Pharmaceutical compositions for the coordinated delivery of NSAIDs
SE0102993D0 (sv) 2001-09-07 2001-09-07 Astrazeneca Ab New self emulsifying drug delivery system
WO2005009986A1 (en) * 2003-07-28 2005-02-03 Talluri Veera Venkata Satyanar One-pot preparation of s-(guanidino-4-yl-methyl)-isothiourea dihydrochoride
WO2005115527A2 (en) * 2004-05-24 2005-12-08 Auris Medical, Llc. Combined otic aspirator and medication dispenser
KR20110079641A (ko) 2008-09-09 2011-07-07 아스트라제네카 아베 제약 조성물을 이를 필요로 하는 환자에게 전달하는 방법
MX2011013467A (es) 2009-06-25 2012-02-13 Astrazeneca Ab Metodo para tratar un paciente que corre el riesgo de desarollar una ulcera asociada a antiinflamatorio no esteroide (aine).
US9539214B2 (en) 2011-12-28 2017-01-10 Pozen Inc. Compositions and methods for delivery of omeprazole plus acetylsalicylic acid

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2533821A1 (de) * 1975-07-29 1977-02-17 Hoechst Ag Thiazolidinderivate und verfahren zu ihrer herstellung
NZ186965A (en) * 1977-04-20 1980-02-21 Ici Ltd Guanidino derivatives and pharmaceutical compositions
JPS6056143B2 (ja) * 1979-08-02 1985-12-09 山之内製薬株式会社 アミジン誘導体ならびにその製造法
PH16099A (en) * 1979-03-06 1983-06-24 Yamanouchi Pharma Co Ltd Guanidinothiazole compounds,process for preparing them and medical composition containing them

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6399065A (ja) * 1986-08-05 1988-04-30 リヒタ−　ゲデオン　ベジエセテイ　ジヤ−ル　ア−ル．テ−． 形態学的に均質型のチアゾ−ル誘導体の製造方法
JPH07316141A (ja) * 1986-08-05 1995-12-05 Richter Gedeon V G Rt 形態学的に均質型のチアゾール誘導体の製造方法

Also Published As

Publication number Publication date
US4562261A (en) 1985-12-31
JPH0460990B2 (enExample) 1992-09-29
US4609737A (en) 1986-09-02
EP0128736B1 (en) 1987-02-25
EP0128736A1 (en) 1984-12-19

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