JPS59227818A - ゲル状軟膏剤 - Google Patents
ゲル状軟膏剤Info
- Publication number
- JPS59227818A JPS59227818A JP10338383A JP10338383A JPS59227818A JP S59227818 A JPS59227818 A JP S59227818A JP 10338383 A JP10338383 A JP 10338383A JP 10338383 A JP10338383 A JP 10338383A JP S59227818 A JPS59227818 A JP S59227818A
- Authority
- JP
- Japan
- Prior art keywords
- indomethacin
- water
- ointment
- stability
- gel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002674 ointment Substances 0.000 title claims abstract description 18
- CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 claims abstract description 38
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 20
- 229960000905 indomethacin Drugs 0.000 claims abstract description 19
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 18
- 239000003349 gelling agent Substances 0.000 claims abstract description 7
- 235000011187 glycerol Nutrition 0.000 claims description 7
- 150000001298 alcohols Chemical class 0.000 claims description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract description 12
- 229920002125 Sokalan® Polymers 0.000 abstract description 5
- 239000013078 crystal Substances 0.000 abstract description 3
- 238000001556 precipitation Methods 0.000 abstract description 3
- 229920000609 methyl cellulose Polymers 0.000 abstract description 2
- 239000001923 methylcellulose Substances 0.000 abstract description 2
- 235000010981 methylcellulose Nutrition 0.000 abstract description 2
- 239000000730 antalgic agent Substances 0.000 abstract 1
- 238000002845 discoloration Methods 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 abstract 1
- 239000000758 substrate Substances 0.000 abstract 1
- -1 carboxyl vinyl Chemical group 0.000 description 12
- 239000000203 mixture Substances 0.000 description 12
- 238000003756 stirring Methods 0.000 description 7
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 5
- 235000014113 dietary fatty acids Nutrition 0.000 description 5
- 239000000194 fatty acid Substances 0.000 description 5
- 229930195729 fatty acid Natural products 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 238000002156 mixing Methods 0.000 description 5
- DWAQJAXMDSEUJJ-UHFFFAOYSA-M Sodium bisulfite Chemical compound [Na+].OS([O-])=O DWAQJAXMDSEUJJ-UHFFFAOYSA-M 0.000 description 4
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 description 4
- 235000010267 sodium hydrogen sulphite Nutrition 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- LVTYICIALWPMFW-UHFFFAOYSA-N diisopropanolamine Chemical compound CC(O)CNCC(C)O LVTYICIALWPMFW-UHFFFAOYSA-N 0.000 description 3
- 229940043276 diisopropanolamine Drugs 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 3
- 239000002736 nonionic surfactant Substances 0.000 description 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- 239000001361 adipic acid Substances 0.000 description 2
- 235000011037 adipic acid Nutrition 0.000 description 2
- 125000004432 carbon atom Chemical group C* 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 2
- 235000010262 sodium metabisulphite Nutrition 0.000 description 2
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 description 1
- 101100440696 Caenorhabditis elegans cor-1 gene Proteins 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 description 1
- 241000283986 Lepus Species 0.000 description 1
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- WNLRTRBMVRJNCN-UHFFFAOYSA-L adipate(2-) Chemical compound [O-]C(=O)CCCCC([O-])=O WNLRTRBMVRJNCN-UHFFFAOYSA-L 0.000 description 1
- 150000005215 alkyl ethers Chemical class 0.000 description 1
- 150000001349 alkyl fluorides Chemical class 0.000 description 1
- 125000005037 alkyl phenyl group Chemical group 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 235000010323 ascorbic acid Nutrition 0.000 description 1
- 229960005070 ascorbic acid Drugs 0.000 description 1
- 239000011668 ascorbic acid Substances 0.000 description 1
- 229910021538 borax Inorganic materials 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 235000018417 cysteine Nutrition 0.000 description 1
- 229960002433 cysteine Drugs 0.000 description 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 1
- 150000001991 dicarboxylic acids Chemical class 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 229940079826 hydrogen sulfite Drugs 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 150000002763 monocarboxylic acids Chemical class 0.000 description 1
- PJUIMOJAAPLTRJ-UHFFFAOYSA-N monothioglycerol Chemical compound OCC(O)CS PJUIMOJAAPLTRJ-UHFFFAOYSA-N 0.000 description 1
- 235000011118 potassium hydroxide Nutrition 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 235000017550 sodium carbonate Nutrition 0.000 description 1
- 229940079827 sodium hydrogen sulfite Drugs 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 235000011008 sodium phosphates Nutrition 0.000 description 1
- 239000004328 sodium tetraborate Substances 0.000 description 1
- 235000010339 sodium tetraborate Nutrition 0.000 description 1
- AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 description 1
- 229940001474 sodium thiosulfate Drugs 0.000 description 1
- 235000019345 sodium thiosulphate Nutrition 0.000 description 1
- 230000003637 steroidlike Effects 0.000 description 1
- TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 description 1
- 229940035024 thioglycerol Drugs 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10338383A JPS59227818A (ja) | 1983-06-09 | 1983-06-09 | ゲル状軟膏剤 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10338383A JPS59227818A (ja) | 1983-06-09 | 1983-06-09 | ゲル状軟膏剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS59227818A true JPS59227818A (ja) | 1984-12-21 |
| JPH0587483B2 JPH0587483B2 (enExample) | 1993-12-16 |
Family
ID=14352558
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP10338383A Granted JPS59227818A (ja) | 1983-06-09 | 1983-06-09 | ゲル状軟膏剤 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS59227818A (enExample) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63104914A (ja) * | 1986-10-23 | 1988-05-10 | Mitsubishi Kasei Corp | 皮膚用製剤 |
| JPS6456622A (en) * | 1987-08-28 | 1989-03-03 | Ss Pharmaceutical Co | Percutaneous absorbefacient base composition |
| JP2002029971A (ja) * | 2000-07-14 | 2002-01-29 | Teikoku Seiyaku Co Ltd | インドメタシン水溶性貼付剤 |
| WO2004010994A1 (ja) | 2002-07-29 | 2004-02-05 | Kowa Company, Ltd. | インドメタシン外用剤 |
| KR101326468B1 (ko) * | 2005-10-17 | 2013-11-07 | 코와 가부시키가이샤 | 인도메타신을 함유하는 외용 액제 |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS54132225A (en) * | 1978-03-31 | 1979-10-15 | Landstingens Inkopscentral | Skin disinfecting ointment agent and production |
| JPS5610886A (en) * | 1979-07-06 | 1981-02-03 | Fuji Kuuchiyou Kogyo Kk | Elbow |
| JPS5651410A (en) * | 1979-10-01 | 1981-05-09 | Sumitomo Chem Co Ltd | Ointment |
| JPS56108867A (en) * | 1980-02-04 | 1981-08-28 | Nisshin Steel Co Ltd | Wiping spray nozzle of hot dipping apparatus |
| JPS56135413A (en) * | 1980-02-18 | 1981-10-22 | Sorufuon Arutsunaimitsuteru Fu | Local drug containing indomethacin |
| JPS57165313A (en) * | 1981-04-07 | 1982-10-12 | Nichibei Zoki Kk | Indomethacin for external use |
| JPS584713A (ja) * | 1981-06-30 | 1983-01-11 | Yuutoku Yakuhin Kogyo Kk | 消炎鎮痛軟膏剤及びその製法 |
-
1983
- 1983-06-09 JP JP10338383A patent/JPS59227818A/ja active Granted
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS54132225A (en) * | 1978-03-31 | 1979-10-15 | Landstingens Inkopscentral | Skin disinfecting ointment agent and production |
| JPS5610886A (en) * | 1979-07-06 | 1981-02-03 | Fuji Kuuchiyou Kogyo Kk | Elbow |
| JPS5651410A (en) * | 1979-10-01 | 1981-05-09 | Sumitomo Chem Co Ltd | Ointment |
| JPS56108867A (en) * | 1980-02-04 | 1981-08-28 | Nisshin Steel Co Ltd | Wiping spray nozzle of hot dipping apparatus |
| JPS56135413A (en) * | 1980-02-18 | 1981-10-22 | Sorufuon Arutsunaimitsuteru Fu | Local drug containing indomethacin |
| JPS57165313A (en) * | 1981-04-07 | 1982-10-12 | Nichibei Zoki Kk | Indomethacin for external use |
| JPS584713A (ja) * | 1981-06-30 | 1983-01-11 | Yuutoku Yakuhin Kogyo Kk | 消炎鎮痛軟膏剤及びその製法 |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63104914A (ja) * | 1986-10-23 | 1988-05-10 | Mitsubishi Kasei Corp | 皮膚用製剤 |
| JPS6456622A (en) * | 1987-08-28 | 1989-03-03 | Ss Pharmaceutical Co | Percutaneous absorbefacient base composition |
| JP2002029971A (ja) * | 2000-07-14 | 2002-01-29 | Teikoku Seiyaku Co Ltd | インドメタシン水溶性貼付剤 |
| WO2004010994A1 (ja) | 2002-07-29 | 2004-02-05 | Kowa Company, Ltd. | インドメタシン外用剤 |
| CN100438869C (zh) * | 2002-07-29 | 2008-12-03 | 兴和株式会社 | 吲哚美辛外用剂 |
| US7553865B2 (en) | 2002-07-29 | 2009-06-30 | Kowa Company, Ltd. | Indomethacin external preparation |
| JP4494202B2 (ja) * | 2002-07-29 | 2010-06-30 | 興和株式会社 | インドメタシン外用剤 |
| JP2010163454A (ja) * | 2002-07-29 | 2010-07-29 | Kowa Co | インドメタシン含有ゲルクリーム剤 |
| KR101326468B1 (ko) * | 2005-10-17 | 2013-11-07 | 코와 가부시키가이샤 | 인도메타신을 함유하는 외용 액제 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0587483B2 (enExample) | 1993-12-16 |
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