JPS59176277A - 縮合イミダゾ−ル化合物 - Google Patents

縮合イミダゾ−ル化合物

Info

Publication number
JPS59176277A
JPS59176277A JP59054683A JP5468384A JPS59176277A JP S59176277 A JPS59176277 A JP S59176277A JP 59054683 A JP59054683 A JP 59054683A JP 5468384 A JP5468384 A JP 5468384A JP S59176277 A JPS59176277 A JP S59176277A
Authority
JP
Japan
Prior art keywords
compound
group
reaction
acid
salts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP59054683A
Other languages
English (en)
Japanese (ja)
Inventor
Ikuo Ueda
育男 植田
Masayuki Kato
真行 加藤
Masanobu Nagano
正信 長野
Atsushi Akaha
厚 赤羽
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Publication of JPS59176277A publication Critical patent/JPS59176277A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/10—Radicals substituted by halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP59054683A 1983-03-22 1984-03-21 縮合イミダゾ−ル化合物 Pending JPS59176277A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8307865 1983-03-22
GB838307865A GB8307865D0 (en) 1983-03-22 1983-03-22 Benzimidazole derivatives

Publications (1)

Publication Number Publication Date
JPS59176277A true JPS59176277A (ja) 1984-10-05

Family

ID=10540007

Family Applications (1)

Application Number Title Priority Date Filing Date
JP59054683A Pending JPS59176277A (ja) 1983-03-22 1984-03-21 縮合イミダゾ−ル化合物

Country Status (13)

Country Link
US (1) US4563455A (en, 2012)
EP (1) EP0125756A3 (en, 2012)
JP (1) JPS59176277A (en, 2012)
KR (1) KR840008016A (en, 2012)
AU (1) AU2587384A (en, 2012)
DK (1) DK110384A (en, 2012)
ES (1) ES8506001A1 (en, 2012)
FI (1) FI841082L (en, 2012)
GB (1) GB8307865D0 (en, 2012)
GR (1) GR79774B (en, 2012)
IL (1) IL71310A0 (en, 2012)
NO (1) NO841106L (en, 2012)
ZA (1) ZA841393B (en, 2012)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4728741A (en) * 1985-01-08 1988-03-01 Smithkline Beckman Corporation 1-substituted-2-mercapto benzimidazole compounds and intermediates
WO1997003077A1 (en) * 1995-07-12 1997-01-30 Yungjin Pharmaceutical Co., Ltd. Benz- or pyrido-imidazole derivatives
WO2011072694A1 (en) 2009-12-17 2011-06-23 H. Lundbeck A/S Heteroaromatic phenylimidazole derivatives as pde10a enzyme inhibitors
WO2011072696A1 (en) 2009-12-17 2011-06-23 H. Lundbeck A/S 2-arylimidazole derivatives as pde10a enzyme inhibitors
WO2011072697A1 (en) 2009-12-17 2011-06-23 H. Lundbeck A/S Heteroaromatic aryl triazole derivatives as pde10a enzyme inhibitors
WO2012007006A1 (en) 2010-07-16 2012-01-19 H. Lundbeck A/S Triazolo- and pyrazoloquinazoline derivatives as pde10a enzyme inhibitor
WO2012065612A1 (en) 2010-11-19 2012-05-24 H. Lundbeck A/S Imidazole derivatives as pde10a enzyme inhibitors

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0187977B1 (en) * 1984-12-18 1990-08-29 Otsuka Pharmaceutical Co., Ltd. Tetrahydroquinoline derivatives, process for preparing the same and anti-peptic ulcer compositions containg the same
DE3501497A1 (de) * 1985-01-18 1986-07-24 Boehringer Mannheim Gmbh, 6800 Mannheim Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel sowie zwischenprodukte
KR950001015B1 (ko) * 1986-01-10 1995-02-07 닛뽕 케미화 가부시끼가이샤 술폭시드 유도체의 제조방법
CA1327010C (en) * 1986-02-13 1994-02-15 Tadashi Makino Stabilized solid pharmaceutical composition containing antiulcer benzimidazole compound and its production
US5433959A (en) 1986-02-13 1995-07-18 Takeda Chemical Industries, Ltd. Stabilized pharmaceutical composition
US6749864B2 (en) * 1986-02-13 2004-06-15 Takeda Chemical Industries, Ltd. Stabilized pharmaceutical composition
GB8612796D0 (en) * 1986-05-27 1986-07-02 Fbc Ltd Fungicides
US4772600A (en) * 1986-06-09 1988-09-20 A. H. Robins Company, Inc. Fused imidazoheterocyclic compounds and pharmaceutical compositions
NZ221729A (en) * 1986-09-15 1989-07-27 Janssen Pharmaceutica Nv Imidazolyl methyl-substituted benzimidazole derivatives and pharmaceutical compositions
DE3634066A1 (de) * 1986-10-07 1988-04-21 Boehringer Mannheim Gmbh Neue 5-alkylbenzimidazole, verfahren zu ihrer herstellung sowie arzneimittel
SE8604566D0 (sv) * 1986-10-27 1986-10-27 Haessle Ab Novel compunds
FI91754C (fi) * 1986-12-02 1994-08-10 Tanabe Seiyaku Co Analogiamenetelmä lääkeaineena käyttökelpoisen imidatsolijohdannaisen valmistamiseksi
EP0434999B1 (en) * 1989-11-29 1994-08-17 Toa Eiyo Ltd. Cycloheptenopyridine derivatives, process for preparation thereof and antiulcer agents containing the same
US5200419A (en) * 1990-05-21 1993-04-06 Warner-Lambert Company Substituted tetrazoles and derivatives thereof acting at muscarinic receptors
KR100224135B1 (ko) * 1993-01-28 1999-10-15 다께다 구니오 퀴놀린 또는 퀴나졸린 유도체, 그 제조 및 용도
SE508669C2 (sv) * 1996-04-26 1998-10-26 Astra Ab Nytt förfarande
JP3256513B2 (ja) * 1998-02-11 2002-02-12 ファイザー製薬株式会社 ベンゾイミダゾールシクロオキシゲナーゼ−２阻害剤
UA80393C2 (uk) 2000-12-07 2007-09-25 Алтана Фарма Аг Фармацевтична композиція, яка містить інгібітор фде 4, диспергований в матриці
MY140561A (en) 2002-02-20 2009-12-31 Nycomed Gmbh Dosage form containing pde 4 inhibitor as active ingredient
WO2003080607A1 (en) * 2002-03-27 2003-10-02 Altana Pharma Ag Novel alkoxypyridine-derivatives
HRP20050799A8 (en) * 2003-02-25 2007-10-31 Altana Pharma Ag Imidazo[4,5-b]quinoline-derivatives and their use as no-synthase inhibitors
WO2004080967A1 (en) 2003-03-10 2004-09-23 Altana Pharma Ag Novel process for the preparation of roflumilast
DE10344897A1 (de) * 2003-09-26 2005-04-21 Bosch Gmbh Robert Ventil zur Steuerung einer Verbindung in einem Hochdruckflüssigkeitssystem, insbesondere einer Kraftstoffeinspritzeinrichtung für eine Brennkraftmaschine
CA2540230A1 (en) * 2003-10-01 2005-07-07 Altana Pharma Ag Aminopyridine-derivatives as inductible no-synthase inhibitors
WO2005030771A1 (en) * 2003-10-01 2005-04-07 Altana Pharma Ag Imidazopyridine-derivatives as inductible no-synthase inhibitors
AU2004276012A1 (en) 2003-10-01 2005-04-07 Altana Pharma Ag Imidazo(4,5-b)pyridine-derivatives as inducible no-synthase inhibitors
CA2540242A1 (en) * 2003-10-01 2005-04-07 Altana Pharma Ag Imidazopyridine-derivatives as inducible no-synthase inhibitors
JP2007507466A (ja) 2003-10-01 2007-03-29 アルタナ　ファルマ　アクチエンゲゼルシャフト 誘導性ｎｏシンターゼ阻害剤としてのイミダゾピリジン誘導体
ES2421916T3 (es) * 2005-03-16 2013-09-06 Nycomed Gmbh Forma farmacéutica de sabor enmascarado que contiene roflumilast
PE20070427A1 (es) * 2005-08-30 2007-04-21 Novartis Ag Compuestos derivados de benzimidazoles sustituidos como inhibidores de tirosina quinasas
FR2949469A1 (fr) * 2009-08-25 2011-03-04 Sanofi Aventis Derives anticancereux, leur preparation et leur application en therapeutique

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1476560A (fr) * 1965-08-05 1967-04-14 Chimetron Sarl Thiazolylalcoyl-2 benzimidazoles et thiadiazolylalcoyl-2 benzimidazoles alpha-halogénés ou alpha-aminés
FR2104717A1 (en) * 1970-09-28 1972-04-21 Dynachim Sarl Organophosphorus pesticides stabilised with benzimidazole derivs - - for controlling insects and internal parasites of animals
JPS50116474A (en) * 1974-02-18 1975-09-11 Haessle Ab Shinkinakagobutsuno seizoho

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH262959A (de) * 1944-12-21 1949-07-31 Ciba Geigy Verfahren zur Herstellung des neuen a-(Benzthiazyl-(2))-B-(benzimidazyl-(2))-äthylens.
BE569485A (en, 2012) * 1957-07-17
US3897432A (en) * 1971-04-21 1975-07-29 Merck & Co Inc Substituted benzimidazole derivatives
SU455104A1 (ru) * 1971-08-11 1974-12-30 Ордена Трудового Красного Знамени Институт Тонкой Органической Химии Им. А.Л.Мнджояна Способ получени 2-метил-3-( -алкил -бензимидазолил-2")-этилиндолов
US4294837A (en) * 1980-03-28 1981-10-13 Sterling Drug Inc. 1,3-Dihydro-6-(pyridinyl)-2H-imidazo[4,5-b]pyridin-2-ones and -imidazo[4,5-b]pyridine-2-thiones and their cardiotonic use
GB2101115A (en) * 1980-10-23 1983-01-12 Pfizer Ltd Thromboxane synthetase inhibitors

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1476560A (fr) * 1965-08-05 1967-04-14 Chimetron Sarl Thiazolylalcoyl-2 benzimidazoles et thiadiazolylalcoyl-2 benzimidazoles alpha-halogénés ou alpha-aminés
FR2104717A1 (en) * 1970-09-28 1972-04-21 Dynachim Sarl Organophosphorus pesticides stabilised with benzimidazole derivs - - for controlling insects and internal parasites of animals
JPS50116474A (en) * 1974-02-18 1975-09-11 Haessle Ab Shinkinakagobutsuno seizoho

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4728741A (en) * 1985-01-08 1988-03-01 Smithkline Beckman Corporation 1-substituted-2-mercapto benzimidazole compounds and intermediates
WO1997003077A1 (en) * 1995-07-12 1997-01-30 Yungjin Pharmaceutical Co., Ltd. Benz- or pyrido-imidazole derivatives
WO2011072694A1 (en) 2009-12-17 2011-06-23 H. Lundbeck A/S Heteroaromatic phenylimidazole derivatives as pde10a enzyme inhibitors
WO2011072696A1 (en) 2009-12-17 2011-06-23 H. Lundbeck A/S 2-arylimidazole derivatives as pde10a enzyme inhibitors
WO2011072697A1 (en) 2009-12-17 2011-06-23 H. Lundbeck A/S Heteroaromatic aryl triazole derivatives as pde10a enzyme inhibitors
WO2012007006A1 (en) 2010-07-16 2012-01-19 H. Lundbeck A/S Triazolo- and pyrazoloquinazoline derivatives as pde10a enzyme inhibitor
WO2012065612A1 (en) 2010-11-19 2012-05-24 H. Lundbeck A/S Imidazole derivatives as pde10a enzyme inhibitors

Also Published As

Publication number Publication date
US4563455A (en) 1986-01-07
DK110384A (da) 1984-09-23
DK110384D0 (da) 1984-02-27
FI841082A0 (fi) 1984-03-19
FI841082A7 (fi) 1984-09-23
ES530810A0 (es) 1985-06-16
ES8506001A1 (es) 1985-06-16
ZA841393B (en) 1984-10-31
EP0125756A2 (en) 1984-11-21
IL71310A0 (en) 1984-06-29
EP0125756A3 (en) 1987-04-08
GR79774B (en, 2012) 1984-10-31
GB8307865D0 (en) 1983-04-27
KR840008016A (ko) 1984-12-12
NO841106L (no) 1984-09-24
FI841082L (fi) 1984-09-23
AU2587384A (en) 1984-09-27

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