JPS59141559A - ラクタムペプチド及びその製造方法並びに該ペプチドを含有する医薬 - Google Patents

ラクタムペプチド及びその製造方法並びに該ペプチドを含有する医薬

Info

Publication number
JPS59141559A
JPS59141559A JP59011110A JP1111084A JPS59141559A JP S59141559 A JPS59141559 A JP S59141559A JP 59011110 A JP59011110 A JP 59011110A JP 1111084 A JP1111084 A JP 1111084A JP S59141559 A JPS59141559 A JP S59141559A
Authority
JP
Japan
Prior art keywords
group
formula
compound
groups
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP59011110A
Other languages
English (en)
Japanese (ja)
Inventor
ビリアム・ベンツエ
プルノ・カムバー
アンジエロ・ストルニ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of JPS59141559A publication Critical patent/JPS59141559A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP59011110A 1983-01-27 1984-01-26 ラクタムペプチド及びその製造方法並びに該ペプチドを含有する医薬 Pending JPS59141559A (ja)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH45383 1983-01-27

Publications (1)

Publication Number Publication Date
JPS59141559A true JPS59141559A (ja) 1984-08-14

Family

ID=4187370

Family Applications (1)

Application Number Title Priority Date Filing Date
JP59011110A Pending JPS59141559A (ja) 1983-01-27 1984-01-26 ラクタムペプチド及びその製造方法並びに該ペプチドを含有する医薬

Country Status (12)

Country Link
EP (1) EP0115472A3 (OSRAM)
JP (1) JPS59141559A (OSRAM)
KR (1) KR840007571A (OSRAM)
AU (1) AU2383884A (OSRAM)
DD (1) DD216005A5 (OSRAM)
DK (1) DK35884A (OSRAM)
FI (1) FI840260L (OSRAM)
GR (1) GR81746B (OSRAM)
IL (1) IL70772A0 (OSRAM)
NO (1) NO840310L (OSRAM)
PT (1) PT78007B (OSRAM)
ZA (1) ZA84560B (OSRAM)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991009612A1 (fr) * 1989-12-25 1991-07-11 Koken Co., Ltd. Inhibiteur de croissance de cellules tumorales

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE943625C (de) * 1943-06-28 1956-05-24 Ferguson Harry Inc Seitensteuerungseinrichtung fuer ein landwirtschaftliches Schlepperanbaugeraet
JPH0696574B2 (ja) * 1987-09-16 1994-11-30 三菱化成株式会社 ４−ピペリジンカルボキサミド誘導体
JPH0696575B2 (ja) * 1987-09-17 1994-11-30 三菱化成株式会社 ４−アミノピリジン誘導体及びその酸付加塩
EP0725650A4 (en) * 1993-09-30 1999-02-03 Merck & Co Inc FARNESYL-PROTEIN TRANSFERASE INHIBITORS
JP2002538151A (ja) 1999-03-02 2002-11-12 ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド カテプシンの可逆的インヒビターとして有用な化合物
US6420364B1 (en) 1999-09-13 2002-07-16 Boehringer Ingelheim Pharmaceuticals, Inc. Compound useful as reversible inhibitors of cysteine proteases
US20050065205A1 (en) 2002-03-07 2005-03-24 Daniel Alkon Methods for Alzheimer's disease treatment and cognitive enhance
US6825229B2 (en) 2002-03-07 2004-11-30 Blanchette Rockefeller Neurosciences Institute Methods for Alzheimer's Disease treatment and cognitive enhancement
TW201206425A (en) 2004-05-18 2012-02-16 Brni Neurosciences Inst Treatment of depressive disorders
KR20130122630A (ko) 2005-07-29 2013-11-07 블랜체트 록펠러 뉴로사이언시즈 인스티튜트 단독의 또는 ｐｋｃ 억제제와 배합된 ｐｋｃ 활성화제의 장기 기억 향상을 위한 용도
EP2754448A3 (en) 2007-02-09 2014-12-24 Blanchette Rockefeller Neurosciences, Institute Therapeutic effects of bryostatins, bryologs, and other related substances on head trauma-induced memory impairment and brain injury

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT360980B (de) * 1976-01-14 1981-02-10 Pliva Pharm & Chem Works Verfahren zur herstellung von n-alkylamiden des 2-oxo-1-pyrrolidins
GB1539817A (en) * 1976-10-22 1979-02-07 Ucb Sa N-substituted lactams

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991009612A1 (fr) * 1989-12-25 1991-07-11 Koken Co., Ltd. Inhibiteur de croissance de cellules tumorales

Also Published As

Publication number Publication date
KR840007571A (ko) 1984-12-08
DK35884D0 (da) 1984-01-26
FI840260A7 (fi) 1984-07-28
DK35884A (da) 1984-07-28
ZA84560B (en) 1984-09-26
GR81746B (OSRAM) 1984-12-12
EP0115472A3 (de) 1985-10-02
DD216005A5 (de) 1984-11-28
NO840310L (no) 1984-07-30
AU2383884A (en) 1984-08-02
FI840260A0 (fi) 1984-01-23
PT78007A (en) 1984-02-01
PT78007B (en) 1986-06-18
FI840260L (fi) 1984-07-28
IL70772A0 (en) 1984-04-30
EP0115472A2 (de) 1984-08-08

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