JPS59102436A - 吸着体 - Google Patents
吸着体Info
- Publication number
- JPS59102436A JPS59102436A JP57212379A JP21237982A JPS59102436A JP S59102436 A JPS59102436 A JP S59102436A JP 57212379 A JP57212379 A JP 57212379A JP 21237982 A JP21237982 A JP 21237982A JP S59102436 A JPS59102436 A JP S59102436A
- Authority
- JP
- Japan
- Prior art keywords
- gel
- lipoprotein
- ldl
- adsorbent
- molecular weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003463 adsorbent Substances 0.000 title claims abstract description 27
- 102000004895 Lipoproteins Human genes 0.000 claims abstract description 17
- 108090001030 Lipoproteins Proteins 0.000 claims abstract description 17
- 229920000642 polymer Polymers 0.000 claims abstract description 12
- 102000034238 globular proteins Human genes 0.000 claims abstract description 6
- 108091005896 globular proteins Proteins 0.000 claims abstract description 6
- 229920001282 polysaccharide Polymers 0.000 claims abstract description 6
- 239000005017 polysaccharide Substances 0.000 claims abstract description 6
- 229920002567 Chondroitin Polymers 0.000 claims abstract description 5
- DLGJWSVWTWEWBJ-HGGSSLSASA-N chondroitin Chemical compound CC(O)=N[C@@H]1[C@H](O)O[C@H](CO)[C@H](O)[C@@H]1OC1[C@H](O)[C@H](O)C=C(C(O)=O)O1 DLGJWSVWTWEWBJ-HGGSSLSASA-N 0.000 claims abstract description 5
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims abstract description 4
- 229920000669 heparin Polymers 0.000 claims abstract description 4
- 229960002897 heparin Drugs 0.000 claims abstract description 4
- 150000004676 glycans Chemical class 0.000 claims abstract 3
- 230000007717 exclusion Effects 0.000 claims description 24
- 150000001875 compounds Chemical class 0.000 claims description 12
- -1 dextran sulfate Chemical compound 0.000 claims description 6
- 229920002678 cellulose Polymers 0.000 claims description 3
- 239000001913 cellulose Substances 0.000 claims description 3
- 229960000633 dextran sulfate Drugs 0.000 claims description 3
- 229920001059 synthetic polymer Polymers 0.000 claims description 3
- 239000008280 blood Substances 0.000 abstract description 16
- 210000004369 blood Anatomy 0.000 abstract description 16
- PTHCMJGKKRQCBF-UHFFFAOYSA-N Cellulose, microcrystalline Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC)C(CO)O1 PTHCMJGKKRQCBF-UHFFFAOYSA-N 0.000 abstract description 5
- 229920002307 Dextran Polymers 0.000 abstract description 4
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 abstract description 4
- 229920000447 polyanionic polymer Polymers 0.000 abstract description 4
- 229920001577 copolymer Polymers 0.000 abstract description 3
- 201000005577 familial hyperlipidemia Diseases 0.000 abstract description 3
- 230000003100 immobilizing effect Effects 0.000 abstract description 3
- 206010003210 Arteriosclerosis Diseases 0.000 abstract description 2
- 208000011775 arteriosclerosis disease Diseases 0.000 abstract description 2
- 210000002381 plasma Anatomy 0.000 abstract description 2
- 210000002966 serum Anatomy 0.000 abstract description 2
- 239000000463 material Substances 0.000 abstract 1
- 239000000499 gel Substances 0.000 description 36
- 102000007330 LDL Lipoproteins Human genes 0.000 description 23
- 108010007622 LDL Lipoproteins Proteins 0.000 description 23
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 15
- 238000000034 method Methods 0.000 description 15
- 239000011148 porous material Substances 0.000 description 15
- 239000002245 particle Substances 0.000 description 13
- 102000004169 proteins and genes Human genes 0.000 description 10
- 108090000623 proteins and genes Proteins 0.000 description 10
- 238000001179 sorption measurement Methods 0.000 description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 10
- 239000003446 ligand Substances 0.000 description 8
- 125000003277 amino group Chemical group 0.000 description 7
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 6
- 239000000203 mixture Substances 0.000 description 6
- 239000000243 solution Substances 0.000 description 5
- 238000006243 chemical reaction Methods 0.000 description 4
- 229910021645 metal ion Inorganic materials 0.000 description 4
- 239000012266 salt solution Substances 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- 238000002560 therapeutic procedure Methods 0.000 description 4
- 229920000936 Agarose Polymers 0.000 description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 235000012000 cholesterol Nutrition 0.000 description 3
- 229960002086 dextran Drugs 0.000 description 3
- 125000000524 functional group Chemical group 0.000 description 3
- 239000012528 membrane Substances 0.000 description 3
- 150000004804 polysaccharides Chemical class 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 2
- BRLQWZUYTZBJKN-UHFFFAOYSA-N Epichlorohydrin Chemical compound ClCC1CO1 BRLQWZUYTZBJKN-UHFFFAOYSA-N 0.000 description 2
- 230000005526 G1 to G0 transition Effects 0.000 description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 description 2
- 206010045261 Type IIa hyperlipidaemia Diseases 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 239000011543 agarose gel Substances 0.000 description 2
- 125000003172 aldehyde group Chemical group 0.000 description 2
- 235000011114 ammonium hydroxide Nutrition 0.000 description 2
- 239000000427 antigen Substances 0.000 description 2
- 102000036639 antigens Human genes 0.000 description 2
- 108091007433 antigens Proteins 0.000 description 2
- 239000000969 carrier Substances 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- 229920002451 polyvinyl alcohol Polymers 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- 239000012279 sodium borohydride Substances 0.000 description 2
- 229910000033 sodium borohydride Inorganic materials 0.000 description 2
- 239000006228 supernatant Substances 0.000 description 2
- DBTMGCOVALSLOR-DEVYUCJPSA-N (2s,3r,4s,5r,6r)-4-[(2s,3r,4s,5r,6r)-3,5-dihydroxy-6-(hydroxymethyl)-4-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-6-(hydroxymethyl)oxane-2,3,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](CO)O[C@H](O)[C@@H]2O)O)O[C@H](CO)[C@H]1O DBTMGCOVALSLOR-DEVYUCJPSA-N 0.000 description 1
- LMDZBCPBFSXMTL-UHFFFAOYSA-N 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide Chemical compound CCN=C=NCCCN(C)C LMDZBCPBFSXMTL-UHFFFAOYSA-N 0.000 description 1
- PYSRRFNXTXNWCD-UHFFFAOYSA-N 3-(2-phenylethenyl)furan-2,5-dione Chemical compound O=C1OC(=O)C(C=CC=2C=CC=CC=2)=C1 PYSRRFNXTXNWCD-UHFFFAOYSA-N 0.000 description 1
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 description 1
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 1
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 1
- 102000009027 Albumins Human genes 0.000 description 1
- 108010088751 Albumins Proteins 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 229920002101 Chitin Polymers 0.000 description 1
- 229920001661 Chitosan Polymers 0.000 description 1
- 229920001268 Cholestyramine Polymers 0.000 description 1
- 229920001287 Chondroitin sulfate Polymers 0.000 description 1
- 229920002527 Glycogen Polymers 0.000 description 1
- 229920001202 Inulin Polymers 0.000 description 1
- 229920001543 Laminarin Polymers 0.000 description 1
- 239000005717 Laminarin Substances 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 239000004952 Polyamide Substances 0.000 description 1
- 229920001213 Polysorbate 20 Polymers 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 229920000147 Styrene maleic anhydride Polymers 0.000 description 1
- 125000004018 acid anhydride group Chemical group 0.000 description 1
- 238000001042 affinity chromatography Methods 0.000 description 1
- 229940072056 alginate Drugs 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 229910001420 alkaline earth metal ion Inorganic materials 0.000 description 1
- 125000003368 amide group Chemical group 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- RUVINXPYWBROJD-UHFFFAOYSA-N anethole Polymers COC1=CC=C(C=CC)C=C1 RUVINXPYWBROJD-UHFFFAOYSA-N 0.000 description 1
- 229910052788 barium Inorganic materials 0.000 description 1
- DSAJWYNOEDNPEQ-UHFFFAOYSA-N barium atom Chemical compound [Ba] DSAJWYNOEDNPEQ-UHFFFAOYSA-N 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 125000001309 chloro group Chemical group Cl* 0.000 description 1
- 229940059329 chondroitin sulfate Drugs 0.000 description 1
- 229910017052 cobalt Inorganic materials 0.000 description 1
- 239000010941 cobalt Substances 0.000 description 1
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 description 1
- 238000005056 compaction Methods 0.000 description 1
- 210000004351 coronary vessel Anatomy 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000000378 dietary effect Effects 0.000 description 1
- HPNMFZURTQLUMO-UHFFFAOYSA-N diethylamine Chemical compound CCNCC HPNMFZURTQLUMO-UHFFFAOYSA-N 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 125000003700 epoxy group Chemical group 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000005227 gel permeation chromatography Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 229940096919 glycogen Drugs 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 239000012510 hollow fiber Substances 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- JYJIGFIDKWBXDU-MNNPPOADSA-N inulin Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(OC[C@]3(OC[C@]4(OC[C@]5(OC[C@]6(OC[C@]7(OC[C@]8(OC[C@]9(OC[C@]%10(OC[C@]%11(OC[C@]%12(OC[C@]%13(OC[C@]%14(OC[C@]%15(OC[C@]%16(OC[C@]%17(OC[C@]%18(OC[C@]%19(OC[C@]%20(OC[C@]%21(OC[C@]%22(OC[C@]%23(OC[C@]%24(OC[C@]%25(OC[C@]%26(OC[C@]%27(OC[C@]%28(OC[C@]%29(OC[C@]%30(OC[C@]%31(OC[C@]%32(OC[C@]%33(OC[C@]%34(OC[C@]%35(OC[C@]%36(O[C@@H]%37[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O%37)O)[C@H]([C@H](O)[C@@H](CO)O%36)O)[C@H]([C@H](O)[C@@H](CO)O%35)O)[C@H]([C@H](O)[C@@H](CO)O%34)O)[C@H]([C@H](O)[C@@H](CO)O%33)O)[C@H]([C@H](O)[C@@H](CO)O%32)O)[C@H]([C@H](O)[C@@H](CO)O%31)O)[C@H]([C@H](O)[C@@H](CO)O%30)O)[C@H]([C@H](O)[C@@H](CO)O%29)O)[C@H]([C@H](O)[C@@H](CO)O%28)O)[C@H]([C@H](O)[C@@H](CO)O%27)O)[C@H]([C@H](O)[C@@H](CO)O%26)O)[C@H]([C@H](O)[C@@H](CO)O%25)O)[C@H]([C@H](O)[C@@H](CO)O%24)O)[C@H]([C@H](O)[C@@H](CO)O%23)O)[C@H]([C@H](O)[C@@H](CO)O%22)O)[C@H]([C@H](O)[C@@H](CO)O%21)O)[C@H]([C@H](O)[C@@H](CO)O%20)O)[C@H]([C@H](O)[C@@H](CO)O%19)O)[C@H]([C@H](O)[C@@H](CO)O%18)O)[C@H]([C@H](O)[C@@H](CO)O%17)O)[C@H]([C@H](O)[C@@H](CO)O%16)O)[C@H]([C@H](O)[C@@H](CO)O%15)O)[C@H]([C@H](O)[C@@H](CO)O%14)O)[C@H]([C@H](O)[C@@H](CO)O%13)O)[C@H]([C@H](O)[C@@H](CO)O%12)O)[C@H]([C@H](O)[C@@H](CO)O%11)O)[C@H]([C@H](O)[C@@H](CO)O%10)O)[C@H]([C@H](O)[C@@H](CO)O9)O)[C@H]([C@H](O)[C@@H](CO)O8)O)[C@H]([C@H](O)[C@@H](CO)O7)O)[C@H]([C@H](O)[C@@H](CO)O6)O)[C@H]([C@H](O)[C@@H](CO)O5)O)[C@H]([C@H](O)[C@@H](CO)O4)O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JYJIGFIDKWBXDU-MNNPPOADSA-N 0.000 description 1
- 229940029339 inulin Drugs 0.000 description 1
- 108010027678 lagenin Proteins 0.000 description 1
- 150000002605 large molecules Chemical class 0.000 description 1
- AIHDCSAXVMAMJH-GFBKWZILSA-N levan Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@@H]1[C@@H](O)[C@H](O)[C@](CO)(CO[C@@H]2[C@H]([C@H](O)[C@@](O)(CO)O2)O)O1 AIHDCSAXVMAMJH-GFBKWZILSA-N 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
- 229910052753 mercury Inorganic materials 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- 238000005192 partition Methods 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 230000010412 perfusion Effects 0.000 description 1
- 230000002572 peristaltic effect Effects 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- IYDGMDWEHDFVQI-UHFFFAOYSA-N phosphoric acid;trioxotungsten Chemical compound O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.OP(O)(O)=O IYDGMDWEHDFVQI-UHFFFAOYSA-N 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
- 229920000137 polyphosphoric acid Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- JQWHASGSAFIOCM-UHFFFAOYSA-M sodium periodate Chemical compound [Na+].[O-]I(=O)(=O)=O JQWHASGSAFIOCM-UHFFFAOYSA-M 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 125000006850 spacer group Chemical group 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 229910052712 strontium Inorganic materials 0.000 description 1
- CIOAGBVUUVVLOB-UHFFFAOYSA-N strontium atom Chemical compound [Sr] CIOAGBVUUVVLOB-UHFFFAOYSA-N 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 125000003396 thiol group Chemical group [H]S* 0.000 description 1
- RUVINXPYWBROJD-ONEGZZNKSA-N trans-anethole Polymers COC1=CC=C(\C=C\C)C=C1 RUVINXPYWBROJD-ONEGZZNKSA-N 0.000 description 1
- 229920001221 xylan Polymers 0.000 description 1
Landscapes
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- External Artificial Organs (AREA)
Priority Applications (16)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP57212379A JPS59102436A (ja) | 1982-12-02 | 1982-12-02 | 吸着体 |
| CA000442312A CA1221307A (en) | 1982-12-02 | 1983-11-30 | Adsorbent and process for preparing the same |
| ZA838908A ZA838908B (en) | 1982-12-02 | 1983-11-30 | Absorbent and process for preparing the same |
| AU21832/83A AU571855B2 (en) | 1982-12-02 | 1983-11-30 | Adsorbent for removing harmful substances from blood |
| EP91115793A EP0464872B2 (en) | 1982-12-02 | 1983-12-01 | Adsorbent and process for preparing the same |
| AT91115793T ATE195891T1 (de) | 1982-12-02 | 1983-12-01 | Sorbentmittel und dessen herstellungsverfahren |
| EP87100215A EP0225867B1 (en) | 1982-12-02 | 1983-12-01 | Adsorbent and process for preparing the same |
| EP83112042A EP0110409B2 (en) | 1982-12-02 | 1983-12-01 | Adsorbent and process for preparing the same |
| AT83112042T ATE42222T1 (de) | 1982-12-02 | 1983-12-01 | Adsorbent und verfahren zu dessen herstellung. |
| AT87100215T ATE97832T1 (de) | 1982-12-02 | 1983-12-01 | Adsorbens und verfahren zu dessen herstellung. |
| US06/557,061 US4576928A (en) | 1982-12-02 | 1983-12-01 | Adsorbent and process for preparing the same |
| DE8383112042T DE3379644D1 (en) | 1982-12-02 | 1983-12-01 | Adsorbent and process for preparing the same |
| DE3382834T DE3382834T3 (de) | 1982-12-02 | 1983-12-01 | Sorbentmittel und dessen Herstellungsverfahren |
| DE87100215T DE3382723T2 (de) | 1982-12-02 | 1983-12-01 | Adsorbens und Verfahren zu dessen Herstellung. |
| US06/737,880 US4637994A (en) | 1982-12-02 | 1985-05-28 | Adsorbent and process for preparing the same |
| AU12621/88A AU598643B2 (en) | 1982-12-02 | 1988-03-01 | Adsorbent and process for preparing the same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP57212379A JPS59102436A (ja) | 1982-12-02 | 1982-12-02 | 吸着体 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP63249652A Division JPH01145071A (ja) | 1988-10-03 | 1988-10-03 | リポ蛋白を除去した血漿の製造方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS59102436A true JPS59102436A (ja) | 1984-06-13 |
| JPS6256782B2 JPS6256782B2 (enrdf_load_stackoverflow) | 1987-11-27 |
Family
ID=16621591
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP57212379A Granted JPS59102436A (ja) | 1982-12-02 | 1982-12-02 | 吸着体 |
Country Status (2)
| Country | Link |
|---|---|
| JP (1) | JPS59102436A (enrdf_load_stackoverflow) |
| ZA (1) | ZA838908B (enrdf_load_stackoverflow) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61268355A (ja) * | 1985-05-23 | 1986-11-27 | Kanegafuchi Chem Ind Co Ltd | 体外循環治療用リポ蛋白吸着体およびその製法 |
| JPS6222658A (ja) * | 1985-07-23 | 1987-01-30 | 旭化成株式会社 | 低比重リポ蛋白質吸着装置 |
| JP2005315666A (ja) * | 2004-04-28 | 2005-11-10 | Toshihiko Hanai | 糖結合充填剤およびその製造方法 |
| CN100455349C (zh) * | 2006-03-28 | 2009-01-28 | 南京赛邦医疗用品有限公司 | 用于血液体外循环去除低密度脂蛋白的吸附剂及其制法 |
| WO2012121073A1 (ja) * | 2011-03-04 | 2012-09-13 | Dic株式会社 | 糖類固定化ウイルス除去用高分子基材、及びウイルスの除去方法 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS525393A (en) * | 1975-06-25 | 1977-01-17 | Ajinomoto Kk | Production of carboxy alkylation substance |
| JPS5493689A (en) * | 1977-12-02 | 1979-07-24 | Baylor College Medicine | Resin of selectively removing antibacterial from bacteria infected sap sample and its use |
| JPS57190003A (en) * | 1981-05-18 | 1982-11-22 | Asahi Chem Ind Co Ltd | Wholly porous activated gel |
| JPS5812656A (ja) * | 1981-07-17 | 1983-01-24 | 旭化成株式会社 | 体外循環治療用吸着材 |
-
1982
- 1982-12-02 JP JP57212379A patent/JPS59102436A/ja active Granted
-
1983
- 1983-11-30 ZA ZA838908A patent/ZA838908B/xx unknown
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS525393A (en) * | 1975-06-25 | 1977-01-17 | Ajinomoto Kk | Production of carboxy alkylation substance |
| JPS5493689A (en) * | 1977-12-02 | 1979-07-24 | Baylor College Medicine | Resin of selectively removing antibacterial from bacteria infected sap sample and its use |
| JPS57190003A (en) * | 1981-05-18 | 1982-11-22 | Asahi Chem Ind Co Ltd | Wholly porous activated gel |
| JPS5812656A (ja) * | 1981-07-17 | 1983-01-24 | 旭化成株式会社 | 体外循環治療用吸着材 |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61268355A (ja) * | 1985-05-23 | 1986-11-27 | Kanegafuchi Chem Ind Co Ltd | 体外循環治療用リポ蛋白吸着体およびその製法 |
| JPS6222658A (ja) * | 1985-07-23 | 1987-01-30 | 旭化成株式会社 | 低比重リポ蛋白質吸着装置 |
| JP2005315666A (ja) * | 2004-04-28 | 2005-11-10 | Toshihiko Hanai | 糖結合充填剤およびその製造方法 |
| CN100455349C (zh) * | 2006-03-28 | 2009-01-28 | 南京赛邦医疗用品有限公司 | 用于血液体外循环去除低密度脂蛋白的吸附剂及其制法 |
| WO2012121073A1 (ja) * | 2011-03-04 | 2012-09-13 | Dic株式会社 | 糖類固定化ウイルス除去用高分子基材、及びウイルスの除去方法 |
| JP5140211B2 (ja) * | 2011-03-04 | 2013-02-06 | Ｄｉｃ株式会社 | 糖類固定化ウイルス除去用基材、及びウイルスの除去器具 |
Also Published As
| Publication number | Publication date |
|---|---|
| ZA838908B (en) | 1984-07-25 |
| JPS6256782B2 (enrdf_load_stackoverflow) | 1987-11-27 |
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