JPS5835967B2 - 微細結晶ワルフアリンの製造方法 - Google Patents

微細結晶ワルフアリンの製造方法

Info

Publication number
JPS5835967B2
JPS5835967B2 JP50095464A JP9546475A JPS5835967B2 JP S5835967 B2 JPS5835967 B2 JP S5835967B2 JP 50095464 A JP50095464 A JP 50095464A JP 9546475 A JP9546475 A JP 9546475A JP S5835967 B2 JPS5835967 B2 JP S5835967B2
Authority
JP
Japan
Prior art keywords
warfarin
acid
warfaric
sodium
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
JP50095464A
Other languages
English (en)
Japanese (ja)
Other versions
JPS5141361A (OSRAM
Inventor
ダブリユ バツドラン ネイスリ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Meda Pharmaceuticals Inc
Original Assignee
Carter Wallace Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Carter Wallace Inc filed Critical Carter Wallace Inc
Publication of JPS5141361A publication Critical patent/JPS5141361A/ja
Publication of JPS5835967B2 publication Critical patent/JPS5835967B2/ja
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/42—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4
    • C07D311/44—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 with one hydrogen atom in position 3
    • C07D311/46—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 with one hydrogen atom in position 3 unsubstituted in the carbocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
JP50095464A 1974-08-13 1975-08-07 微細結晶ワルフアリンの製造方法 Expired JPS5835967B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US05/496,932 US4113744A (en) 1974-08-13 1974-08-13 Microcrystalline 3-(alpha-acetonylbenzyl)-4-hydroxycoumarin (warfarin) and methods of making
US496932 1974-08-13

Publications (2)

Publication Number Publication Date
JPS5141361A JPS5141361A (OSRAM) 1976-04-07
JPS5835967B2 true JPS5835967B2 (ja) 1983-08-05

Family

ID=23974780

Family Applications (1)

Application Number Title Priority Date Filing Date
JP50095464A Expired JPS5835967B2 (ja) 1974-08-13 1975-08-07 微細結晶ワルフアリンの製造方法

Country Status (13)

Country Link
US (1) US4113744A (OSRAM)
JP (1) JPS5835967B2 (OSRAM)
BE (1) BE832395A (OSRAM)
BR (1) BR7504996A (OSRAM)
CA (1) CA1077502A (OSRAM)
DE (1) DE2535228A1 (OSRAM)
ES (1) ES440221A1 (OSRAM)
FR (1) FR2281754A1 (OSRAM)
GB (1) GB1513399A (OSRAM)
IN (1) IN141166B (OSRAM)
LU (1) LU73199A1 (OSRAM)
NL (1) NL7509661A (OSRAM)
ZA (1) ZA754795B (OSRAM)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5696274A (en) * 1995-12-28 1997-12-09 Hoechst Celanese Corporation Syntheses based on 2-hydroxyacetophenone
AU4068299A (en) * 1998-03-30 1999-10-18 Sloan-Kettering Institute For Cancer Research Bismuth-213 generator and uses thereof
US6512005B2 (en) 2001-02-28 2003-01-28 Taro Pharmaceutical Industries, Ltd. Process for synthesis of pure warfarin acid, warfarin alkali metal salts and corresponding clathrates
US6673944B2 (en) 2001-02-28 2004-01-06 Taro Pharmaceutical Industries, Ltd. Preparation of warfarin sodium from warfarin acid
US6610862B2 (en) 2001-02-28 2003-08-26 Taro Pharmaceutical Industries Ltd. Preparation of warfarin sodium from warfarin sodium-2-propanol clathrate by solvent expulsion
CA2439488A1 (en) * 2001-02-28 2002-09-12 Taro Pharmaceutical Industries Ltd. Process for purification of warfarin acid, warfarin alkali metal salts and corresponding clathrates
EP1589930A2 (en) * 2003-01-08 2005-11-02 Flacco-Nesselroad Family Trust Combination therapy for anticoagulation
GB0329303D0 (en) * 2003-12-18 2004-01-21 Whelan Ian P Rodenticide bait system
GB2635614A (en) * 2023-07-22 2025-05-21 Liqmeds Worldwide Ltd A ready-to-use oral liquid formulation of warfarin sodium
WO2025022245A1 (en) * 2023-07-22 2025-01-30 Liqmeds Worldwide Limited A ready-to-use oral liquid formulation of warfarin sodium
CN117169390B (zh) * 2023-10-18 2024-05-03 宁波市疾病预防控制中心(宁波市健康教育与促进中心) 一种测定血液中安妥的方法、试剂盒及应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2666064A (en) * 1951-07-10 1954-01-12 S B Penick & Company Inc Manufacture of 3-(alpha-phenyl-beta-acetylethyl)-4-hydroxycoumarin
US2777859A (en) * 1953-02-05 1957-01-15 Wisconsin Alumni Res Found Warfarin-alkali metal derivatives and processes of preparing the same
US2752360A (en) * 1953-03-23 1956-06-26 S B Penick & Company Inc Improvement in the manufacture of 3-substituted 4-hydroxycoumarins
US2932652A (en) * 1957-02-11 1960-04-12 Nicholas M Molnar 3-(1'-(alpha-naphthyl) 3'-oxo-butyl) 4-hydroxy coumarin and salts thereof

Also Published As

Publication number Publication date
LU73199A1 (OSRAM) 1976-08-13
BR7504996A (pt) 1976-08-31
CA1077502A (en) 1980-05-13
NL7509661A (nl) 1976-02-17
IN141166B (OSRAM) 1977-01-29
JPS5141361A (OSRAM) 1976-04-07
AU8356175A (en) 1977-02-03
GB1513399A (en) 1978-06-07
DE2535228A1 (de) 1976-02-26
ZA754795B (en) 1977-03-30
FR2281754B1 (OSRAM) 1978-11-10
BE832395A (fr) 1976-02-13
US4113744A (en) 1978-09-12
FR2281754A1 (fr) 1976-03-12
ES440221A1 (es) 1977-03-01

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