ZA754795B - A method of preparing microcrystalline warfarin and its use as anticoagulant and rodenticidal agents - Google Patents
A method of preparing microcrystalline warfarin and its use as anticoagulant and rodenticidal agentsInfo
- Publication number
- ZA754795B ZA754795B ZA754795A ZA754795A ZA754795B ZA 754795 B ZA754795 B ZA 754795B ZA 754795 A ZA754795 A ZA 754795A ZA 754795 A ZA754795 A ZA 754795A ZA 754795 B ZA754795 B ZA 754795B
- Authority
- ZA
- South Africa
- Prior art keywords
- warfarin
- anticoagulant
- preparing microcrystalline
- rodenticidal
- agents
- Prior art date
Links
- BBOSKMPTDUUMKL-UHFFFAOYSA-N 4-hydroxy-3-(3-hydroxy-1-phenylbut-3-enyl)chromen-2-one Chemical compound OC=1C2=CC=CC=C2OC(=O)C=1C(CC(=C)O)C1=CC=CC=C1 BBOSKMPTDUUMKL-UHFFFAOYSA-N 0.000 title 1
- 239000003146 anticoagulant agent Substances 0.000 title 1
- 229940127219 anticoagulant drug Drugs 0.000 title 1
- 239000003795 chemical substances by application Substances 0.000 title 1
- 230000001119 rodenticidal effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/42—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4
- C07D311/44—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 with one hydrogen atom in position 3
- C07D311/46—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 with one hydrogen atom in position 3 unsubstituted in the carbocyclic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/496,932 US4113744A (en) | 1974-08-13 | 1974-08-13 | Microcrystalline 3-(alpha-acetonylbenzyl)-4-hydroxycoumarin (warfarin) and methods of making |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA754795B true ZA754795B (en) | 1977-03-30 |
Family
ID=23974780
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA754795A ZA754795B (en) | 1974-08-13 | 1975-07-25 | A method of preparing microcrystalline warfarin and its use as anticoagulant and rodenticidal agents |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US4113744A (OSRAM) |
| JP (1) | JPS5835967B2 (OSRAM) |
| BE (1) | BE832395A (OSRAM) |
| BR (1) | BR7504996A (OSRAM) |
| CA (1) | CA1077502A (OSRAM) |
| DE (1) | DE2535228A1 (OSRAM) |
| ES (1) | ES440221A1 (OSRAM) |
| FR (1) | FR2281754A1 (OSRAM) |
| GB (1) | GB1513399A (OSRAM) |
| IN (1) | IN141166B (OSRAM) |
| LU (1) | LU73199A1 (OSRAM) |
| NL (1) | NL7509661A (OSRAM) |
| ZA (1) | ZA754795B (OSRAM) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5696274A (en) * | 1995-12-28 | 1997-12-09 | Hoechst Celanese Corporation | Syntheses based on 2-hydroxyacetophenone |
| AU4068299A (en) * | 1998-03-30 | 1999-10-18 | Sloan-Kettering Institute For Cancer Research | Bismuth-213 generator and uses thereof |
| US6512005B2 (en) | 2001-02-28 | 2003-01-28 | Taro Pharmaceutical Industries, Ltd. | Process for synthesis of pure warfarin acid, warfarin alkali metal salts and corresponding clathrates |
| US6673944B2 (en) | 2001-02-28 | 2004-01-06 | Taro Pharmaceutical Industries, Ltd. | Preparation of warfarin sodium from warfarin acid |
| US6610862B2 (en) | 2001-02-28 | 2003-08-26 | Taro Pharmaceutical Industries Ltd. | Preparation of warfarin sodium from warfarin sodium-2-propanol clathrate by solvent expulsion |
| CA2439488A1 (en) * | 2001-02-28 | 2002-09-12 | Taro Pharmaceutical Industries Ltd. | Process for purification of warfarin acid, warfarin alkali metal salts and corresponding clathrates |
| EP1589930A2 (en) * | 2003-01-08 | 2005-11-02 | Flacco-Nesselroad Family Trust | Combination therapy for anticoagulation |
| GB0329303D0 (en) * | 2003-12-18 | 2004-01-21 | Whelan Ian P | Rodenticide bait system |
| GB2635614A (en) * | 2023-07-22 | 2025-05-21 | Liqmeds Worldwide Ltd | A ready-to-use oral liquid formulation of warfarin sodium |
| WO2025022245A1 (en) * | 2023-07-22 | 2025-01-30 | Liqmeds Worldwide Limited | A ready-to-use oral liquid formulation of warfarin sodium |
| CN117169390B (zh) * | 2023-10-18 | 2024-05-03 | 宁波市疾病预防控制中心(宁波市健康教育与促进中心) | 一种测定血液中安妥的方法、试剂盒及应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2666064A (en) * | 1951-07-10 | 1954-01-12 | S B Penick & Company Inc | Manufacture of 3-(alpha-phenyl-beta-acetylethyl)-4-hydroxycoumarin |
| US2777859A (en) * | 1953-02-05 | 1957-01-15 | Wisconsin Alumni Res Found | Warfarin-alkali metal derivatives and processes of preparing the same |
| US2752360A (en) * | 1953-03-23 | 1956-06-26 | S B Penick & Company Inc | Improvement in the manufacture of 3-substituted 4-hydroxycoumarins |
| US2932652A (en) * | 1957-02-11 | 1960-04-12 | Nicholas M Molnar | 3-(1'-(alpha-naphthyl) 3'-oxo-butyl) 4-hydroxy coumarin and salts thereof |
-
1974
- 1974-08-13 US US05/496,932 patent/US4113744A/en not_active Expired - Lifetime
-
1975
- 1975-07-25 ZA ZA754795A patent/ZA754795B/xx unknown
- 1975-07-31 CA CA232,784A patent/CA1077502A/en not_active Expired
- 1975-07-31 IN IN1515/CAL/1975A patent/IN141166B/en unknown
- 1975-08-05 BR BR7504996A patent/BR7504996A/pt unknown
- 1975-08-07 DE DE19752535228 patent/DE2535228A1/de not_active Withdrawn
- 1975-08-07 JP JP50095464A patent/JPS5835967B2/ja not_active Expired
- 1975-08-12 FR FR7525087A patent/FR2281754A1/fr active Granted
- 1975-08-13 LU LU73199A patent/LU73199A1/xx unknown
- 1975-08-13 ES ES440221A patent/ES440221A1/es not_active Expired
- 1975-08-13 BE BE159171A patent/BE832395A/xx unknown
- 1975-08-13 NL NL7509661A patent/NL7509661A/xx not_active Application Discontinuation
- 1975-08-13 GB GB33672/75A patent/GB1513399A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| LU73199A1 (OSRAM) | 1976-08-13 |
| BR7504996A (pt) | 1976-08-31 |
| CA1077502A (en) | 1980-05-13 |
| NL7509661A (nl) | 1976-02-17 |
| IN141166B (OSRAM) | 1977-01-29 |
| JPS5835967B2 (ja) | 1983-08-05 |
| JPS5141361A (OSRAM) | 1976-04-07 |
| AU8356175A (en) | 1977-02-03 |
| GB1513399A (en) | 1978-06-07 |
| DE2535228A1 (de) | 1976-02-26 |
| FR2281754B1 (OSRAM) | 1978-11-10 |
| BE832395A (fr) | 1976-02-13 |
| US4113744A (en) | 1978-09-12 |
| FR2281754A1 (fr) | 1976-03-12 |
| ES440221A1 (es) | 1977-03-01 |
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