JPS58185564A - キノリン誘導体、その製法及び該誘導体を含有する５−ｈｔ拮抗作用を有する製薬学的製剤 - Google Patents

キノリン誘導体、その製法及び該誘導体を含有する５−ｈｔ拮抗作用を有する製薬学的製剤

Info

Publication number
JPS58185564A
JPS58185564A JP58058800A JP5880083A JPS58185564A JP S58185564 A JPS58185564 A JP S58185564A JP 58058800 A JP58058800 A JP 58058800A JP 5880083 A JP5880083 A JP 5880083A JP S58185564 A JPS58185564 A JP S58185564A
Authority
JP
Japan
Prior art keywords
group
acid addition
acceptable acid
pharmaceutically acceptable
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP58058800A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0319228B2 (enExample
Inventor
ロバ−ト・ジエ−ムズ・パ−ス
クレイグ・ウイラ−ド・ソ−ンバ−
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Imperial Chemical Industries Ltd
Original Assignee
Imperial Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imperial Chemical Industries Ltd filed Critical Imperial Chemical Industries Ltd
Publication of JPS58185564A publication Critical patent/JPS58185564A/ja
Publication of JPH0319228B2 publication Critical patent/JPH0319228B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
JP58058800A 1982-04-07 1983-04-05 キノリン誘導体、その製法及び該誘導体を含有する５−ｈｔ拮抗作用を有する製薬学的製剤 Granted JPS58185564A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8210261 1982-04-07
GB8210261 1982-04-07

Publications (2)

Publication Number Publication Date
JPS58185564A true JPS58185564A (ja) 1983-10-29
JPH0319228B2 JPH0319228B2 (enExample) 1991-03-14

Family

ID=10529572

Family Applications (1)

Application Number Title Priority Date Filing Date
JP58058800A Granted JPS58185564A (ja) 1982-04-07 1983-04-05 キノリン誘導体、その製法及び該誘導体を含有する５−ｈｔ拮抗作用を有する製薬学的製剤

Country Status (5)

Country Link
US (1) US4607040A (enExample)
EP (1) EP0091198B1 (enExample)
JP (1) JPS58185564A (enExample)
AT (1) ATE27152T1 (enExample)
DE (1) DE3371511D1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8308601D0 (en) * 1983-03-29 1983-05-05 Ici Plc Heterocyclic compounds
FI903966A7 (fi) * 1989-08-11 1991-02-12 Ici Plc Typpiyhdisteitä
GB9025123D0 (en) * 1990-11-19 1991-01-02 Ici Plc Nitrogen compounds
US7115399B2 (en) * 2001-07-31 2006-10-03 Allergan, Inc. Pinna reflex assay
CN115684399B (zh) * 2022-10-27 2024-12-20 贵州健安德科技有限公司 一种氯醇亚胺的高效液相检测及含量测定方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US16394A (en) * 1857-01-13 Improvement in gotton-gins
DE430960C (de) * 1924-07-11 1926-06-23 J G Farbenindustrie Akt Ges Verfahren zur Darstellung von basischen AEthern von Chinolinderivaten
US1572768A (en) * 1925-06-26 1926-02-09 Winthrop Chem Co Inc Pharmaceutical product
US1860286A (en) * 1929-05-16 1932-05-24 Soc Of Chemical Ind Basic ethers of aryl-quinolines
GB349761A (en) * 1929-05-16 1931-06-04 Chem Ind Basel Manufacture of aminoalkoxy-derivatives of aryl-quinolines
US4035374A (en) * 1973-05-03 1977-07-12 Smith Kline & French Laboratories Limited Imidazolyl alkylaminopyridone and pyridinethione compounds
US4260764A (en) * 1976-12-22 1981-04-07 Pfizer Inc. 9-Hydroxyoctahydrobenzo [C] quinolines and intermediates therefor
US4343805A (en) * 1978-12-16 1982-08-10 John Wyeth & Brother Limited Heterocyclic compounds
US4235909A (en) * 1979-04-19 1980-11-25 Eli Lilly And Company Octahydro-2H-pyrrolo[3,4-g]quinolines
GR73576B (enExample) * 1980-03-01 1984-03-20 Wyeth John & Brother Ltd
IN158970B (enExample) * 1981-06-09 1987-02-28 Ici Plc

Also Published As

Publication number Publication date
ATE27152T1 (de) 1987-05-15
EP0091198A2 (en) 1983-10-12
US4607040A (en) 1986-08-19
JPH0319228B2 (enExample) 1991-03-14
EP0091198B1 (en) 1987-05-13
EP0091198A3 (en) 1985-04-17
DE3371511D1 (en) 1987-06-19

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