JPS58177986A - Ｌ−アスコルビン酸の製造方法 - Google Patents

Ｌ−アスコルビン酸の製造方法

Info

Publication number
JPS58177986A
JPS58177986A JP57060121A JP6012182A JPS58177986A JP S58177986 A JPS58177986 A JP S58177986A JP 57060121 A JP57060121 A JP 57060121A JP 6012182 A JP6012182 A JP 6012182A JP S58177986 A JPS58177986 A JP S58177986A
Authority
JP
Japan
Prior art keywords
slurry
reaction
2klg
sodium
salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP57060121A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0142271B2 (https=
Inventor
Kenji Igawa
井川　健二
Kanji Tokuyama
徳山　幹治
Masumi Kiyokawa
清川　真澄
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Priority to JP57060121A priority Critical patent/JPS58177986A/ja
Priority to US06/477,925 priority patent/US4491668A/en
Priority to GB08309350A priority patent/GB2118187B/en
Priority to HU831200A priority patent/HU189641B/hu
Priority to DD83249694A priority patent/DD209627A5/de
Priority to ES521332A priority patent/ES521332A0/es
Priority to EP83103440A priority patent/EP0091134B1/en
Priority to KR1019830001462A priority patent/KR900003279B1/ko
Priority to DE8383103440T priority patent/DE3368056D1/de
Priority to DK156983A priority patent/DK159109C/da
Priority to AU13273/83A priority patent/AU559281B2/en
Priority to IE817/83A priority patent/IE55094B1/en
Priority to CA000425591A priority patent/CA1190552A/en
Publication of JPS58177986A publication Critical patent/JPS58177986A/ja
Publication of JPH0142271B2 publication Critical patent/JPH0142271B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/62—Three oxygen atoms, e.g. ascorbic acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Furan Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
JP57060121A 1982-04-09 1982-04-09 Ｌ−アスコルビン酸の製造方法 Granted JPS58177986A (ja)

Priority Applications (13)

Application Number Priority Date Filing Date Title
JP57060121A JPS58177986A (ja) 1982-04-09 1982-04-09 Ｌ−アスコルビン酸の製造方法
US06/477,925 US4491668A (en) 1982-04-09 1983-03-23 Process for preparing L-ascorbic acid
GB08309350A GB2118187B (en) 1982-04-09 1983-04-06 Process for preparing l-ascorbic acid
HU831200A HU189641B (en) 1982-04-09 1983-04-07 Process for preparing l-ascorbic acid
DD83249694A DD209627A5 (de) 1982-04-09 1983-04-08 Verfahren zur herstellung von l-ascorbinsaeure
ES521332A ES521332A0 (es) 1982-04-09 1983-04-08 Un procedimiento para preparar acido l-ascorbico.
EP83103440A EP0091134B1 (en) 1982-04-09 1983-04-08 Process for preparing l-ascorbic acid
KR1019830001462A KR900003279B1 (ko) 1982-04-09 1983-04-08 L-아스코르브산의 제조방법
DE8383103440T DE3368056D1 (en) 1982-04-09 1983-04-08 Process for preparing l-ascorbic acid
DK156983A DK159109C (da) 1982-04-09 1983-04-08 Fremgangsmaade til fremstilling af l-ascorbinsyre
AU13273/83A AU559281B2 (en) 1982-04-09 1983-04-08 L-ascorbic acid from 2-keto-l-gulonate
IE817/83A IE55094B1 (en) 1982-04-09 1983-04-11 Process for preparing l-ascorbic acid
CA000425591A CA1190552A (en) 1982-04-09 1983-04-11 Process for preparing l-ascorbic acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP57060121A JPS58177986A (ja) 1982-04-09 1982-04-09 Ｌ−アスコルビン酸の製造方法

Publications (2)

Publication Number Publication Date
JPS58177986A true JPS58177986A (ja) 1983-10-18
JPH0142271B2 JPH0142271B2 (https=) 1989-09-11

Family

ID=13132970

Family Applications (1)

Application Number Title Priority Date Filing Date
JP57060121A Granted JPS58177986A (ja) 1982-04-09 1982-04-09 Ｌ−アスコルビン酸の製造方法

Country Status (13)

Country Link
US (1) US4491668A (https=)
EP (1) EP0091134B1 (https=)
JP (1) JPS58177986A (https=)
KR (1) KR900003279B1 (https=)
AU (1) AU559281B2 (https=)
CA (1) CA1190552A (https=)
DD (1) DD209627A5 (https=)
DE (1) DE3368056D1 (https=)
DK (1) DK159109C (https=)
ES (1) ES521332A0 (https=)
GB (1) GB2118187B (https=)
HU (1) HU189641B (https=)
IE (1) IE55094B1 (https=)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0779285A1 (de) 1995-12-16 1997-06-18 MERCK PATENT GmbH Verfahren zur Herstellung von Ascorbinsäure
US6197977B1 (en) 1999-04-28 2001-03-06 Basf Aktiengesellschaft Process for the preparation of L-ascorbic acid
US6274744B1 (en) 1999-11-12 2001-08-14 Basf Aktiengesellschaft Preparation of alkali metal salts of L-ascorbic acid
US6617463B2 (en) 2000-05-10 2003-09-09 Basf Aktiengesellschaft Method for the production of L-ascorbic acid by lactonization of 2-keto-L-gulonic acid or s2-keto-L-gulonate esters
JP2015508758A (ja) * 2012-02-08 2015-03-23 ピュラック バイオケム ビー． ブイ． カルボキシレートの酸性化

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN86105960A (zh) * 1985-08-09 1987-05-13 鲁布里佐尔公司 在基本无水条件下从2-酮-l-古洛糖酸制备l-抗坏血酸
DE3819045C2 (de) * 1987-06-08 1997-06-19 Takeda Chemical Industries Ltd Herstellung von L-Ascorbinsäure
EP0324261A1 (en) * 1988-01-06 1989-07-19 Pfizer Inc. Production of L-ascorbic acid from 2-keto-L-gulonic acid with an acid catalyst and a lipophilic surfactant having a low hydrophilic: lipophilic balance under substantially anhydrous conditions
FR2648136B1 (fr) * 1989-06-12 1994-06-17 Rhone Poulenc Sante Procede de preparation de l'acide ascorbique
DE4330701A1 (de) * 1993-09-10 1995-03-16 Boehringer Ingelheim Kg Neues Verfahren zur Herstellung von 1,2-5,6-Diaceton-D-glucose
CN1050356C (zh) * 1995-11-24 2000-03-15 中原制药厂 L-抗坏血酸钠或钾的制备方法
JP3976832B2 (ja) * 1996-04-30 2007-09-19 ディーエスエム アイピー アセッツ ビー．ブイ． ２−ケト−ｌ−グロン酸の単離方法
RU2126800C1 (ru) * 1997-07-16 1999-02-27 Открытое акционерное общество "Востоквит" Способ обработки водного маточного раствора, полученного при выделении аскорбиновой кислоты
US5998634A (en) * 1999-03-15 1999-12-07 The United States Of America As Represented By The Secretary Of The Interior One-step synthesis of vitamin-C (L-ascorbic acid)
DE10149869A1 (de) * 2001-10-10 2003-04-24 Basf Ag Verfahren zur Isolierung von Salzen von organischen Säuren aus einer Fermentationsbrühe und zur Freisetzung der organischen Säure
CN104693160B (zh) * 2015-02-16 2016-10-05 安徽泰格生物技术股份有限公司 一种维生素c的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD86627A (https=) *
FR779883A (fr) * 1933-10-25 1935-04-13 Hoffmann La Roche Procédé de préparation de l'acide 1-ascorbique
US2129317A (en) * 1935-06-18 1938-09-06 Hoffmann La Roche Process for the manufacture of laevoascorbic acid
DE684725C (de) * 1936-01-15 1939-12-04 Merck Chem Fab E Verfahren zur Herstellung von Ascorbinsaeure
US2179978A (en) * 1936-06-06 1939-11-14 Hoffmann La Roche Process for the manufacture of levo-ascorbic acid
AT164552B (de) * 1942-05-07 1949-11-25 Chinoin Gyogyszer Es Vegyeszet Verfahren zur Herstellung von Vitamin C
US2462251A (en) * 1945-05-16 1949-02-22 Merck & Co Inc Process for preparing ascorbic acids
CH490368A (fr) * 1968-02-01 1970-05-15 Politechnika Slaska Im Wincent Procédé de production de vitamine C

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0779285A1 (de) 1995-12-16 1997-06-18 MERCK PATENT GmbH Verfahren zur Herstellung von Ascorbinsäure
US6197977B1 (en) 1999-04-28 2001-03-06 Basf Aktiengesellschaft Process for the preparation of L-ascorbic acid
US6274744B1 (en) 1999-11-12 2001-08-14 Basf Aktiengesellschaft Preparation of alkali metal salts of L-ascorbic acid
US6617463B2 (en) 2000-05-10 2003-09-09 Basf Aktiengesellschaft Method for the production of L-ascorbic acid by lactonization of 2-keto-L-gulonic acid or s2-keto-L-gulonate esters
JP2015508758A (ja) * 2012-02-08 2015-03-23 ピュラック バイオケム ビー． ブイ． カルボキシレートの酸性化
JP2017052772A (ja) * 2012-02-08 2017-03-16 ピュラック バイオケム ビー． ブイ． カルボキシレートの酸性化

Also Published As

Publication number Publication date
GB2118187A (en) 1983-10-26
DK156983D0 (da) 1983-04-08
DE3368056D1 (en) 1987-01-15
DK159109C (da) 1991-02-18
DD209627A5 (de) 1984-05-16
GB2118187B (en) 1985-10-09
KR840004416A (ko) 1984-10-15
AU559281B2 (en) 1987-03-05
JPH0142271B2 (https=) 1989-09-11
IE830817L (en) 1983-10-09
DK156983A (da) 1983-10-10
DK159109B (da) 1990-09-03
EP0091134B1 (en) 1986-12-03
EP0091134A3 (en) 1984-12-19
ES8404999A1 (es) 1984-05-16
US4491668A (en) 1985-01-01
ES521332A0 (es) 1984-05-16
KR900003279B1 (ko) 1990-05-12
EP0091134A2 (en) 1983-10-12
CA1190552A (en) 1985-07-16
AU1327383A (en) 1983-10-13
HU189641B (en) 1986-07-28
IE55094B1 (en) 1990-05-23

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