JPS5817466B2 - 〔１−イミダゾリル−（１）〕−〔２−（４′−（４′′−クロルフエニル）フエノキシ〕−４，４−ジメチル−ペンタン−３−オン及びその塩の製造法 - Google Patents
〔１−イミダゾリル−（１）〕−〔２−（４′−（４′′−クロルフエニル）フエノキシ〕−４，４−ジメチル−ペンタン−３−オン及びその塩の製造法Info
- Publication number
- JPS5817466B2 JPS5817466B2 JP50073251A JP7325175A JPS5817466B2 JP S5817466 B2 JPS5817466 B2 JP S5817466B2 JP 50073251 A JP50073251 A JP 50073251A JP 7325175 A JP7325175 A JP 7325175A JP S5817466 B2 JPS5817466 B2 JP S5817466B2
- Authority
- JP
- Japan
- Prior art keywords
- imidazolyl
- compound
- acid
- salts
- chlorophenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
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- OYACROKNLOSFPA-UHFFFAOYSA-N calcium;dioxido(oxo)silane Chemical compound [Ca+2].[O-][Si]([O-])=O OYACROKNLOSFPA-UHFFFAOYSA-N 0.000 description 1
- 201000003984 candidiasis Diseases 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 1
- 150000001735 carboxylic acids Chemical class 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 229960000541 cetyl alcohol Drugs 0.000 description 1
- 150000005827 chlorofluoro hydrocarbons Chemical class 0.000 description 1
- 229960004022 clotrimazole Drugs 0.000 description 1
- VNFPBHJOKIVQEB-UHFFFAOYSA-N clotrimazole Chemical compound ClC1=CC=CC=C1C(N1C=NC=C1)(C=1C=CC=CC=1)C1=CC=CC=C1 VNFPBHJOKIVQEB-UHFFFAOYSA-N 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 201000003929 dermatomycosis Diseases 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000007884 disintegrant Substances 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 229940093499 ethyl acetate Drugs 0.000 description 1
- 239000010642 eucalyptus oil Substances 0.000 description 1
- 229940044949 eucalyptus oil Drugs 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000003925 fat Substances 0.000 description 1
- 235000019197 fats Nutrition 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 210000003608 fece Anatomy 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 239000008098 formaldehyde solution Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000012458 free base Substances 0.000 description 1
- 239000001530 fumaric acid Substances 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 150000002334 glycols Chemical class 0.000 description 1
- 125000005843 halogen group Chemical group 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 150000002460 imidazoles Chemical class 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 229940079865 intestinal antiinfectives imidazole derivative Drugs 0.000 description 1
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 239000007937 lozenge Substances 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 229960002509 miconazole Drugs 0.000 description 1
- 230000002906 microbiologic effect Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000003094 microcapsule Substances 0.000 description 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
- 239000008108 microcrystalline cellulose Substances 0.000 description 1
- 229940016286 microcrystalline cellulose Drugs 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- CQDGTJPVBWZJAZ-UHFFFAOYSA-N monoethyl carbonate Chemical compound CCOC(O)=O CQDGTJPVBWZJAZ-UHFFFAOYSA-N 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 208000030194 mouth disease Diseases 0.000 description 1
- NCXMLFZGDNKEPB-FFPOYIOWSA-N natamycin Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C[C@@H](C)OC(=O)/C=C/[C@H]2O[C@@H]2C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 NCXMLFZGDNKEPB-FFPOYIOWSA-N 0.000 description 1
- 229960003255 natamycin Drugs 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 239000000312 peanut oil Substances 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 229960004063 propylene glycol Drugs 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 229940081974 saccharin Drugs 0.000 description 1
- 235000019204 saccharin Nutrition 0.000 description 1
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 125000005624 silicic acid group Chemical class 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000010902 straw Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- BSYVTEYKTMYBMK-UHFFFAOYSA-N tetrahydrofurfuryl alcohol Chemical compound OCC1CCCO1 BSYVTEYKTMYBMK-UHFFFAOYSA-N 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- ILWRPSCZWQJDMK-UHFFFAOYSA-N triethylazanium;chloride Chemical compound Cl.CCN(CC)CC ILWRPSCZWQJDMK-UHFFFAOYSA-N 0.000 description 1
- 235000019871 vegetable fat Nutrition 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2429513 | 1974-06-20 | ||
| DE2429513A DE2429513A1 (de) | 1974-06-20 | 1974-06-20 | Eckige klammer auf 1-imidazolyl-(1) eckige klammer zu-eckige klammer auf 2-(4'(4''-chlorphenyl)-phenoxy eckige klammer zu -4,4-dimethyl-pentan-3-on und seine salze, ein verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5113769A JPS5113769A (en) | 1976-02-03 |
| JPS5817466B2 true JPS5817466B2 (ja) | 1983-04-07 |
Family
ID=5918460
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP50073251A Expired JPS5817466B2 (ja) | 1974-06-20 | 1975-06-18 | 〔１−イミダゾリル−（１）〕−〔２−（４′−（４′′−クロルフエニル）フエノキシ〕−４，４−ジメチル−ペンタン−３−オン及びその塩の製造法 |
Country Status (23)
| Country | Link |
|---|---|
| JP (1) | JPS5817466B2 (pt-PT) |
| AR (1) | AR205746A1 (pt-PT) |
| AT (1) | AT340410B (pt-PT) |
| BE (1) | BE830413A (pt-PT) |
| CA (1) | CA1048512A (pt-PT) |
| CH (1) | CH617682A5 (pt-PT) |
| DD (1) | DD121939A5 (pt-PT) |
| DE (1) | DE2429513A1 (pt-PT) |
| DK (1) | DK137644C (pt-PT) |
| EG (1) | EG11806A (pt-PT) |
| ES (1) | ES438717A1 (pt-PT) |
| FI (1) | FI751818A (pt-PT) |
| FR (1) | FR2275204A1 (pt-PT) |
| GB (1) | GB1456180A (pt-PT) |
| IE (1) | IE41167B1 (pt-PT) |
| IL (1) | IL47502A (pt-PT) |
| LU (1) | LU72761A1 (pt-PT) |
| NL (1) | NL7507326A (pt-PT) |
| NO (1) | NO140009C (pt-PT) |
| PH (1) | PH11567A (pt-PT) |
| PL (1) | PL94003B1 (pt-PT) |
| SE (1) | SE7507014L (pt-PT) |
| ZA (1) | ZA753934B (pt-PT) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3019049A1 (de) * | 1980-05-19 | 1981-12-03 | Basf Ag, 6700 Ludwigshafen | Neue azolverbindungen |
-
1974
- 1974-06-20 DE DE2429513A patent/DE2429513A1/de not_active Withdrawn
-
1975
- 1975-01-01 AR AR259254A patent/AR205746A1/es active
- 1975-05-20 GB GB2151675A patent/GB1456180A/en not_active Expired
- 1975-05-30 CA CA75228121A patent/CA1048512A/en not_active Expired
- 1975-06-06 NO NO75752017A patent/NO140009C/no unknown
- 1975-06-14 EG EG347A patent/EG11806A/xx active
- 1975-06-16 ZA ZA00753934A patent/ZA753934B/xx unknown
- 1975-06-17 PH PH17274A patent/PH11567A/en unknown
- 1975-06-17 IL IL7547502A patent/IL47502A/xx unknown
- 1975-06-18 LU LU72761A patent/LU72761A1/xx unknown
- 1975-06-18 JP JP50073251A patent/JPS5817466B2/ja not_active Expired
- 1975-06-18 FI FI751818A patent/FI751818A/fi not_active Application Discontinuation
- 1975-06-18 AT AT467175A patent/AT340410B/de not_active IP Right Cessation
- 1975-06-18 PL PL1975181326A patent/PL94003B1/pl unknown
- 1975-06-18 CH CH793175A patent/CH617682A5/de not_active IP Right Cessation
- 1975-06-18 DD DD186730A patent/DD121939A5/xx unknown
- 1975-06-18 SE SE7507014A patent/SE7507014L/xx unknown
- 1975-06-19 DK DK278475A patent/DK137644C/da active
- 1975-06-19 NL NL7507326A patent/NL7507326A/xx not_active Application Discontinuation
- 1975-06-19 IE IE1369/75A patent/IE41167B1/xx unknown
- 1975-06-19 ES ES438717A patent/ES438717A1/es not_active Expired
- 1975-06-19 BE BE157481A patent/BE830413A/xx unknown
- 1975-06-20 FR FR7519416A patent/FR2275204A1/fr active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| BE830413A (fr) | 1975-12-19 |
| ZA753934B (en) | 1976-05-26 |
| ATA467175A (de) | 1977-04-15 |
| FR2275204B1 (pt-PT) | 1978-10-06 |
| ES438717A1 (es) | 1977-03-16 |
| JPS5113769A (en) | 1976-02-03 |
| CA1048512A (en) | 1979-02-13 |
| DK137644C (da) | 1978-09-18 |
| IL47502A (en) | 1978-06-15 |
| LU72761A1 (pt-PT) | 1976-04-13 |
| CH617682A5 (en) | 1980-06-13 |
| GB1456180A (en) | 1976-11-17 |
| SE7507014L (sv) | 1975-12-22 |
| DE2429513A1 (de) | 1976-01-15 |
| DK278475A (da) | 1975-12-21 |
| NO140009C (no) | 1979-06-20 |
| FR2275204A1 (fr) | 1976-01-16 |
| EG11806A (en) | 1977-11-30 |
| IE41167B1 (en) | 1979-11-07 |
| NO140009B (no) | 1979-03-12 |
| PH11567A (en) | 1978-03-31 |
| NL7507326A (nl) | 1975-12-23 |
| NO752017L (pt-PT) | 1975-12-23 |
| AU8222175A (en) | 1976-12-23 |
| DD121939A5 (pt-PT) | 1976-09-05 |
| AR205746A1 (es) | 1976-05-31 |
| PL94003B1 (pt-PT) | 1977-07-30 |
| IE41167L (en) | 1975-12-20 |
| FI751818A (pt-PT) | 1975-12-21 |
| IL47502A0 (en) | 1975-08-31 |
| AT340410B (de) | 1977-12-12 |
| DK137644B (da) | 1978-04-10 |
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