JPS58159490A - １，４−ジヒドロピリジン化合物 - Google Patents

１，４−ジヒドロピリジン化合物

Info

Publication number
JPS58159490A
JPS58159490A JP57026790A JP2679082A JPS58159490A JP S58159490 A JPS58159490 A JP S58159490A JP 57026790 A JP57026790 A JP 57026790A JP 2679082 A JP2679082 A JP 2679082A JP S58159490 A JPS58159490 A JP S58159490A
Authority
JP
Japan
Prior art keywords
compound
dihydropyridine
formula
lower alkyl
alkyl ester
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP57026790A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0129794B2 (en, 2012
Inventor
Yoichi Inoue
陽一 井上
Toshio Matsumoto
敏夫 松本
Hirosuke Niwa
丹羽　弘亮
Kenichi Suzuki
健一 鈴木
Yasuo Hoshiide
星出　安雄
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
INST ORGAN SINTEZA AN LATV SSR
NIKKEN KAGAKU KK
Kowa Co Ltd
Original Assignee
INST ORGAN SINTEZA AN LATV SSR
NIKKEN KAGAKU KK
Nikken Chemicals Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by INST ORGAN SINTEZA AN LATV SSR, NIKKEN KAGAKU KK, Nikken Chemicals Co Ltd filed Critical INST ORGAN SINTEZA AN LATV SSR
Priority to JP57026790A priority Critical patent/JPS58159490A/ja
Priority to DE8383101664T priority patent/DE3361093D1/de
Priority to EP83101664A priority patent/EP0087156B1/en
Priority to US06/468,663 priority patent/US4495356A/en
Priority to ES519990A priority patent/ES8403889A1/es
Publication of JPS58159490A publication Critical patent/JPS58159490A/ja
Publication of JPH0129794B2 publication Critical patent/JPH0129794B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
JP57026790A 1982-02-23 1982-02-23 １，４−ジヒドロピリジン化合物 Granted JPS58159490A (ja)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP57026790A JPS58159490A (ja) 1982-02-23 1982-02-23 １，４−ジヒドロピリジン化合物
DE8383101664T DE3361093D1 (en) 1982-02-23 1983-02-21 1,4-dihydropyridine compound and a preparation method thereof
EP83101664A EP0087156B1 (en) 1982-02-23 1983-02-21 1,4-dihydropyridine compound and a preparation method thereof
US06/468,663 US4495356A (en) 1982-02-23 1983-02-22 1,4-Dihydropyridine compound
ES519990A ES8403889A1 (es) 1982-02-23 1983-02-22 Un metodo para preparar un compuesto de 1,4-dihidropiridina.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP57026790A JPS58159490A (ja) 1982-02-23 1982-02-23 １，４−ジヒドロピリジン化合物

Publications (2)

Publication Number Publication Date
JPS58159490A true JPS58159490A (ja) 1983-09-21
JPH0129794B2 JPH0129794B2 (en, 2012) 1989-06-14

Family

ID=12203104

Family Applications (1)

Application Number Title Priority Date Filing Date
JP57026790A Granted JPS58159490A (ja) 1982-02-23 1982-02-23 １，４−ジヒドロピリジン化合物

Country Status (5)

Country Link
US (1) US4495356A (en, 2012)
EP (1) EP0087156B1 (en, 2012)
JP (1) JPS58159490A (en, 2012)
DE (1) DE3361093D1 (en, 2012)
ES (1) ES8403889A1 (en, 2012)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES8601891A1 (es) * 1983-03-04 1985-11-01 Nikken Chemicals Co Ltd Un metodo para preparar compuestos de 1, 4-dihidropiridina
EP0149475B1 (en) * 1984-01-13 1990-04-18 Yamanouchi Pharmaceutical Co. Ltd. Medicaments for the treatment and prevention of liver damage
US4833150A (en) * 1985-03-14 1989-05-23 Nelson Research & Development Co. 1,4-dihydropyridines
US4849436A (en) * 1986-03-11 1989-07-18 Nelson Research & Development Co. 1,4-dihydropyridines
US4985558A (en) * 1988-07-28 1991-01-15 Nikken Chemicals Co., Ltd. 1,4-dihydropyridine derivative
GB9119983D0 (en) * 1991-09-19 1991-11-06 Erba Carlo Spa Dihydropyridine derivatives useful in antitumor therapy

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3511847A (en) * 1967-02-07 1970-05-12 Smithkline Corp 2,6-di-lower alkyl - 1,4-dihydro - 4-(2-trifluoromethylphenyl) - 3,5 - pyridinedicarboxylic acid esters
DE1670827C3 (de) * 1967-03-20 1974-10-24 Bayer Ag, 5090 Leverkusen 4-(2'-Nitrophenyl)-2,6-dimethyl-3,5-dicarbmethoxy-1,4-dihydropyridin
DE1813436C3 (de) * 1968-12-07 1979-01-11 Bayer Ag, 5090 Leverkusen N-Substituierte 2,6-Dimethyl-l,4dihydropyridine
DE1923990C3 (de) * 1969-05-10 1978-11-23 Bayer Ag Verfahren zur Herstellung von N-substituierten M-Dihydropyridin-S.S-dicarbonsäureestern
DE2117573C3 (de) * 1971-04-10 1978-07-27 Bayer Ag, 5090 Leverkusen Verfahren zur Herstellung von unsymmetrischen l,4-Dihydropyridin-3,5dicarbonsäureestern, sowie ihre Verwendung als Arzneimittel
DE2117571C3 (de) * 1971-04-10 1979-10-11 Bayer Ag, 5090 Leverkusen Unsymmetrische 1,4-Dihydropyridin-33-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel
DE2218644C3 (de) * 1972-04-18 1982-08-19 Bayer Ag, 5090 Leverkusen Basische Ester von 1,4-Dihydropyridinen, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel
DE2349538C2 (de) * 1973-10-02 1982-08-26 Ordena trudovogo krasnogo znameni institut organičeskogo sinteza Akademii Nauk Latvijskoj SSR, Riga Arzneimittel zur Behandlung von Lebererkrankungen
DE3022030A1 (de) * 1980-06-12 1981-12-17 Bayer Ag, 5090 Leverkusen 4-thiazol- bzw. 4-imidazol-substituierte, 1,4-dihydropyridine, verfahren zu deren herstellung sowie diese enthaltende arzneimittel

Also Published As

Publication number Publication date
EP0087156B1 (en) 1985-10-30
ES519990A0 (es) 1984-04-01
JPH0129794B2 (en, 2012) 1989-06-14
ES8403889A1 (es) 1984-04-01
DE3361093D1 (en) 1985-12-05
EP0087156A1 (en) 1983-08-31
US4495356A (en) 1985-01-22

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