JPS58154591A - リン脂質類似モノマ−の製造法 - Google Patents
リン脂質類似モノマ−の製造法Info
- Publication number
- JPS58154591A JPS58154591A JP57036868A JP3686882A JPS58154591A JP S58154591 A JPS58154591 A JP S58154591A JP 57036868 A JP57036868 A JP 57036868A JP 3686882 A JP3686882 A JP 3686882A JP S58154591 A JPS58154591 A JP S58154591A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- reacting
- general formula
- tertiary amine
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000178 monomer Substances 0.000 title abstract 3
- 150000003904 phospholipids Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract description 18
- 150000003512 tertiary amines Chemical class 0.000 claims abstract description 9
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 5
- 125000000962 organic group Chemical group 0.000 claims abstract description 3
- 238000004519 manufacturing process Methods 0.000 claims description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- 239000000126 substance Substances 0.000 claims description 2
- 229920002818 (Hydroxyethyl)methacrylate Polymers 0.000 abstract description 3
- WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 abstract description 3
- -1 acrylate compound Chemical class 0.000 abstract description 2
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 description 13
- GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical compound CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 description 10
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 9
- 238000000034 method Methods 0.000 description 7
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 3
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 3
- 238000000921 elemental analysis Methods 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 1
- MQWSHBCKOSWEFJ-UHFFFAOYSA-N CC[P] Chemical compound CC[P] MQWSHBCKOSWEFJ-UHFFFAOYSA-N 0.000 description 1
- 241000234435 Lilium Species 0.000 description 1
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000009056 active transport Effects 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 230000006837 decompression Effects 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 210000002683 foot Anatomy 0.000 description 1
- 210000004744 fore-foot Anatomy 0.000 description 1
- UACSZOWTRIJIFU-UHFFFAOYSA-N hydroxymethyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCO UACSZOWTRIJIFU-UHFFFAOYSA-N 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000007127 saponification reaction Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000004575 stone Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts
Landscapes
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP57036868A JPS58154591A (ja) | 1982-03-09 | 1982-03-09 | リン脂質類似モノマ−の製造法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP57036868A JPS58154591A (ja) | 1982-03-09 | 1982-03-09 | リン脂質類似モノマ−の製造法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS58154591A true JPS58154591A (ja) | 1983-09-14 |
| JPH0249316B2 JPH0249316B2 (it) | 1990-10-29 |
Family
ID=12481758
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP57036868A Granted JPS58154591A (ja) | 1982-03-09 | 1982-03-09 | リン脂質類似モノマ−の製造法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS58154591A (it) |
Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995014701A1 (en) * | 1993-11-23 | 1995-06-01 | Biocompatibles Limited | Ethylenically unsaturated compounds |
| WO1995014702A1 (en) * | 1993-11-23 | 1995-06-01 | Biocompatibles Limited | Ethylenically unsaturated compounds |
| WO1996031566A1 (en) | 1995-04-03 | 1996-10-10 | Nof Corporation | Process for producing an aqueous solution of phosphorylcholine group bearing polymer and aqueous solution of phosphorylcholine group bearing polymer |
| US5599587A (en) * | 1990-11-05 | 1997-02-04 | Biocompatibles Limited | Phosphoric acid esters and their use in the preparation of biocompatible surfaces |
| WO1998054194A1 (en) * | 1997-05-30 | 1998-12-03 | Nof Corporation | Process for producing (meth)acrylate derivatives |
| US5981786A (en) * | 1997-05-30 | 1999-11-09 | Nof Corporation | Process for producing (meth)acrylate derivatives |
| WO2001034700A1 (en) | 1999-11-09 | 2001-05-17 | Nof Corporation | Composition for hydrogel, hydrogel, and use thereof |
| US7166476B2 (en) | 2000-08-29 | 2007-01-23 | Kyowa Medex Co., Ltd. | Highly reproducible agglutination immunoassay method and reagents |
| WO2012175923A1 (en) | 2011-06-24 | 2012-12-27 | Biointeractions Limited, University Of Reading | Biocompatible, biomimetic ampholyte materials |
| WO2013033554A1 (en) | 2011-09-01 | 2013-03-07 | Vertellus Specialties Inc. | Biocompatible material |
| WO2013128633A1 (ja) | 2012-03-02 | 2013-09-06 | 日油株式会社 | コンタクトレンズ用ケア製剤及びパッケージング溶液 |
| CN109438516A (zh) * | 2018-12-19 | 2019-03-08 | 安庆构友生物材料科技有限公司 | 一种制备乙撑2-（甲基丙烯酰氧）乙基磷酸酯的方法 |
| WO2023276858A1 (ja) | 2021-06-29 | 2023-01-05 | 日油株式会社 | ソフトコンタクトレンズ用溶液 |
| US11912784B2 (en) | 2019-10-10 | 2024-02-27 | Kodiak Sciences Inc. | Methods of treating an eye disorder |
| US12071476B2 (en) | 2018-03-02 | 2024-08-27 | Kodiak Sciences Inc. | IL-6 antibodies and fusion constructs and conjugates thereof |
-
1982
- 1982-03-09 JP JP57036868A patent/JPS58154591A/ja active Granted
Cited By (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5599587A (en) * | 1990-11-05 | 1997-02-04 | Biocompatibles Limited | Phosphoric acid esters and their use in the preparation of biocompatible surfaces |
| WO1995014701A1 (en) * | 1993-11-23 | 1995-06-01 | Biocompatibles Limited | Ethylenically unsaturated compounds |
| WO1995014702A1 (en) * | 1993-11-23 | 1995-06-01 | Biocompatibles Limited | Ethylenically unsaturated compounds |
| WO1996031566A1 (en) | 1995-04-03 | 1996-10-10 | Nof Corporation | Process for producing an aqueous solution of phosphorylcholine group bearing polymer and aqueous solution of phosphorylcholine group bearing polymer |
| WO1998054194A1 (en) * | 1997-05-30 | 1998-12-03 | Nof Corporation | Process for producing (meth)acrylate derivatives |
| EP0922709A4 (it) * | 1997-05-30 | 1999-07-21 | ||
| US5981786A (en) * | 1997-05-30 | 1999-11-09 | Nof Corporation | Process for producing (meth)acrylate derivatives |
| WO2001034700A1 (en) | 1999-11-09 | 2001-05-17 | Nof Corporation | Composition for hydrogel, hydrogel, and use thereof |
| US7166476B2 (en) | 2000-08-29 | 2007-01-23 | Kyowa Medex Co., Ltd. | Highly reproducible agglutination immunoassay method and reagents |
| WO2012175923A1 (en) | 2011-06-24 | 2012-12-27 | Biointeractions Limited, University Of Reading | Biocompatible, biomimetic ampholyte materials |
| US9567357B2 (en) | 2011-06-24 | 2017-02-14 | Biointeractions Ltd. | Biocompatible, biomimetic ampholyte materials |
| US10251982B2 (en) | 2011-06-24 | 2019-04-09 | Biointeractions Ltd. | Biocompatible, biomimetic ampholyte materials |
| WO2013033554A1 (en) | 2011-09-01 | 2013-03-07 | Vertellus Specialties Inc. | Biocompatible material |
| WO2013128633A1 (ja) | 2012-03-02 | 2013-09-06 | 日油株式会社 | コンタクトレンズ用ケア製剤及びパッケージング溶液 |
| US12071476B2 (en) | 2018-03-02 | 2024-08-27 | Kodiak Sciences Inc. | IL-6 antibodies and fusion constructs and conjugates thereof |
| CN109438516A (zh) * | 2018-12-19 | 2019-03-08 | 安庆构友生物材料科技有限公司 | 一种制备乙撑2-（甲基丙烯酰氧）乙基磷酸酯的方法 |
| CN109438516B (zh) * | 2018-12-19 | 2021-05-07 | 安庆构友生物材料科技有限公司 | 一种制备乙撑2-（甲基丙烯酰氧）乙基磷酸酯的方法 |
| US11912784B2 (en) | 2019-10-10 | 2024-02-27 | Kodiak Sciences Inc. | Methods of treating an eye disorder |
| WO2023276858A1 (ja) | 2021-06-29 | 2023-01-05 | 日油株式会社 | ソフトコンタクトレンズ用溶液 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0249316B2 (it) | 1990-10-29 |
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