JPS58121210A - 瞬間口中放出性舌下軟カプセル剤の製造方法 - Google Patents
瞬間口中放出性舌下軟カプセル剤の製造方法Info
- Publication number
- JPS58121210A JPS58121210A JP14786682A JP14786682A JPS58121210A JP S58121210 A JPS58121210 A JP S58121210A JP 14786682 A JP14786682 A JP 14786682A JP 14786682 A JP14786682 A JP 14786682A JP S58121210 A JPS58121210 A JP S58121210A
- Authority
- JP
- Japan
- Prior art keywords
- parts
- capsule
- gelatin
- sublingual
- instantaneous
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000004519 manufacturing process Methods 0.000 title claims description 8
- 239000007901 soft capsule Substances 0.000 title claims description 7
- 239000003814 drug Substances 0.000 title description 9
- 238000007599 discharging Methods 0.000 title 1
- 239000002775 capsule Substances 0.000 claims description 45
- 108010010803 Gelatin Proteins 0.000 claims description 27
- 229920000159 gelatin Polymers 0.000 claims description 27
- 239000008273 gelatin Substances 0.000 claims description 27
- 235000019322 gelatine Nutrition 0.000 claims description 27
- 235000011852 gelatine desserts Nutrition 0.000 claims description 27
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 8
- 125000004432 carbon atom Chemical group C* 0.000 claims description 5
- 229920001515 polyalkylene glycol Polymers 0.000 claims description 5
- 230000000304 vasodilatating effect Effects 0.000 claims description 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 3
- 125000002947 alkylene group Chemical group 0.000 claims description 2
- HYIMSNHJOBLJNT-UHFFFAOYSA-N nifedipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1[N+]([O-])=O HYIMSNHJOBLJNT-UHFFFAOYSA-N 0.000 claims 1
- 239000000203 mixture Substances 0.000 description 39
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 34
- 239000004480 active ingredient Substances 0.000 description 18
- 235000011187 glycerol Nutrition 0.000 description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 17
- 238000000034 method Methods 0.000 description 12
- 238000009472 formulation Methods 0.000 description 10
- 238000011049 filling Methods 0.000 description 9
- YNGDWRXWKFWCJY-UHFFFAOYSA-N 1,4-Dihydropyridine Chemical class C1C=CNC=C1 YNGDWRXWKFWCJY-UHFFFAOYSA-N 0.000 description 8
- 229940079593 drug Drugs 0.000 description 8
- 239000000243 solution Substances 0.000 description 8
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 7
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 6
- 238000001035 drying Methods 0.000 description 6
- 239000007903 gelatin capsule Substances 0.000 description 6
- 239000007788 liquid Substances 0.000 description 6
- 238000004080 punching Methods 0.000 description 6
- 206010002383 Angina Pectoris Diseases 0.000 description 5
- 239000000975 dye Substances 0.000 description 5
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 4
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- 235000013980 iron oxide Nutrition 0.000 description 4
- 239000003921 oil Substances 0.000 description 4
- 235000019198 oils Nutrition 0.000 description 4
- 229920001223 polyethylene glycol Polymers 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 239000000600 sorbitol Substances 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 3
- PURJGKXXWJKIQR-UHFFFAOYSA-N 4-[(4-hydroxynaphthalen-1-yl)diazenyl]benzenesulfonic acid Chemical compound C12=CC=CC=C2C(O)=CC=C1N=NC1=CC=C(S(O)(=O)=O)C=C1 PURJGKXXWJKIQR-UHFFFAOYSA-N 0.000 description 3
- 241000282472 Canis lupus familiaris Species 0.000 description 3
- 239000002202 Polyethylene glycol Substances 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 3
- -1 brown iron oxide Chemical compound 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 238000007598 dipping method Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000001525 mentha piperita l. herb oil Substances 0.000 description 3
- 229910052760 oxygen Inorganic materials 0.000 description 3
- 239000001301 oxygen Substances 0.000 description 3
- 235000019477 peppermint oil Nutrition 0.000 description 3
- 229940068918 polyethylene glycol 400 Drugs 0.000 description 3
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 3
- 239000004408 titanium dioxide Substances 0.000 description 3
- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 description 2
- PAYRUJLWNCNPSJ-UHFFFAOYSA-N Aniline Chemical compound NC1=CC=CC=C1 PAYRUJLWNCNPSJ-UHFFFAOYSA-N 0.000 description 2
- 241000416162 Astragalus gummifer Species 0.000 description 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
- 239000004698 Polyethylene Substances 0.000 description 2
- 229920001615 Tragacanth Polymers 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 229910000019 calcium carbonate Inorganic materials 0.000 description 2
- SOPYTFSYTUAGFR-OEAKJJBVSA-N chembl2431390 Chemical compound C1=CC=C2C(/C=N/NC(=O)CCN3C4=CC=CC=C4N=C3C)=C(O)C=CC2=C1 SOPYTFSYTUAGFR-OEAKJJBVSA-N 0.000 description 2
- 239000008298 dragée Substances 0.000 description 2
- 238000001802 infusion Methods 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 239000003605 opacifier Substances 0.000 description 2
- 229920000573 polyethylene Polymers 0.000 description 2
- 229940085605 saccharin sodium Drugs 0.000 description 2
- 238000007789 sealing Methods 0.000 description 2
- 239000004149 tartrazine Substances 0.000 description 2
- UJMBCXLDXJUMFB-GLCFPVLVSA-K tartrazine Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)C1=NN(C=2C=CC(=CC=2)S([O-])(=O)=O)C(=O)C1\N=N\C1=CC=C(S([O-])(=O)=O)C=C1 UJMBCXLDXJUMFB-GLCFPVLVSA-K 0.000 description 2
- 229960000943 tartrazine Drugs 0.000 description 2
- 235000012756 tartrazine Nutrition 0.000 description 2
- 239000000196 tragacanth Substances 0.000 description 2
- 235000010487 tragacanth Nutrition 0.000 description 2
- 229940116362 tragacanth Drugs 0.000 description 2
- BHMLFPOTZYRDKA-IRXDYDNUSA-N (2s)-2-[(s)-(2-iodophenoxy)-phenylmethyl]morpholine Chemical compound IC1=CC=CC=C1O[C@@H](C=1C=CC=CC=1)[C@H]1OCCNC1 BHMLFPOTZYRDKA-IRXDYDNUSA-N 0.000 description 1
- 241000251468 Actinopterygii Species 0.000 description 1
- 208000019901 Anxiety disease Diseases 0.000 description 1
- 235000005747 Carum carvi Nutrition 0.000 description 1
- 240000000467 Carum carvi Species 0.000 description 1
- 235000019501 Lemon oil Nutrition 0.000 description 1
- 240000006240 Linum usitatissimum Species 0.000 description 1
- 235000006679 Mentha X verticillata Nutrition 0.000 description 1
- 235000002899 Mentha suaveolens Nutrition 0.000 description 1
- 235000001636 Mentha x rotundifolia Nutrition 0.000 description 1
- SNIOPGDIGTZGOP-UHFFFAOYSA-N Nitroglycerin Chemical compound [O-][N+](=O)OCC(O[N+]([O-])=O)CO[N+]([O-])=O SNIOPGDIGTZGOP-UHFFFAOYSA-N 0.000 description 1
- 239000000006 Nitroglycerin Substances 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 206010034960 Photophobia Diseases 0.000 description 1
- 241000545760 Unio Species 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 150000003863 ammonium salts Chemical class 0.000 description 1
- 230000036506 anxiety Effects 0.000 description 1
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 229940067573 brown iron oxide Drugs 0.000 description 1
- 239000008395 clarifying agent Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000036461 convulsion Effects 0.000 description 1
- 210000003748 coronary sinus Anatomy 0.000 description 1
- 239000003218 coronary vasodilator agent Substances 0.000 description 1
- 210000004351 coronary vessel Anatomy 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- IZEKFCXSFNUWAM-UHFFFAOYSA-N dipyridamole Chemical compound C=12N=C(N(CCO)CCO)N=C(N3CCCCC3)C2=NC(N(CCO)CCO)=NC=1N1CCCCC1 IZEKFCXSFNUWAM-UHFFFAOYSA-N 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 239000010642 eucalyptus oil Substances 0.000 description 1
- 229940044949 eucalyptus oil Drugs 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 230000009969 flowable effect Effects 0.000 description 1
- 239000000989 food dye Substances 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 229960003711 glyceryl trinitrate Drugs 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- WTFXARWRTYJXII-UHFFFAOYSA-N iron(2+);iron(3+);oxygen(2-) Chemical compound [O-2].[O-2].[O-2].[O-2].[Fe+2].[Fe+3].[Fe+3] WTFXARWRTYJXII-UHFFFAOYSA-N 0.000 description 1
- VBMVTYDPPZVILR-UHFFFAOYSA-N iron(2+);oxygen(2-) Chemical class [O-2].[Fe+2] VBMVTYDPPZVILR-UHFFFAOYSA-N 0.000 description 1
- SZVJSHCCFOBDDC-UHFFFAOYSA-N iron(II,III) oxide Inorganic materials O=[Fe]O[Fe]O[Fe]=O SZVJSHCCFOBDDC-UHFFFAOYSA-N 0.000 description 1
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 1
- 239000010501 lemon oil Substances 0.000 description 1
- 208000013469 light sensitivity Diseases 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 238000009740 moulding (composite fabrication) Methods 0.000 description 1
- 208000010125 myocardial infarction Diseases 0.000 description 1
- 210000004165 myocardium Anatomy 0.000 description 1
- 210000003739 neck Anatomy 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
- 238000006303 photolysis reaction Methods 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 229940068886 polyethylene glycol 300 Drugs 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 229940081974 saccharin Drugs 0.000 description 1
- 235000019204 saccharin Nutrition 0.000 description 1
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
- 238000009751 slip forming Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2142316 | 1971-08-24 | ||
| DE2142316.5 | 1971-08-24 | ||
| DE2209526.7 | 1972-02-29 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS58121210A true JPS58121210A (ja) | 1983-07-19 |
| JPS6119604B2 JPS6119604B2 (enrdf_load_html_response) | 1986-05-17 |
Family
ID=5817609
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP14786682A Granted JPS58121210A (ja) | 1971-08-24 | 1982-08-27 | 瞬間口中放出性舌下軟カプセル剤の製造方法 |
| JP14786782A Pending JPS58121211A (ja) | 1971-08-24 | 1982-08-27 | 瞬間口中放出性舌下軟カプセル剤の製造方法 |
| JP14786882A Pending JPS58113126A (ja) | 1971-08-24 | 1982-08-27 | 瞬間口中放出性舌下軟カプセル剤の製造方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP14786782A Pending JPS58121211A (ja) | 1971-08-24 | 1982-08-27 | 瞬間口中放出性舌下軟カプセル剤の製造方法 |
| JP14786882A Pending JPS58113126A (ja) | 1971-08-24 | 1982-08-27 | 瞬間口中放出性舌下軟カプセル剤の製造方法 |
Country Status (3)
| Country | Link |
|---|---|
| JP (3) | JPS58121210A (enrdf_load_html_response) |
| GT (1) | GT197749906A (enrdf_load_html_response) |
| ZA (1) | ZA725808B (enrdf_load_html_response) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6397668A (ja) * | 1986-10-13 | 1988-04-28 | Lion Corp | 耐光性カロチン |
| JPS63238016A (ja) * | 1987-03-26 | 1988-10-04 | Tokai Kapuseru Kk | 塩酸ニカルジピン軟カプセル剤 |
| JPH08157354A (ja) * | 1986-10-17 | 1996-06-18 | Rp Scherer Corp | ソフトゲル充填若しくはツーピースカプセル封入若しくは錠剤製造用の塩基性医薬品溶液 |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60105611A (ja) * | 1983-11-14 | 1985-06-11 | Nippon Chemiphar Co Ltd | ニフエジピン軟カプセル剤 |
| EP1502588B1 (en) * | 2002-05-09 | 2013-03-06 | Chugai Seiyaku Kabushiki Kaisha | Light-stabilized soft capsule for formulations |
| MX2015006022A (es) * | 2014-02-07 | 2015-10-14 | Scilabs Pharmaceuticals | Sistemas de administracion de farmacos sublinguales, totalmente naturales, no toxicos. |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3155587A (en) * | 1963-01-23 | 1964-11-03 | American Cyanamid Co | Stable liquid preparations of 7-chlorotetracycline |
| GB1173862A (en) * | 1967-03-20 | 1969-12-10 | Bayer Ag | 4-Aryl-1,4-Dihydropyridine Derivatives and their production |
| JPS4828621A (enrdf_load_html_response) * | 1971-08-24 | 1973-04-16 | ||
| JPS5434048A (en) * | 1977-08-22 | 1979-03-13 | Nippon Electric Co | Method of making electrolytic capacitor |
| JPS5637209A (en) * | 1979-09-05 | 1981-04-10 | Nissan Chem Ind Ltd | Continuous manufacture of phosphoric acid from unpulverized phosphate ore |
| JPS6119604A (ja) * | 1984-07-05 | 1986-01-28 | Mitsubishi Electric Corp | 水溶性光重合開始剤の製法 |
-
1972
- 1972-08-23 ZA ZA725808A patent/ZA725808B/xx unknown
-
1977
- 1977-12-14 GT GT197749906A patent/GT197749906A/es unknown
-
1982
- 1982-08-27 JP JP14786682A patent/JPS58121210A/ja active Granted
- 1982-08-27 JP JP14786782A patent/JPS58121211A/ja active Pending
- 1982-08-27 JP JP14786882A patent/JPS58113126A/ja active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3155587A (en) * | 1963-01-23 | 1964-11-03 | American Cyanamid Co | Stable liquid preparations of 7-chlorotetracycline |
| GB1173862A (en) * | 1967-03-20 | 1969-12-10 | Bayer Ag | 4-Aryl-1,4-Dihydropyridine Derivatives and their production |
| JPS4828621A (enrdf_load_html_response) * | 1971-08-24 | 1973-04-16 | ||
| JPS5434048A (en) * | 1977-08-22 | 1979-03-13 | Nippon Electric Co | Method of making electrolytic capacitor |
| JPS5637209A (en) * | 1979-09-05 | 1981-04-10 | Nissan Chem Ind Ltd | Continuous manufacture of phosphoric acid from unpulverized phosphate ore |
| JPS6119604A (ja) * | 1984-07-05 | 1986-01-28 | Mitsubishi Electric Corp | 水溶性光重合開始剤の製法 |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6397668A (ja) * | 1986-10-13 | 1988-04-28 | Lion Corp | 耐光性カロチン |
| JPH08157354A (ja) * | 1986-10-17 | 1996-06-18 | Rp Scherer Corp | ソフトゲル充填若しくはツーピースカプセル封入若しくは錠剤製造用の塩基性医薬品溶液 |
| JPS63238016A (ja) * | 1987-03-26 | 1988-10-04 | Tokai Kapuseru Kk | 塩酸ニカルジピン軟カプセル剤 |
Also Published As
| Publication number | Publication date |
|---|---|
| GT197749906A (es) | 1979-06-07 |
| JPS58113126A (ja) | 1983-07-05 |
| ZA725808B (en) | 1973-05-30 |
| JPS58121211A (ja) | 1983-07-19 |
| JPS6119604B2 (enrdf_load_html_response) | 1986-05-17 |
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