JPS5772982A - Antibiotic substance and its preparation - Google Patents

Antibiotic substance and its preparation

Info

Publication number
JPS5772982A
JPS5772982A JP55149177A JP14917780A JPS5772982A JP S5772982 A JPS5772982 A JP S5772982A JP 55149177 A JP55149177 A JP 55149177A JP 14917780 A JP14917780 A JP 14917780A JP S5772982 A JPS5772982 A JP S5772982A
Authority
JP
Japan
Prior art keywords
substances
exchange resin
antibiotic substance
solution
adsorb
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP55149177A
Other languages
Japanese (ja)
Inventor
Masao Oguchi
Masato Nakayama
Akio Iwasaki
Shigeru Kimura
Toshimi Mizoguchi
Sohei Tanabe
Akira Murakami
Hisakatsu Itou
Toshito Mori
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KOUWA KK
Kowa Co Ltd
Original Assignee
KOUWA KK
Kowa Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by KOUWA KK, Kowa Co Ltd filed Critical KOUWA KK
Priority to JP55149177A priority Critical patent/JPS5772982A/en
Priority to EP81304957A priority patent/EP0050961B1/en
Priority to DE8181304957T priority patent/DE3170632D1/en
Priority to ES506470A priority patent/ES506470A0/en
Priority to US06/314,028 priority patent/US4468350A/en
Priority to AT81304957T priority patent/ATE13431T1/en
Priority to DK469481A priority patent/DK469481A/en
Priority to CA000388574A priority patent/CA1167400A/en
Publication of JPS5772982A publication Critical patent/JPS5772982A/en
Pending legal-status Critical Current

Links

Abstract

NEW MATERIAL:Antibiotic substance KA-6643-D of formulaI, antibiotic substance KA-6643-F of formula II, their salts or their esters.
USE: Antimicrobial agent effective to Gram-positive and Gram-negative bacteria, and having strong β-lactamase-inhibiting activity.
PROCESS: Streptomyces KC-6643 strain (FERM-P No.4467) is cultured in a liquid medium under aerobic conditions, and the filtrate of the cultured medium is passed through e.g. a basic anion-exchange resin to adsorb the group of KA-6643 substances, which are eluted with a salt solution, etc. The eluate is passed through a strongly basic ion exchange resin to adsorb the group of KA-6643 substances. The KA-6643-A, -B, -D and -F-substances are eluted successively by passing a phosphate bubber solution through the ion exchange resin gradually changing the concentration of sodium chloride in the solution. By further purification and separation, the objective KA-6643-D and -F substances can be obtained.
COPYRIGHT: (C)1982,JPO&Japio
JP55149177A 1980-10-24 1980-10-24 Antibiotic substance and its preparation Pending JPS5772982A (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
JP55149177A JPS5772982A (en) 1980-10-24 1980-10-24 Antibiotic substance and its preparation
EP81304957A EP0050961B1 (en) 1980-10-24 1981-10-22 Novel antibiotics, a process for producing the same, medical compositions containing the same, and a novel strain of the genus streptomyces for use in producing the same
DE8181304957T DE3170632D1 (en) 1980-10-24 1981-10-22 Novel antibiotics, a process for producing the same, medical compositions containing the same, and a novel strain of the genus streptomyces for use in producing the same
ES506470A ES506470A0 (en) 1980-10-24 1981-10-22 PRODUCTION PROCESS OF A DRUG COMPOUND CONTAINING KA-6643 SERIES ANTIBIOTICS
US06/314,028 US4468350A (en) 1980-10-24 1981-10-22 KA-6643-Series antibiotics, process for producing same and medical composition containing same
AT81304957T ATE13431T1 (en) 1980-10-24 1981-10-22 ANTIBIOTICS, PROCESS FOR THEIR MANUFACTURE, MEDICATIONS CONTAINING THEM AND A STREPTOMYCES SPECIES STRAIN USED FOR THEIR MANUFACTURE.
DK469481A DK469481A (en) 1980-10-24 1981-10-23 PROCEDURE FOR THE MANUFACTURE OF ANTIBIOTICS
CA000388574A CA1167400A (en) 1980-10-24 1981-10-23 Ka-6643-series antibiotics, process for producing same and medical composition containing same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP55149177A JPS5772982A (en) 1980-10-24 1980-10-24 Antibiotic substance and its preparation

Publications (1)

Publication Number Publication Date
JPS5772982A true JPS5772982A (en) 1982-05-07

Family

ID=15469472

Family Applications (1)

Application Number Title Priority Date Filing Date
JP55149177A Pending JPS5772982A (en) 1980-10-24 1980-10-24 Antibiotic substance and its preparation

Country Status (1)

Country Link
JP (1) JPS5772982A (en)

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