JPS5772982A - Antibiotic substance and its preparation - Google Patents
Antibiotic substance and its preparationInfo
- Publication number
- JPS5772982A JPS5772982A JP55149177A JP14917780A JPS5772982A JP S5772982 A JPS5772982 A JP S5772982A JP 55149177 A JP55149177 A JP 55149177A JP 14917780 A JP14917780 A JP 14917780A JP S5772982 A JPS5772982 A JP S5772982A
- Authority
- JP
- Japan
- Prior art keywords
- substances
- exchange resin
- antibiotic substance
- solution
- adsorb
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
NEW MATERIAL:Antibiotic substance KA-6643-D of formulaI, antibiotic substance KA-6643-F of formula II, their salts or their esters.
USE: Antimicrobial agent effective to Gram-positive and Gram-negative bacteria, and having strong β-lactamase-inhibiting activity.
PROCESS: Streptomyces KC-6643 strain (FERM-P No.4467) is cultured in a liquid medium under aerobic conditions, and the filtrate of the cultured medium is passed through e.g. a basic anion-exchange resin to adsorb the group of KA-6643 substances, which are eluted with a salt solution, etc. The eluate is passed through a strongly basic ion exchange resin to adsorb the group of KA-6643 substances. The KA-6643-A, -B, -D and -F-substances are eluted successively by passing a phosphate bubber solution through the ion exchange resin gradually changing the concentration of sodium chloride in the solution. By further purification and separation, the objective KA-6643-D and -F substances can be obtained.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP55149177A JPS5772982A (en) | 1980-10-24 | 1980-10-24 | Antibiotic substance and its preparation |
EP81304957A EP0050961B1 (en) | 1980-10-24 | 1981-10-22 | Novel antibiotics, a process for producing the same, medical compositions containing the same, and a novel strain of the genus streptomyces for use in producing the same |
DE8181304957T DE3170632D1 (en) | 1980-10-24 | 1981-10-22 | Novel antibiotics, a process for producing the same, medical compositions containing the same, and a novel strain of the genus streptomyces for use in producing the same |
ES506470A ES506470A0 (en) | 1980-10-24 | 1981-10-22 | PRODUCTION PROCESS OF A DRUG COMPOUND CONTAINING KA-6643 SERIES ANTIBIOTICS |
US06/314,028 US4468350A (en) | 1980-10-24 | 1981-10-22 | KA-6643-Series antibiotics, process for producing same and medical composition containing same |
AT81304957T ATE13431T1 (en) | 1980-10-24 | 1981-10-22 | ANTIBIOTICS, PROCESS FOR THEIR MANUFACTURE, MEDICATIONS CONTAINING THEM AND A STREPTOMYCES SPECIES STRAIN USED FOR THEIR MANUFACTURE. |
DK469481A DK469481A (en) | 1980-10-24 | 1981-10-23 | PROCEDURE FOR THE MANUFACTURE OF ANTIBIOTICS |
CA000388574A CA1167400A (en) | 1980-10-24 | 1981-10-23 | Ka-6643-series antibiotics, process for producing same and medical composition containing same |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP55149177A JPS5772982A (en) | 1980-10-24 | 1980-10-24 | Antibiotic substance and its preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5772982A true JPS5772982A (en) | 1982-05-07 |
Family
ID=15469472
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP55149177A Pending JPS5772982A (en) | 1980-10-24 | 1980-10-24 | Antibiotic substance and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5772982A (en) |
-
1980
- 1980-10-24 JP JP55149177A patent/JPS5772982A/en active Pending
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