JPS5643284A - Antibiotic and its preparation - Google Patents

Antibiotic and its preparation

Info

Publication number
JPS5643284A
JPS5643284A JP11913979A JP11913979A JPS5643284A JP S5643284 A JPS5643284 A JP S5643284A JP 11913979 A JP11913979 A JP 11913979A JP 11913979 A JP11913979 A JP 11913979A JP S5643284 A JPS5643284 A JP S5643284A
Authority
JP
Japan
Prior art keywords
substance
eluted
solution
salt
antibiotic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP11913979A
Other languages
Japanese (ja)
Inventor
Masato Nakayama
Akio Iwasaki
Shigeru Kimura
Sohei Tanabe
Toshimi Mizoguchi
Akira Murakami
Isamu Watanabe
Masao Oguchi
Hisakatsu Itou
Toshito Mori
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kowa Co Ltd
Original Assignee
Kowa Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kowa Co Ltd filed Critical Kowa Co Ltd
Priority to JP11913979A priority Critical patent/JPS5643284A/en
Priority to US06/137,259 priority patent/US4530791A/en
Priority to GB8011860A priority patent/GB2047700B/en
Priority to FR8008325A priority patent/FR2454441A1/en
Priority to PT71091A priority patent/PT71091A/en
Priority to DE19803014434 priority patent/DE3014434A1/en
Priority to IT21374/80A priority patent/IT1194646B/en
Priority to ES490574A priority patent/ES490574A0/en
Priority to DD80220468A priority patent/DD157345A5/en
Priority to SE8002827A priority patent/SE8002827L/en
Priority to DK161880A priority patent/DK161880A/en
Priority to NL8002210A priority patent/NL8002210A/en
Priority to AT0205080A priority patent/AT371146B/en
Priority to NO802574A priority patent/NO802574L/en
Priority to FI802805A priority patent/FI802805A/en
Priority to BE0/202064A priority patent/BE885186A/en
Priority to PL1980226700A priority patent/PL127697B1/en
Priority to PH24599A priority patent/PH15818A/en
Priority to GR62878A priority patent/GR69825B/el
Priority to AU62406/80A priority patent/AU6240680A/en
Publication of JPS5643284A publication Critical patent/JPS5643284A/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/182—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system
    • C12P17/184—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system containing a beta-lactam ring, e.g. thienamycin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

NEW MATERIAL:An antibiotic KA-6643-B shown by the formula and its salt. USE:An antibiotic effective against Gram-positive and Gramnegative bacterial, and effective against bacteria having resistance to various kinds of beta-lactam antibiotics. PROCESS:A streptomyces sp KC-6643(FERM-P 4467) is cultured aerobically at 3-35 deg.C, preferably at 27-33 deg.C by liquid cultivation, especially deep part cultivation, and the culture solution is subjected to centrifugation or filtration to remove the mold. The culture filtrate is made to flow through a basic anion exchange resin, and substance KA-6643 is adsorbed. The substance KA-6643 is eluted with s salt solution or an aqueous methanol solution of salt. The solution is made to flow a strongly basic ion exchange resin, and the substance FA-6643 is eluted by changing a salt concentration in a buffer solution of phosphoric acid stepwise. The substance KA-6643-A is eluted at early stage, and the substance KA-6643-B shown by the formula is then eluted. Both substance are separated.
JP11913979A 1979-04-16 1979-09-17 Antibiotic and its preparation Pending JPS5643284A (en)

Priority Applications (20)

Application Number Priority Date Filing Date Title
JP11913979A JPS5643284A (en) 1979-09-17 1979-09-17 Antibiotic and its preparation
US06/137,259 US4530791A (en) 1979-04-16 1980-04-04 β-Lactam antibiotics
GB8011860A GB2047700B (en) 1979-04-16 1980-04-10 Antibiotic and process for producing the same
FR8008325A FR2454441A1 (en) 1979-04-16 1980-04-14 NOVEL ANTIBIOTIC AND PROCESS FOR THEIR PREPARATION FROM STRAINS BELONGING TO THE GENUS STREPTOMYCES
PT71091A PT71091A (en) 1979-04-16 1980-04-14 An antibiotic and a process for producing same
DE19803014434 DE3014434A1 (en) 1979-04-16 1980-04-15 ANTIBIOTIC, METHOD FOR THE PRODUCTION THEREOF, AND MEDICINAL PRODUCT CONTAINING IT
IT21374/80A IT1194646B (en) 1979-04-16 1980-04-15 ANTIBIOTIC AND PROCEDURE FOR ITS PRODUCTION
ES490574A ES490574A0 (en) 1979-04-16 1980-04-15 PROCESS TO OBTAIN AN ANTIBIOTIC SUBSTANCE AND LAMISMA SALTS.
DD80220468A DD157345A5 (en) 1979-04-16 1980-04-15 A METHOD OF PREPARING AN ANTIBIOTIC SUBSTANCE
SE8002827A SE8002827L (en) 1979-04-16 1980-04-15 ANTIBIOTIC AND SET FOR ITS PREPARATION
DK161880A DK161880A (en) 1979-04-16 1980-04-16 Method and apparatus for packaging of stacked goods with shrink film
NL8002210A NL8002210A (en) 1979-04-16 1980-04-16 ANTIBIOTIC AND METHOD FOR PREPARING IT.
AT0205080A AT371146B (en) 1979-04-16 1980-04-16 METHOD FOR PRODUCING A NEW ANTIBIOTIC SUBSTANCE
NO802574A NO802574L (en) 1979-09-17 1980-09-01 PROCEDURE FOR THE PREPARATION OF ANTIBIOTICS KA-6643
FI802805A FI802805A (en) 1979-09-17 1980-09-08 ANTIBIOT OCH FOERFARANDE FOER DESS FRAMSTAELLNING
BE0/202064A BE885186A (en) 1979-09-17 1980-09-11 NOVEL ANTIBIOTIC AND PROCESS FOR THEIR PREPARATION FROM STRAINS BELONGING TO THE GENUS STREPTOMYCES
PL1980226700A PL127697B1 (en) 1979-09-17 1980-09-11 Process for preparing novel antibiotic
PH24599A PH15818A (en) 1979-09-17 1980-09-11 Antibiotic-ka-6643-a and ka-6643-b
GR62878A GR69825B (en) 1979-09-17 1980-09-12
AU62406/80A AU6240680A (en) 1979-09-17 1980-09-15 Antibiotic and process

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP11913979A JPS5643284A (en) 1979-09-17 1979-09-17 Antibiotic and its preparation

Publications (1)

Publication Number Publication Date
JPS5643284A true JPS5643284A (en) 1981-04-21

Family

ID=14753889

Family Applications (1)

Application Number Title Priority Date Filing Date
JP11913979A Pending JPS5643284A (en) 1979-04-16 1979-09-17 Antibiotic and its preparation

Country Status (8)

Country Link
JP (1) JPS5643284A (en)
AU (1) AU6240680A (en)
BE (1) BE885186A (en)
FI (1) FI802805A (en)
GR (1) GR69825B (en)
NO (1) NO802574L (en)
PH (1) PH15818A (en)
PL (1) PL127697B1 (en)

Also Published As

Publication number Publication date
AU6240680A (en) 1981-03-26
PL226700A1 (en) 1981-09-04
BE885186A (en) 1980-12-31
PL127697B1 (en) 1983-11-30
GR69825B (en) 1982-07-13
PH15818A (en) 1983-03-28
FI802805A (en) 1981-03-18
NO802574L (en) 1981-03-18

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