JPS57188570A - Benzylazole derivative - Google Patents

Benzylazole derivative

Info

Publication number
JPS57188570A
JPS57188570A JP56072986A JP7298681A JPS57188570A JP S57188570 A JPS57188570 A JP S57188570A JP 56072986 A JP56072986 A JP 56072986A JP 7298681 A JP7298681 A JP 7298681A JP S57188570 A JPS57188570 A JP S57188570A
Authority
JP
Japan
Prior art keywords
alkyl
compound expressed
halogen
benzylazole
derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP56072986A
Other languages
English (en)
Japanese (ja)
Other versions
JPS6325583B2 (enExample
Inventor
Hide Ogata
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Priority to JP56072986A priority Critical patent/JPS57188570A/ja
Priority to US06/372,951 priority patent/US4430331A/en
Priority to NZ200471A priority patent/NZ200471A/en
Priority to AU83180/82A priority patent/AU554243B2/en
Priority to ZA823207A priority patent/ZA823207B/xx
Priority to CA000403693A priority patent/CA1193255A/en
Priority to IE1134/82A priority patent/IE52989B1/en
Priority to IL65735A priority patent/IL65735A/xx
Priority to ES512151A priority patent/ES512151A0/es
Priority to EP82104196A priority patent/EP0066144B1/en
Priority to GB08213956A priority patent/GB2103600B/en
Priority to HU821509A priority patent/HU188059B/hu
Priority to DE198282104196T priority patent/DE66144T1/de
Priority to PH27294A priority patent/PH17989A/en
Priority to DK216282A priority patent/DK161317C/da
Priority to DE8282104196T priority patent/DE3269141D1/de
Priority to KR8202102A priority patent/KR860001580B1/ko
Publication of JPS57188570A publication Critical patent/JPS57188570A/ja
Publication of JPS6325583B2 publication Critical patent/JPS6325583B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/60—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/68—One oxygen atom attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
JP56072986A 1981-05-14 1981-05-14 Benzylazole derivative Granted JPS57188570A (en)

Priority Applications (17)

Application Number Priority Date Filing Date Title
JP56072986A JPS57188570A (en) 1981-05-14 1981-05-14 Benzylazole derivative
US06/372,951 US4430331A (en) 1981-05-14 1982-04-29 Antiarrhytmic benzylimidazole
NZ200471A NZ200471A (en) 1981-05-14 1982-04-30 Benzylazole derivatives and pharmaceutical compositions
AU83180/82A AU554243B2 (en) 1981-05-14 1982-04-30 Benzylazole derivatives
ZA823207A ZA823207B (en) 1981-05-14 1982-05-10 Benzylazole derivatives
CA000403693A CA1193255A (en) 1981-05-14 1982-05-11 Benzylazone derivatives
IE1134/82A IE52989B1 (en) 1981-05-14 1982-05-11 Phenoxypropanolamine derivatives
IL65735A IL65735A (en) 1981-05-14 1982-05-11 Azolylalkyl(alkenyl)phenoxypropanolamine derivatives,process for their preparation and pharmaceutical or veterinary formulations comprising them
ES512151A ES512151A0 (es) 1981-05-14 1982-05-13 "procedimiento para preparar derivados de bencilazol."
EP82104196A EP0066144B1 (en) 1981-05-14 1982-05-13 Benzylazole derivatives
GB08213956A GB2103600B (en) 1981-05-14 1982-05-13 Phenoxypropanolamines
HU821509A HU188059B (en) 1981-05-14 1982-05-13 Process for producing benzylazole derivatives
DE198282104196T DE66144T1 (de) 1981-05-14 1982-05-13 Benzylazole-derivate.
PH27294A PH17989A (en) 1981-05-14 1982-05-13 Benzylazole derivatives
DK216282A DK161317C (da) 1981-05-14 1982-05-13 Analogifremgangsmaade til fremstilling af 2-(1-(1-imidazolyl)vinyl)-phenoxypropanolderivater
DE8282104196T DE3269141D1 (de) 1981-05-14 1982-05-13 Benzylazole derivatives
KR8202102A KR860001580B1 (ko) 1981-05-14 1982-05-14 벤질아졸 유도체의 제조 방법

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56072986A JPS57188570A (en) 1981-05-14 1981-05-14 Benzylazole derivative

Publications (2)

Publication Number Publication Date
JPS57188570A true JPS57188570A (en) 1982-11-19
JPS6325583B2 JPS6325583B2 (enExample) 1988-05-26

Family

ID=13505217

Family Applications (1)

Application Number Title Priority Date Filing Date
JP56072986A Granted JPS57188570A (en) 1981-05-14 1981-05-14 Benzylazole derivative

Country Status (16)

Country Link
US (1) US4430331A (enExample)
EP (1) EP0066144B1 (enExample)
JP (1) JPS57188570A (enExample)
KR (1) KR860001580B1 (enExample)
AU (1) AU554243B2 (enExample)
CA (1) CA1193255A (enExample)
DE (2) DE3269141D1 (enExample)
DK (1) DK161317C (enExample)
ES (1) ES512151A0 (enExample)
GB (1) GB2103600B (enExample)
HU (1) HU188059B (enExample)
IE (1) IE52989B1 (enExample)
IL (1) IL65735A (enExample)
NZ (1) NZ200471A (enExample)
PH (1) PH17989A (enExample)
ZA (1) ZA823207B (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3343671A1 (de) * 1983-12-02 1985-06-20 Basf Ag, 6700 Ludwigshafen Aminopropanolderivate von substituierten 2-hydroxy-propiophenonen, verfahren zu ihrer herstellung und diese enthaltende therapeutische mittel
CA1334092C (en) * 1986-07-11 1995-01-24 David John Carini Angiotensin ii receptor blocking imidazoles

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3870726A (en) 1970-09-09 1975-03-11 Bayer Ag Derivatives of 3-azolylpropyne and processes for their preparation and use
CH584695A5 (en) * 1973-02-20 1977-02-15 Ciba Geigy Ag 3-amino-2-hydroxypropoxy substd. diazines and pyridines - with beta-adrenergic blocking or stimulating activity
SE7601713L (sv) * 1975-03-03 1976-09-06 Merck & Co Inc Nya, substituerad imidazoler
ZA785863B (en) * 1977-10-19 1980-05-28 Wellcome Found Imidazole derivatives and their salts
US4210653A (en) * 1978-06-27 1980-07-01 Merck & Co., Inc. Pyridyloxypropanolamines
JPS5951943B2 (ja) * 1978-08-21 1984-12-17 キツセイ薬品工業株式会社 新規なイミダゾ−ル誘導体
GB2041363B (en) * 1979-01-19 1982-10-06 Pfizer Ltd N-benzyl-imidazoles
DK157860C (da) * 1979-06-07 1990-07-30 Shionogi & Co Analogifremgangsmaade til fremstilling af benzylimidazolderivater samt farmaceutisk acceptable syreadditionssalte deraf
EP0034116A3 (en) * 1980-02-11 1981-09-02 Berlex Laboratories, Inc. N-(3-phenoxy-2-hydroxypropyl)benzimidazole-1-alkanamines
CA1156661A (en) * 1980-02-25 1983-11-08 Hoffmann-La Roche Limited Phenoxy-aminopropanol derivatives

Also Published As

Publication number Publication date
JPS6325583B2 (enExample) 1988-05-26
US4430331A (en) 1984-02-07
CA1193255A (en) 1985-09-10
ES8303400A1 (es) 1983-02-01
PH17989A (en) 1985-02-28
IL65735A (en) 1986-04-29
EP0066144A3 (en) 1983-11-30
DK216282A (da) 1982-11-15
DK161317B (da) 1991-06-24
KR860001580B1 (ko) 1986-10-10
NZ200471A (en) 1985-08-30
AU8318082A (en) 1982-11-18
DK161317C (da) 1991-12-30
EP0066144A2 (en) 1982-12-08
GB2103600B (en) 1985-01-09
GB2103600A (en) 1983-02-23
DE66144T1 (de) 1983-05-26
ES512151A0 (es) 1983-02-01
ZA823207B (en) 1983-03-30
IL65735A0 (en) 1982-08-31
DE3269141D1 (de) 1986-03-27
EP0066144B1 (en) 1986-02-19
IE821134L (en) 1982-11-14
HU188059B (en) 1986-03-28
AU554243B2 (en) 1986-08-14
IE52989B1 (en) 1988-04-27
KR830010079A (ko) 1983-12-26

Similar Documents

Publication Publication Date Title
MY109937A (en) Substituted azoles, processes for the preparation thereof, agents containing these, and the use thereof.
AU583874B2 (en) Tetrahydrobenzthiazoles
DE3370621D1 (en) 1-aryloxy-2,3,4,5-tetrahydro-3-benzazepines, a process for preparing the same and their use as medicaments
ES300059A1 (es) Procedimiento de preparación de aminas y sus derivados de adición
PL249749A1 (en) Process for preparing novel derivatives of piperidinedione
YU182581A (en) Process for preparing new 5,10-dihydro-11h-dibenzo-(b,e)(1,4)diazepine-11-ones substituted in position 5
NZ216750A (en) Morpholino derivatives and fungicides
JPS57188570A (en) Benzylazole derivative
JPS5618969A (en) Novel 1-(4-aminobenzyl)-2,3-dioxopiperazine derivative, its acid addition salt, and their preparation
GB1122756A (en) Amino-substituted naphthalene derivatives
JPS51125291A (en) A process for preparing novel carbostyryl derivatives
EP0031388A4 (en) METHOD FOR PRODUCING IMIDAZOLE DERIVATIVES.
EP0090993A3 (en) Substituted hydroxyalkyl azoles, process for preparing them and their use as antimycotics
ES8302679A1 (es) Procedimiento de preparacion de una 1-(trialcoxibencil)pi- perazina.
JPS57175174A (en) Trithiotriazine compound and vulcanization of rubber using the same
ES319943A1 (es) Procedimiento para la obtencion de 3',4',5'-trimetoxi-3-aminoacrilofenona.
JPS5661373A (en) Piperazine derivative
JPS52153963A (en) Novel 3-substituted pyrrolidine derivatives and method of preparing same
HUT54355A (en) Process for producing imidazole derivatives of substituted benzoylurea, as well as antitumoural compositions comprising such compounds
GB740307A (en) New amide-like derivatives of piperidine and process for their preparation
JPS5714585A (en) 1-cycloalkylmethylpiperazine derivative
IE32544B1 (en) Halocinnamoyl piperidines and morpholines and pharmaceutical compositions containing them
JPS5659760A (en) 3-aminopyrazole derivative
ES472897A1 (es) Metodo de preparar derivados de antraquinona
ES444064A1 (es) Procedimiento de preparacion de nuevos (aroil-2'-et-1'-il)- 1-(acetamido-4"-piperazin-1"-il-metil)-2-bencimidazoles.