ES8302679A1 - Procedimiento de preparacion de una 1-(trialcoxibencil)pi- perazina. - Google Patents

Procedimiento de preparacion de una 1-(trialcoxibencil)pi- perazina.

Info

Publication number
ES8302679A1
ES8302679A1 ES506814A ES506814A ES8302679A1 ES 8302679 A1 ES8302679 A1 ES 8302679A1 ES 506814 A ES506814 A ES 506814A ES 506814 A ES506814 A ES 506814A ES 8302679 A1 ES8302679 A1 ES 8302679A1
Authority
ES
Spain
Prior art keywords
trialkoxybenzyl
piperazinone
piperadine
manufacture
prepared
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES506814A
Other languages
English (en)
Other versions
ES506814A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Science Union et Cie
Original Assignee
Science Union et Cie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Science Union et Cie filed Critical Science Union et Cie
Publication of ES506814A0 publication Critical patent/ES506814A0/es
Publication of ES8302679A1 publication Critical patent/ES8302679A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE 1-(TRIALCOXIBENCIL)PIPERAZINA, DE FORMULA (I), EN LA QUE R , R Y R SON ALCOHILOS C <003> . CONSISTE EN LA REACCION DE UN MOL DE CLORURO DE TRIALCOXIBENCILO, DE FORMULA (II), EN LA QUE R , R Y R SON LOS MISMOS QUE EN LA FORMULA (I), CON DOS MOLES DE PIPERAZINONA-2, EN TOLUENO; SEGUIDA DE LA REDUCCION DEL COMPUESTO FORMADO POR TRATAMIENTO CON UN HIDRURO, TAL COMO HIDRURO DE LITIO Y ALUMINIO O HIDRURO DE BORO, EN TETRAHIDROFURANO. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SUS PROPIEDADES VASODILATADORAS.
ES506814A 1980-11-06 1981-11-03 Procedimiento de preparacion de una 1-(trialcoxibencil)pi- perazina. Expired ES8302679A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8023678A FR2493316A1 (fr) 1980-11-06 1980-11-06 Nouveau procede de preparation des (trialcoxy benzyl)-1 piperazines et notamment de la (trimethoxy-2', 3', 4' benzyl)-1 piperazine

Publications (2)

Publication Number Publication Date
ES506814A0 ES506814A0 (es) 1983-02-01
ES8302679A1 true ES8302679A1 (es) 1983-02-01

Family

ID=9247720

Family Applications (1)

Application Number Title Priority Date Filing Date
ES506814A Expired ES8302679A1 (es) 1980-11-06 1981-11-03 Procedimiento de preparacion de una 1-(trialcoxibencil)pi- perazina.

Country Status (16)

Country Link
JP (1) JPS57108086A (es)
AU (1) AU546225B2 (es)
BE (1) BE891012A (es)
CA (1) CA1181069A (es)
CH (1) CH651031A5 (es)
DE (1) DE3144235A1 (es)
EG (1) EG15454A (es)
ES (1) ES8302679A1 (es)
FR (1) FR2493316A1 (es)
GR (1) GR75036B (es)
IT (1) IT1142928B (es)
LU (1) LU83738A1 (es)
MA (1) MA19322A1 (es)
MX (1) MX6973E (es)
OA (1) OA06939A (es)
PT (1) PT73935B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH650176A5 (fr) * 1982-08-23 1985-07-15 Daussan & Co Dispositif pour la coulee du metal fondu.
FR2661176B1 (fr) * 1990-04-20 1992-06-12 Adir Nouveau procede de preparation de la 1-(2,3,4-trimethoxybenzyl) piperazine en amination reductive.
FR2703048B1 (fr) * 1993-03-24 1996-01-05 Adir Nouveaux composes n-benzylpiperazine, leur procede de preparation et les compositions pharmaceutiques les renfermant.
CN100413854C (zh) * 2004-06-29 2008-08-27 北京德众万全药物技术开发有限公司 一种曲美他嗪及其药用盐的制备方法
CN102993122B (zh) * 2012-12-24 2015-03-04 武汉武药制药有限公司 盐酸曲美他嗪的合成新路线

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2438725A1 (de) * 1974-08-12 1976-02-26 Knoll Ag Piperazinderivate

Also Published As

Publication number Publication date
DE3144235A1 (de) 1982-06-24
PT73935B (fr) 1983-11-30
ES506814A0 (es) 1983-02-01
FR2493316A1 (fr) 1982-05-07
FR2493316B1 (es) 1983-04-15
AU546225B2 (en) 1985-08-22
PT73935A (fr) 1981-12-01
MX6973E (es) 1987-01-13
MA19322A1 (fr) 1982-07-01
JPS57108086A (en) 1982-07-05
BE891012A (fr) 1982-05-05
CH651031A5 (fr) 1985-08-30
EG15454A (en) 1985-12-31
LU83738A1 (fr) 1982-06-30
GR75036B (es) 1984-07-12
IT1142928B (it) 1986-10-15
OA06939A (fr) 1983-07-31
CA1181069A (fr) 1985-01-15
AU7712181A (en) 1982-05-13
IT8149630A0 (it) 1981-11-04

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Legal Events

Date Code Title Description
MM4A Patent lapsed

Effective date: 19960401