ES8407318A1 - Procedimiento de preparacion de derivados de piperacina. - Google Patents

Procedimiento de preparacion de derivados de piperacina.

Info

Publication number
ES8407318A1
ES8407318A1 ES522653A ES522653A ES8407318A1 ES 8407318 A1 ES8407318 A1 ES 8407318A1 ES 522653 A ES522653 A ES 522653A ES 522653 A ES522653 A ES 522653A ES 8407318 A1 ES8407318 A1 ES 8407318A1
Authority
ES
Spain
Prior art keywords
denotes
group
lower alkyl
alkyl group
piperazine derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES522653A
Other languages
English (en)
Other versions
ES522653A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fordonal SA
Original Assignee
Fordonal SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB838304528A external-priority patent/GB8304528D0/en
Application filed by Fordonal SA filed Critical Fordonal SA
Publication of ES522653A0 publication Critical patent/ES522653A0/es
Publication of ES8407318A1 publication Critical patent/ES8407318A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/092—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings with aromatic radicals attached to the chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/104—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/108—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE PIPERACINA, DE FORMULA (I), EN LA QUE R1-R4 PUEDE SER VARIOS TIPOS DE RADICALES.CONSISTE EN LA REACCION DE UNA N-ARILMETILPIPERACINA DE FORMULA (II) CON UN HIDROXI HALURO DE FORMULA (III), EN LAS QUE X ES CLORO O BROMO Y LOS DEMAS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION SE LLEVA A CABO EN UN DISOLVENTE INERTE, EN PRESENCIA DE UN FIJADOR DE ACIDO, A UNA TEMPERATURA ENTRE 80JC Y 140JC.ESTOS COMPUESTOS TIENEN APLIACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE LA ANGINA, INSUFICIENCIA VASCULAR PERIFERICAO CEREBRAL Y VERTIGO Y EN CASOS DE ALERGIA Y RINITIS.
ES522653A 1982-05-25 1983-05-24 Procedimiento de preparacion de derivados de piperacina. Expired ES8407318A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8215219 1982-05-25
GB838304528A GB8304528D0 (en) 1983-02-18 1983-02-18 Piperazine derivatives

Publications (2)

Publication Number Publication Date
ES522653A0 ES522653A0 (es) 1984-09-16
ES8407318A1 true ES8407318A1 (es) 1984-09-16

Family

ID=26282941

Family Applications (6)

Application Number Title Priority Date Filing Date
ES522650A Granted ES522650A0 (es) 1982-05-25 1983-05-24 Procedimiento de preparacion de derivados de piperacina
ES522652A Expired ES8502981A1 (es) 1982-05-25 1983-05-24 Procedimiento de preparacion de derivados de piperacina.
ES522653A Expired ES8407318A1 (es) 1982-05-25 1983-05-24 Procedimiento de preparacion de derivados de piperacina.
ES522651A Expired ES8406457A1 (es) 1982-05-25 1983-05-24 Procedimiento de preparacion de derivados de piperacina
ES535909A Expired ES8600636A1 (es) 1982-05-25 1984-09-14 Procedimiento de preparacion de derivados de piperacina
ES535910A Granted ES535910A0 (es) 1982-05-25 1984-09-14 Procedimiento de preparacion de derivados de piperacina

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES522650A Granted ES522650A0 (es) 1982-05-25 1983-05-24 Procedimiento de preparacion de derivados de piperacina
ES522652A Expired ES8502981A1 (es) 1982-05-25 1983-05-24 Procedimiento de preparacion de derivados de piperacina.

Family Applications After (3)

Application Number Title Priority Date Filing Date
ES522651A Expired ES8406457A1 (es) 1982-05-25 1983-05-24 Procedimiento de preparacion de derivados de piperacina
ES535909A Expired ES8600636A1 (es) 1982-05-25 1984-09-14 Procedimiento de preparacion de derivados de piperacina
ES535910A Granted ES535910A0 (es) 1982-05-25 1984-09-14 Procedimiento de preparacion de derivados de piperacina

Country Status (4)

Country Link
DE (1) DE3318577A1 (es)
ES (6) ES522650A0 (es)
FR (1) FR2527605A1 (es)
IT (1) IT1169416B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES8506679A2 (es) * 1984-01-17 1985-08-01 Ferrer Int Mejoras en el objeto de la patente de invencion n 514.340 que se refiere a: procedimiento de obtencion de nuevos derivados de piperazina
ITMI20021327A1 (it) * 2002-06-14 2003-12-15 Recordati Chem Pharm Nuove ossialchilpiperazine
US7071197B2 (en) 2002-06-14 2006-07-04 Recordati S.A. N,N-disubstituted diazocycloalkanes
CN1326845C (zh) * 2003-11-05 2007-07-18 河北医科大学 双苯氟嗪的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2997474A (en) * 1959-10-12 1961-08-22 Paul A J Janssen 1-aryl-omega-(4-arylpiperazine) alkanols
FR1485246A (fr) * 1966-06-30 1967-06-16 Science Union & Cie Nouveaux dérivés de la piperonyl-piperazine et leur procédé de préparation
BE758380A (fr) * 1969-11-04 1971-04-16 Sumitomo Chemical Co Procede de preparation de derives d'aryl-cetones
FR2081579B1 (es) * 1970-03-18 1973-04-06 Delalande Sa

Also Published As

Publication number Publication date
ES522651A0 (es) 1984-08-01
ES8406456A1 (es) 1984-08-01
ES522653A0 (es) 1984-09-16
ES522652A0 (es) 1985-02-01
ES8502981A1 (es) 1985-02-01
DE3318577A1 (de) 1983-12-01
ES535909A0 (es) 1985-10-16
FR2527605A1 (fr) 1983-12-02
ES8600636A1 (es) 1985-10-16
IT8321230A0 (it) 1983-05-23
ES8406457A1 (es) 1984-08-01
IT1169416B (it) 1987-05-27
ES8600637A1 (es) 1985-10-16
ES535910A0 (es) 1985-10-16
ES522650A0 (es) 1984-08-01

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