JPS5661373A - Piperazine derivative - Google Patents

Piperazine derivative

Info

Publication number
JPS5661373A
JPS5661373A JP13596979A JP13596979A JPS5661373A JP S5661373 A JPS5661373 A JP S5661373A JP 13596979 A JP13596979 A JP 13596979A JP 13596979 A JP13596979 A JP 13596979A JP S5661373 A JPS5661373 A JP S5661373A
Authority
JP
Japan
Prior art keywords
formula
compound
acid
addition salt
piperazine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP13596979A
Other languages
Japanese (ja)
Other versions
JPS6040433B2 (en
Inventor
Eiichi Etsuchu
Nobuo Ogawa
Sakae Kurata
Terusato Yamagishi
Hideo Kato
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Japan Co Ltd
Original Assignee
Hokuriku Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hokuriku Pharmaceutical Co Ltd filed Critical Hokuriku Pharmaceutical Co Ltd
Priority to JP13596979A priority Critical patent/JPS6040433B2/en
Publication of JPS5661373A publication Critical patent/JPS5661373A/en
Publication of JPS6040433B2 publication Critical patent/JPS6040433B2/en
Expired legal-status Critical Current

Links

Landscapes

  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A piperazine derivative expressed by formula I (Y is CH2 or CO; m is 0 or 1; n is 0 or 3) and an acid addition salt thereof.
EXAMPLE: 1-[ 2-[3,3-(Dithien-2-yl)]propenyl ]-4-( 3,4,5-trimethoxybenzoyl )piperazine.
USE: A vasodilator.
PROCESS: The compound of formula I is obtained by any one of the following methods (a)W(c): (a) A compound of formula II is condensed with a compound of formula III, and the reaction product is reduced with sodium boron hydride. (b) A novel compound of formula VI is dehydrated. (c) A novel compound of formula V is reacted with a compound of formula VI (X is halogen). The compound of formula I can be further converted into the corresponding acid addition salt with an inorganic acid, e.g. hydrochloric, hydrobromic, phosphoric or sulfuric acid, or an organic acid, e.g. acetic, citric, oxalic or fumaric acid.
COPYRIGHT: (C)1981,JPO&Japio
JP13596979A 1979-10-23 1979-10-23 piperazine derivatives Expired JPS6040433B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP13596979A JPS6040433B2 (en) 1979-10-23 1979-10-23 piperazine derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP13596979A JPS6040433B2 (en) 1979-10-23 1979-10-23 piperazine derivatives

Publications (2)

Publication Number Publication Date
JPS5661373A true JPS5661373A (en) 1981-05-26
JPS6040433B2 JPS6040433B2 (en) 1985-09-11

Family

ID=15164085

Family Applications (1)

Application Number Title Priority Date Filing Date
JP13596979A Expired JPS6040433B2 (en) 1979-10-23 1979-10-23 piperazine derivatives

Country Status (1)

Country Link
JP (1) JPS6040433B2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000014086A1 (en) * 1998-09-04 2000-03-16 Millenium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
WO2001009119A3 (en) * 1999-07-28 2001-08-16 Millennium Pharm Inc Chemokine receptor antagonists

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000014086A1 (en) * 1998-09-04 2000-03-16 Millenium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
US6503926B2 (en) 1998-09-04 2003-01-07 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
WO2001009119A3 (en) * 1999-07-28 2001-08-16 Millennium Pharm Inc Chemokine receptor antagonists

Also Published As

Publication number Publication date
JPS6040433B2 (en) 1985-09-11

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