JPS5661373A - Piperazine derivative - Google Patents
Piperazine derivativeInfo
- Publication number
- JPS5661373A JPS5661373A JP13596979A JP13596979A JPS5661373A JP S5661373 A JPS5661373 A JP S5661373A JP 13596979 A JP13596979 A JP 13596979A JP 13596979 A JP13596979 A JP 13596979A JP S5661373 A JPS5661373 A JP S5661373A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- acid
- addition salt
- piperazine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A piperazine derivative expressed by formula I (Y is CH2 or CO; m is 0 or 1; n is 0 or 3) and an acid addition salt thereof.
EXAMPLE: 1-[ 2-[3,3-(Dithien-2-yl)]propenyl ]-4-( 3,4,5-trimethoxybenzoyl )piperazine.
USE: A vasodilator.
PROCESS: The compound of formula I is obtained by any one of the following methods (a)W(c): (a) A compound of formula II is condensed with a compound of formula III, and the reaction product is reduced with sodium boron hydride. (b) A novel compound of formula VI is dehydrated. (c) A novel compound of formula V is reacted with a compound of formula VI (X is halogen). The compound of formula I can be further converted into the corresponding acid addition salt with an inorganic acid, e.g. hydrochloric, hydrobromic, phosphoric or sulfuric acid, or an organic acid, e.g. acetic, citric, oxalic or fumaric acid.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP13596979A JPS6040433B2 (en) | 1979-10-23 | 1979-10-23 | piperazine derivatives |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP13596979A JPS6040433B2 (en) | 1979-10-23 | 1979-10-23 | piperazine derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5661373A true JPS5661373A (en) | 1981-05-26 |
JPS6040433B2 JPS6040433B2 (en) | 1985-09-11 |
Family
ID=15164085
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP13596979A Expired JPS6040433B2 (en) | 1979-10-23 | 1979-10-23 | piperazine derivatives |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS6040433B2 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000014086A1 (en) * | 1998-09-04 | 2000-03-16 | Millenium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
WO2001009119A3 (en) * | 1999-07-28 | 2001-08-16 | Millennium Pharm Inc | Chemokine receptor antagonists |
-
1979
- 1979-10-23 JP JP13596979A patent/JPS6040433B2/en not_active Expired
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000014086A1 (en) * | 1998-09-04 | 2000-03-16 | Millenium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
US6503926B2 (en) | 1998-09-04 | 2003-01-07 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
WO2001009119A3 (en) * | 1999-07-28 | 2001-08-16 | Millennium Pharm Inc | Chemokine receptor antagonists |
Also Published As
Publication number | Publication date |
---|---|
JPS6040433B2 (en) | 1985-09-11 |
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