JPS57159489A - Developement of polypeptide in yeast - Google Patents
Developement of polypeptide in yeastInfo
- Publication number
- JPS57159489A JPS57159489A JP57028252A JP2825282A JPS57159489A JP S57159489 A JPS57159489 A JP S57159489A JP 57028252 A JP57028252 A JP 57028252A JP 2825282 A JP2825282 A JP 2825282A JP S57159489 A JPS57159489 A JP S57159489A
- Authority
- JP
- Japan
- Prior art keywords
- yeast
- bacteria
- polypeptide
- derived
- phenotypic selection
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/56—IFN-alpha
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/57581—Thymosin; Related peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormones [GH] (Somatotropin)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/911—Microorganisms using fungi
- Y10S435/94—Saccharomyces
- Y10S435/942—Saccharomyces cerevisiae
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plant Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US23791381A | 1981-02-25 | 1981-02-25 | |
US237913 | 1981-02-25 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP8311020A Division JPH09182585A (ja) | 1981-02-25 | 1996-11-21 | 酵母中でのポリペプチドの発現 |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS57159489A true JPS57159489A (en) | 1982-10-01 |
JPH0757190B2 JPH0757190B2 (ja) | 1995-06-21 |
Family
ID=22895764
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP57028252A Expired - Lifetime JPH0757190B2 (ja) | 1981-02-25 | 1982-02-25 | 酵母中でのポリペプチドの発現 |
JP8311020A Pending JPH09182585A (ja) | 1981-02-25 | 1996-11-21 | 酵母中でのポリペプチドの発現 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP8311020A Pending JPH09182585A (ja) | 1981-02-25 | 1996-11-21 | 酵母中でのポリペプチドの発現 |
Country Status (10)
Country | Link |
---|---|
US (4) | US5919651A (ja) |
EP (1) | EP0060057B1 (ja) |
JP (2) | JPH0757190B2 (ja) |
AT (1) | ATE27000T1 (ja) |
AU (1) | AU553885B2 (ja) |
CA (1) | CA1205026A (ja) |
DE (1) | DE3276241D1 (ja) |
MY (1) | MY101599A (ja) |
NZ (1) | NZ199722A (ja) |
ZA (1) | ZA821079B (ja) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5974986A (ja) * | 1982-10-20 | 1984-04-27 | Suntory Ltd | 酵母の高発現ベクタープラスミドを用いたペプチドの生産方法 |
JPS60501290A (ja) * | 1983-05-19 | 1985-08-15 | ユニリ−バ− ナ−ムロ−ゼ ベンノ−トシヤ−プ | 酵母細胞に新しく導入した遺伝子の発現改良 |
JPS611389A (ja) * | 1984-05-30 | 1986-01-07 | ノボ ノルディスク アクティーゼルスカブ | インシュリンの製造方法 |
US5804410A (en) * | 1994-07-29 | 1998-09-08 | Teijin Limited | Nucleic acid sequence encoding trypsin-like enzyme and process for producing the enzyme |
WO2006137597A1 (ja) | 2005-06-24 | 2006-12-28 | Teijin Pharma Limited | 新規生理物質nesfatinとその関連物質、およびそれらの用途 |
Families Citing this family (140)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FI77877C (fi) * | 1979-04-20 | 1989-05-10 | Technobiotic Ltd | Foerfarande foer framstaellning och rening av human le-formig interferonprotein. |
US4460685A (en) * | 1980-05-29 | 1984-07-17 | New York University | Method of enhancing the production of human γ Interferon |
DE3280127D1 (de) * | 1981-03-27 | 1990-04-12 | Ici Plc | Genetisch modifizierte mikroorganismen. |
JPS58146281A (ja) * | 1981-10-19 | 1983-08-31 | Suntory Ltd | 酵母細胞の形質転換法 |
US4775622A (en) * | 1982-03-08 | 1988-10-04 | Genentech, Inc. | Expression, processing and secretion of heterologous protein by yeast |
HU204097B (en) * | 1982-05-19 | 1991-11-28 | Gist Brocades Nv | Process for producing cloning system relating to kluyveromyces species |
GB2125047B (en) * | 1982-08-09 | 1986-02-19 | Ciba Geigy Ag | Yeast hybrid vectors and their use for the production of polypeptides |
AU584580B2 (en) * | 1982-09-08 | 1989-06-01 | Smith Kline - Rit | Hepatitis B virus vaccine |
DE3382547D1 (de) * | 1983-01-12 | 1992-05-27 | Chiron Corp | Sekretorische expression in eukaryoten. |
NO172595C (no) * | 1983-02-07 | 1993-08-11 | Battelle Memorial Institute | Fremgangsmaate og ekspresjonsplasmid for fremstilling av hemagglutinin under kontroll av drosophila hsp-promoter |
CA1341302C (en) * | 1983-02-22 | 2001-10-09 | Rae Lyn Burke | Yeast expression systems with vectors having gapdh or pyk promoters and synthesis of foreign protein |
US4876197A (en) * | 1983-02-22 | 1989-10-24 | Chiron Corporation | Eukaryotic regulatable transcription |
US4661454A (en) * | 1983-02-28 | 1987-04-28 | Collaborative Research, Inc. | GAL1 yeast promoter linked to non galactokinase gene |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
WO1984004330A1 (en) * | 1983-04-22 | 1984-11-08 | Amgen | Secretion of exogenous polypeptides from yeast |
US7198919B1 (en) | 1983-04-25 | 2007-04-03 | Genentech, Inc. | Use of alpha factor sequences in yeast expression systems |
ZA843275B (en) * | 1983-05-05 | 1984-12-24 | Hoffmann La Roche | Novel vectors for interferon expression |
WO1984004539A1 (fr) * | 1983-05-19 | 1984-11-22 | Transgene Sa | Production de la catechol 2,3-oxygenase par des levures, plasmide pour sa mise en oeuvre et application |
US4870008A (en) * | 1983-08-12 | 1989-09-26 | Chiron Corporation | Secretory expression in eukaryotes |
FR2562090B2 (fr) * | 1984-03-27 | 1988-04-08 | Transgene Sa | Proteine antigenique de la rage glycosylee |
FR2552776B1 (fr) * | 1983-10-03 | 1986-05-09 | Transgene Sa | Vecteurs d'expression d'une proteine antigenique de la rage dans les cellules eucaryotes et leur application a la preparation d'un vaccin |
WO1985001516A1 (fr) * | 1983-10-03 | 1985-04-11 | Transgene S.A. | Vecteurs d'expression d'une proteine antigenique de la rage dans les cellules eucaryotes et leur application a la preparation d'un vaccin |
US5639639A (en) * | 1983-11-02 | 1997-06-17 | Genzyme Corporation | Recombinant heterodimeric human fertility hormones, and methods, cells, vectors and DNA for the production thereof |
PH23920A (en) * | 1983-12-20 | 1990-01-23 | Cetus Corp | Glucoamylase cdna |
GB8334261D0 (en) * | 1983-12-22 | 1984-02-01 | Bass Plc | Fermentation processes |
EP0154576A1 (en) * | 1984-02-06 | 1985-09-11 | INTERFERON SCIENCES, INC a Delaware Corporation | Hybrid nucleic acid sequences having tandemly arranged genes |
US4626505A (en) * | 1984-02-24 | 1986-12-02 | E. I. Du Pont De Nemours And Company | Selectable markers for yeast transformation |
US4745057A (en) * | 1984-05-18 | 1988-05-17 | Eli Lilly And Company | Method, vectors and transformants for high expression of heterologous polypeptides in yeast |
US5683688A (en) * | 1984-05-31 | 1997-11-04 | Genentech, Inc. | Unglycosylated recombinant human lymphotoxin polypeptides and compositions |
SE8403929L (sv) * | 1984-07-31 | 1986-02-21 | Sten Gatenbeck | Rekombinant-dna-molekyl, transformerade mikroorganismer och forfarande for framstellning av penicillin v-amidas |
US4752473A (en) * | 1984-10-12 | 1988-06-21 | The Regents Of The University Of California | Expression of glycosylated human influenza hemagglutinin proteins |
US7285271B1 (en) | 1984-10-31 | 2007-10-23 | Novartis Vaccines And Diagnostics, Inc. | Antigenic composition comprising an HIV gag or env polypeptide |
US7273695B1 (en) | 1984-10-31 | 2007-09-25 | Novartis Vaccines And Diagnostics, Inc. | HIV immunoassays using synthetic envelope polypeptides |
CA1341423C (en) | 1984-10-31 | 2003-03-04 | Paul A. Luciw | Recombinant proteins of viruses associated with lymphadenopathy syndrome and/or acquired immune deficiency syndrome |
US4812405A (en) * | 1986-02-18 | 1989-03-14 | Phillips Petroleum Company | Double auxotrophic mutants of Pichia pastoris and methods for preparation |
JPS6447380A (en) * | 1987-08-19 | 1989-02-21 | Agency Ind Science Techn | Steroid-oxidizing yeast strain |
US7442525B1 (en) * | 1987-12-24 | 2008-10-28 | Novartis Vaccines And Diagnostics, Inc. | Method for expressing HIV polypeptides |
US5580734A (en) * | 1990-07-13 | 1996-12-03 | Transkaryotic Therapies, Inc. | Method of producing a physical map contigous DNA sequences |
IE914102A1 (en) | 1990-11-26 | 1992-06-03 | Genetics Inst | Expression of pace in host cells and methods of use thereof |
FR2686899B1 (fr) * | 1992-01-31 | 1995-09-01 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant. |
US5629167A (en) | 1994-04-19 | 1997-05-13 | Biocine S.P.A. | Detection of antibodies against Chlamydia trachomatis pgp3 antigen in patient sera by enzyme-linked immunosorbent assay |
GB9526733D0 (en) | 1995-12-30 | 1996-02-28 | Delta Biotechnology Ltd | Fusion proteins |
AU4977697A (en) | 1996-09-25 | 1998-04-17 | Vanderbilt University | Genetically engineered yeast with modified signal peptidase complex |
MX9605082A (es) | 1996-10-24 | 1998-04-30 | Univ Autonoma De Nuevo Leon | Levaduras metilotroficas modificadas geneticamente para la produccion y secrecion de hormona de crecimiento humano. |
ATE476508T1 (de) | 1997-11-06 | 2010-08-15 | Novartis Vaccines & Diagnostic | Neisseriale antigene |
EP2210945B1 (en) | 1998-01-14 | 2013-06-26 | Novartis Vaccines and Diagnostics S.r.l. | Neisseria meningitidis antigens |
JP2002502977A (ja) | 1998-02-04 | 2002-01-29 | インビトロジェン コーポレイション | マイクロアレイとその使用 |
GB9808932D0 (en) | 1998-04-27 | 1998-06-24 | Chiron Spa | Polyepitope carrier protein |
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US7368261B1 (en) | 1999-04-30 | 2008-05-06 | Novartis Vaccines And Diagnostics Srl | Conserved Neisserial antigens |
GB9911683D0 (en) | 1999-05-19 | 1999-07-21 | Chiron Spa | Antigenic peptides |
GB9916529D0 (en) | 1999-07-14 | 1999-09-15 | Chiron Spa | Antigenic peptides |
MXPA02004283A (es) | 1999-10-29 | 2002-10-17 | Chiron Spa | Peptidos antigenicos neisseriales. |
US6232074B1 (en) * | 1999-12-10 | 2001-05-15 | Complegen, Inc. | Functional gene array in yeast |
DK1248647T3 (da) | 2000-01-17 | 2010-09-27 | Novartis Vaccines & Diagnostic | Ydre membranvesikel (OMV) vaccine omfattende N. meningitidis serogruppe B ydre membranproteiner |
US20060269575A1 (en) * | 2000-02-08 | 2006-11-30 | Allergan, Inc. | Botulinum toxin pharmaceutical compositions formulated with recombinant albumin |
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Also Published As
Publication number | Publication date |
---|---|
US5854018A (en) | 1998-12-29 |
JPH0757190B2 (ja) | 1995-06-21 |
ZA821079B (en) | 1983-04-27 |
US5919651A (en) | 1999-07-06 |
CA1205026A (en) | 1986-05-27 |
MY101599A (en) | 1991-12-17 |
ATE27000T1 (de) | 1987-05-15 |
AU8065782A (en) | 1982-09-02 |
EP0060057A1 (en) | 1982-09-15 |
NZ199722A (en) | 1985-12-13 |
EP0060057B1 (en) | 1987-05-06 |
JPH09182585A (ja) | 1997-07-15 |
US5618676A (en) | 1997-04-08 |
DE3276241D1 (en) | 1987-06-11 |
US5856123A (en) | 1999-01-05 |
AU553885B2 (en) | 1986-07-31 |
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