JPS57130950A - 3,5-di-tert-butyl-4-hydroxystyrene derivative and anti- inflammatory, analgesic, antipyretic agent and inhibitor for blood platelet aggregation - Google Patents
3,5-di-tert-butyl-4-hydroxystyrene derivative and anti- inflammatory, analgesic, antipyretic agent and inhibitor for blood platelet aggregationInfo
- Publication number
- JPS57130950A JPS57130950A JP1660281A JP1660281A JPS57130950A JP S57130950 A JPS57130950 A JP S57130950A JP 1660281 A JP1660281 A JP 1660281A JP 1660281 A JP1660281 A JP 1660281A JP S57130950 A JPS57130950 A JP S57130950A
- Authority
- JP
- Japan
- Prior art keywords
- tert
- butyl
- analgesic
- inflammatory
- inhibitor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
NEW MATERIAL:A compound of formulaI[R1 is carboxyl or ester of -COOR3 (R3 is lower alkyl); R2 is lower alkyl, lower hydroxyalkyl or together with R1 may form a ring of formula II or III (R4 is H or lower alkyl; X is O or CH2)] and a salt thereof.
EXAMPLE: α-(3,5-Di-tert-butyl-4-hydroxybenzylidene)-γ-butyrolactone.
USE: An anti-inflammatory, analgesic, antipyretic agent and inhibitor for blood platelet aggregation.
PROCESS: 3,5-Di-tert-butyl-4-hydroxybenzaldehyde is reacted with a compound of formula IV (Ar is aryl) or a compound of formula V according to the method of G.A. Howie et al. to give the compound of formulaIin which R1 and R2 are linked to the carbon atom at the β-position in styrene to form a ring.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1660281A JPS57130950A (en) | 1981-02-05 | 1981-02-05 | 3,5-di-tert-butyl-4-hydroxystyrene derivative and anti- inflammatory, analgesic, antipyretic agent and inhibitor for blood platelet aggregation |
US06/337,168 US4431656A (en) | 1981-02-05 | 1982-01-05 | 3,5-di-Tert-butylstyrene derivatives, salts thereof, and pharmaceutical compositions containing the same as an active ingredient |
US06/337,130 US4440784A (en) | 1981-02-05 | 1982-01-05 | Anti-inflammatory, analgesic, and antipyretic pharmaceutical composition |
CA000395217A CA1187505A (en) | 1981-02-05 | 1982-01-29 | 3,5-di-tert-butylstyrene derivatives, salts thereof, and pharmaceutical compositions containing the same as an active ingredient |
CA000395171A CA1167767A (en) | 1981-02-05 | 1982-01-29 | Anti-inflammatory, analgesic, and antipyretic pharmaceutical composition |
AT82100661T ATE18907T1 (en) | 1981-02-05 | 1982-01-30 | 3,5-DI-TERT-BUTYLSTYRENE DERIVATIVES, PROCESSES FOR THEIR MANUFACTURE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. |
EP82100660A EP0057881B1 (en) | 1981-02-05 | 1982-01-30 | An anti-inflammatory, analgesic, and antipyretic pharmaceutical composition, and method for producing it |
EP82100661A EP0057882B1 (en) | 1981-02-05 | 1982-01-30 | 3,5-di-tert-butylstyrene derivatives, processes for their preparations, and pharmaceutical compositions containing them |
AT82100660T ATE16765T1 (en) | 1981-02-05 | 1982-01-30 | PHARMACEUTICAL COMPOSITION WITH ANTI-INFLAMMATORY, ANCITAL AND ANTIPYRETIC PROPERTIES AND THE METHOD FOR THEIR PRODUCTION. |
DE8282100661T DE3270202D1 (en) | 1981-02-05 | 1982-01-30 | 3,5-di-tert-butylstyrene derivatives, processes for their preparations, and pharmaceutical compositions containing them |
DE8282100660T DE3267728D1 (en) | 1981-02-05 | 1982-01-30 | An anti-inflammatory, analgesic, and antipyretic pharmaceutical composition, and method for producing it |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1660281A JPS57130950A (en) | 1981-02-05 | 1981-02-05 | 3,5-di-tert-butyl-4-hydroxystyrene derivative and anti- inflammatory, analgesic, antipyretic agent and inhibitor for blood platelet aggregation |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS57130950A true JPS57130950A (en) | 1982-08-13 |
JPS6360015B2 JPS6360015B2 (en) | 1988-11-22 |
Family
ID=11920839
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP1660281A Granted JPS57130950A (en) | 1981-02-05 | 1981-02-05 | 3,5-di-tert-butyl-4-hydroxystyrene derivative and anti- inflammatory, analgesic, antipyretic agent and inhibitor for blood platelet aggregation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57130950A (en) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6157553A (en) * | 1984-08-28 | 1986-03-24 | Kanegafuchi Chem Ind Co Ltd | Novel 3,5-ditertiary butylphenyl derivative |
JPS61218571A (en) * | 1985-03-23 | 1986-09-29 | Kanegafuchi Chem Ind Co Ltd | Novel lactam derivative, novel thiolactam derivative and anti-inflammatory agent |
JPS61257967A (en) * | 1985-05-09 | 1986-11-15 | Eisai Co Ltd | 2-pyrrolidone derivative |
JPS6229570A (en) * | 1985-07-29 | 1987-02-07 | Kanegafuchi Chem Ind Co Ltd | 3,5-diisopropylbenzylidene heterocyclic compound |
JPS6242977A (en) * | 1985-08-09 | 1987-02-24 | イ−ライ・リリ−・アンド・カンパニ− | Di-t-butylphenol compound |
JP2007503453A (en) * | 2003-05-14 | 2007-02-22 | ノボ ノルディスク アクティーゼルスカブ | Novel compounds for treating obesity |
-
1981
- 1981-02-05 JP JP1660281A patent/JPS57130950A/en active Granted
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6157553A (en) * | 1984-08-28 | 1986-03-24 | Kanegafuchi Chem Ind Co Ltd | Novel 3,5-ditertiary butylphenyl derivative |
JPS61218571A (en) * | 1985-03-23 | 1986-09-29 | Kanegafuchi Chem Ind Co Ltd | Novel lactam derivative, novel thiolactam derivative and anti-inflammatory agent |
JPS61257967A (en) * | 1985-05-09 | 1986-11-15 | Eisai Co Ltd | 2-pyrrolidone derivative |
JPS6229570A (en) * | 1985-07-29 | 1987-02-07 | Kanegafuchi Chem Ind Co Ltd | 3,5-diisopropylbenzylidene heterocyclic compound |
JPH0574587B2 (en) * | 1985-07-29 | 1993-10-18 | Kanegafuchi Chemical Ind | |
JPS6242977A (en) * | 1985-08-09 | 1987-02-24 | イ−ライ・リリ−・アンド・カンパニ− | Di-t-butylphenol compound |
JP2007503453A (en) * | 2003-05-14 | 2007-02-22 | ノボ ノルディスク アクティーゼルスカブ | Novel compounds for treating obesity |
Also Published As
Publication number | Publication date |
---|---|
JPS6360015B2 (en) | 1988-11-22 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JPS57130950A (en) | 3,5-di-tert-butyl-4-hydroxystyrene derivative and anti- inflammatory, analgesic, antipyretic agent and inhibitor for blood platelet aggregation | |
JPS5795984A (en) | Pyridinecarboxamide derivative and its preparation | |
JPS559060A (en) | Thia(oxa)zolidinecarboxylic acid derivative and its prepatation | |
JPS52111528A (en) | Phenoxyphenoxyalkane carboxylic acid derivatives and herbicidal compos ition containing the same | |
JPS55143973A (en) | Phenylacetic acid derivative | |
JPS5732260A (en) | Mercaptofatty acid derivative and its preparation | |
JPS5589245A (en) | 9,10-dihydroanthracene-2-alkanoic acid derivative | |
JPS5764639A (en) | Novel stilbene derivative, its preparation, and medical composition containing the same as active ingredent | |
JPS5448770A (en) | 5-alkoxypicolinic acid ester, its preparation and hypotensive agent containing the same | |
JPS55153782A (en) | Dibenzo (b,f) thiepin derivative | |
JPS5592363A (en) | New 2-azetidinone derivative | |
JPS5524141A (en) | 1-alkyl-5-(p-toluoyl)-pyrrolyl-2thioacetamide derivative | |
ES8104179A1 (en) | Esters of 2-(6-methoxy-2- naphthyl)-1-propanol, method of preparation and pharmaceutical compositions thereof | |
GB1502662A (en) | Pharmaceutically useful indanylpropionic acid derivatives | |
JPS57212137A (en) | Preparation of phenyl aliphtic acid derivative | |
JPS53108923A (en) | Epoxysuccinylamino acid derivative | |
JPS55377A (en) | Preparation of dibenzoxepin derivative | |
JPS52118445A (en) | 2-cyano-3-methyl-3-(4-isobutylphenyl)acrylic acid derivatives and met hod of preparing the same | |
JPS5441849A (en) | Novel cyclopentane derivative | |
JPS51141863A (en) | Process for preparing organo-phosphoric acid esters | |
JPS56125340A (en) | Cyclohexenone derivative | |
JPS52116490A (en) | Novel 7alpha-methoxycephalosporanic acid derivatives and method of preparing the same | |
JPS54157582A (en) | Dibenzoxepin derivative and its preparation | |
JPS5527163A (en) | Tetrahydroxanthene-2-carboxylic derivative | |
JPS5285140A (en) | Novel 2-(substituted phenyl)alkanoic acids or non-toxic salts thereof, or anti-inflammatory, analgesic, or antirheumatic drugs containing sa me |