JPS5524141A - 1-alkyl-5-(p-toluoyl)-pyrrolyl-2thioacetamide derivative - Google Patents
1-alkyl-5-(p-toluoyl)-pyrrolyl-2thioacetamide derivativeInfo
- Publication number
- JPS5524141A JPS5524141A JP9739278A JP9739278A JPS5524141A JP S5524141 A JPS5524141 A JP S5524141A JP 9739278 A JP9739278 A JP 9739278A JP 9739278 A JP9739278 A JP 9739278A JP S5524141 A JPS5524141 A JP S5524141A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- reacting
- toluoyl
- alkyl
- pyrrolyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pyrrole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A compound I (R is lower alkyl, R1, R2 and H, alkyl; R1 and R2 may together with an N atom form a ring).
EXAMPLE: N,N-Dimethyl[1-methyl-5-(p-toluoyl)pyrrolyl-2]thioacetamide.
USE: Intermediate for the safe and easy synthesis of antiphlogistic and analgesic agent.
PROCESS: The compound I is prepared by (1) reacting a compound II with a compound of CH3SCOCH3 in the presence of a strong base such as butyl lithium to obtain a compound III, (2) reacting the compound III with an acid anhydride in the presence of a base, (3) reacting the resulting compound IV (R is methyl, etc.) with an amine compound V, and finally (4) reacting the resulting compound VI with toluoyl chloride in the presence of a metal halide such as AlCl3, etc.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP9739278A JPS5524141A (en) | 1978-08-11 | 1978-08-11 | 1-alkyl-5-(p-toluoyl)-pyrrolyl-2thioacetamide derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP9739278A JPS5524141A (en) | 1978-08-11 | 1978-08-11 | 1-alkyl-5-(p-toluoyl)-pyrrolyl-2thioacetamide derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5524141A true JPS5524141A (en) | 1980-02-21 |
JPS5744668B2 JPS5744668B2 (en) | 1982-09-22 |
Family
ID=14191236
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP9739278A Granted JPS5524141A (en) | 1978-08-11 | 1978-08-11 | 1-alkyl-5-(p-toluoyl)-pyrrolyl-2thioacetamide derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5524141A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS58159458A (en) * | 1982-02-26 | 1983-09-21 | シグマ−タウ・インズストリエ・フアルマチエウチケ・リウニテ・エツセ・ピ・ア | Pyrrole acetic acid amide, manufacture and medicine |
US4568690A (en) * | 1983-07-29 | 1986-02-04 | Medosan Industrie Biochimide Riunite S.P.A. | 1-Methyl-5-p-methylbenzoylpyrrole-2-acetamidoacetanilides with antiinflammatory, analgesic, antipyretic and anti-platelet aggregant activity |
-
1978
- 1978-08-11 JP JP9739278A patent/JPS5524141A/en active Granted
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS58159458A (en) * | 1982-02-26 | 1983-09-21 | シグマ−タウ・インズストリエ・フアルマチエウチケ・リウニテ・エツセ・ピ・ア | Pyrrole acetic acid amide, manufacture and medicine |
US4578481A (en) * | 1982-02-26 | 1986-03-25 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Pyrrolacetic amides having antiinflammatory activity |
JPH0350728B2 (en) * | 1982-02-26 | 1991-08-02 | Sigma Tau Ind Farmaceuti | |
US4568690A (en) * | 1983-07-29 | 1986-02-04 | Medosan Industrie Biochimide Riunite S.P.A. | 1-Methyl-5-p-methylbenzoylpyrrole-2-acetamidoacetanilides with antiinflammatory, analgesic, antipyretic and anti-platelet aggregant activity |
Also Published As
Publication number | Publication date |
---|---|
JPS5744668B2 (en) | 1982-09-22 |
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