JPS5524141A - 1-alkyl-5-(p-toluoyl)-pyrrolyl-2thioacetamide derivative - Google Patents

1-alkyl-5-(p-toluoyl)-pyrrolyl-2thioacetamide derivative

Info

Publication number
JPS5524141A
JPS5524141A JP9739278A JP9739278A JPS5524141A JP S5524141 A JPS5524141 A JP S5524141A JP 9739278 A JP9739278 A JP 9739278A JP 9739278 A JP9739278 A JP 9739278A JP S5524141 A JPS5524141 A JP S5524141A
Authority
JP
Japan
Prior art keywords
compound
reacting
toluoyl
alkyl
pyrrolyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP9739278A
Other languages
Japanese (ja)
Other versions
JPS5744668B2 (en
Inventor
Katsuyuki Ogura
Genichi Dobashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sagami Chemical Research Institute
Original Assignee
Sagami Chemical Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sagami Chemical Research Institute filed Critical Sagami Chemical Research Institute
Priority to JP9739278A priority Critical patent/JPS5524141A/en
Publication of JPS5524141A publication Critical patent/JPS5524141A/en
Publication of JPS5744668B2 publication Critical patent/JPS5744668B2/ja
Granted legal-status Critical Current

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  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A compound I (R is lower alkyl, R1, R2 and H, alkyl; R1 and R2 may together with an N atom form a ring).
EXAMPLE: N,N-Dimethyl[1-methyl-5-(p-toluoyl)pyrrolyl-2]thioacetamide.
USE: Intermediate for the safe and easy synthesis of antiphlogistic and analgesic agent.
PROCESS: The compound I is prepared by (1) reacting a compound II with a compound of CH3SCOCH3 in the presence of a strong base such as butyl lithium to obtain a compound III, (2) reacting the compound III with an acid anhydride in the presence of a base, (3) reacting the resulting compound IV (R is methyl, etc.) with an amine compound V, and finally (4) reacting the resulting compound VI with toluoyl chloride in the presence of a metal halide such as AlCl3, etc.
COPYRIGHT: (C)1980,JPO&Japio
JP9739278A 1978-08-11 1978-08-11 1-alkyl-5-(p-toluoyl)-pyrrolyl-2thioacetamide derivative Granted JPS5524141A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP9739278A JPS5524141A (en) 1978-08-11 1978-08-11 1-alkyl-5-(p-toluoyl)-pyrrolyl-2thioacetamide derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP9739278A JPS5524141A (en) 1978-08-11 1978-08-11 1-alkyl-5-(p-toluoyl)-pyrrolyl-2thioacetamide derivative

Publications (2)

Publication Number Publication Date
JPS5524141A true JPS5524141A (en) 1980-02-21
JPS5744668B2 JPS5744668B2 (en) 1982-09-22

Family

ID=14191236

Family Applications (1)

Application Number Title Priority Date Filing Date
JP9739278A Granted JPS5524141A (en) 1978-08-11 1978-08-11 1-alkyl-5-(p-toluoyl)-pyrrolyl-2thioacetamide derivative

Country Status (1)

Country Link
JP (1) JPS5524141A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58159458A (en) * 1982-02-26 1983-09-21 シグマ−タウ・インズストリエ・フアルマチエウチケ・リウニテ・エツセ・ピ・ア Pyrrole acetic acid amide, manufacture and medicine
US4568690A (en) * 1983-07-29 1986-02-04 Medosan Industrie Biochimide Riunite S.P.A. 1-Methyl-5-p-methylbenzoylpyrrole-2-acetamidoacetanilides with antiinflammatory, analgesic, antipyretic and anti-platelet aggregant activity

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58159458A (en) * 1982-02-26 1983-09-21 シグマ−タウ・インズストリエ・フアルマチエウチケ・リウニテ・エツセ・ピ・ア Pyrrole acetic acid amide, manufacture and medicine
US4578481A (en) * 1982-02-26 1986-03-25 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Pyrrolacetic amides having antiinflammatory activity
JPH0350728B2 (en) * 1982-02-26 1991-08-02 Sigma Tau Ind Farmaceuti
US4568690A (en) * 1983-07-29 1986-02-04 Medosan Industrie Biochimide Riunite S.P.A. 1-Methyl-5-p-methylbenzoylpyrrole-2-acetamidoacetanilides with antiinflammatory, analgesic, antipyretic and anti-platelet aggregant activity

Also Published As

Publication number Publication date
JPS5744668B2 (en) 1982-09-22

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