JPS5681560A - Preparation of 1-(4-hydroxyphenyl)-2-(4-benzylpiperidino)-1- propanol and its addition salt - Google Patents
Preparation of 1-(4-hydroxyphenyl)-2-(4-benzylpiperidino)-1- propanol and its addition saltInfo
- Publication number
- JPS5681560A JPS5681560A JP15811279A JP15811279A JPS5681560A JP S5681560 A JPS5681560 A JP S5681560A JP 15811279 A JP15811279 A JP 15811279A JP 15811279 A JP15811279 A JP 15811279A JP S5681560 A JPS5681560 A JP S5681560A
- Authority
- JP
- Japan
- Prior art keywords
- benzylpiperidino
- hydroxyphenyl
- propanol
- hydroxypropiophenone
- brominating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- UYNVMODNBIQBMV-UHFFFAOYSA-N 4-[1-hydroxy-2-[4-(phenylmethyl)-1-piperidinyl]propyl]phenol Chemical compound C1CC(CC=2C=CC=CC=2)CCN1C(C)C(O)C1=CC=C(O)C=C1 UYNVMODNBIQBMV-UHFFFAOYSA-N 0.000 title abstract 3
- 150000003839 salts Chemical class 0.000 title 1
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 6
- CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 abstract 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- 238000010438 heat treatment Methods 0.000 abstract 2
- 239000011261 inert gas Substances 0.000 abstract 2
- RARSHUDCJQSEFJ-UHFFFAOYSA-N p-Hydroxypropiophenone Chemical compound CCC(=O)C1=CC=C(O)C=C1 RARSHUDCJQSEFJ-UHFFFAOYSA-N 0.000 abstract 2
- 239000011541 reaction mixture Substances 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- DBOLXXRVIFGDTI-UHFFFAOYSA-N 4-benzylpyridine Chemical compound C=1C=NC=CC=1CC1=CC=CC=C1 DBOLXXRVIFGDTI-UHFFFAOYSA-N 0.000 abstract 1
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium on carbon Substances [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 abstract 1
- 238000005574 benzylation reaction Methods 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 238000010531 catalytic reduction reaction Methods 0.000 abstract 1
- 230000002490 cerebral effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000005494 condensation Effects 0.000 abstract 1
- 238000006482 condensation reaction Methods 0.000 abstract 1
- 150000002170 ethers Chemical class 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 229960003998 ifenprodil Drugs 0.000 abstract 1
- 230000003902 lesion Effects 0.000 abstract 1
- 238000006722 reduction reaction Methods 0.000 abstract 1
- 238000010992 reflux Methods 0.000 abstract 1
Landscapes
- Hydrogenated Pyridines (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Priority Applications (14)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15811279A JPS5681560A (en) | 1979-12-07 | 1979-12-07 | Preparation of 1-(4-hydroxyphenyl)-2-(4-benzylpiperidino)-1- propanol and its addition salt |
| GB8038771A GB2067187B (en) | 1979-12-07 | 1980-12-03 | Process for the preparation of 1-(4-hydroxyphenyl)-2-(4-benzylpiperidino)-1-propanol and acid addition salts thereof |
| PH24937A PH16735A (en) | 1979-12-07 | 1980-12-03 | A new process for the preparation of 1-(4-hydroxyphenyl)-2-(4-benzylpiperidino)-1-propanol and acid addition salts thereof |
| US06/213,033 US4377691A (en) | 1979-12-07 | 1980-12-04 | Process for the preparation of 1-(4-hydroxyphenyl)-2-(4-benzylpiperidino)-1-propanol and acid-addition salts thereof |
| CA000366167A CA1141387A (en) | 1979-12-07 | 1980-12-04 | Process for the preparation of 1-(4-hydroxyphenyl)-2- (4-benzylpiperidino)-1-propanol and acid-addition salts thereof |
| ES497527A ES497527A0 (es) | 1979-12-07 | 1980-12-05 | Un procedimiento para la preparacion de 1-(4-hidroxifenil)- 2-(4-bencilpiperidino)-1-propanol |
| IT26487/80A IT1148744B (it) | 1979-12-07 | 1980-12-05 | Processo per la preparazione di 1-(4-idrossifenil)-2-(4-benzilpiperidino)-1-propanolo e relativi sali di addizione con acido |
| FR8025923A FR2471374A1 (fr) | 1979-12-07 | 1980-12-05 | Nouveau procede pour la preparation du 1-(4-hydroxyphenyl)-2-(4-benzylpiperidino)-propanol et de ses sels d'addition d'acides |
| AR283504A AR229157A1 (es) | 1979-12-07 | 1980-12-05 | Procedimiento para la preparacion de 1-(4-hidroxifenil)-2-(4-bencilpiperidino)-1-propanol |
| DE19803045916 DE3045916A1 (de) | 1979-12-07 | 1980-12-05 | Verfahren zur herstellung von 4-benzyl- (alpha) -(p-hydroxyphenyl)- (beta) -methyl-1-piperidinaethanol und seinen salzen mit saeuren |
| BR8008020A BR8008020A (pt) | 1979-12-07 | 1980-12-08 | Processo para a preparacao de 1-(4-hidroxifenil)-2-(4-benzilpiperidino)-1-propanol e seus sais de adicao de acido |
| CH9032/80A CH648550A5 (de) | 1979-12-07 | 1980-12-08 | Verfahren zur herstellung von 4-benzyl-alpha-(p-hydroxyphenyl)-beta-methyl-1-piperidinaethanol und seinen salzen mit saeuren. |
| AT0597580A AT374181B (de) | 1979-12-07 | 1980-12-09 | Verfahren zur herstellung von 4-benzyl-alpha-(p |
| HK71984A HK71984A (en) | 1979-12-07 | 1984-09-20 | Process for the preparation of 1-(4-hydroxyphenyl)-2-(4-benzylpiperidino)-1- propanol and acid-addition salts |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15811279A JPS5681560A (en) | 1979-12-07 | 1979-12-07 | Preparation of 1-(4-hydroxyphenyl)-2-(4-benzylpiperidino)-1- propanol and its addition salt |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5681560A true JPS5681560A (en) | 1981-07-03 |
| JPS6239153B2 JPS6239153B2 (enrdf_load_stackoverflow) | 1987-08-21 |
Family
ID=15664557
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP15811279A Granted JPS5681560A (en) | 1979-12-07 | 1979-12-07 | Preparation of 1-(4-hydroxyphenyl)-2-(4-benzylpiperidino)-1- propanol and its addition salt |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5681560A (enrdf_load_stackoverflow) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE112006001701T5 (de) | 2005-06-27 | 2008-09-04 | Alps Pharmaceutical Ind. Co., Ltd., Hida | Verfahren zur Herstellung von optisch aktiven Benzylaminderivaten |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0655045U (ja) * | 1993-01-04 | 1994-07-26 | 義明 谷西 | 着火装置 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS501478U (enrdf_load_stackoverflow) * | 1973-05-11 | 1975-01-09 | ||
| JPS5059274U (enrdf_load_stackoverflow) * | 1973-10-12 | 1975-06-02 |
-
1979
- 1979-12-07 JP JP15811279A patent/JPS5681560A/ja active Granted
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS501478U (enrdf_load_stackoverflow) * | 1973-05-11 | 1975-01-09 | ||
| JPS5059274U (enrdf_load_stackoverflow) * | 1973-10-12 | 1975-06-02 |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE112006001701T5 (de) | 2005-06-27 | 2008-09-04 | Alps Pharmaceutical Ind. Co., Ltd., Hida | Verfahren zur Herstellung von optisch aktiven Benzylaminderivaten |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6239153B2 (enrdf_load_stackoverflow) | 1987-08-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JPS5616424A (en) | Method of manufacturing methylltertiaryy butylether as well as obtaining isobutene simultaneously | |
| IL58936A (en) | Simultaneous manufacture of pure methyl tert.-butyl ether and an isobutene-free mixture of c4-hydrocarbons | |
| Takahashi et al. | Mechanism of formation of methyl formate from formaldehyde over copper catalysts | |
| JPS5681560A (en) | Preparation of 1-(4-hydroxyphenyl)-2-(4-benzylpiperidino)-1- propanol and its addition salt | |
| Villacorta et al. | Lithium tungsten dioxide promoted Claisen-Tishchenko condensation of aromatic and aliphatic aldehydes | |
| JPS57102837A (en) | Preparation of glucolic acid | |
| JPS5746929A (en) | Preparation of ethanol | |
| JPS5742654A (en) | Preparation of dimethyl oxalate | |
| JPS56135469A (en) | Preparation of 2- 4-benzylpiperidino -1- 4-hydroxyphenyl -1- propanol and addition salt thereof | |
| JPS565429A (en) | Preparation of acetal | |
| ES8200342A1 (es) | Un procedimiento para la preparacion de 1-(4-hidroxifenil)- 2-(4-bencilpiperidino)-1-propanol | |
| JPS5795928A (en) | Preparation of 2,6-di-t-butylphenol | |
| JPS579733A (en) | Preparation of acetaldehyde | |
| JPS5726634A (en) | Preparation of aromatic alcohol | |
| KR860001042A (ko) | 헤미아세탈로부터 플루오랄 및 헥사플루오로아세톤의 순수한 히드레이트를 제조하는 방법 | |
| JPS5626829A (en) | Preparation of phenylacetaldehyde dialkyl acetal | |
| JPS51122030A (en) | Process for preparation of dihydric phenol monoalkyl ether | |
| JPS5785335A (en) | Production of bisphenol | |
| JPS5731629A (en) | Preparation of bisphenolethane | |
| JPS57139064A (en) | Preparation of indole | |
| JPS5527015A (en) | Preparation of catalyst solution | |
| JPS57123811A (en) | Production of carbon monoxide | |
| SU481602A1 (ru) | Способ получени окиси пропилена и уксусной кислоты | |
| JPS5748930A (en) | Preparation of acetal | |
| JPS57183731A (en) | 9-hydroxy-7-nonen-1-al and its preparation |