JPS5630978A - Novel mitomycin and its preparation - Google Patents

Novel mitomycin and its preparation

Info

Publication number
JPS5630978A
JPS5630978A JP10706979A JP10706979A JPS5630978A JP S5630978 A JPS5630978 A JP S5630978A JP 10706979 A JP10706979 A JP 10706979A JP 10706979 A JP10706979 A JP 10706979A JP S5630978 A JPS5630978 A JP S5630978A
Authority
JP
Japan
Prior art keywords
formula
compound
preparation
phenoxycarbonyloxy
mitomycins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP10706979A
Other languages
English (en)
Other versions
JPS626718B2 (ja
Inventor
Masaji Kasai
Kimikatsu Shirahata
Kazumichi Kono
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH Neochem Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Priority to JP10706979A priority Critical patent/JPS5630978A/ja
Publication of JPS5630978A publication Critical patent/JPS5630978A/ja
Priority to US06/323,847 priority patent/US4395558A/en
Publication of JPS626718B2 publication Critical patent/JPS626718B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP10706979A 1979-08-24 1979-08-24 Novel mitomycin and its preparation Granted JPS5630978A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP10706979A JPS5630978A (en) 1979-08-24 1979-08-24 Novel mitomycin and its preparation
US06/323,847 US4395558A (en) 1979-08-24 1981-11-23 9-Epi-mitomycin B and D compounds

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10706979A JPS5630978A (en) 1979-08-24 1979-08-24 Novel mitomycin and its preparation

Publications (2)

Publication Number Publication Date
JPS5630978A true JPS5630978A (en) 1981-03-28
JPS626718B2 JPS626718B2 (ja) 1987-02-13

Family

ID=14449693

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10706979A Granted JPS5630978A (en) 1979-08-24 1979-08-24 Novel mitomycin and its preparation

Country Status (2)

Country Link
US (1) US4395558A (ja)
JP (1) JPS5630978A (ja)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4395558A (en) * 1979-08-24 1983-07-26 Kyowa Hakko Kogyo Kabushiki Kaisha 9-Epi-mitomycin B and D compounds
JPS61189283A (ja) * 1985-02-19 1986-08-22 Kyowa Hakko Kogyo Co Ltd ７−ｎ−アミノメチレンマイトマイシン誘導体、製造法及び抗腫瘍剤
JPS6335520A (ja) * 1986-07-31 1988-02-16 Kyowa Hakko Kogyo Co Ltd 抗腫瘍剤
EP0284380B1 (en) * 1987-03-25 1992-06-10 Kyowa Hakko Kogyo Kabushiki Kaisha Mitomycin derivatives

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61176590A (ja) * 1985-01-31 1986-08-08 Kyowa Hakko Kogyo Co Ltd ７−ｎ−アミノメチレンマイトマイシン誘導体、製造法及び抗腫瘍剤
US4720543A (en) * 1985-06-06 1988-01-19 Georgetown University 1a-7-substituted derivatives of mitomycin and uses thereof
JPS63246379A (ja) * 1987-03-31 1988-10-13 Kyowa Hakko Kogyo Co Ltd ７−ｎ，８−ｎ−エチレンマイトマイシン８−イミン類
JPS63193872U (ja) * 1987-06-02 1988-12-14
US5023253A (en) * 1987-12-21 1991-06-11 University Patents, Inc. 6-substituted mitomycin analogs
JPH0249786A (ja) * 1988-05-30 1990-02-20 Kyowa Hakko Kogyo Co Ltd 新規なマイトマイシン誘導体およびその中間体
WO1990001931A1 (en) * 1988-08-23 1990-03-08 Georgetown University Mitomycin derivatives having reduced bone marrow toxicity, processes for their preparation, and the uses thereof
US5091523A (en) * 1990-04-25 1992-02-25 Georgetown University Mitomycin derivatives having reduced bone marrow toxicity, processes for their preparation, and the uses thereof
US6495348B1 (en) * 1993-10-07 2002-12-17 Regents Of The University Of Minnesota Mitomycin biosynthetic gene cluster
US6524812B1 (en) 1993-10-07 2003-02-25 Regents Of The University Of Minnesota Genes encoding resistance to DNA alkylating agents
US5965734A (en) * 1997-01-31 1999-10-12 Celgene Corporation Processes and intermediates for preparing 2-substituted piperidine stereoisomers

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3738998A (en) * 1968-04-11 1973-06-12 Kyowa Hakko Kogyo Kk Decarbamoylmitosanes
JPS588397B2 (ja) * 1978-07-18 1983-02-15 協和醗酵工業株式会社 新規なマイトマイシン誘導体およびその製造法
JPS5630978A (en) * 1979-08-24 1981-03-28 Kyowa Hakko Kogyo Co Ltd Novel mitomycin and its preparation

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4395558A (en) * 1979-08-24 1983-07-26 Kyowa Hakko Kogyo Kabushiki Kaisha 9-Epi-mitomycin B and D compounds
JPS61189283A (ja) * 1985-02-19 1986-08-22 Kyowa Hakko Kogyo Co Ltd ７−ｎ−アミノメチレンマイトマイシン誘導体、製造法及び抗腫瘍剤
JPS6335520A (ja) * 1986-07-31 1988-02-16 Kyowa Hakko Kogyo Co Ltd 抗腫瘍剤
EP0284380B1 (en) * 1987-03-25 1992-06-10 Kyowa Hakko Kogyo Kabushiki Kaisha Mitomycin derivatives

Also Published As

Publication number Publication date
US4395558A (en) 1983-07-26
JPS626718B2 (ja) 1987-02-13

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