JPS5618914A - Ubidecarenone composition having good absorbability - Google Patents
Ubidecarenone composition having good absorbabilityInfo
- Publication number
- JPS5618914A JPS5618914A JP9363679A JP9363679A JPS5618914A JP S5618914 A JPS5618914 A JP S5618914A JP 9363679 A JP9363679 A JP 9363679A JP 9363679 A JP9363679 A JP 9363679A JP S5618914 A JPS5618914 A JP S5618914A
- Authority
- JP
- Japan
- Prior art keywords
- ubidecarenone
- composition
- good absorbability
- granule
- powder
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 title abstract 5
- ACTIUHUUMQJHFO-UHFFFAOYSA-N Coenzym Q10 Natural products COC1=C(OC)C(=O)C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UHFFFAOYSA-N 0.000 title abstract 4
- ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 title abstract 4
- 235000017471 coenzyme Q10 Nutrition 0.000 title abstract 4
- 229960004747 ubidecarenone Drugs 0.000 title abstract 4
- 235000014113 dietary fatty acids Nutrition 0.000 abstract 2
- 229930195729 fatty acid Natural products 0.000 abstract 2
- 239000000194 fatty acid Substances 0.000 abstract 2
- 150000004665 fatty acids Chemical class 0.000 abstract 2
- 239000008187 granular material Substances 0.000 abstract 2
- 239000000843 powder Substances 0.000 abstract 2
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 abstract 1
- LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical compound OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 abstract 1
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 abstract 1
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 abstract 1
- OYHQOLUKZRVURQ-HZJYTTRNSA-N Linoleic acid Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(O)=O OYHQOLUKZRVURQ-HZJYTTRNSA-N 0.000 abstract 1
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 abstract 1
- DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 abstract 1
- 235000020661 alpha-linolenic acid Nutrition 0.000 abstract 1
- 239000011230 binding agent Substances 0.000 abstract 1
- 239000002775 capsule Substances 0.000 abstract 1
- 239000007891 compressed tablet Substances 0.000 abstract 1
- 239000000470 constituent Substances 0.000 abstract 1
- 125000005456 glyceride group Chemical group 0.000 abstract 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 abstract 1
- 235000020778 linoleic acid Nutrition 0.000 abstract 1
- OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 abstract 1
- 229960004488 linolenic acid Drugs 0.000 abstract 1
- KQQKGWQCNNTQJW-UHFFFAOYSA-N linolenic acid Natural products CC=CCCC=CCC=CCCCCCCCC(O)=O KQQKGWQCNNTQJW-UHFFFAOYSA-N 0.000 abstract 1
- 150000002888 oleic acid derivatives Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Emergency Medicine (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Priority Applications (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP9363679A JPS5618914A (en) | 1979-07-25 | 1979-07-25 | Ubidecarenone composition having good absorbability |
| US06/169,194 US4325942A (en) | 1979-07-25 | 1980-07-15 | Ubidecarenone compositions having enhanced absorption properties |
| CA000356975A CA1159767A (en) | 1979-07-25 | 1980-07-24 | Ubidecarenone composition enhancing the absorption |
| DE8080104371T DE3070508D1 (en) | 1979-07-25 | 1980-07-24 | Ubidecarenone composition enhancing the absorption |
| EP80104371A EP0023349B1 (en) | 1979-07-25 | 1980-07-24 | Ubidecarenone composition enhancing the absorption |
| ES493679A ES8106408A1 (es) | 1979-07-25 | 1980-07-24 | Procedimiento para preparar una composicion de ubidecarenona |
| PH24335A PH16762A (en) | 1979-07-25 | 1980-07-25 | Ubedecabenone compositions having enhanced absorption properties |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP9363679A JPS5618914A (en) | 1979-07-25 | 1979-07-25 | Ubidecarenone composition having good absorbability |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5618914A true JPS5618914A (en) | 1981-02-23 |
| JPS6410494B2 JPS6410494B2 (enExample) | 1989-02-22 |
Family
ID=14087821
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP9363679A Granted JPS5618914A (en) | 1979-07-25 | 1979-07-25 | Ubidecarenone composition having good absorbability |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US4325942A (enExample) |
| EP (1) | EP0023349B1 (enExample) |
| JP (1) | JPS5618914A (enExample) |
| CA (1) | CA1159767A (enExample) |
| DE (1) | DE3070508D1 (enExample) |
| ES (1) | ES8106408A1 (enExample) |
| PH (1) | PH16762A (enExample) |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61221131A (ja) * | 1985-03-28 | 1986-10-01 | Eisai Co Ltd | 吸収促進したユビデカレノン含有組成物 |
| JPS62294612A (ja) * | 1986-06-16 | 1987-12-22 | Eisai Co Ltd | 吸収性の改良されたメナテトレノン含有組成物 |
| JPS63188623A (ja) * | 1987-01-31 | 1988-08-04 | Taisho Pharmaceut Co Ltd | 吸収改善ユビデカレノン製剤 |
| JPH09511744A (ja) * | 1994-04-07 | 1997-11-25 | ファーマヴィーン,インコーポレイテッド | 多薄層薬物送達システム |
| JP2002510329A (ja) * | 1997-07-29 | 2002-04-02 | ファルマシア・アンド・アップジョン・カンパニー | 親油性化合物用の自己乳化性処方 |
| JP2004261005A (ja) * | 2003-01-17 | 2004-09-24 | Taiyo Kagaku Co Ltd | ユビデカレノン製剤 |
| JP2005538090A (ja) * | 2002-07-20 | 2005-12-15 | コリア インスティテュート オブ サイエンス アンド テクノロジー | パクリタキセルの可溶化用組成物及びその製造方法 |
| JP2006176415A (ja) * | 2004-12-21 | 2006-07-06 | Molecular Physiological Chemistry Laboratory Inc | 吸収性の改善されたコエンザイムq10経口製剤 |
| JP2008214275A (ja) * | 2007-03-05 | 2008-09-18 | Taisho Pharmaceutical Co Ltd | ユビデカレノン含有固形製剤用組成物 |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58113127A (ja) * | 1981-12-28 | 1983-07-05 | Ajinomoto Co Inc | ユビデカレノン含有水性液 |
| IT1157269B (it) * | 1982-03-19 | 1987-02-11 | Seuref Ag | Nuove formulazioni farmaceutiche contenenti il coenzima q10 adatte per la somministrazione topica |
| JPS5913710A (ja) * | 1982-07-15 | 1984-01-24 | Shiseido Co Ltd | 養毛料 |
| EP0104043A3 (en) * | 1982-09-20 | 1984-06-06 | Ajinomoto Co., Inc. | Foodstuffs and pharmaceuticals |
| IT1191608B (it) * | 1985-02-01 | 1988-03-23 | Zambon Spa | Composizione farmaceutica e forme farmaceutiche che la contengono |
| IE59067B1 (en) * | 1985-04-02 | 1993-12-15 | Yesair David W | Composition for delivery of orally administered drugs and other substances |
| US4874795A (en) * | 1985-04-02 | 1989-10-17 | Yesair David W | Composition for delivery of orally administered drugs and other substances |
| US4824669A (en) * | 1985-04-11 | 1989-04-25 | Board Of Regents, The University Of Texas System | Formulations of coenzyme Q10 for intravenous use |
| EP0287646B1 (en) * | 1986-10-23 | 1992-05-20 | Arval S.P.A. | Cosmetic preparations containing ubidecarenones |
| US5641504A (en) * | 1988-06-09 | 1997-06-24 | Alza Corporation | Skin permeation enhancer compositions using glycerol monolinoleate |
| US5189066A (en) * | 1989-11-22 | 1993-02-23 | The Procter & Gamble Company | Pharmaceutical compositions of tebufelone |
| EP0448091B1 (en) * | 1990-03-23 | 1998-08-05 | The Green Cross Corporation | Pharmaceutical composition containing slightly water-soluble drug |
| US5571517A (en) * | 1990-08-13 | 1996-11-05 | Yesair; David W. | Mixed lipid-bicarbonate colloidal particles for delivering drugs or calories |
| US5891466A (en) * | 1990-08-13 | 1999-04-06 | Yesair; David W. | Mixed Liped-Bicarbonate colloidal particles for delivering drugs or calories |
| WO1992003121A1 (en) * | 1990-08-13 | 1992-03-05 | Yesair David W | Mixed lipid-bicarbonate colloidal particles for delivering drugs or calories |
| PT100502A (pt) * | 1991-05-20 | 1993-08-31 | Alza Corp | Composicoes farmaceuticas para aumentar a capacidade de permeacao na pele utilizando monolinoleato de glicerol |
| US5281420A (en) * | 1992-05-19 | 1994-01-25 | The Procter & Gamble Company | Solid dispersion compositions of tebufelone |
| JP3106820B2 (ja) * | 1993-12-08 | 2000-11-06 | アールティーエー・アソシエーツ有限会社 | 畜肉、魚肉およびこれらの加工品の鮮度保持剤並びに生産性改善剤 |
| IT1304406B1 (it) * | 1998-10-21 | 2001-03-19 | Danital Italia S R L | Preparazione per la veicolazione di principi attivi basata su acidigrassi polinsaturi del gruppo omega 3. |
| US7179483B2 (en) | 2000-04-26 | 2007-02-20 | Watson Pharmaceuticals, Inc. | Compositions and methods for transdermal oxybutynin therapy |
| DE10133305B4 (de) * | 2001-07-12 | 2004-06-03 | Aquanova German Solubilisate Technologies (Agt) Gmbh | Ubichinon Konzentrat |
| JP2003055204A (ja) * | 2001-08-21 | 2003-02-26 | Sansho Iyaku Kk | ユビデカレノン組成物及び同組成物を内容物とするカプセル |
| CA2513276C (en) * | 2003-01-17 | 2012-09-04 | Taiyo Kagaku Co., Ltd. | Compositions containing coenzyme q10 |
| US20050260752A1 (en) * | 2003-04-01 | 2005-11-24 | Wilding Martin G | Culture medium containing enhancers of oxidative phosphorylation |
| US8491888B2 (en) * | 2006-05-05 | 2013-07-23 | Softgel Formulators, Inc. | Highly absorbable coenzyme Q10 composition and method of producing same |
| EP3366280A1 (en) | 2010-03-12 | 2018-08-29 | Berg LLC | Intravenous formulations of coenzyme q10 (coq10) and methods of use thereof |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3426125A (en) * | 1965-04-07 | 1969-02-04 | Yukio Shigeta | Method of treating diabetes mellitus |
| US3317381A (en) * | 1965-10-04 | 1967-05-02 | Takeda Chemical Industries Ltd | Method for treating peptic ulcer |
| US3534137A (en) * | 1965-09-30 | 1970-10-13 | Takeda Chemical Industries Ltd | Method of systemic therapy for severe early destructive periodontal disease |
| US3452144A (en) * | 1966-03-26 | 1969-06-24 | Takeda Chemical Industries Ltd | Method for treatment of congestive heart failure with coenzyme qn |
| US3808330A (en) * | 1972-07-13 | 1974-04-30 | Eisai Co Ltd | Method for treatment of hypertensive disease |
| DE2631282A1 (de) * | 1976-07-12 | 1978-01-19 | Kali Chemie Pharma Gmbh | Verfahren zur erhoehung der loeslichkeit und des dispersitaetsgrades von schwerloeslichen arzneistoffen zum zwecke deren applikation in gelatinekapseln |
| DE2700371A1 (de) * | 1977-01-07 | 1978-07-13 | Kali Chemie Pharma Gmbh | Verfahren zur herstellung fester und fluessiger loesungen von arzneistoffen zur oralen applikation |
| DE2700433A1 (de) * | 1977-01-07 | 1978-07-20 | Kali Chemie Pharma Gmbh | Arzneimittelzubereitungen mit verbesserten resorptionseigenschaften |
| DE2700501A1 (de) * | 1977-01-07 | 1978-07-20 | Kali Chemie Pharma Gmbh | Verfahren zur herstellung fester und fluessiger loesungen von arzneistoffen zur oralen applikation |
-
1979
- 1979-07-25 JP JP9363679A patent/JPS5618914A/ja active Granted
-
1980
- 1980-07-15 US US06/169,194 patent/US4325942A/en not_active Expired - Lifetime
- 1980-07-24 DE DE8080104371T patent/DE3070508D1/de not_active Expired
- 1980-07-24 ES ES493679A patent/ES8106408A1/es not_active Expired
- 1980-07-24 EP EP80104371A patent/EP0023349B1/en not_active Expired
- 1980-07-24 CA CA000356975A patent/CA1159767A/en not_active Expired
- 1980-07-25 PH PH24335A patent/PH16762A/en unknown
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61221131A (ja) * | 1985-03-28 | 1986-10-01 | Eisai Co Ltd | 吸収促進したユビデカレノン含有組成物 |
| JPS62294612A (ja) * | 1986-06-16 | 1987-12-22 | Eisai Co Ltd | 吸収性の改良されたメナテトレノン含有組成物 |
| JPS63188623A (ja) * | 1987-01-31 | 1988-08-04 | Taisho Pharmaceut Co Ltd | 吸収改善ユビデカレノン製剤 |
| JPH09511744A (ja) * | 1994-04-07 | 1997-11-25 | ファーマヴィーン,インコーポレイテッド | 多薄層薬物送達システム |
| JP2002510329A (ja) * | 1997-07-29 | 2002-04-02 | ファルマシア・アンド・アップジョン・カンパニー | 親油性化合物用の自己乳化性処方 |
| JP2005538090A (ja) * | 2002-07-20 | 2005-12-15 | コリア インスティテュート オブ サイエンス アンド テクノロジー | パクリタキセルの可溶化用組成物及びその製造方法 |
| US8075917B2 (en) | 2002-07-20 | 2011-12-13 | Daehwa Pharm. Co., Ltd. | Composition for solubilization of paclitaxel and preparation method thereof |
| JP2004261005A (ja) * | 2003-01-17 | 2004-09-24 | Taiyo Kagaku Co Ltd | ユビデカレノン製剤 |
| JP2006176415A (ja) * | 2004-12-21 | 2006-07-06 | Molecular Physiological Chemistry Laboratory Inc | 吸収性の改善されたコエンザイムq10経口製剤 |
| JP2008214275A (ja) * | 2007-03-05 | 2008-09-18 | Taisho Pharmaceutical Co Ltd | ユビデカレノン含有固形製剤用組成物 |
Also Published As
| Publication number | Publication date |
|---|---|
| CA1159767A (en) | 1984-01-03 |
| EP0023349A3 (en) | 1982-03-10 |
| JPS6410494B2 (enExample) | 1989-02-22 |
| PH16762A (en) | 1984-02-15 |
| US4325942A (en) | 1982-04-20 |
| ES493679A0 (es) | 1981-07-01 |
| EP0023349A2 (en) | 1981-02-04 |
| DE3070508D1 (en) | 1985-05-23 |
| ES8106408A1 (es) | 1981-07-01 |
| EP0023349B1 (en) | 1985-04-17 |
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