JPS56169645A - Preparation of 2- 3-benzoylphenyl propionic acid - Google Patents
Preparation of 2- 3-benzoylphenyl propionic acidInfo
- Publication number
- JPS56169645A JPS56169645A JP7275580A JP7275580A JPS56169645A JP S56169645 A JPS56169645 A JP S56169645A JP 7275580 A JP7275580 A JP 7275580A JP 7275580 A JP7275580 A JP 7275580A JP S56169645 A JPS56169645 A JP S56169645A
- Authority
- JP
- Japan
- Prior art keywords
- benzoylphenyl
- propionic acid
- formula
- bromophenyl
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE: To obtain the titled compound useful as a drug having anti-inflammatory action, by reacting benzonitrile with a Grignard complex of 2-(3-bromophenyl) propionaldehyde acetal, followed by hydrolysis and oxidation.
CONSTITUTION: Benzonitrile is reacted with a Grignard complex of 2-(3-bromophenyl)propionaldehyde acetal shown by the formula III (R1 and R2 are lower alkyl, form together ethylene or propylene) in a solvent, e.g., THF, etc. at room temperature or under reflux to give a 2-(3-benzoylphenyl)propionaldehyde acetal shown by the formula IV. This compound is hydrolyzed with a mineral acid, and oxidized with a proper oxidizing agent, to give a 2-(3-benzoylphenyl)propionic acid shown by the formula I.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP7275580A JPS56169645A (en) | 1980-06-02 | 1980-06-02 | Preparation of 2- 3-benzoylphenyl propionic acid |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP7275580A JPS56169645A (en) | 1980-06-02 | 1980-06-02 | Preparation of 2- 3-benzoylphenyl propionic acid |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS56169645A true JPS56169645A (en) | 1981-12-26 |
Family
ID=13498481
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP7275580A Pending JPS56169645A (en) | 1980-06-02 | 1980-06-02 | Preparation of 2- 3-benzoylphenyl propionic acid |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS56169645A (en) |
-
1980
- 1980-06-02 JP JP7275580A patent/JPS56169645A/en active Pending
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