JPS56169645A - Preparation of 2- 3-benzoylphenyl propionic acid - Google Patents

Preparation of 2- 3-benzoylphenyl propionic acid

Info

Publication number
JPS56169645A
JPS56169645A JP7275580A JP7275580A JPS56169645A JP S56169645 A JPS56169645 A JP S56169645A JP 7275580 A JP7275580 A JP 7275580A JP 7275580 A JP7275580 A JP 7275580A JP S56169645 A JPS56169645 A JP S56169645A
Authority
JP
Japan
Prior art keywords
benzoylphenyl
propionic acid
formula
bromophenyl
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP7275580A
Other languages
Japanese (ja)
Inventor
Kazuo Ohira
Shigenori Matsumura
Tadashi Itou
Mikio Hori
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Taiyo Pharmaceutical Industry Co Ltd
Original Assignee
Taiyo Pharmaceutical Industry Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taiyo Pharmaceutical Industry Co Ltd filed Critical Taiyo Pharmaceutical Industry Co Ltd
Priority to JP7275580A priority Critical patent/JPS56169645A/en
Publication of JPS56169645A publication Critical patent/JPS56169645A/en
Pending legal-status Critical Current

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE: To obtain the titled compound useful as a drug having anti-inflammatory action, by reacting benzonitrile with a Grignard complex of 2-(3-bromophenyl) propionaldehyde acetal, followed by hydrolysis and oxidation.
CONSTITUTION: Benzonitrile is reacted with a Grignard complex of 2-(3-bromophenyl)propionaldehyde acetal shown by the formula III (R1 and R2 are lower alkyl, form together ethylene or propylene) in a solvent, e.g., THF, etc. at room temperature or under reflux to give a 2-(3-benzoylphenyl)propionaldehyde acetal shown by the formula IV. This compound is hydrolyzed with a mineral acid, and oxidized with a proper oxidizing agent, to give a 2-(3-benzoylphenyl)propionic acid shown by the formula I.
COPYRIGHT: (C)1981,JPO&Japio
JP7275580A 1980-06-02 1980-06-02 Preparation of 2- 3-benzoylphenyl propionic acid Pending JPS56169645A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP7275580A JPS56169645A (en) 1980-06-02 1980-06-02 Preparation of 2- 3-benzoylphenyl propionic acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP7275580A JPS56169645A (en) 1980-06-02 1980-06-02 Preparation of 2- 3-benzoylphenyl propionic acid

Publications (1)

Publication Number Publication Date
JPS56169645A true JPS56169645A (en) 1981-12-26

Family

ID=13498481

Family Applications (1)

Application Number Title Priority Date Filing Date
JP7275580A Pending JPS56169645A (en) 1980-06-02 1980-06-02 Preparation of 2- 3-benzoylphenyl propionic acid

Country Status (1)

Country Link
JP (1) JPS56169645A (en)

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