JPS56123940A - Biphenyl derivative and its preparation - Google Patents

Biphenyl derivative and its preparation

Info

Publication number
JPS56123940A
JPS56123940A JP2863780A JP2863780A JPS56123940A JP S56123940 A JPS56123940 A JP S56123940A JP 2863780 A JP2863780 A JP 2863780A JP 2863780 A JP2863780 A JP 2863780A JP S56123940 A JPS56123940 A JP S56123940A
Authority
JP
Japan
Prior art keywords
substituted
phase
biphenylyl
medicines
halogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2863780A
Other languages
Japanese (ja)
Other versions
JPS621381B2 (en
Inventor
Yasumitsu Tamura
Masao Murayama
Shingo Matsumura
Yoshihiko Yoshimoto
Shinichi Tanda
Katsutoshi Kunimoto
Hiroshi Enomoto
Yoshihisa Shibata
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Shinyaku Co Ltd
Original Assignee
Nippon Shinyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Shinyaku Co Ltd filed Critical Nippon Shinyaku Co Ltd
Priority to JP2863780A priority Critical patent/JPS56123940A/en
Publication of JPS56123940A publication Critical patent/JPS56123940A/en
Publication of JPS621381B2 publication Critical patent/JPS621381B2/ja
Granted legal-status Critical Current

Links

Abstract

PURPOSE: To prepare the titled compound useful as a synthetic intermediate of medicines, in high yield, by methylating 4',5-di-substituted-3-biphenylylacetic acid ester with a methylating agent in a two-phase system comprising methylene chloride and water, in the presence of a phase-transfer catalyst.
CONSTITUTION: A 2-(4', 5-di-substituted-3-biphenylyl)propionic acid ester of formula II (R1 is H, lower alkoxy, or halogen; R2 is H or halogen; R3 is lower alkyl) is prepared by reacting a 4', 5-di-substituted-3-biphenylylacetic acid este with a methylating agent such as CH3I, in a two-phase system comprising methylene chloride and water, in the presence of a phase-transfer catalyst such as tetrabutylammonium hydroxide.
EFFECT: As the reaction system is not anhydrous, the methylated objective compound can be separated easily.
USE: A synthetic intermediate of medicines having excellent antiphlogistic and analgesic activities, e.g. 2-(4',5-di-substituted-3-biphenylyl)propionic acid.
COPYRIGHT: (C)1981,JPO&Japio
JP2863780A 1980-03-06 1980-03-06 Biphenyl derivative and its preparation Granted JPS56123940A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2863780A JPS56123940A (en) 1980-03-06 1980-03-06 Biphenyl derivative and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2863780A JPS56123940A (en) 1980-03-06 1980-03-06 Biphenyl derivative and its preparation

Publications (2)

Publication Number Publication Date
JPS56123940A true JPS56123940A (en) 1981-09-29
JPS621381B2 JPS621381B2 (en) 1987-01-13

Family

ID=12254039

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2863780A Granted JPS56123940A (en) 1980-03-06 1980-03-06 Biphenyl derivative and its preparation

Country Status (1)

Country Link
JP (1) JPS56123940A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5946242A (en) * 1982-09-09 1984-03-15 Agency Of Ind Science & Technol Preparation of propionic acid having aromatic group at alpha-position and its ester

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5126433A (en) * 1974-08-29 1976-03-04 Fujitsu Ltd JOHOSHORISHISUTEMUSEIGYOHOSHIKI
JPS5145584A (en) * 1974-10-16 1976-04-19 Hitachi Ltd
JPS5210859A (en) * 1975-07-16 1977-01-27 Matsushita Electric Ind Co Ltd Ion wind generator
JPS5218189A (en) * 1975-08-01 1977-02-10 Nippon Telegr & Teleph Corp <Ntt> Zinc selenide light emitting diode process

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5126433A (en) * 1974-08-29 1976-03-04 Fujitsu Ltd JOHOSHORISHISUTEMUSEIGYOHOSHIKI
JPS5145584A (en) * 1974-10-16 1976-04-19 Hitachi Ltd
JPS5210859A (en) * 1975-07-16 1977-01-27 Matsushita Electric Ind Co Ltd Ion wind generator
JPS5218189A (en) * 1975-08-01 1977-02-10 Nippon Telegr & Teleph Corp <Ntt> Zinc selenide light emitting diode process

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5946242A (en) * 1982-09-09 1984-03-15 Agency Of Ind Science & Technol Preparation of propionic acid having aromatic group at alpha-position and its ester

Also Published As

Publication number Publication date
JPS621381B2 (en) 1987-01-13

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