JPS56123940A - Biphenyl derivative and its preparation - Google Patents
Biphenyl derivative and its preparationInfo
- Publication number
- JPS56123940A JPS56123940A JP2863780A JP2863780A JPS56123940A JP S56123940 A JPS56123940 A JP S56123940A JP 2863780 A JP2863780 A JP 2863780A JP 2863780 A JP2863780 A JP 2863780A JP S56123940 A JPS56123940 A JP S56123940A
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- phase
- biphenylyl
- medicines
- halogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
PURPOSE: To prepare the titled compound useful as a synthetic intermediate of medicines, in high yield, by methylating 4',5-di-substituted-3-biphenylylacetic acid ester with a methylating agent in a two-phase system comprising methylene chloride and water, in the presence of a phase-transfer catalyst.
CONSTITUTION: A 2-(4', 5-di-substituted-3-biphenylyl)propionic acid ester of formula II (R1 is H, lower alkoxy, or halogen; R2 is H or halogen; R3 is lower alkyl) is prepared by reacting a 4', 5-di-substituted-3-biphenylylacetic acid este with a methylating agent such as CH3I, in a two-phase system comprising methylene chloride and water, in the presence of a phase-transfer catalyst such as tetrabutylammonium hydroxide.
EFFECT: As the reaction system is not anhydrous, the methylated objective compound can be separated easily.
USE: A synthetic intermediate of medicines having excellent antiphlogistic and analgesic activities, e.g. 2-(4',5-di-substituted-3-biphenylyl)propionic acid.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2863780A JPS56123940A (en) | 1980-03-06 | 1980-03-06 | Biphenyl derivative and its preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2863780A JPS56123940A (en) | 1980-03-06 | 1980-03-06 | Biphenyl derivative and its preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS56123940A true JPS56123940A (en) | 1981-09-29 |
JPS621381B2 JPS621381B2 (en) | 1987-01-13 |
Family
ID=12254039
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2863780A Granted JPS56123940A (en) | 1980-03-06 | 1980-03-06 | Biphenyl derivative and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS56123940A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5946242A (en) * | 1982-09-09 | 1984-03-15 | Agency Of Ind Science & Technol | Preparation of propionic acid having aromatic group at alpha-position and its ester |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5126433A (en) * | 1974-08-29 | 1976-03-04 | Fujitsu Ltd | JOHOSHORISHISUTEMUSEIGYOHOSHIKI |
JPS5145584A (en) * | 1974-10-16 | 1976-04-19 | Hitachi Ltd | |
JPS5210859A (en) * | 1975-07-16 | 1977-01-27 | Matsushita Electric Ind Co Ltd | Ion wind generator |
JPS5218189A (en) * | 1975-08-01 | 1977-02-10 | Nippon Telegr & Teleph Corp <Ntt> | Zinc selenide light emitting diode process |
-
1980
- 1980-03-06 JP JP2863780A patent/JPS56123940A/en active Granted
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5126433A (en) * | 1974-08-29 | 1976-03-04 | Fujitsu Ltd | JOHOSHORISHISUTEMUSEIGYOHOSHIKI |
JPS5145584A (en) * | 1974-10-16 | 1976-04-19 | Hitachi Ltd | |
JPS5210859A (en) * | 1975-07-16 | 1977-01-27 | Matsushita Electric Ind Co Ltd | Ion wind generator |
JPS5218189A (en) * | 1975-08-01 | 1977-02-10 | Nippon Telegr & Teleph Corp <Ntt> | Zinc selenide light emitting diode process |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5946242A (en) * | 1982-09-09 | 1984-03-15 | Agency Of Ind Science & Technol | Preparation of propionic acid having aromatic group at alpha-position and its ester |
Also Published As
Publication number | Publication date |
---|---|
JPS621381B2 (en) | 1987-01-13 |
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