JPS5562039A - Preparation of substituted acetophenone - Google Patents
Preparation of substituted acetophenoneInfo
- Publication number
- JPS5562039A JPS5562039A JP13395078A JP13395078A JPS5562039A JP S5562039 A JPS5562039 A JP S5562039A JP 13395078 A JP13395078 A JP 13395078A JP 13395078 A JP13395078 A JP 13395078A JP S5562039 A JPS5562039 A JP S5562039A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- tin
- zinc
- alkaline conditions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE: To obtain the title compound easily, without the formation of by-products, by reacting a substituted benzoic acid ester and dimsyl sodium, and heating the resulting β-ketosulfoxide together with zinc or tin in a heterogeneous solvent system under alkaline conditions.
CONSTITUTION: The title compound of formula III is obtained by reacting a compound of formula I (R is lower alkoxy; R' is lower alkyl) and dimsyl sodium (CH3SOCH2Na) and heating the formed compound of formula II together with zinc or tin in a heterogeneous solvent under alkaline conditions. In order to fulfil the alkaline conditions, NaOH, etc. is used. The heterogeneous solvent is a mixed solvent of water and an organic solvent (e.g. benzene) which dissolves reaction products and is immissible with water. Zinc or tin is pref. of powdery state and the amount is at least 1 gram atom per mole of the compound of formula I.
USE: Precursor of phenylacetic acid derivatives which are important as anti-inflammatory analgesics.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP53133950A JPS5811414B2 (en) | 1978-10-31 | 1978-10-31 | Method for producing substituted acetophenone |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP53133950A JPS5811414B2 (en) | 1978-10-31 | 1978-10-31 | Method for producing substituted acetophenone |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5562039A true JPS5562039A (en) | 1980-05-10 |
JPS5811414B2 JPS5811414B2 (en) | 1983-03-02 |
Family
ID=15116852
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP53133950A Expired JPS5811414B2 (en) | 1978-10-31 | 1978-10-31 | Method for producing substituted acetophenone |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5811414B2 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2592905A1 (en) | 2003-07-31 | 2013-05-15 | Mitsubishi Chemical Corporation | Compound, charge transporting material and organic electroluminescent element |
-
1978
- 1978-10-31 JP JP53133950A patent/JPS5811414B2/en not_active Expired
Non-Patent Citations (1)
Title |
---|
JOURNAL OF AMERICAN CHEMICAL SOCIETY=1966 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2592905A1 (en) | 2003-07-31 | 2013-05-15 | Mitsubishi Chemical Corporation | Compound, charge transporting material and organic electroluminescent element |
Also Published As
Publication number | Publication date |
---|---|
JPS5811414B2 (en) | 1983-03-02 |
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