JPS5562077A - Novel preparation of pindolol - Google Patents
Novel preparation of pindololInfo
- Publication number
- JPS5562077A JPS5562077A JP13524578A JP13524578A JPS5562077A JP S5562077 A JPS5562077 A JP S5562077A JP 13524578 A JP13524578 A JP 13524578A JP 13524578 A JP13524578 A JP 13524578A JP S5562077 A JPS5562077 A JP S5562077A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- hydroxyindole
- oxazolidine
- chloromethyl
- hydrolyzing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
PURPOSE: To prepare the title compound useful as a remedy for hypotension and extrasystole, economically, in one step, by hydrolyzing a reaction product of a specific 2-substituted-3-isopropyl-5-chloromethyl oxazolidine with 4-hydroxyindole.
CONSTITUTION: The title compound of formula II is prepared by (1) reacting 2-substituted-3-isopropyl-5-chloromethyl oxazolidine of formula I (R is phenyl or lower alkyl) with 4-hydroxyindole or its alkali metal salt in an inert atmosphere in a solvent pref. anhydrous dimethylamide or anhydrous methanol, in the presence of a condensing agent such as sodium methoxide, and (2) hydrolyzing the reaction product in an alkaline or acidic aqueous solution. The compound of formula I can be prepared by adding epichlorohydrine to a mixture of benzaldehyde and isopropylamine.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP13524578A JPS5562077A (en) | 1978-11-01 | 1978-11-01 | Novel preparation of pindolol |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP13524578A JPS5562077A (en) | 1978-11-01 | 1978-11-01 | Novel preparation of pindolol |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5562077A true JPS5562077A (en) | 1980-05-10 |
Family
ID=15147192
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP13524578A Pending JPS5562077A (en) | 1978-11-01 | 1978-11-01 | Novel preparation of pindolol |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5562077A (en) |
-
1978
- 1978-11-01 JP JP13524578A patent/JPS5562077A/en active Pending
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CH610582A5 (en) | Process for the preparation of a stilbene derivative having analgesic and anti-inflammatory properties | |
JPS5562077A (en) | Novel preparation of pindolol | |
JPS5517324A (en) | Preparation of thiophosphoric acid ester | |
JPS5758637A (en) | Preparation of ether | |
JPS5585547A (en) | Preparation of substituted phenylacetic acid | |
JPS54148786A (en) | Preparation of 1,3-dimethyl-4-(2,4-dichlorobenzoyl)-5- hydroxypyrazole | |
JPS55153777A (en) | Improved method of preparation of 3-methyl-3-(substituted phenyl)-glycidic ester | |
JPS5545615A (en) | Derivative of (n-allyl-o-(2,6-dichloroanilino) phenyl) acetic acid | |
JPS5543004A (en) | Preparation of alpha-thio-gammadelta-unsaturated carbonyl compound | |
JPS5253839A (en) | Preparation of 2-(2,2-dihalovinyl) cyclopropane crboxylic acids | |
JPS55143960A (en) | Novel acetal compound and its preparation | |
JPS5553241A (en) | Preparation of carboxylic ester | |
JPS54144347A (en) | 3-(2-fluoro-4-biphenylyl)-2-butanone | |
JPS54112842A (en) | Preparation of alpha-biphenylyl-propionic acid derivative | |
JPS5569563A (en) | Preparation of 2-methoxy-5-sulfamoylbenzoic acid amide | |
JPS5517335A (en) | 5-fluoro-6-hydroxy-6-carboxy-5,6-dihydro-uracil and its preparation | |
JPS56113736A (en) | Preparation of 2-arylalkanoic acid | |
JPS5441869A (en) | 1-methylsulfinyl-1-methylthio-2-(n-alkylpyrrolyl-2)- ethylene | |
IE43426L (en) | Ureidoacetic acid fungicides. | |
JPS5677266A (en) | Synthesis of 2,3-dioxopiperazine derivative | |
JPS5699471A (en) | Preparation of 2- 4- 2-thenoyl phenyl propionc acid | |
JPS55143925A (en) | Preparation of cyclopentenolone | |
JPS5655356A (en) | Preparation of alkylenediamine derivative | |
JPS5461158A (en) | 4-1-acetamido-3-(dichlorophenyl) propyl tropolones | |
JPS5461153A (en) | Inositolsulfate ammonium salt and its preparation |