JPS5562077A - Novel preparation of pindolol - Google Patents

Novel preparation of pindolol

Info

Publication number
JPS5562077A
JPS5562077A JP13524578A JP13524578A JPS5562077A JP S5562077 A JPS5562077 A JP S5562077A JP 13524578 A JP13524578 A JP 13524578A JP 13524578 A JP13524578 A JP 13524578A JP S5562077 A JPS5562077 A JP S5562077A
Authority
JP
Japan
Prior art keywords
formula
hydroxyindole
oxazolidine
chloromethyl
hydrolyzing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP13524578A
Other languages
Japanese (ja)
Inventor
Dotaro Fujimoto
Toshimitsu Shigeari
Giichi Funatsukuri
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujimoto Pharmaceutical Corp
Original Assignee
Fujimoto Pharmaceutical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujimoto Pharmaceutical Corp filed Critical Fujimoto Pharmaceutical Corp
Priority to JP13524578A priority Critical patent/JPS5562077A/en
Publication of JPS5562077A publication Critical patent/JPS5562077A/en
Pending legal-status Critical Current

Links

Landscapes

  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

PURPOSE: To prepare the title compound useful as a remedy for hypotension and extrasystole, economically, in one step, by hydrolyzing a reaction product of a specific 2-substituted-3-isopropyl-5-chloromethyl oxazolidine with 4-hydroxyindole.
CONSTITUTION: The title compound of formula II is prepared by (1) reacting 2-substituted-3-isopropyl-5-chloromethyl oxazolidine of formula I (R is phenyl or lower alkyl) with 4-hydroxyindole or its alkali metal salt in an inert atmosphere in a solvent pref. anhydrous dimethylamide or anhydrous methanol, in the presence of a condensing agent such as sodium methoxide, and (2) hydrolyzing the reaction product in an alkaline or acidic aqueous solution. The compound of formula I can be prepared by adding epichlorohydrine to a mixture of benzaldehyde and isopropylamine.
COPYRIGHT: (C)1980,JPO&Japio
JP13524578A 1978-11-01 1978-11-01 Novel preparation of pindolol Pending JPS5562077A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP13524578A JPS5562077A (en) 1978-11-01 1978-11-01 Novel preparation of pindolol

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP13524578A JPS5562077A (en) 1978-11-01 1978-11-01 Novel preparation of pindolol

Publications (1)

Publication Number Publication Date
JPS5562077A true JPS5562077A (en) 1980-05-10

Family

ID=15147192

Family Applications (1)

Application Number Title Priority Date Filing Date
JP13524578A Pending JPS5562077A (en) 1978-11-01 1978-11-01 Novel preparation of pindolol

Country Status (1)

Country Link
JP (1) JPS5562077A (en)

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