JPS5538340A - Preparation of 2- 4-(2-thienylcarbonyl)phenyl propionic acid - Google Patents

Preparation of 2- 4-(2-thienylcarbonyl)phenyl propionic acid

Info

Publication number
JPS5538340A
JPS5538340A JP11199178A JP11199178A JPS5538340A JP S5538340 A JPS5538340 A JP S5538340A JP 11199178 A JP11199178 A JP 11199178A JP 11199178 A JP11199178 A JP 11199178A JP S5538340 A JPS5538340 A JP S5538340A
Authority
JP
Japan
Prior art keywords
thienylcarbonyl
preparation
propionic acid
cyanothiophene
bromophenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP11199178A
Other languages
Japanese (ja)
Other versions
JPS5728709B2 (en
Inventor
Kazuo Ohira
Shigenori Matsumura
Hajime Yoshida
Mikio Hori
Hajime Fujimura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Taiyo Pharmaceutical Industry Co Ltd
Original Assignee
Taiyo Pharmaceutical Industry Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taiyo Pharmaceutical Industry Co Ltd filed Critical Taiyo Pharmaceutical Industry Co Ltd
Priority to JP11199178A priority Critical patent/JPS5538340A/en
Priority to GB7906726A priority patent/GB2030131B/en
Priority to FR7907298A priority patent/FR2436146A1/en
Priority to DE19792912052 priority patent/DE2912052C2/en
Publication of JPS5538340A publication Critical patent/JPS5538340A/en
Publication of JPS5728709B2 publication Critical patent/JPS5728709B2/ja
Granted legal-status Critical Current

Links

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  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PURPOSE: To prepare the title compound useful as an anit-phlogistic agent, easily, by reacting 2-cyanothiophene with a specific Grignard complex of 2-(4-bromophenyl)-propionaldehyde acetal, and hydrolyzing and oxidizing the product.
CONSTITUTION: The objective compound III is prepared by (1) reacting 2-cyanothiophene with a Grignard complex of 2-(4-bromophenyl)propionaldehyde acetal of formula I (R1,2 are lower alkyl or together form ethylene or propylene) in a solvent such as tetrahydrofuran, (2) hydrolyzing the resulting 2-[4-(2-thienylcarbonyl)-phenyl]propionaldehyde acetal of formula II with a mineral acid such as sulfuric acid, and (3) oxidizing the hydrolyzate with chromium oxide, potassium permanganate, etc., in the presence of an aicd such as sulfuric acid.
COPYRIGHT: (C)1980,JPO&Japio
JP11199178A 1978-09-12 1978-09-12 Preparation of 2- 4-(2-thienylcarbonyl)phenyl propionic acid Granted JPS5538340A (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP11199178A JPS5538340A (en) 1978-09-12 1978-09-12 Preparation of 2- 4-(2-thienylcarbonyl)phenyl propionic acid
GB7906726A GB2030131B (en) 1978-09-12 1979-02-26 Process for producing 2-(4-(2-thienyl-carbonyl) phenyl) propionic acid
FR7907298A FR2436146A1 (en) 1978-09-12 1979-03-22 PROCESS FOR THE PRODUCTION OF ACID ((THIENYL-2 CARBONYL) -4 PHENYL) -2 PROPIONIC
DE19792912052 DE2912052C2 (en) 1978-09-12 1979-03-27 Process for the preparation of 2- [4- (2-thienylcarbonyl) phenyl] propionic acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP11199178A JPS5538340A (en) 1978-09-12 1978-09-12 Preparation of 2- 4-(2-thienylcarbonyl)phenyl propionic acid

Publications (2)

Publication Number Publication Date
JPS5538340A true JPS5538340A (en) 1980-03-17
JPS5728709B2 JPS5728709B2 (en) 1982-06-18

Family

ID=14575197

Family Applications (1)

Application Number Title Priority Date Filing Date
JP11199178A Granted JPS5538340A (en) 1978-09-12 1978-09-12 Preparation of 2- 4-(2-thienylcarbonyl)phenyl propionic acid

Country Status (1)

Country Link
JP (1) JPS5538340A (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4993346A (en) * 1972-10-24 1974-09-05

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4993346A (en) * 1972-10-24 1974-09-05

Also Published As

Publication number Publication date
JPS5728709B2 (en) 1982-06-18

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