JPS5538340A - Preparation of 2- 4-(2-thienylcarbonyl)phenyl propionic acid - Google Patents
Preparation of 2- 4-(2-thienylcarbonyl)phenyl propionic acidInfo
- Publication number
- JPS5538340A JPS5538340A JP11199178A JP11199178A JPS5538340A JP S5538340 A JPS5538340 A JP S5538340A JP 11199178 A JP11199178 A JP 11199178A JP 11199178 A JP11199178 A JP 11199178A JP S5538340 A JPS5538340 A JP S5538340A
- Authority
- JP
- Japan
- Prior art keywords
- thienylcarbonyl
- preparation
- propionic acid
- cyanothiophene
- bromophenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PURPOSE: To prepare the title compound useful as an anit-phlogistic agent, easily, by reacting 2-cyanothiophene with a specific Grignard complex of 2-(4-bromophenyl)-propionaldehyde acetal, and hydrolyzing and oxidizing the product.
CONSTITUTION: The objective compound III is prepared by (1) reacting 2-cyanothiophene with a Grignard complex of 2-(4-bromophenyl)propionaldehyde acetal of formula I (R1,2 are lower alkyl or together form ethylene or propylene) in a solvent such as tetrahydrofuran, (2) hydrolyzing the resulting 2-[4-(2-thienylcarbonyl)-phenyl]propionaldehyde acetal of formula II with a mineral acid such as sulfuric acid, and (3) oxidizing the hydrolyzate with chromium oxide, potassium permanganate, etc., in the presence of an aicd such as sulfuric acid.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11199178A JPS5538340A (en) | 1978-09-12 | 1978-09-12 | Preparation of 2- 4-(2-thienylcarbonyl)phenyl propionic acid |
GB7906726A GB2030131B (en) | 1978-09-12 | 1979-02-26 | Process for producing 2-(4-(2-thienyl-carbonyl) phenyl) propionic acid |
FR7907298A FR2436146A1 (en) | 1978-09-12 | 1979-03-22 | PROCESS FOR THE PRODUCTION OF ACID ((THIENYL-2 CARBONYL) -4 PHENYL) -2 PROPIONIC |
DE19792912052 DE2912052C2 (en) | 1978-09-12 | 1979-03-27 | Process for the preparation of 2- [4- (2-thienylcarbonyl) phenyl] propionic acid |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11199178A JPS5538340A (en) | 1978-09-12 | 1978-09-12 | Preparation of 2- 4-(2-thienylcarbonyl)phenyl propionic acid |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5538340A true JPS5538340A (en) | 1980-03-17 |
JPS5728709B2 JPS5728709B2 (en) | 1982-06-18 |
Family
ID=14575197
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP11199178A Granted JPS5538340A (en) | 1978-09-12 | 1978-09-12 | Preparation of 2- 4-(2-thienylcarbonyl)phenyl propionic acid |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5538340A (en) |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS4993346A (en) * | 1972-10-24 | 1974-09-05 |
-
1978
- 1978-09-12 JP JP11199178A patent/JPS5538340A/en active Granted
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS4993346A (en) * | 1972-10-24 | 1974-09-05 |
Also Published As
Publication number | Publication date |
---|---|
JPS5728709B2 (en) | 1982-06-18 |
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