JPS5748983A - Thiazoldine derivative - Google Patents

Thiazoldine derivative

Info

Publication number
JPS5748983A
JPS5748983A JP12370280A JP12370280A JPS5748983A JP S5748983 A JPS5748983 A JP S5748983A JP 12370280 A JP12370280 A JP 12370280A JP 12370280 A JP12370280 A JP 12370280A JP S5748983 A JPS5748983 A JP S5748983A
Authority
JP
Japan
Prior art keywords
compound
formula
pyridyl
hydrolysis
halogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP12370280A
Other languages
Japanese (ja)
Other versions
JPS639517B2 (en
Inventor
Yutaka Kawamatsu
Yujiro Yamamoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SENJIYU SEIYAKU KK
Senju Pharmaceutical Co Ltd
Takeda Pharmaceutical Co Ltd
Original Assignee
SENJIYU SEIYAKU KK
Senju Pharmaceutical Co Ltd
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SENJIYU SEIYAKU KK, Senju Pharmaceutical Co Ltd, Takeda Chemical Industries Ltd filed Critical SENJIYU SEIYAKU KK
Priority to JP12370280A priority Critical patent/JPS5748983A/en
Publication of JPS5748983A publication Critical patent/JPS5748983A/en
Publication of JPS639517B2 publication Critical patent/JPS639517B2/ja
Granted legal-status Critical Current

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  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A compound of formula I (R is thienyl or pyridyl, which may have substituents such as lower alkyl, alkoxy or halogen on the ring).
EXAMPLE: 5-(2-Ethoxy-5-pyridyl)thiazolidin-2,4-dione.
USE: Preventive for diabetic cataract, neurosis and retinopathy.
PREPARATION: The reaction between a compound of formula II (X is halogen; Z is nitrile, carboxyl, alkoxycarbonyl) and thiourea is followed by the hydrolysis of the product, the compound of formula III, to give the compound of formula I. The first reaction is conducted in a solvent such as alcohol, ether or DMF at 100W130°C. The hydrolysis is effected in the presence of water and a mineral acid in a solvent such as sulfolane under heating.
COPYRIGHT: (C)1982,JPO&Japio
JP12370280A 1980-09-05 1980-09-05 Thiazoldine derivative Granted JPS5748983A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP12370280A JPS5748983A (en) 1980-09-05 1980-09-05 Thiazoldine derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP12370280A JPS5748983A (en) 1980-09-05 1980-09-05 Thiazoldine derivative

Publications (2)

Publication Number Publication Date
JPS5748983A true JPS5748983A (en) 1982-03-20
JPS639517B2 JPS639517B2 (en) 1988-02-29

Family

ID=14867221

Family Applications (1)

Application Number Title Priority Date Filing Date
JP12370280A Granted JPS5748983A (en) 1980-09-05 1980-09-05 Thiazoldine derivative

Country Status (1)

Country Link
JP (1) JPS5748983A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992014730A1 (en) * 1991-02-25 1992-09-03 Kyorin Pharmaceutical Co., Ltd. Thiazolidine-2,4-dione derivative, salt thereof, and production thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992014730A1 (en) * 1991-02-25 1992-09-03 Kyorin Pharmaceutical Co., Ltd. Thiazolidine-2,4-dione derivative, salt thereof, and production thereof
US5308856A (en) * 1991-02-25 1994-05-03 Kyorin Pharmaceutical Co., Ltd. Thiazolidine-2,4-dione derivatives, salts and preparation processes thereof

Also Published As

Publication number Publication date
JPS639517B2 (en) 1988-02-29

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