JPS5728075A - Thiazolidine derivative - Google Patents

Thiazolidine derivative

Info

Publication number
JPS5728075A
JPS5728075A JP10471880A JP10471880A JPS5728075A JP S5728075 A JPS5728075 A JP S5728075A JP 10471880 A JP10471880 A JP 10471880A JP 10471880 A JP10471880 A JP 10471880A JP S5728075 A JPS5728075 A JP S5728075A
Authority
JP
Japan
Prior art keywords
formula
compound shown
thiazolidine
alkyl
give
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP10471880A
Other languages
Japanese (ja)
Other versions
JPH0118905B2 (en
Inventor
Yutaka Kawamatsu
Yujiro Yamamoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SENJIYU SEIYAKU KK
Senju Pharmaceutical Co Ltd
Takeda Pharmaceutical Co Ltd
Original Assignee
SENJIYU SEIYAKU KK
Senju Pharmaceutical Co Ltd
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SENJIYU SEIYAKU KK, Senju Pharmaceutical Co Ltd, Takeda Chemical Industries Ltd filed Critical SENJIYU SEIYAKU KK
Priority to JP10471880A priority Critical patent/JPS5728075A/en
Priority to AU66100/81A priority patent/AU6610081A/en
Priority to PH25117A priority patent/PH15937A/en
Priority to US06/227,786 priority patent/US4387101A/en
Priority to GR63938A priority patent/GR72992B/el
Priority to AR284033A priority patent/AR228144A1/en
Priority to PT72390A priority patent/PT72390B/en
Priority to DK30781A priority patent/DK30781A/en
Priority to EP81300308A priority patent/EP0033617A3/en
Priority to ES508490A priority patent/ES508490A0/en
Publication of JPS5728075A publication Critical patent/JPS5728075A/en
Publication of JPH0118905B2 publication Critical patent/JPH0118905B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

NEW MATERIAL:A thiazolidine derivative shown by the formula I (R is phenyl having two or more substitutent groups selected from the group consisting of alkyl, alkoxy, OH, halogen etc. on the ring or having a methlenedioxy in adjoining positions on the ring; R1 is H or alkyl).
EXAMPLE: 5-(3,4-Diethoxyphenyl)thiazolidine-2,4-dione.
USE: Useful for diabetic cataract, diabetic neurosis and retinopathy.
PROCESS: A compound shown by the formula II (X is halogen; Z is nitrile, carboxy, alkoxycarbonyl, etc.) is reacted with thio urea to give a compound shown by the formula III (Y is O or imino), which is hydrolyzed to give a compound shown by the formula I.
COPYRIGHT: (C)1982,JPO&Japio
JP10471880A 1980-01-24 1980-07-29 Thiazolidine derivative Granted JPS5728075A (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
JP10471880A JPS5728075A (en) 1980-07-29 1980-07-29 Thiazolidine derivative
AU66100/81A AU6610081A (en) 1980-01-24 1981-01-09 Thiazolidine derivatives
PH25117A PH15937A (en) 1980-01-24 1981-01-21 Thiazolidine derivatives and their pharmaceutical compositions
US06/227,786 US4387101A (en) 1980-01-24 1981-01-21 Thiazolidine derivatives and their use
GR63938A GR72992B (en) 1980-01-24 1981-01-22
AR284033A AR228144A1 (en) 1980-01-24 1981-01-22 PROCEDURE FOR OBTAINING DERIVATIVES OF 5-PHENYL-TRIAZOLIDINE-2,4-DIONA AND ITS SALTS
PT72390A PT72390B (en) 1980-01-24 1981-01-23 Thiazol dine derivatives and their production and use
DK30781A DK30781A (en) 1980-01-24 1981-01-23 PROCEDURE FOR THE PREPARATION OF TRIAZOLIDE INGREDIATES
EP81300308A EP0033617A3 (en) 1980-01-24 1981-01-23 Thiazolidine derivatives and their production and medicinal compositions containing them
ES508490A ES508490A0 (en) 1980-01-24 1981-12-31 "A METHOD OF PRODUCTION OF THIAZOLIDINE DERIVATIVES".

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10471880A JPS5728075A (en) 1980-07-29 1980-07-29 Thiazolidine derivative

Publications (2)

Publication Number Publication Date
JPS5728075A true JPS5728075A (en) 1982-02-15
JPH0118905B2 JPH0118905B2 (en) 1989-04-07

Family

ID=14388256

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10471880A Granted JPS5728075A (en) 1980-01-24 1980-07-29 Thiazolidine derivative

Country Status (1)

Country Link
JP (1) JPS5728075A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59137474A (en) * 1983-01-17 1984-08-07 ファイザ−・インコ−ポレ−テッド 5-(2-alkoxyphenyl)thiazolidindiones inhibiting aldose reductase
JPS6143114A (en) * 1984-08-03 1986-03-01 Takeda Chem Ind Ltd Eye drop for remedy of iridal and ciliary disease

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59137474A (en) * 1983-01-17 1984-08-07 ファイザ−・インコ−ポレ−テッド 5-(2-alkoxyphenyl)thiazolidindiones inhibiting aldose reductase
JPH0329073B2 (en) * 1983-01-17 1991-04-23 Pfizer
JPS6143114A (en) * 1984-08-03 1986-03-01 Takeda Chem Ind Ltd Eye drop for remedy of iridal and ciliary disease
JPH027574B2 (en) * 1984-08-03 1990-02-19 Takeda Yakuhin Kogyo Kk

Also Published As

Publication number Publication date
JPH0118905B2 (en) 1989-04-07

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