JPS6419077A - Thiazolidine derivative - Google Patents

Thiazolidine derivative

Info

Publication number
JPS6419077A
JPS6419077A JP17526487A JP17526487A JPS6419077A JP S6419077 A JPS6419077 A JP S6419077A JP 17526487 A JP17526487 A JP 17526487A JP 17526487 A JP17526487 A JP 17526487A JP S6419077 A JPS6419077 A JP S6419077A
Authority
JP
Japan
Prior art keywords
formula
halogen
compound shown
imidazolyl
benzyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP17526487A
Other languages
Japanese (ja)
Inventor
Kunihiro Niigata
Minoru Okada
Takashi Yoneda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yamanouchi Pharmaceutical Co Ltd
Original Assignee
Yamanouchi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamanouchi Pharmaceutical Co Ltd filed Critical Yamanouchi Pharmaceutical Co Ltd
Priority to JP17526487A priority Critical patent/JPS6419077A/en
Publication of JPS6419077A publication Critical patent/JPS6419077A/en
Pending legal-status Critical Current

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  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A compound shown by formula I [ring A is unsubstituted or contains 1-2 halogens; R is H or substituent group (group shown by formula III, imidazolyl, thienyl or naphthyl which may contain halogen): ring B contains substituent group (1-5 halogen, NO2, NH2, imidazolyl-1-ylmethyl or group shown by formula IV); n is 3, 4 or 5] or a salt thereof. EXAMPLE:5-[ 3,4-Dihydro-3-[p-[5-bromo-2-(3-pyridyl)-4-thiazolyl ]benzyl] -4-oxo-1- phthalazinyl]thiazolidine-2,4-dione. USE:An aldose reductase inhibitor useful for preventing and treating diabetic complication. PREPARATION:A compound shown by formula II (R<1> is halogen or organic sulfonyloxy; R<2> is H, lower alkyl or benzyl) is reacted with thiourea and hydro lyzed to give a compound shown by formula I.
JP17526487A 1987-07-13 1987-07-13 Thiazolidine derivative Pending JPS6419077A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP17526487A JPS6419077A (en) 1987-07-13 1987-07-13 Thiazolidine derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP17526487A JPS6419077A (en) 1987-07-13 1987-07-13 Thiazolidine derivative

Publications (1)

Publication Number Publication Date
JPS6419077A true JPS6419077A (en) 1989-01-23

Family

ID=15993112

Family Applications (1)

Application Number Title Priority Date Filing Date
JP17526487A Pending JPS6419077A (en) 1987-07-13 1987-07-13 Thiazolidine derivative

Country Status (1)

Country Link
JP (1) JPS6419077A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01211585A (en) * 1987-12-21 1989-08-24 Pfizer Inc Heterocyclic oxophtharadinyl acetic acids
WO1991012251A1 (en) * 1990-02-19 1991-08-22 Chugai Seiyaku Kabushiki Kaisha Novel fused heterocyclic compound and antiasthmatic agent prepared therefrom
WO1992014730A1 (en) * 1991-02-25 1992-09-03 Kyorin Pharmaceutical Co., Ltd. Thiazolidine-2,4-dione derivative, salt thereof, and production thereof
WO2002085885A1 (en) * 2001-04-25 2002-10-31 Altana Pharma Ag Piperazino-derivatives and their use as pde4 inhibitor

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01211585A (en) * 1987-12-21 1989-08-24 Pfizer Inc Heterocyclic oxophtharadinyl acetic acids
WO1991012251A1 (en) * 1990-02-19 1991-08-22 Chugai Seiyaku Kabushiki Kaisha Novel fused heterocyclic compound and antiasthmatic agent prepared therefrom
WO1992014730A1 (en) * 1991-02-25 1992-09-03 Kyorin Pharmaceutical Co., Ltd. Thiazolidine-2,4-dione derivative, salt thereof, and production thereof
US5308856A (en) * 1991-02-25 1994-05-03 Kyorin Pharmaceutical Co., Ltd. Thiazolidine-2,4-dione derivatives, salts and preparation processes thereof
WO2002085885A1 (en) * 2001-04-25 2002-10-31 Altana Pharma Ag Piperazino-derivatives and their use as pde4 inhibitor

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