JPS6419077A - Thiazolidine derivative - Google Patents
Thiazolidine derivativeInfo
- Publication number
- JPS6419077A JPS6419077A JP17526487A JP17526487A JPS6419077A JP S6419077 A JPS6419077 A JP S6419077A JP 17526487 A JP17526487 A JP 17526487A JP 17526487 A JP17526487 A JP 17526487A JP S6419077 A JPS6419077 A JP S6419077A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- halogen
- compound shown
- imidazolyl
- benzyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A compound shown by formula I [ring A is unsubstituted or contains 1-2 halogens; R is H or substituent group (group shown by formula III, imidazolyl, thienyl or naphthyl which may contain halogen): ring B contains substituent group (1-5 halogen, NO2, NH2, imidazolyl-1-ylmethyl or group shown by formula IV); n is 3, 4 or 5] or a salt thereof. EXAMPLE:5-[ 3,4-Dihydro-3-[p-[5-bromo-2-(3-pyridyl)-4-thiazolyl ]benzyl] -4-oxo-1- phthalazinyl]thiazolidine-2,4-dione. USE:An aldose reductase inhibitor useful for preventing and treating diabetic complication. PREPARATION:A compound shown by formula II (R<1> is halogen or organic sulfonyloxy; R<2> is H, lower alkyl or benzyl) is reacted with thiourea and hydro lyzed to give a compound shown by formula I.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP17526487A JPS6419077A (en) | 1987-07-13 | 1987-07-13 | Thiazolidine derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP17526487A JPS6419077A (en) | 1987-07-13 | 1987-07-13 | Thiazolidine derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS6419077A true JPS6419077A (en) | 1989-01-23 |
Family
ID=15993112
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP17526487A Pending JPS6419077A (en) | 1987-07-13 | 1987-07-13 | Thiazolidine derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS6419077A (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH01211585A (en) * | 1987-12-21 | 1989-08-24 | Pfizer Inc | Heterocyclic oxophtharadinyl acetic acids |
WO1991012251A1 (en) * | 1990-02-19 | 1991-08-22 | Chugai Seiyaku Kabushiki Kaisha | Novel fused heterocyclic compound and antiasthmatic agent prepared therefrom |
WO1992014730A1 (en) * | 1991-02-25 | 1992-09-03 | Kyorin Pharmaceutical Co., Ltd. | Thiazolidine-2,4-dione derivative, salt thereof, and production thereof |
WO2002085885A1 (en) * | 2001-04-25 | 2002-10-31 | Altana Pharma Ag | Piperazino-derivatives and their use as pde4 inhibitor |
-
1987
- 1987-07-13 JP JP17526487A patent/JPS6419077A/en active Pending
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH01211585A (en) * | 1987-12-21 | 1989-08-24 | Pfizer Inc | Heterocyclic oxophtharadinyl acetic acids |
WO1991012251A1 (en) * | 1990-02-19 | 1991-08-22 | Chugai Seiyaku Kabushiki Kaisha | Novel fused heterocyclic compound and antiasthmatic agent prepared therefrom |
WO1992014730A1 (en) * | 1991-02-25 | 1992-09-03 | Kyorin Pharmaceutical Co., Ltd. | Thiazolidine-2,4-dione derivative, salt thereof, and production thereof |
US5308856A (en) * | 1991-02-25 | 1994-05-03 | Kyorin Pharmaceutical Co., Ltd. | Thiazolidine-2,4-dione derivatives, salts and preparation processes thereof |
WO2002085885A1 (en) * | 2001-04-25 | 2002-10-31 | Altana Pharma Ag | Piperazino-derivatives and their use as pde4 inhibitor |
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