JPS6452765A - Thiazolidine derivative - Google Patents

Thiazolidine derivative

Info

Publication number
JPS6452765A
JPS6452765A JP20950087A JP20950087A JPS6452765A JP S6452765 A JPS6452765 A JP S6452765A JP 20950087 A JP20950087 A JP 20950087A JP 20950087 A JP20950087 A JP 20950087A JP S6452765 A JPS6452765 A JP S6452765A
Authority
JP
Japan
Prior art keywords
formula
compound expressed
alkyl
lower alkyl
alkenylene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP20950087A
Other languages
Japanese (ja)
Other versions
JP2558473B2 (en
Inventor
Yasuyuki Mizuta
Makoto Murata
Shunsuke Naruto
Buichi Fujitani
Toshiaki Kadokawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dainippon Pharmaceutical Co Ltd
Original Assignee
Dainippon Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dainippon Pharmaceutical Co Ltd filed Critical Dainippon Pharmaceutical Co Ltd
Priority to JP62209500A priority Critical patent/JP2558473B2/en
Publication of JPS6452765A publication Critical patent/JPS6452765A/en
Application granted granted Critical
Publication of JP2558473B2 publication Critical patent/JP2558473B2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A compound expressed by formula I [R1 is H, 1-15C alkyl which may have a substituent group (COOH or lower alkoxycarbonyl) or amino which may have acyl; R2 is H or lower alkyl; X is S or O; R3 is formula II-V; R4 is H, lower alkyl or aralkyl; R5-R8 are H, OH, halogen, lower alkyl, lower alkoxy, CN, CF3 or NH2; A is lower alkylene or lower alkenylene, provided that A is >=2C lower alkylene or >=3C lower alkenylene when X is S; R5 and R8 are H; R1 is H, C4H5 or CH2COOH] and salts thereof. EXAMPLE:5-( 3-Carboxymethoxy-4-methoxybenzylidene )-4-oxo-2-thioxothiazolidi ne-3-acetic acid. USE:An aldose reductase inhibitor and hypoglycemic agent useful for preventing and treating diabetic complications. PREPARATION:A compound expressed by formula VI is reacted with a compound expressed by formula VII to afford the aimed compound expressed by formula I.
JP62209500A 1987-08-24 1987-08-24 Thiazolidine derivative Expired - Lifetime JP2558473B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP62209500A JP2558473B2 (en) 1987-08-24 1987-08-24 Thiazolidine derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP62209500A JP2558473B2 (en) 1987-08-24 1987-08-24 Thiazolidine derivative

Publications (2)

Publication Number Publication Date
JPS6452765A true JPS6452765A (en) 1989-02-28
JP2558473B2 JP2558473B2 (en) 1996-11-27

Family

ID=16573835

Family Applications (1)

Application Number Title Priority Date Filing Date
JP62209500A Expired - Lifetime JP2558473B2 (en) 1987-08-24 1987-08-24 Thiazolidine derivative

Country Status (1)

Country Link
JP (1) JP2558473B2 (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU701068B2 (en) * 1995-08-28 1999-01-21 American Home Products Corporation Phenoxy acetic acids as aldose reductase inhibitors and antihyperglycemic agents
US5889025A (en) * 1996-05-06 1999-03-30 Reddy's Research Foundation Antidiabetic compounds having hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
US5919782A (en) * 1996-05-06 1999-07-06 Dr. Reddy's Research Foundation Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
US5985884A (en) * 1996-07-01 1999-11-16 Dr. Reddy's Research Foundation Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
US6114526A (en) * 1996-07-01 2000-09-05 Dr. Reddy's Research Foundation Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
US6372750B2 (en) 1996-07-01 2002-04-16 Dr. Reddy's Research Foundation Heterocyclic compounds, process for their preparation and pharmaceutical compounds containing them and their use in the treatment of diabetes and related diseases
USRE39266E1 (en) 1996-07-01 2006-09-05 Dr. Reddy's Laboratories, Limited Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU701068B2 (en) * 1995-08-28 1999-01-21 American Home Products Corporation Phenoxy acetic acids as aldose reductase inhibitors and antihyperglycemic agents
US5889025A (en) * 1996-05-06 1999-03-30 Reddy's Research Foundation Antidiabetic compounds having hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
US5919782A (en) * 1996-05-06 1999-07-06 Dr. Reddy's Research Foundation Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
US5985884A (en) * 1996-07-01 1999-11-16 Dr. Reddy's Research Foundation Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
US6114526A (en) * 1996-07-01 2000-09-05 Dr. Reddy's Research Foundation Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
US6310069B1 (en) 1996-07-01 2001-10-30 Dr. Reddy's Research Foundation Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
US6372750B2 (en) 1996-07-01 2002-04-16 Dr. Reddy's Research Foundation Heterocyclic compounds, process for their preparation and pharmaceutical compounds containing them and their use in the treatment of diabetes and related diseases
US6573268B1 (en) 1996-07-01 2003-06-03 Dr. Reddy's Laboratories Ltd. Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
US6780992B2 (en) 1996-07-01 2004-08-24 Dr. Reddy's Laboratories Ltd. Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
USRE39266E1 (en) 1996-07-01 2006-09-05 Dr. Reddy's Laboratories, Limited Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases

Also Published As

Publication number Publication date
JP2558473B2 (en) 1996-11-27

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