RU92004433A - AROMATIC AMINOSPIRAL DERIVATIVES, METHOD FOR THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITION - Google Patents

AROMATIC AMINOSPIRAL DERIVATIVES, METHOD FOR THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITION

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Publication number
RU92004433A
RU92004433A RU92004433/04A RU92004433A RU92004433A RU 92004433 A RU92004433 A RU 92004433A RU 92004433/04 A RU92004433/04 A RU 92004433/04A RU 92004433 A RU92004433 A RU 92004433A RU 92004433 A RU92004433 A RU 92004433A
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RU
Russia
Prior art keywords
aminospiral
aromatic
derivatives
production
pharmaceutical composition
Prior art date
Application number
RU92004433/04A
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Russian (ru)
Other versions
RU2095344C1 (en
Inventor
Фудзита Такаси
Есиока Такао
Хорикоси Хироеси
Есиока Синдзи
Original Assignee
Санкио Компани Лимитед
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Publication date
Application filed by Санкио Компани Лимитед filed Critical Санкио Компани Лимитед
Publication of RU92004433A publication Critical patent/RU92004433A/en
Application granted granted Critical
Publication of RU2095344C1 publication Critical patent/RU2095344C1/en

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Claims (1)

Предложены соединения формулы
Figure 00000001

где R0 - водородный атом, метил или гидроксиметил; R1 - замещенный алкил; каждый из R2 и R3 - атом водорода или галогена, гидрокси, алкокси-, карбоксигруппа, алкоксикарбонил, алкил, нитрогруппа, галоидалкил или замещенный алкил; X - атом кислорода или серы; Ar - возможно замещенный фенил или нафтил; их фармацевтически приемлемые соли, обладающие различными ценными фармацевтическими активностями, включая антидиабетическую активность и активность против ожирения. Кроме того, они пригодны для лечения или профилактики гиперлицемии и гипергликемии, а благодаря ингибированию действия альдозоредуктазы они также могут быть эффективными при лечении и профилактике осложнений диабетов.The proposed compounds of the formula
Figure 00000001

where R 0 is a hydrogen atom, methyl or hydroxymethyl; R 1 is substituted alkyl; each of R 2 and R 3 is a hydrogen or halogen atom, a hydroxy, alkoxy, carboxy group, alkoxycarbonyl, alkyl, nitro, haloalkyl or substituted alkyl; X is an oxygen or sulfur atom; Ar - possibly substituted phenyl or naphthyl; their pharmaceutically acceptable salts with various valuable pharmaceutical activities, including anti-diabetic and anti-obesity activities. In addition, they are suitable for treating or preventing hyperlicemia and hyperglycemia, and by inhibiting the action of aldose reductase, they can also be effective in treating and preventing complications of diabetes.
RU92004433/04A 1991-11-20 1992-11-19 1-amino-2-substituted phenylethanol derivatives and method of preparing thereof (variants) RU2095344C1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP30458191 1991-11-20
JP3-304581 1991-11-20

Related Child Applications (1)

Application Number Title Priority Date Filing Date
RU94036004/04A Division RU2081113C1 (en) 1991-11-20 1994-09-30 Thiazoliden-2,4-dione derivative, process for preparation thereof, thiazolidin-2,4-dione derivative as intermediate product when preparing aromatic aminoalcohol derivatives

Publications (2)

Publication Number Publication Date
RU92004433A true RU92004433A (en) 1996-04-27
RU2095344C1 RU2095344C1 (en) 1997-11-10

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ID=17934718

Family Applications (2)

Application Number Title Priority Date Filing Date
RU92004433/04A RU2095344C1 (en) 1991-11-20 1992-11-19 1-amino-2-substituted phenylethanol derivatives and method of preparing thereof (variants)
RU94036004/04A RU2081113C1 (en) 1991-11-20 1994-09-30 Thiazoliden-2,4-dione derivative, process for preparation thereof, thiazolidin-2,4-dione derivative as intermediate product when preparing aromatic aminoalcohol derivatives

Family Applications After (1)

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RU94036004/04A RU2081113C1 (en) 1991-11-20 1994-09-30 Thiazoliden-2,4-dione derivative, process for preparation thereof, thiazolidin-2,4-dione derivative as intermediate product when preparing aromatic aminoalcohol derivatives

Country Status (23)

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US (3) US5977374A (en)
EP (1) EP0543662B1 (en)
JP (2) JP2654323B2 (en)
KR (1) KR0149679B1 (en)
CN (3) CN1033750C (en)
AT (1) ATE143002T1 (en)
AU (2) AU655689B2 (en)
CA (1) CA2083323A1 (en)
CZ (2) CZ280820B6 (en)
DE (1) DE69213892T2 (en)
DK (1) DK0543662T3 (en)
ES (1) ES2094308T3 (en)
FI (1) FI925255A (en)
GR (1) GR3021245T3 (en)
HK (1) HK218496A (en)
HU (1) HUT66816A (en)
IL (3) IL110804A (en)
MX (1) MX9206740A (en)
NO (1) NO179246C (en)
NZ (1) NZ245188A (en)
RU (2) RU2095344C1 (en)
TW (2) TW290543B (en)
ZA (1) ZA928960B (en)

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