ES454656A1 - Heterocyclic compounds - Google Patents

Heterocyclic compounds

Info

Publication number
ES454656A1
ES454656A1 ES454656A ES454656A ES454656A1 ES 454656 A1 ES454656 A1 ES 454656A1 ES 454656 A ES454656 A ES 454656A ES 454656 A ES454656 A ES 454656A ES 454656 A1 ES454656 A1 ES 454656A1
Authority
ES
Spain
Prior art keywords
ring
het
optionally substituted
bromine
sulfur
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES454656A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Smith Kline and French Laboratories Ltd
Original Assignee
Smith Kline and French Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smith Kline and French Laboratories Ltd filed Critical Smith Kline and French Laboratories Ltd
Publication of ES454656A1 publication Critical patent/ES454656A1/en
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/56One oxygen atom and one sulfur atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Procedure for preparing 4-pyrimidone and 4-thione derivatives, of formula: **(See formula)** wherein Het is a 2- or 4-imidazolyl ring optionally substituted by lower alkyl (preferably methyl), halogen (preferably chlorine or bromine), trifluoromethyl or hydroxymethyl, a 2-pyridium ring optionally substituted by lower alkyl (preferably methyl), lower alkoxy (preferably methoxy), halogen (preferably chlorine or bromine), amino or hydroxy, a 2-thiazolyl ring, a 3-isothiazolyl ring optionally substituted by chlorine or bromine, a 3- (l, 2,5) -thiadiazolyl ring optionally substituted by chlorine or bromine, or a 2- (5-amino-1,3,4-thiadiazolyl) ring; Y is sulfur or a methylene group; Z is hydrogen or lower alkyl (preferably methyl); X is oxygen or sulfur; W is methylene, oxygen or sulfur; p and q are such that their sum is from 1 to 4 when w is oxygen or sulfur, or from 0 to 4 when W is methylene; Het'is a 5- or 6-membered heterocycle such as pyridine, furan, thiophene, thiazole, oxazole, isothiazole, imidazole, pyrimidine, pyrazine, or pyridazine, the ring of which is optionally substituted by lower alkyl, lower alkoxy, or may have a benzene ring or substituted benzene ring fused thereto; characterized in that it comprises treating an isocytosine of the formula: **(See formula)** where Z, W, p, q and Het'are defined as above and Q is lower alkylthio, benzylthio, halogen or other group conveniently displaced by an amine, with an amine of formula: Het-CH2-Y- (CH2) 2-HH2 where Het and Y are defined as above. (Machine-translation by Google Translate, not legally binding)
ES454656A 1975-12-29 1976-12-29 Heterocyclic compounds Expired ES454656A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB5300175 1975-12-29

Publications (1)

Publication Number Publication Date
ES454656A1 true ES454656A1 (en) 1977-11-16

Family

ID=10466233

Family Applications (1)

Application Number Title Priority Date Filing Date
ES454656A Expired ES454656A1 (en) 1975-12-29 1976-12-29 Heterocyclic compounds

Country Status (37)

Country Link
JP (1) JPS5283388A (en)
AR (1) AR222290A1 (en)
AT (1) AT360024B (en)
AU (1) AU508123B2 (en)
BE (1) BE849810A (en)
BG (1) BG29722A3 (en)
CA (1) CA1073458A (en)
CH (1) CH631981A5 (en)
CS (1) CS203995B2 (en)
DD (1) DD128588A5 (en)
DE (1) DE2658267A1 (en)
DK (1) DK587076A (en)
EG (1) EG12439A (en)
ES (1) ES454656A1 (en)
FI (1) FI62668C (en)
FR (1) FR2336935A1 (en)
GR (1) GR62441B (en)
HU (1) HU175171B (en)
IE (1) IE45082B1 (en)
IL (1) IL51040A (en)
IT (2) IT1124740B (en)
LU (1) LU76481A1 (en)
MW (1) MW5076A1 (en)
MX (1) MX5119E (en)
NL (1) NL7614538A (en)
NO (1) NO146396C (en)
NZ (1) NZ182759A (en)
OA (1) OA05526A (en)
PH (1) PH14723A (en)
PL (1) PL104376B1 (en)
PT (1) PT65949B (en)
RO (1) RO72475A (en)
SE (1) SE431544B (en)
SU (1) SU791235A3 (en)
YU (1) YU311676A (en)
ZA (1) ZA767198B (en)
ZM (1) ZM14376A1 (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ186511A (en) 1977-03-19 1980-11-14 Smith Kline French Lab 3-substituted alkylamino-6-substituted alkyl-1,2,4-triazin-5-ones and pharmaceutical compositions 3-substituted thio-1,2,4-triazin-5-ones
IL56265A (en) * 1977-12-28 1982-08-31 Om Lab Sa Process for preparing imidazolyl methylthio guanidine derivatives and a novel intermediate therefor
IN151188B (en) * 1978-02-13 1983-03-05 Smith Kline French Lab
US4539207A (en) * 1978-02-13 1985-09-03 Smith Kline & French Laboratories Limited Pyrimidine compounds
AU527202B2 (en) * 1978-04-11 1983-02-24 Smith Kline & French Laboratories Limited 2-aminopyrimidones
ZA792607B (en) * 1978-05-30 1980-07-30 Smith Kline French Lab Nitro compounds
ZA793392B (en) * 1978-07-15 1980-08-27 Smith Kline French Lab Isoureas and isothioureas
US4374836A (en) 1978-10-16 1983-02-22 Imperial Chemical Industries Ltd. Antisecretory heterocyclic derivatives, process for their manufacture and pharmaceutical compositions containing them
US4309435A (en) 1978-10-16 1982-01-05 Imperial Chemical Industries Ltd. Antisecretory guanidine derivatives and pharmaceutical compositions containing them
US4496567A (en) * 1978-11-13 1985-01-29 Smith Kline & French Laboratories Limited Phenyl alkylaminopyrimidones
US4521418A (en) * 1979-02-21 1985-06-04 Smith Kline & French Laboratories Limited Guanidinothiazolyl derivatives
US4255428A (en) 1979-03-24 1981-03-10 Smith Kline & French Laboratories Limited 5-(Hydroxypyridylalkyl)-4-pyrimidones
JPS55133379A (en) * 1979-04-05 1980-10-17 Smith Kline French Lab Pyrimidone compound
DE2962542D1 (en) * 1979-04-11 1982-06-03 Smith Kline French Lab Pyrimidone derivatives, process for preparing them and pharmaceutical compositions containing them
JPS55145683A (en) * 1979-04-26 1980-11-13 Smith Kline French Lab Pyrimidone derivative
CA1155842A (en) * 1980-03-29 1983-10-25 Thomas H. Brown Compounds
ZW21281A1 (en) * 1980-10-01 1981-11-18 Smith Kline French Lab Amine derivatives
IE53068B1 (en) * 1981-06-15 1988-05-25 Merck & Co Inc Diamino isothiazole-1-oxides and -1,1-dioxides as gastic secretion inhibitors
PT75074B (en) * 1981-06-27 1986-02-26 Smith Kline French Lab Process for preparing certain pyrimidone derivatives and compositions containing them
US6417366B2 (en) * 1999-06-24 2002-07-09 Abbott Laboratories Preparation of quinoline-substituted carbonate and carbamate derivatives

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1419994A (en) * 1973-05-03 1976-01-07 Smith Kline French Lab Heterocyclicalkylaminotheterocyclic compounds methods for their preparation and compositions comprising them
IN146736B (en) * 1975-10-02 1979-08-25 Smith Kline French Lab

Also Published As

Publication number Publication date
ATA960876A (en) 1980-05-15
RO72475A (en) 1982-10-26
DK587076A (en) 1977-06-30
AT360024B (en) 1980-12-10
SE7614620L (en) 1977-06-30
FI62668B (en) 1982-10-29
IE45082L (en) 1977-06-29
HU175171B (en) 1980-05-28
NO764370L (en) 1977-06-30
IL51040A0 (en) 1977-02-28
ZA767198B (en) 1977-11-30
FI763664A (en) 1977-06-30
FI62668C (en) 1983-02-10
PT65949A (en) 1977-01-01
CS203995B2 (en) 1981-03-31
NO146396B (en) 1982-06-14
ZM14376A1 (en) 1977-08-22
PH14723A (en) 1981-11-13
PL104376B1 (en) 1979-08-31
IT7919107A0 (en) 1979-01-05
AU508123B2 (en) 1980-03-13
AR222290A1 (en) 1981-05-15
EG12439A (en) 1979-09-30
FR2336935B1 (en) 1980-03-21
JPS5283388A (en) 1977-07-12
JPS6129355B2 (en) 1986-07-05
CA1073458A (en) 1980-03-11
PT65949B (en) 1978-06-15
NL7614538A (en) 1977-07-01
GR62441B (en) 1979-04-12
IT1124740B (en) 1986-05-14
OA05526A (en) 1981-04-30
IE45082B1 (en) 1982-06-16
YU311676A (en) 1983-01-21
SE431544B (en) 1984-02-13
SU791235A3 (en) 1980-12-23
MW5076A1 (en) 1978-02-08
AU2097676A (en) 1978-07-06
DD128588A5 (en) 1977-11-30
FR2336935A1 (en) 1977-07-29
MX5119E (en) 1983-03-24
DE2658267A1 (en) 1977-07-07
NO146396C (en) 1982-09-22
BG29722A3 (en) 1981-01-15
NZ182759A (en) 1978-06-02
LU76481A1 (en) 1977-06-15
CH631981A5 (en) 1982-09-15
BE849810A (en) 1977-06-23
IL51040A (en) 1980-12-31

Similar Documents

Publication Publication Date Title
ES454656A1 (en) Heterocyclic compounds
DK276985A (en) BENZOFURAND DERIVATIVES AND PHARMACEUTICAL PREPARATIONS CONTAINING SUCH A RELATIONSHIP
ECSP941146A (en) BENZOFURAN DERIVATIVES
KR890005095A (en) New compounds
ES452060A1 (en) Heterocyclic compound
KR870004981A (en) Process for the preparation of heterocyclic oxophthalazinyl acetic acid
ES517331A0 (en) PROCEDURE FOR PREPARING PIRIDAZINONE DERIVATIVES.
JPS5553288A (en) Heterocyclic derivative*its manufacture and medical composition containing it and having secretion controlling activity
KR850008489A (en) Preparation of Cephalosporin Derivatives
DE3768578D1 (en) CHINOLINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THE MICROBICIDES CONTAINING THE SAME AND THE USE THEREOF FOR CONTROLLING BACTERIA AND MUSHROOMS.
ES467953A1 (en) Pharmacologically active triazinones
ES450309A1 (en) Pharmacologically active compounds 4-substituted-imidazole-5-methanols
SE7603951L (en) PROCEDURE FOR THE PREPARATION OF 7-ALFA- (4-HYDROCI-1,5-NAFTHYDRINE-3CARBONAMIDO) ALFA-PHENYLACETAMIDO-CEPHALOSPORINE DERIVATIVES
ES481119A1 (en) 3-Nitro pyrrole compounds, processes for preparing them and pharmaceutical compositions containing them.
SE7908024L (en) Heterocyclic Associations
ES456991A1 (en) 1,2,3-Thiadiazole-5-yl-urea derivatives, process for making the same and plant retardation and defoliation composition containing same
GR3017814T3 (en) Herbicidal 2-(2-imidazolin -2-yl)-benzazoles.
MY101938A (en) Benzothiazoline fungicides
KR840007420A (en) Method for preparing substituted carboxy-thiazolo [3,2-α] pyrimidine derivatives
AU6368080A (en) Thiazolyl derivatives
KR890002092A (en) 1,3-dithiol-2-ylidene derivative and its preparation method
JPS5227798A (en) Process for preparing heterocyclic compounds
JPS5283887A (en) Heterocyclic compounds
ES458844A1 (en) A procedure for the preparation of new cephalosporins. (Machine-translation by Google Translate, not legally binding)
ES458846A1 (en) A procedure for the preparation of new cephalosporins. (Machine-translation by Google Translate, not legally binding)