ES450309A1 - Pharmacologically active compounds 4-substituted-imidazole-5-methanols - Google Patents
Pharmacologically active compounds 4-substituted-imidazole-5-methanolsInfo
- Publication number
- ES450309A1 ES450309A1 ES450309A ES450309A ES450309A1 ES 450309 A1 ES450309 A1 ES 450309A1 ES 450309 A ES450309 A ES 450309A ES 450309 A ES450309 A ES 450309A ES 450309 A1 ES450309 A1 ES 450309A1
- Authority
- ES
- Spain
- Prior art keywords
- sulfur
- formula
- chno2
- methylene
- lower alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Procedure to prepare anti-histamine compounds, of formula: **(See formula)** where n is 2 or 3; 2 is sulfur or methylene; X ex sulfur, CHNO2 or NCH; Y is hydrogen, lower alkyl, or Het CH2Z'(CH2) n', where Het is 5-Mdroxymethyl-4-imidazolyl or is an imidazole ring optionally substituted by methyl or bromine, a pyridine ring optionally substituted by hydroxy, methoxy, chlorine or bromine, a thiazolyl ring, or an isothiazolyl ring; Z'is sulfur or methylene; and n'is 2 or 3, characterized in that it comprises reacting a compound of formula: **(See formula)** where X is NCN or CHNO2, Q is lower alkyl, B is SQ', OQ', where Q'is lower alkyl, or NHY, where Y is defined as above, and A is sulfur, oxygen or when X is CHNO2 and B is SQ', SO, with a compound of the formula: **(See formula)** where Z is sulfur or methylene and n is 2 or 3. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB31968/75A GB1565647A (en) | 1975-07-31 | 1975-07-31 | Pharmacologically active compounds 4-substituted-imidazole-5-methanols |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES450309A1 true ES450309A1 (en) | 1977-12-01 |
Family
ID=10331071
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES450309A Expired ES450309A1 (en) | 1975-07-31 | 1976-07-30 | Pharmacologically active compounds 4-substituted-imidazole-5-methanols |
Country Status (28)
| Country | Link |
|---|---|
| JP (1) | JPS5219663A (en) |
| AR (1) | AR213100A1 (en) |
| AT (1) | AT356668B (en) |
| AU (1) | AU508262B2 (en) |
| BE (1) | BE843840A (en) |
| CA (1) | CA1075702A (en) |
| CS (1) | CS203054B2 (en) |
| DD (1) | DD125205A5 (en) |
| DE (1) | DE2634430A1 (en) |
| DK (1) | DK316376A (en) |
| ES (1) | ES450309A1 (en) |
| FI (1) | FI762191A (en) |
| FR (1) | FR2319341A1 (en) |
| GB (1) | GB1565647A (en) |
| GR (1) | GR61114B (en) |
| HU (1) | HU174068B (en) |
| IL (1) | IL50006A0 (en) |
| LU (1) | LU75495A1 (en) |
| NL (1) | NL7608505A (en) |
| NO (1) | NO762659L (en) |
| OA (1) | OA05405A (en) |
| PH (1) | PH13417A (en) |
| PT (1) | PT65377B (en) |
| RO (1) | RO72312B (en) |
| SE (1) | SE7608478L (en) |
| SU (1) | SU655310A3 (en) |
| ZA (1) | ZA763686B (en) |
| ZM (1) | ZM9676A1 (en) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ186965A (en) | 1977-04-20 | 1980-02-21 | Ici Ltd | Guanidino derivatives and pharmaceutical compositions |
| US4165378A (en) | 1977-04-20 | 1979-08-21 | Ici Americas Inc. | Guanidine derivatives of imidazoles and thiazoles |
| US4112234A (en) | 1977-08-22 | 1978-09-05 | Bristol-Myers Company | Imidazolylmethylthioethyl alkynyl guanidines |
| USRE31588E (en) * | 1977-06-03 | 1984-05-22 | Bristol-Myers Company | Imidazolylmethylthioethyl alkynyl guanidines |
| US4233302A (en) | 1977-12-23 | 1980-11-11 | Glaxo Group Limited | Amine derivatives and pharmaceutical compositions containing them |
| EP0008596A1 (en) * | 1978-09-04 | 1980-03-19 | DEVINTER Europe S.A. Société anonyme dite: | Preparation of 4-hydroxymethyl-imidazole derivatives from the corresponding 4-imidazole carboxylic acid esters |
| US4200760A (en) * | 1978-09-26 | 1980-04-29 | Bristol-Myers Company | Imidazolylalkylthioalkylamino-ethylene derivatives |
| JPS5914460B2 (en) * | 1978-12-27 | 1984-04-04 | 相互薬工株式会社 | Production method of cimetidine, an anti-H↓2 receptor |
| CN103288742A (en) * | 2013-06-04 | 2013-09-11 | 四川百利药业有限责任公司 | Preparation method for high-purity ingavirin raw material |
| EP4196793A1 (en) | 2020-08-11 | 2023-06-21 | Université de Strasbourg | H2 blockers targeting liver macrophages for the prevention and treatment of liver disease and cancer |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA938556A (en) * | 1970-06-25 | 1973-12-18 | Smith Kline And French Laboratories Limited | Pharmaceutical compositions containing thiourea derivatives |
-
1975
- 1975-07-31 GB GB31968/75A patent/GB1565647A/en not_active Expired
-
1976
- 1976-06-21 ZA ZA763686A patent/ZA763686B/en unknown
- 1976-07-06 BE BE168682A patent/BE843840A/en not_active IP Right Cessation
- 1976-07-09 IL IL50006A patent/IL50006A0/en unknown
- 1976-07-09 PH PH18667A patent/PH13417A/en unknown
- 1976-07-13 DK DK316376A patent/DK316376A/en unknown
- 1976-07-16 PT PT65377A patent/PT65377B/en unknown
- 1976-07-20 FR FR7622069A patent/FR2319341A1/en active Granted
- 1976-07-21 CS CS764839A patent/CS203054B2/en unknown
- 1976-07-22 CA CA257,589A patent/CA1075702A/en not_active Expired
- 1976-07-23 ZM ZM96/76A patent/ZM9676A1/en unknown
- 1976-07-27 SE SE7608478A patent/SE7608478L/en unknown
- 1976-07-27 AT AT552376A patent/AT356668B/en not_active IP Right Cessation
- 1976-07-27 GR GR51356A patent/GR61114B/en unknown
- 1976-07-29 LU LU75495A patent/LU75495A1/xx unknown
- 1976-07-30 SU SU762386215A patent/SU655310A3/en active
- 1976-07-30 AU AU16447/76A patent/AU508262B2/en not_active Expired
- 1976-07-30 NL NL7608505A patent/NL7608505A/en not_active Application Discontinuation
- 1976-07-30 AR AR264157A patent/AR213100A1/en active
- 1976-07-30 ES ES450309A patent/ES450309A1/en not_active Expired
- 1976-07-30 DE DE19762634430 patent/DE2634430A1/en not_active Withdrawn
- 1976-07-30 NO NO762659A patent/NO762659L/no unknown
- 1976-07-30 DD DD194154A patent/DD125205A5/xx unknown
- 1976-07-30 JP JP51092242A patent/JPS5219663A/en active Pending
- 1976-07-30 FI FI762191A patent/FI762191A/fi not_active Application Discontinuation
- 1976-07-30 HU HU76SI1532A patent/HU174068B/en unknown
- 1976-07-31 RO RO87167A patent/RO72312B/en unknown
- 1976-07-31 OA OA55903A patent/OA05405A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| LU75495A1 (en) | 1977-03-03 |
| BE843840A (en) | 1977-01-06 |
| FR2319341A1 (en) | 1977-02-25 |
| GR61114B (en) | 1978-09-13 |
| AT356668B (en) | 1980-05-12 |
| PH13417A (en) | 1980-03-30 |
| AU1644776A (en) | 1978-02-02 |
| NL7608505A (en) | 1977-02-02 |
| DE2634430A1 (en) | 1977-02-10 |
| PT65377A (en) | 1976-08-01 |
| AR213100A1 (en) | 1978-12-15 |
| CA1075702A (en) | 1980-04-15 |
| PT65377B (en) | 1978-01-19 |
| ZA763686B (en) | 1977-05-25 |
| FI762191A (en) | 1977-02-01 |
| SU655310A3 (en) | 1979-03-30 |
| HU174068B (en) | 1979-10-28 |
| NO762659L (en) | 1977-02-01 |
| FR2319341B1 (en) | 1979-01-12 |
| SE7608478L (en) | 1977-02-01 |
| CS203054B2 (en) | 1981-02-27 |
| IL50006A0 (en) | 1976-09-30 |
| DK316376A (en) | 1977-02-01 |
| GB1565647A (en) | 1980-04-23 |
| DD125205A5 (en) | 1977-04-06 |
| RO72312A (en) | 1984-03-15 |
| RO72312B (en) | 1984-03-31 |
| AU508262B2 (en) | 1980-03-13 |
| ZM9676A1 (en) | 1977-07-21 |
| JPS5219663A (en) | 1977-02-15 |
| OA05405A (en) | 1981-02-28 |
| ATA552376A (en) | 1979-10-15 |
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