JPS56161388A - Novel vincamine derivative - Google Patents
Novel vincamine derivativeInfo
- Publication number
- JPS56161388A JPS56161388A JP6577480A JP6577480A JPS56161388A JP S56161388 A JPS56161388 A JP S56161388A JP 6577480 A JP6577480 A JP 6577480A JP 6577480 A JP6577480 A JP 6577480A JP S56161388 A JPS56161388 A JP S56161388A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- vincamine
- alkyl
- novel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- RXPRRQLKFXBCSJ-GIVPXCGWSA-N vincamine Chemical class C1=CC=C2C(CCN3CCC4)=C5[C@@H]3[C@]4(CC)C[C@](O)(C(=O)OC)N5C2=C1 RXPRRQLKFXBCSJ-GIVPXCGWSA-N 0.000 title abstract 4
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 230000002490 cerebral effect Effects 0.000 abstract 2
- 206010003210 Arteriosclerosis Diseases 0.000 abstract 1
- 206010008190 Cerebrovascular accident Diseases 0.000 abstract 1
- 108090000371 Esterases Proteins 0.000 abstract 1
- 206010019233 Headaches Diseases 0.000 abstract 1
- 208000006011 Stroke Diseases 0.000 abstract 1
- -1 Thioethyl ester Chemical class 0.000 abstract 1
- UXMCFEBDJVHVNH-HOJAQTOUSA-N ac1l52id Chemical compound C1=CC=C2C(CCN3CCC4)=C5[C@@H]3[C@]4(CC)C[C@](O)(C(O)=O)N5C2=C1 UXMCFEBDJVHVNH-HOJAQTOUSA-N 0.000 abstract 1
- 208000011775 arteriosclerosis disease Diseases 0.000 abstract 1
- 238000001816 cooling Methods 0.000 abstract 1
- 230000003247 decreasing effect Effects 0.000 abstract 1
- 208000002173 dizziness Diseases 0.000 abstract 1
- RXPRRQLKFXBCSJ-UHFFFAOYSA-N dl-Vincamin Natural products C1=CC=C2C(CCN3CCC4)=C5C3C4(CC)CC(O)(C(=O)OC)N5C2=C1 RXPRRQLKFXBCSJ-UHFFFAOYSA-N 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 231100000869 headache Toxicity 0.000 abstract 1
- 230000002440 hepatic effect Effects 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 230000004060 metabolic process Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
- 229960002726 vincamine Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D461/00—Heterocyclic compounds containing indolo [3,2,1-d,e] pyrido [3,2,1,j] [1,5]-naphthyridine ring systems, e.g. vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Saccharide Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP6577480A JPS56161388A (en) | 1980-05-16 | 1980-05-16 | Novel vincamine derivative |
| US06/261,977 US4364947A (en) | 1980-05-16 | 1981-05-08 | Vincamine derivatives useful as cerebral metabolic and circulatory regulators |
| AT81302119T ATE4717T1 (de) | 1980-05-16 | 1981-05-13 | Vincaminderivate, ihre herstellung und sie enthaltende pharmazeutische zusammensetzungen. |
| DE8181302119T DE3160940D1 (en) | 1980-05-16 | 1981-05-13 | New vincamine derivatives, their production and pharmaceutical compositions containing them |
| EP81302119A EP0040507B1 (en) | 1980-05-16 | 1981-05-13 | New vincamine derivatives, their production and pharmaceutical compositions containing them |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP6577480A JPS56161388A (en) | 1980-05-16 | 1980-05-16 | Novel vincamine derivative |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS56161388A true JPS56161388A (en) | 1981-12-11 |
| JPH0128034B2 JPH0128034B2 (enrdf_load_stackoverflow) | 1989-05-31 |
Family
ID=13296705
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP6577480A Granted JPS56161388A (en) | 1980-05-16 | 1980-05-16 | Novel vincamine derivative |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US4364947A (enrdf_load_stackoverflow) |
| EP (1) | EP0040507B1 (enrdf_load_stackoverflow) |
| JP (1) | JPS56161388A (enrdf_load_stackoverflow) |
| AT (1) | ATE4717T1 (enrdf_load_stackoverflow) |
| DE (1) | DE3160940D1 (enrdf_load_stackoverflow) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5795575A (en) * | 1994-05-06 | 1998-08-18 | Indena S.P.A. | Topical medicament which increases the number of capillaries in damaged skin |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2703019A1 (en) | 2007-09-20 | 2009-03-26 | University Of Rochester | Method and compositions for treatment or prevention of inflammatory conditions |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE790837A (fr) | 1971-11-03 | 1973-02-15 | Richter Gedeon Vegeon Vegyesze | Nouveaux esters alcaloides utiles comme vasodilatateurs cerebraux et leur procede de preparation |
| FR2253502A1 (en) * | 1973-12-07 | 1975-07-04 | Synthelabo | 14,15-Dihydro eburnamenine-14-thione - by treatment of 14,15-dihydro eburnamenine-14-one with a phosphorus sulphide |
| FR2259612B1 (enrdf_load_stackoverflow) | 1974-01-31 | 1977-09-09 | Synthelabo | |
| DE2538095A1 (de) | 1974-09-06 | 1976-03-25 | Sandoz Ag | Neue organische verbindungen, ihre herstellung und verwendung |
| US4123535A (en) * | 1974-09-06 | 1978-10-31 | Sandoz Ltd. | Psychostimulating 14-amino-14,15-dihydroeburnamenines |
-
1980
- 1980-05-16 JP JP6577480A patent/JPS56161388A/ja active Granted
-
1981
- 1981-05-08 US US06/261,977 patent/US4364947A/en not_active Expired - Fee Related
- 1981-05-13 EP EP81302119A patent/EP0040507B1/en not_active Expired
- 1981-05-13 AT AT81302119T patent/ATE4717T1/de not_active IP Right Cessation
- 1981-05-13 DE DE8181302119T patent/DE3160940D1/de not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5795575A (en) * | 1994-05-06 | 1998-08-18 | Indena S.P.A. | Topical medicament which increases the number of capillaries in damaged skin |
Also Published As
| Publication number | Publication date |
|---|---|
| EP0040507B1 (en) | 1983-09-21 |
| DE3160940D1 (en) | 1983-10-27 |
| EP0040507A1 (en) | 1981-11-25 |
| US4364947A (en) | 1982-12-21 |
| JPH0128034B2 (enrdf_load_stackoverflow) | 1989-05-31 |
| ATE4717T1 (de) | 1983-10-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JPS5278848A (en) | Preparation of novel propionic acid ester derivatives | |
| JPS57109787A (en) | Pyrazoloindazole derivative | |
| JPS56161388A (en) | Novel vincamine derivative | |
| JPS57108072A (en) | Preparation of n-acylcarnosine | |
| JPS5711981A (en) | Theobromine derivative and its preparation | |
| AU665980B2 (en) | Process for producing prostaglandin E | |
| JPS57142926A (en) | Preparation of difluoroethene derivative | |
| JPS54109974A (en) | Novel imidazolecarboxylic ester derivative | |
| JPS5699480A (en) | Preparation of pyridopyrimidine derivative | |
| JPS57126427A (en) | Preparation of 1-substituted-azulene derivative | |
| JPS51136649A (en) | Process for preparation of substituted cyclopropanecarboxylic acid est ers | |
| JPS5589245A (en) | 9,10-dihydroanthracene-2-alkanoic acid derivative | |
| JPS5721371A (en) | Quinolinoneiminecarboxylic ester derivative, its preparation and anti-inflammatory and analgesic agent composition containing the same | |
| JPS5217441A (en) | Process for preparation of p-cyanophenylester of 4-substituted- benzoi c acid | |
| JPS56164144A (en) | Preparation of novel aryloxyacid derivative | |
| JPS5772963A (en) | Alpha-(2-pyridyl)arylacetaldehyde | |
| JPS57131792A (en) | Novel 2-oxabicyclo(2.2.2)octan-3-one derivative | |
| JPS55105643A (en) | Novel cyclohexanecarboxylic acid derivative | |
| JPS5543027A (en) | 2-pyridyl-1-phthalazone derivative | |
| JPS57144254A (en) | 2-substituted-2-oxoazetidine derivative and its preparation | |
| JPS56120681A (en) | Preparation of (z)-8-nonen-5-one derivative | |
| JPS5612393A (en) | Novel camptothecin derivative | |
| JPS5555168A (en) | Novel 4-carboxy-2-phenyl-1-phthalazone derivative | |
| JPS5257127A (en) | Process for hexyne-3-ol-1 | |
| JPS5569535A (en) | Preparation of dihydro-coenzyme q analog compound |