JPS56147767A - Novel preparation of pindolol - Google Patents

Novel preparation of pindolol

Info

Publication number
JPS56147767A
JPS56147767A JP4985680A JP4985680A JPS56147767A JP S56147767 A JPS56147767 A JP S56147767A JP 4985680 A JP4985680 A JP 4985680A JP 4985680 A JP4985680 A JP 4985680A JP S56147767 A JPS56147767 A JP S56147767A
Authority
JP
Japan
Prior art keywords
formula
pindolol
isopropylcarbamate
hydroxyindole
dichloropropyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP4985680A
Other languages
Japanese (ja)
Inventor
Dotaro Fujimoto
Takeshi Sakai
Takahide Oida
Giichi Funatsukuri
Toshimitsu Shigeari
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujimoto Pharmaceutical Corp
Original Assignee
Fujimoto Pharmaceutical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujimoto Pharmaceutical Corp filed Critical Fujimoto Pharmaceutical Corp
Priority to JP4985680A priority Critical patent/JPS56147767A/en
Publication of JPS56147767A publication Critical patent/JPS56147767A/en
Pending legal-status Critical Current

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

PURPOSE: To obtain the titled compound useful as a remedy for extrasystolic abnormality advantageously from stoichiometric amount of raw material compounds, by condensing 1,3-dichloropropyl N-isopropylcarbamate with 4-hydroxyindole, and hydrolyzing the resultant condensate with an alkali.
CONSTITUTION: 1,3-Dichloropropyl N-isopropylcarbamate of formula II is condensed with 4-hydroxyindole of formula I in the presence of a basic condensing agent, e.g. K2CO3, in the atmosphere of an inert gas in a dehydrated inert solvent, at a temperature of preferably 80W160°C to give a crude reaction product containing a compound of formula III, which is then hydrolyzed under alkaline conditions to afford pindolol (common name) of formula IV having a β-acceptor protecting and a hypotensive effects advantageously without causing side reactions.
COPYRIGHT: (C)1981,JPO&Japio
JP4985680A 1980-04-15 1980-04-15 Novel preparation of pindolol Pending JPS56147767A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP4985680A JPS56147767A (en) 1980-04-15 1980-04-15 Novel preparation of pindolol

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP4985680A JPS56147767A (en) 1980-04-15 1980-04-15 Novel preparation of pindolol

Publications (1)

Publication Number Publication Date
JPS56147767A true JPS56147767A (en) 1981-11-16

Family

ID=12842689

Family Applications (1)

Application Number Title Priority Date Filing Date
JP4985680A Pending JPS56147767A (en) 1980-04-15 1980-04-15 Novel preparation of pindolol

Country Status (1)

Country Link
JP (1) JPS56147767A (en)

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