JPS56147767A - Novel preparation of pindolol - Google Patents
Novel preparation of pindololInfo
- Publication number
- JPS56147767A JPS56147767A JP4985680A JP4985680A JPS56147767A JP S56147767 A JPS56147767 A JP S56147767A JP 4985680 A JP4985680 A JP 4985680A JP 4985680 A JP4985680 A JP 4985680A JP S56147767 A JPS56147767 A JP S56147767A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- pindolol
- isopropylcarbamate
- hydroxyindole
- dichloropropyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
Abstract
PURPOSE: To obtain the titled compound useful as a remedy for extrasystolic abnormality advantageously from stoichiometric amount of raw material compounds, by condensing 1,3-dichloropropyl N-isopropylcarbamate with 4-hydroxyindole, and hydrolyzing the resultant condensate with an alkali.
CONSTITUTION: 1,3-Dichloropropyl N-isopropylcarbamate of formula II is condensed with 4-hydroxyindole of formula I in the presence of a basic condensing agent, e.g. K2CO3, in the atmosphere of an inert gas in a dehydrated inert solvent, at a temperature of preferably 80W160°C to give a crude reaction product containing a compound of formula III, which is then hydrolyzed under alkaline conditions to afford pindolol (common name) of formula IV having a β-acceptor protecting and a hypotensive effects advantageously without causing side reactions.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4985680A JPS56147767A (en) | 1980-04-15 | 1980-04-15 | Novel preparation of pindolol |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4985680A JPS56147767A (en) | 1980-04-15 | 1980-04-15 | Novel preparation of pindolol |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS56147767A true JPS56147767A (en) | 1981-11-16 |
Family
ID=12842689
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP4985680A Pending JPS56147767A (en) | 1980-04-15 | 1980-04-15 | Novel preparation of pindolol |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS56147767A (en) |
-
1980
- 1980-04-15 JP JP4985680A patent/JPS56147767A/en active Pending
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