JPS5683471A - Novel preparation of pindolol - Google Patents
Novel preparation of pindololInfo
- Publication number
- JPS5683471A JPS5683471A JP16018379A JP16018379A JPS5683471A JP S5683471 A JPS5683471 A JP S5683471A JP 16018379 A JP16018379 A JP 16018379A JP 16018379 A JP16018379 A JP 16018379A JP S5683471 A JPS5683471 A JP S5683471A
- Authority
- JP
- Japan
- Prior art keywords
- condensing
- formula
- pindolol
- hydroxyindole
- oxazolidinone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
Abstract
PURPOSE: To obtain the titled compound such as a hypotensive agent in high yield, by condensing 4-hydroxyindole with a specific oxazolidinone in the presence of an aromatic hydrocarbon as a condensing solvent and an alkali carbonate as a condensing agent, and hydrolyzing the condensate.
CONSTITUTION: 4-Hydroxyindole of formula I is condensed with 3-isopropyl-5- chloromethyl-2-oxazolidinone of formula II, and the resultant reaction product is hydrolyzed to give 4-(2-hydroxy-3-isopropylamino-propoxy)-indole (common name: pindolol) of formula III. In the condensation, an aromatic hydrocarbon, e.g. xylene or mesitylene, is used as a condensing solvent, and an alkali carbonate e.g. sodium carbonate or potassium hydrogencarbonate, is used as a condensing agent.
USE: A remedy for premature beat disorder.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP16018379A JPS5683471A (en) | 1979-12-10 | 1979-12-10 | Novel preparation of pindolol |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP16018379A JPS5683471A (en) | 1979-12-10 | 1979-12-10 | Novel preparation of pindolol |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5683471A true JPS5683471A (en) | 1981-07-08 |
Family
ID=15709615
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP16018379A Pending JPS5683471A (en) | 1979-12-10 | 1979-12-10 | Novel preparation of pindolol |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5683471A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS577465A (en) * | 1980-06-13 | 1982-01-14 | Paamakemu Asia:Kk | Preparation of indole derivative |
-
1979
- 1979-12-10 JP JP16018379A patent/JPS5683471A/en active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS577465A (en) * | 1980-06-13 | 1982-01-14 | Paamakemu Asia:Kk | Preparation of indole derivative |
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