JPS5683471A - Novel preparation of pindolol - Google Patents

Novel preparation of pindolol

Info

Publication number
JPS5683471A
JPS5683471A JP16018379A JP16018379A JPS5683471A JP S5683471 A JPS5683471 A JP S5683471A JP 16018379 A JP16018379 A JP 16018379A JP 16018379 A JP16018379 A JP 16018379A JP S5683471 A JPS5683471 A JP S5683471A
Authority
JP
Japan
Prior art keywords
condensing
formula
pindolol
hydroxyindole
oxazolidinone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP16018379A
Other languages
Japanese (ja)
Inventor
Dotaro Fujimoto
Giichi Funatsukuri
Toshimitsu Shigeari
Ryuichi Fukui
Takahide Oida
Koichi Seki
Shuhei Takamatsu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujimoto Pharmaceutical Corp
Original Assignee
Fujimoto Pharmaceutical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujimoto Pharmaceutical Corp filed Critical Fujimoto Pharmaceutical Corp
Priority to JP16018379A priority Critical patent/JPS5683471A/en
Publication of JPS5683471A publication Critical patent/JPS5683471A/en
Pending legal-status Critical Current

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

PURPOSE: To obtain the titled compound such as a hypotensive agent in high yield, by condensing 4-hydroxyindole with a specific oxazolidinone in the presence of an aromatic hydrocarbon as a condensing solvent and an alkali carbonate as a condensing agent, and hydrolyzing the condensate.
CONSTITUTION: 4-Hydroxyindole of formula I is condensed with 3-isopropyl-5- chloromethyl-2-oxazolidinone of formula II, and the resultant reaction product is hydrolyzed to give 4-(2-hydroxy-3-isopropylamino-propoxy)-indole (common name: pindolol) of formula III. In the condensation, an aromatic hydrocarbon, e.g. xylene or mesitylene, is used as a condensing solvent, and an alkali carbonate e.g. sodium carbonate or potassium hydrogencarbonate, is used as a condensing agent.
USE: A remedy for premature beat disorder.
COPYRIGHT: (C)1981,JPO&Japio
JP16018379A 1979-12-10 1979-12-10 Novel preparation of pindolol Pending JPS5683471A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP16018379A JPS5683471A (en) 1979-12-10 1979-12-10 Novel preparation of pindolol

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP16018379A JPS5683471A (en) 1979-12-10 1979-12-10 Novel preparation of pindolol

Publications (1)

Publication Number Publication Date
JPS5683471A true JPS5683471A (en) 1981-07-08

Family

ID=15709615

Family Applications (1)

Application Number Title Priority Date Filing Date
JP16018379A Pending JPS5683471A (en) 1979-12-10 1979-12-10 Novel preparation of pindolol

Country Status (1)

Country Link
JP (1) JPS5683471A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS577465A (en) * 1980-06-13 1982-01-14 Paamakemu Asia:Kk Preparation of indole derivative

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS577465A (en) * 1980-06-13 1982-01-14 Paamakemu Asia:Kk Preparation of indole derivative

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