JPS56135452A - Manufacture of insulin ester - Google Patents
Manufacture of insulin esterInfo
- Publication number
- JPS56135452A JPS56135452A JP1758081A JP1758081A JPS56135452A JP S56135452 A JPS56135452 A JP S56135452A JP 1758081 A JP1758081 A JP 1758081A JP 1758081 A JP1758081 A JP 1758081A JP S56135452 A JPS56135452 A JP S56135452A
- Authority
- JP
- Japan
- Prior art keywords
- manufacture
- insulin ester
- insulin
- ester
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000004877 Insulin Human genes 0.000 title 1
- 108090001061 Insulin Proteins 0.000 title 1
- 229940125396 insulin Drugs 0.000 title 1
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Substances N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title 1
- -1 insulin ester Chemical class 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Toxicology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Forklifts And Lifting Vehicles (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK57480A DK147109C (da) | 1980-02-11 | 1980-02-11 | Fremgangsmaade til fremstilling af humant insulin eller humane insulinestere eller et salt eller kompleks deraf |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS56135452A true JPS56135452A (en) | 1981-10-22 |
| JPH0211240B2 JPH0211240B2 (enrdf_load_stackoverflow) | 1990-03-13 |
Family
ID=8095095
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP1758081A Granted JPS56135452A (en) | 1980-02-11 | 1981-02-10 | Manufacture of insulin ester |
Country Status (19)
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58190398A (ja) * | 1982-03-13 | 1983-11-07 | ヘキスト・アクチエンゲゼルシヤフト | インシユリンへのプレプロインシユリン類似体の変換法 |
| JPS6094999A (ja) * | 1983-09-23 | 1985-05-28 | ヘキスト・アクチエンゲゼルシヤフト | インシユリン誘導体およびその製法 |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK147437A (en) | 1980-02-11 | 1900-01-01 | Process for preparing human insulin or threonine B30 esters of human insulin, or a salt or complex thereof | |
| DE3101382A1 (de) * | 1981-01-17 | 1982-09-02 | Hoechst Ag, 6000 Frankfurt | "verfahren zur herstellung von humanisulin oder dessen derivaten aus schweineinsulin oder dessen derivaten" |
| CA1174623A (en) * | 1981-09-15 | 1984-09-18 | Finn H. Andresen | Process for preparing human insulin or b-30 esters thereof |
| DK149824C (da) * | 1982-01-22 | 1987-03-16 | Carlsberg Biotechnology Ltd | Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyrer i insuliner |
| EP0087238A1 (en) * | 1982-02-08 | 1983-08-31 | Biogen N.V. | Am improved method for preparing human insulin from non-human insulin |
| NL8201650A (nl) * | 1982-04-21 | 1983-11-16 | Akzo Nv | Semisynthetische bereiding van humane insuline. |
| DK182483A (da) * | 1982-04-23 | 1983-10-24 | Wako Pure Chem Ind Ltd | Fremgangsmaade til semi-syntese af humant insulin og alkalisk protease til anvendelse derved |
| DK55183D0 (da) * | 1983-02-09 | 1983-02-09 | Nordisk Insulinlab | Fremgangsmade til fremstilling af human insulin |
| DK119785D0 (da) * | 1985-03-15 | 1985-03-15 | Nordisk Gentofte | Insulinpraeparat |
| US5157021A (en) * | 1985-03-15 | 1992-10-20 | Novo Nordisk A/S | Insulin derivatives and pharmaceutical preparations containing these derivatives |
| SE449472B (sv) * | 1985-10-15 | 1987-05-04 | Mth Gruppen Ab | Utrustning vid facklager |
| AU612141B2 (en) * | 1987-02-25 | 1991-07-04 | Novo Nordisk A/S | Novel insulin derivatives |
| DK134189D0 (da) * | 1989-03-20 | 1989-03-20 | Nordisk Gentofte | Insulinforbindelser |
| FI96503C (fi) * | 1994-08-26 | 1996-07-10 | Hymatic Ltd Oy | Menetelmä ja laitteisto maston ohjaamiseksi |
| WO2005072803A1 (en) | 2004-01-16 | 2005-08-11 | Biodel, Inc. | Sublingual drug delivery device |
| US20080090753A1 (en) | 2004-03-12 | 2008-04-17 | Biodel, Inc. | Rapid Acting Injectable Insulin Compositions |
| US7713929B2 (en) | 2006-04-12 | 2010-05-11 | Biodel Inc. | Rapid acting and long acting insulin combination formulations |
| US8084420B2 (en) | 2005-09-29 | 2011-12-27 | Biodel Inc. | Rapid acting and long acting insulin combination formulations |
| JP2009533471A (ja) | 2006-04-12 | 2009-09-17 | バイオデル， インコーポレイテッド | 即効型および長時間作用型組合せインスリン製剤 |
| US9060927B2 (en) | 2009-03-03 | 2015-06-23 | Biodel Inc. | Insulin formulations for rapid uptake |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3064479D1 (en) * | 1979-04-13 | 1983-09-08 | Shionogi & Co | Process for preparing a b30-threonine insulin |
| DK147437A (en) | 1980-02-11 | 1900-01-01 | Process for preparing human insulin or threonine B30 esters of human insulin, or a salt or complex thereof | |
| DE3101382A1 (de) * | 1981-01-17 | 1982-09-02 | Hoechst Ag, 6000 Frankfurt | "verfahren zur herstellung von humanisulin oder dessen derivaten aus schweineinsulin oder dessen derivaten" |
-
0
- DK DK147437D patent/DK147437A/da unknown
-
1980
- 1980-02-11 DK DK57480A patent/DK147109C/da not_active IP Right Cessation
-
1981
- 1981-02-09 ES ES499238A patent/ES499238A0/es active Granted
- 1981-02-09 DK DK54081A patent/DK147437C/da not_active IP Right Cessation
- 1981-02-10 FI FI810385A patent/FI77876C/fi not_active IP Right Cessation
- 1981-02-10 SE SE8100928A patent/SE451143B/sv not_active IP Right Cessation
- 1981-02-10 JP JP1758081A patent/JPS56135452A/ja active Granted
- 1981-02-10 GB GB8104114A patent/GB2069502B/en not_active Expired
- 1981-02-10 PT PT72485A patent/PT72485B/pt not_active IP Right Cessation
- 1981-02-10 SE SE8100926A patent/SE427025B/sv not_active IP Right Cessation
- 1981-02-10 NZ NZ196224A patent/NZ196224A/en unknown
- 1981-02-10 CA CA000370483A patent/CA1162868A/en not_active Expired
- 1981-02-10 AR AR284258A patent/AR231277A1/es active
- 1981-02-10 NO NO810443A patent/NO156247C/no unknown
- 1981-02-10 NL NLAANVRAGE8100624,A patent/NL178797C/xx not_active IP Right Cessation
- 1981-02-10 IT IT19620/81A patent/IT1195038B/it active
- 1981-02-11 BE BE6/47396A patent/BE887480A/fr not_active IP Right Cessation
- 1981-02-11 CH CH910/81A patent/CH655949A5/de not_active IP Right Cessation
- 1981-02-11 DE DE3104949A patent/DE3104949C2/de not_active Expired
- 1981-02-11 GR GR64097A patent/GR73844B/el unknown
- 1981-02-11 AU AU67180/81A patent/AU541528B2/en not_active Ceased
- 1981-02-11 ZA ZA00810898A patent/ZA81898B/xx unknown
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58190398A (ja) * | 1982-03-13 | 1983-11-07 | ヘキスト・アクチエンゲゼルシヤフト | インシユリンへのプレプロインシユリン類似体の変換法 |
| JPS6094999A (ja) * | 1983-09-23 | 1985-05-28 | ヘキスト・アクチエンゲゼルシヤフト | インシユリン誘導体およびその製法 |
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