JPS5545700A - 55*44pyridyl**66*44fluorophenyl**2*33 dihydroimidazo*2*11b*thiazole and its manufacture and use - Google Patents

55*44pyridyl**66*44fluorophenyl**2*33 dihydroimidazo*2*11b*thiazole and its manufacture and use

Info

Publication number
JPS5545700A
JPS5545700A JP12524079A JP12524079A JPS5545700A JP S5545700 A JPS5545700 A JP S5545700A JP 12524079 A JP12524079 A JP 12524079A JP 12524079 A JP12524079 A JP 12524079A JP S5545700 A JPS5545700 A JP S5545700A
Authority
JP
Japan
Prior art keywords
dihydroimidazo
thiazole
44pyridyl
manufacture
fluorophenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP12524079A
Other languages
English (en)
Other versions
JPS6157833B2 (ja
Inventor
Eriotsuto Bendaa Pooru
Rantosu Aiban
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GlaxoSmithKline LLC
Original Assignee
SmithKline Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Corp filed Critical SmithKline Corp
Publication of JPS5545700A publication Critical patent/JPS5545700A/ja
Publication of JPS6157833B2 publication Critical patent/JPS6157833B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/46—Oxygen atoms
    • C07D213/50—Ketonic radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
JP12524079A 1978-09-27 1979-09-27 55*44pyridyl**66*44fluorophenyl**2*33 dihydroimidazo*2*11b*thiazole and its manufacture and use Granted JPS5545700A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/946,260 US4175127A (en) 1978-09-27 1978-09-27 Pyridyl substituted 2,3-dihydroimidazo[2,1-b]thiazoles

Publications (2)

Publication Number Publication Date
JPS5545700A true JPS5545700A (en) 1980-03-31
JPS6157833B2 JPS6157833B2 (ja) 1986-12-09

Family

ID=25484215

Family Applications (1)

Application Number Title Priority Date Filing Date
JP12524079A Granted JPS5545700A (en) 1978-09-27 1979-09-27 55*44pyridyl**66*44fluorophenyl**2*33 dihydroimidazo*2*11b*thiazole and its manufacture and use

Country Status (29)

Country Link
US (1) US4175127A (ja)
EP (1) EP0011111B1 (ja)
JP (1) JPS5545700A (ja)
AT (1) ATE1587T1 (ja)
AU (1) AU523815B2 (ja)
CA (1) CA1128947A (ja)
CS (1) CS208153B2 (ja)
DD (1) DD146293A5 (ja)
DE (1) DE2963737D1 (ja)
DK (1) DK146339C (ja)
EG (1) EG14013A (ja)
ES (1) ES484450A1 (ja)
FI (1) FI65435C (ja)
GR (1) GR69989B (ja)
HU (1) HU182595B (ja)
IE (1) IE49077B1 (ja)
IL (1) IL58309A (ja)
IN (1) IN152859B (ja)
IT (1) IT1123753B (ja)
MX (1) MX6186E (ja)
NO (1) NO150839C (ja)
NZ (1) NZ191632A (ja)
PH (1) PH14326A (ja)
PL (1) PL117755B1 (ja)
PT (1) PT70209A (ja)
RO (1) RO77750A (ja)
SU (1) SU940649A3 (ja)
YU (1) YU40761B (ja)
ZA (1) ZA794045B (ja)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62153286A (ja) * 1985-12-12 1987-07-08 スミスクライン・ベツクマン・コ−ポレイシヨン ５−リポキシゲナ−ゼ経路の抑制

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0004648B1 (de) * 1978-04-11 1982-08-25 Ciba-Geigy Ag Neue Mercaptoimidazolderivate, Verfahren zu deren Herstellung, Mercaptoimidazolderivate zur Behandlung entzündlicher Erkrankungen und diese enthaltende pharmazeutische Präparate
FI800004A (fi) * 1979-01-05 1980-07-06 Ciba Geigy Ag Foerfarande foer framstaellning av en ny hoegervridande bicyklisk tiadiazafoerening och dess salter
IL78834A (en) * 1985-05-23 1992-07-15 Smithkline Beckman Corp 2,3-dihydro-5-(1,4-dihydropyridin-4-yl)-6-phenylimidazo(2,1-b)thiazoles and 6,7-dihydro-3-(1,4-dihydropyridin-4-yl)-2-phenyl-5h-imidazo(2,1-b)(1,3)thiazines and their use as intermediates in a process for preparing the corresponding pyridyl-substituted imidazo(2,1-b)thiazoles and 5h-imidazo(2,1-b)(1,3)thiazines
US5008390A (en) * 1985-05-23 1991-04-16 Smithkline Beckman Corporation Compounds for preparing 6-phenyl-2,3-dihydroimidazo[2,1-b]-thiazoles and corresponding thiazines
US4803279A (en) * 1985-05-23 1989-02-07 Smithkline Beckman Corporation 1.4-dihydro-4-pyridyl-substituted imidazo (2,1-b) thiazoles and the corresponding thiazines.
US5002941A (en) * 1985-12-12 1991-03-26 Smithkline Beecham Corporation Pyrrolo(1,2-a)imidazole and imidazo(1,2-a)pyridine derivatives and their use as 5-lipoxygenase pathway inhibitors
US4686231A (en) * 1985-12-12 1987-08-11 Smithkline Beckman Corporation Inhibition of 5-lipoxygenase products
US5134150A (en) * 1985-12-12 1992-07-28 Smithkline Beecham Corporation Inhibition of the 5-lipoxygenase pathway
ZW24186A1 (en) * 1985-12-12 1987-07-08 Smithkline Beckman Corp Inhibition of the 5-lipoxygenase pathway
US4751310A (en) * 1985-12-12 1988-06-14 Smithkline Beckman Corporation Inhibition of the 5-lipoxygenase pathway
US5145858A (en) * 1985-12-12 1992-09-08 Smithkline Beecham Corp. Pyrrolo [1,2-a] imidazole and imidazo [1,2a] pyridine derivatives and their use as 5-lipoxygenase pathway inhibitors
US4794114A (en) * 1986-08-19 1988-12-27 Smithkline Beckman Corporation Inhibition of interleukin-1 production by monocytes and/or macrophages
US4780470A (en) * 1986-08-19 1988-10-25 Smithkline Beckman Corporation Inhibition of interleukin-1 by monocytes and/or macrophages
MY103766A (en) * 1987-09-02 1993-09-30 Smithkline Beckman Corp Pyrrolo[1,2-a]imidazole and imidazo[1,2-a] pyridine derivatives and their use as 5-lipoxygenase pathway inhibitors
AU6355190A (en) * 1989-06-13 1991-01-17 Smithkline Beecham Corporation Inhibition of interleukin-1 and tumor necrosis factor production by monocytes and/or macrophages
US5656644A (en) * 1994-07-20 1997-08-12 Smithkline Beecham Corporation Pyridyl imidazoles
ES2053401B1 (es) * 1992-01-13 1995-03-01 Smithkline Beecham Corp Compuestos de imidazol y procedimientos para su prepacion.
IL104369A0 (en) * 1992-01-13 1993-05-13 Smithkline Beecham Corp Novel compounds and compositions
US5916891A (en) 1992-01-13 1999-06-29 Smithkline Beecham Corporation Pyrimidinyl imidazoles
US5620999A (en) * 1994-07-28 1997-04-15 Weier; Richard M. Benzenesulfonamide subtituted imidazolyl compounds for the treatment of inflammation
US6426360B1 (en) * 1994-07-28 2002-07-30 G D Searle & Co. 4,5-substituted imidazolyl compounds for the treatment of inflammation
US5552422A (en) * 1995-01-11 1996-09-03 Merck Frosst Canada, Inc. Aryl substituted 5,5 fused aromatic nitrogen compounds as anti-inflammatory agents
US6046208A (en) * 1996-01-11 2000-04-04 Smithkline Beecham Corporation Substituted imidazole compounds
US20030050330A1 (en) * 1997-01-10 2003-03-13 G.D. Searle & Co. 4,5-subtstituted imdazolyl compounds for the treatment of inflammation
NZ501714A (en) 1997-06-12 2001-09-28 Rhone Poulenc Rorer Ltd Imidazolyl-cyclic acetal derivatives, resins and intermediates thereof and use as TNF inhibitors
US6040320A (en) * 1997-06-30 2000-03-21 Ortho-Mcneil Pharmaceutical, Inc. 2-substituted imidazoles useful in the treatment of inflammatory diseases
CL2004000366A1 (es) * 2003-02-26 2005-01-07 Pharmacia Corp Sa Organizada B USO DE UNA COMBINACION DE UN COMPUESTO DERIVADO DE PIRAZOL INHIBIDOR DE QUINASA p38, Y UN INHIBIDOR DE ACE PARA TRATAR DISFUNCION RENAL, ENFERMEDAD CARDIOVASCULAR Y VASCULAR, RETINOPATIA, NEUROPATIA, EDEMA, DISFUNCION ENDOTELIAL O INSULINOPATIA.
CN103764655B (zh) * 2011-07-13 2017-04-12 Sk化学公司 作为alk5和／或alk4抑制剂的经2‑吡啶基取代的咪唑

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1488271A (fr) * 1966-03-21 1967-07-13 Chimetron Sarl Nouveaux anthelminthiques imidazothiazoliques
FR1488322A (fr) * 1966-04-28 1967-07-13 Chimetron Sarl Dérivés pyridiniques de l'imidazo [2, 1-b] thiazole
GB1541321A (en) * 1976-03-10 1979-02-28 Metabio 2,3-dihydroimidazo(2,1-b)thiazole derivatives and process for their preparation
US4064260A (en) * 1976-07-29 1977-12-20 E. I. Du Pont De Nemours And Company Anti-inflammatory diarylimidazothiazoles and their corresponding S-oxides
US4263311A (en) * 1976-09-27 1981-04-21 Smithkline Corporation 5,6-Phenyl-2,3-dihydroimidazo [2,1-b] thiazoles
LU77703A1 (de) * 1977-07-07 1979-03-26 Ciba Geigy Ag Verfahren zur herstellung von bicyclischen thia-diaza-verbindungen

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62153286A (ja) * 1985-12-12 1987-07-08 スミスクライン・ベツクマン・コ−ポレイシヨン ５−リポキシゲナ−ゼ経路の抑制

Also Published As

Publication number Publication date
HU182595B (en) 1984-02-28
NO793076L (no) 1980-03-28
DK146339B (da) 1983-09-12
IE791833L (en) 1980-03-27
IN152859B (ja) 1984-04-21
IL58309A0 (en) 1979-12-30
CS208153B2 (en) 1981-08-31
PT70209A (en) 1979-10-01
NO150839B (no) 1984-09-17
IT1123753B (it) 1986-04-30
EP0011111A1 (en) 1980-05-28
DD146293A5 (de) 1981-02-04
CA1128947A (en) 1982-08-03
AU523815B2 (en) 1982-08-19
ZA794045B (en) 1980-09-24
JPS6157833B2 (ja) 1986-12-09
SU940649A3 (ru) 1982-06-30
PH14326A (en) 1981-05-27
EP0011111B1 (en) 1982-09-22
AU5111779A (en) 1980-04-03
YU231679A (en) 1983-01-21
DK400879A (da) 1980-03-28
IL58309A (en) 1984-03-30
PL117755B1 (en) 1981-08-31
MX6186E (es) 1984-12-11
ATE1587T1 (de) 1982-10-15
IE49077B1 (en) 1985-07-24
ES484450A1 (es) 1980-05-16
DK146339C (da) 1984-02-20
PL218526A1 (ja) 1980-06-16
RO77750A (ro) 1981-11-24
NZ191632A (en) 1981-03-16
EG14013A (en) 1983-03-31
YU40761B (en) 1986-06-30
IT7926051A0 (it) 1979-09-27
FI65435C (fi) 1984-05-10
US4175127A (en) 1979-11-20
DE2963737D1 (en) 1982-11-04
NO150839C (no) 1985-01-09
FI65435B (fi) 1984-01-31
FI792969A (fi) 1980-03-28
GR69989B (ja) 1982-07-23

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