JPS55147276A - Thiophenesulfonylhydrazone and its preparation - Google Patents
Thiophenesulfonylhydrazone and its preparationInfo
- Publication number
- JPS55147276A JPS55147276A JP5556279A JP5556279A JPS55147276A JP S55147276 A JPS55147276 A JP S55147276A JP 5556279 A JP5556279 A JP 5556279A JP 5556279 A JP5556279 A JP 5556279A JP S55147276 A JPS55147276 A JP S55147276A
- Authority
- JP
- Japan
- Prior art keywords
- thiophenesulfonylhydrazone
- compound
- lower alkyl
- effective
- agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
NEW MATERIAL:A thiophenesulfonylhydrazone I [R is II (R1 is pyridyl), III or IV; R2 is H, lower alkyl or V (R3 is lower alkyl)].
EXAMPLE: Pyridine-1-oxide-2-carbaldehyde 2-thiophenesulfonylhydrazone.
USE: A carcinostatic substance. It has low toxicity and high antitumor activity. It is effective as a remedy for malignant tumor, e.g. leukemia, sarcoma, cancer, etc.
PROCESS: The compound I is prepared in high yield by reacting a compound R=0, e.g. 2-pyridinecarbaldehyde, etc., with nearly equimolar amount of 2-thiophenesulfonylhydrazide in a solvent, e.g. ethanol, at 1W250°C for 1W10hr under anhydrous condition. A dehydrocondensing agent effective also as a buffer can be used to attain the anhydrous condition. The agent is, e.g. anhydrous sodium acetate, sodium hydrogen carbonate, etc.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP5556279A JPS55147276A (en) | 1979-05-07 | 1979-05-07 | Thiophenesulfonylhydrazone and its preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP5556279A JPS55147276A (en) | 1979-05-07 | 1979-05-07 | Thiophenesulfonylhydrazone and its preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS55147276A true JPS55147276A (en) | 1980-11-17 |
Family
ID=13002135
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP5556279A Pending JPS55147276A (en) | 1979-05-07 | 1979-05-07 | Thiophenesulfonylhydrazone and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS55147276A (en) |
-
1979
- 1979-05-07 JP JP5556279A patent/JPS55147276A/en active Pending
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