JPS5459284A - Novel 2-pyridylimidazole derivative - Google Patents
Novel 2-pyridylimidazole derivativeInfo
- Publication number
- JPS5459284A JPS5459284A JP12499577A JP12499577A JPS5459284A JP S5459284 A JPS5459284 A JP S5459284A JP 12499577 A JP12499577 A JP 12499577A JP 12499577 A JP12499577 A JP 12499577A JP S5459284 A JPS5459284 A JP S5459284A
- Authority
- JP
- Japan
- Prior art keywords
- novel
- imideester
- formula
- imidazole
- low
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Plural Heterocyclic Compounds (AREA)
Abstract
NEW MATERIAL:Imidazole derivatives of formula I.
EXAMPLE: 2-(2'-pyridyl)-5-hydroxy-1H-imidazole-4-carboxyamide.
USE: Carcinostatic agent: the immunosuppression activity is extremely low and the toxicity is also low.
PREPARATION: The reaction of an imideester of formula II (A is iminoethylene with substituents on carbons) and its salt, preferably hydrochloride, with an aminomalonamide is conducted in an organic solvent such as methanol at 0W100°C to form a compound of formla I. The use of a free imideester is preferred in handling and product yield
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (15)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12499577A JPS5459284A (en) | 1977-10-17 | 1977-10-17 | Novel 2-pyridylimidazole derivative |
AU39492/78A AU507066B1 (en) | 1977-09-06 | 1978-09-01 | 2-Substituted-5-Hydroxy-1h-Imidazole 4-Carbozamide Derivatives |
FR7825487A FR2401916A1 (en) | 1977-09-06 | 1978-09-05 | NEW DERIVATIVES OF 5-HYDROXY-1H-IMIDAZOLE-4-CARBOXAMIDE SUBSTITUTED IN POSITION 2, THEIR PRODUCTION PROCESS AND PHARMACEUTICAL COMPOSITION CONTAINING THEM |
CH931278A CH636862A5 (en) | 1977-09-06 | 1978-09-05 | 5-HYDROXY-1H-IMIDAZOLE-4-CARBOXAMIDE DERIVATIVES SUBSTITUTED IN 2-POSITION, THEIR SALTS AND PROCESS FOR THEIR PRODUCTION. |
GB7835686A GB2004544B (en) | 1977-09-06 | 1978-09-05 | 2-substituted 5-hydroxy-1h-imidazole-4-carboxamide derivatives and their preparation and use |
DK392578A DK392578A (en) | 1977-09-06 | 1978-09-05 | PROCEDURE FOR THE PREPARATION OF 2-SUBSTITUTED 5-HYDROXY-1H-IMIDAZOLE-4-CARBOXAMIDE DERIVATIVES OR PHARMACEUTICAL ACCEPTABLE SALTS THEREOF |
NL7809075A NL7809075A (en) | 1977-09-06 | 1978-09-05 | NEW 2-SUBSTITUATED 5-HYDROXY-1H-IMIDAZOLE-4-CARBOXAMIDE DERIVATIVES. |
BE6046598A BE870236A (en) | 1977-09-06 | 1978-09-05 | 5-HYDROXY-1H-IMIDAZOLE-4-CARBOXAMIDE DERIVATIVES SUBSTITUTED IN POSITION 2, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING CZ COMPOUNDS |
AT0640778A AT367412B (en) | 1977-09-06 | 1978-09-05 | METHOD FOR PRODUCING NEW 2-SUBSTITUTED 5-HYDROXY-1H-IMIDAZOLE-4CARBOXAMIDE DERIVATIVES AND THEIR SALTS |
IT69049/78A IT1160633B (en) | 1977-09-06 | 1978-09-05 | 2-SUBSTITUTED DERIVATIVES OF 5-HYDROXY-1H-IMIDAZOL-4-CARBOXAMIDE |
HU78SU989A HU184188B (en) | 1977-09-06 | 1978-09-05 | Process for the preparation of new 2-substituted-5.hydroxy-1h-imidazol-4-carboxamide derivatives |
CA310,576A CA1110623A (en) | 1977-09-06 | 1978-09-05 | 2-substituted 5-hydroxy-1h-imidazole-4-carboxamide derivatives and their preparation and use |
DE19782838892 DE2838892A1 (en) | 1977-09-06 | 1978-09-06 | 2-SUBSTITUTED-5-HYDROXY-1H-IMIDAZOLE-4-CARBOXAMIDE DERIVATIVES, THE PROCESS FOR THEIR MANUFACTURING AND THE PHARMACEUTICAL PRODUCTS CONTAINING THEM |
SE7809373A SE442865B (en) | 1977-09-06 | 1978-09-06 | PHARMACEUTICAL ACTIVE 2-SUBSTITUTED-5-HYDROXY-1H-IMIDAZOLE-4-CARBOXAMIDE DERIVATIVES |
US05/940,131 US4218457A (en) | 1977-09-06 | 1978-09-06 | 2-Substituted 5-hydroxy-1H-imidazole-4-carboxamide derivatives and use |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12499577A JPS5459284A (en) | 1977-10-17 | 1977-10-17 | Novel 2-pyridylimidazole derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5459284A true JPS5459284A (en) | 1979-05-12 |
Family
ID=14899281
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP12499577A Pending JPS5459284A (en) | 1977-09-06 | 1977-10-17 | Novel 2-pyridylimidazole derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5459284A (en) |
-
1977
- 1977-10-17 JP JP12499577A patent/JPS5459284A/en active Pending
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